CN107328949A - A kind of method and device for realizing many parts of spontaneous sequential flowings of liquid - Google Patents
A kind of method and device for realizing many parts of spontaneous sequential flowings of liquid Download PDFInfo
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- CN107328949A CN107328949A CN201710500139.6A CN201710500139A CN107328949A CN 107328949 A CN107328949 A CN 107328949A CN 201710500139 A CN201710500139 A CN 201710500139A CN 107328949 A CN107328949 A CN 107328949A
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- 239000007788 liquid Substances 0.000 title claims abstract description 69
- 238000000034 method Methods 0.000 title claims abstract description 19
- 230000002269 spontaneous effect Effects 0.000 title claims abstract description 18
- 230000000740 bleeding effect Effects 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 3
- 230000004907 flux Effects 0.000 claims description 3
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 3
- 230000035699 permeability Effects 0.000 claims description 3
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 239000007789 gas Substances 0.000 abstract description 11
- 239000000203 mixture Substances 0.000 abstract description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 238000010586 diagram Methods 0.000 description 4
- 238000011282 treatment Methods 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011403 purification operation Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1044—Using pneumatic means
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention provides a kind of method and device for realizing many parts of spontaneous sequential flowings of liquid, the characteristics of this method, is, the inflating pressure first into the system of closed container (3) and connecting tube (4) composition, the internal pressure of system is set to be more than external pressure, then the gas of a part of High Voltage is stopped by the closure of liquid respectively, finally by the turned on outside for converging connection end and system of connecting tube (4), make to form pressure difference between closed container (3) and connecting tube (4), then liquid neous flow in the presence of gases at high pressure, and due to closed container (3) volume it is different when, the runner volume of connecting tube (4) is equal, or during each closed container (3) volume all same, the runner volume of each connecting tube (4) is each unequal, so the time for converging connection end that each part liquid reaches connecting tube (4) is different, so as to realize the sequential flowing of many parts of liquid.
Description
Technical field
The present invention relates to microfluidic art, more particularly to a kind of method for realizing many parts of spontaneous sequential flowings of liquid
And device.
Background technology
In biological and chemical field, the operation purified to certain material is frequently encountered, is generally required in purification
Plurality of liquid (reagent treatment) is handled sample to be purified successively.At present, above-mentioned purification operations need artificial one time one
Different reagent treatments are separately added into sample secondaryly, the reagent adding operation repeated occupies people's substantial amounts of working time,
Have a strong impact on operating efficiency.
Therefore, how to realize that plurality of reagents is added to the order successively of sample by simpler operation, to save labor
Dynamic time, raising operating efficiency, become those skilled in the art's technical problem urgently to be resolved hurrily.
The content of the invention
In view of this, the invention provides a kind of method and device for realizing many parts of spontaneous sequential flowings of liquid, this method
With device workman can be made to realize that plurality of reagents is added to the order successively of sample by simpler operation, so as to effectively save
Working time is saved, operating efficiency is improved.
In order to achieve the above object, the present invention provides following technical scheme：
A kind of method for realizing many parts of spontaneous sequential flowings of liquid, including：
Multiple closed containers with the number respective amount of many parts of liquid are taken, are located at respectively not per a liquid
In the same closed container；
Multiple connecting tubes with the number respective amount of many parts of liquid are taken, when the volume of multiple closed containers is each
When differing, multiple connecting tubes are taken as that runner volume is equal, many when the volume all same of multiple closed containers
The individual connecting tube is taken as that runner volume is each unequal, and connection is converged in one end of multiple connecting tubes, the other end respectively with not
Same closed container connection；
Adjusting the position of the closed container, the liquid in each described closed container is not blocked described closed
Container and the interface of the connecting tube, into the system of multiple closed containers and multiple connecting tube compositions, inflation adds
Pressure, makes the internal pressure of the system be more than external pressure；
Adjusting the position of the closed container again, the liquid in each described closed container is blocked described close
Close the interface of container and the connecting tube；
The connecting tube is converged into connection end and the turned on outside of the system, the volume of each closed container is protected
Hold constant, liquid described in the gas push in the closed container flows to the connection end of converging of the connecting tube.
Preferably, in the above-mentioned methods, to be taken as volume different for multiple closed containers, by adjusting described in each
Volume fraction between closed container adjusts the order for converging connection end that the liquid flows to the connecting tube.
Preferably, in the above-mentioned methods, to be taken as volume identical for multiple closed containers, by adjusting each connection
Length ratio between pipe adjusts the order for converging connection end that the liquid flows to the connecting tube.
A kind of device for realizing many parts of spontaneous sequential flowings of liquid, including：
With multiple closed containers of the number respective amount of many parts of liquid, the closed container is used to place each respectively
Part liquid；
With multiple connecting tubes of the number respective amount of many parts of liquid, company is converged in one end of multiple connecting tubes
Logical, the other end is connected from the different closed containers respectively, and the volume of multiple closed containers is different, and multiple institutes
State that connecting tube runner volume is equal, or multiple closed containers volume all same, and multiple connecting tube runners
Volume is each unequal；
Pressurizer, the pressurizer is used to fill into the system of multiple closed containers and multiple connecting tube compositions
Gas pressurizes.
Preferably, in said apparatus, the connection end of converging of the connecting tube is connected with one end of microchannel, the micro-pipe
The other end in road is communicated with air bleeding valve.
Preferably, in said apparatus, the air bleeding valve is permeability cell or the adjustable air bleeding valve of gas flux.
Preferably, in said apparatus, the connection end of converging of the connecting tube is connected with one end of microchannel, the micro-pipe
Road is the silicone tube being made up of poromeric material.
Preferably, in said apparatus, the microchannel is PDMS chips.
Preferably, in said apparatus, the microchannel is non-breathable pipeline or non-breathable chip.
Preferably, in said apparatus, the closed container and/or the pressurizer are syringe.
It is first in the method for realizing many parts of spontaneous sequential flowings of liquid that the present invention is provided it can be seen from above-mentioned technical proposal
First the inflating pressure into the system of closed container and connecting tube composition, makes the internal pressure of system be more than external pressure, Ran Houtong
The closure for crossing liquid stops the gas of a part of High Voltage respectively, finally leads the outside for converging connection end and system of connecting tube
It is logical, make to form pressure difference between closed container and connecting tube, then liquid neous flow in the presence of gases at high pressure, and due to each
When individual closed container volume is different, the runner volume of each connecting tube is equal, or each closed container volume is homogeneous
Meanwhile, the runner volume of each connecting tube is each unequal, so each part liquid reaches the time for converging connection end of connecting tube not
Together, so as to realize the sequential flowing of many parts of liquid.In summary, the method that provides of the present invention can realize the spontaneous of many parts of liquid
Sequential flowing, therefore only need once-through operation that successively order addition of the plurality of reagents to sample can be achieved, when reaching saving work
Between, improve operating efficiency purpose.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is the accompanying drawing used required in technology description to be briefly described, it should be apparent that, drawings in the following description are only this
The embodiment of invention, for those of ordinary skill in the art, on the premise of not paying creative work, can also basis
The accompanying drawing of offer obtains other accompanying drawings.
Fig. 1 is a kind of schematic diagram for device for realizing many parts of spontaneous sequential flowings of liquid that the embodiment of the present invention one is provided；
Fig. 2 is Fig. 1 experimental result schematic diagram；
Fig. 3 is a kind of schematic diagram for device for realizing many parts of spontaneous sequential flowings of liquid that the embodiment of the present invention two is provided；
Fig. 4 is Fig. 3 experimental result schematic diagram.
Marked in figure：
1st, pressurizer；2nd, gas-adding pipe；21st, intake valve；3rd, closed container；4th, connecting tube；5th, microchannel.
Embodiment
In order to make it easy to understand, the invention will be further described below in conjunction with the accompanying drawings.
It it is a kind of showing for device for realizing many parts of spontaneous sequential flowings of liquid that the embodiment of the present invention one is provided referring to Fig. 1
It is intended to, the device includes pressurizer 1, closed container 3 and connecting tube 4, wherein, the quantity of closed container 3 and part of many parts of liquid
Number correspondence, closed container 3 is used to place each part liquid respectively, and the volume of multiple closed containers 3 is different；The number of connecting tube 4
The number measured also with many parts of liquid is corresponding, and the runner volume of multiple connecting tubes 4 is equal, and company is converged in one end of multiple connecting tubes 4
Logical, the other end is connected from different closed containers 3 respectively；Pressurizer 1 is used for 4 groups of multiple closed containers 3 and multiple connecting tubes
Into system in inflating pressure.
In embodiment one, pressurizer 1 and closed container 3 are syringe, specifically, pressurization are used as using 20ml syringe
Three closed containers 3 are connected by device 1, three 5ml syringes as closed container 3 by gas-adding pipe 2 with pressurizer 1, gas-adding pipe
2 have intake valve 21 close to the position of closed container 3.Three closed containers 3 are fixed to 1ml, 3ml and 5ml position respectively,
And 100 microlitres of blue ink a, red ink b and green ink c are injected separately into three closed containers 3.Closed container 3
End and runner volume equal connecting tube 4 are connected, and three connecting tubes 4 are connected by four-way pipe with microchannel 5, micro-tube
5 end is connected with air bleeding valve (unmarked in figure).
After finishing device assembling, the air bleeding valve of the end of micro-tube 5 is closed, intake valve 21 is opened, by three closed containers 3
Keep flat, ink is not blocked the outlet of closed container 3.Pressurizer 1 is shifted onto 5ml positions and fixation by 20ml positions, close into
Air valve 21, closed container 3 is placed vertically, blocks ink initial inside the outlet of closed container 3, three closed containers 3
Pressure is equal.The slow air bleeding valve for opening the end of microchannel 5, it can be seen that result as shown in Figure 2, as shown in Figure 2, inner bulk
Ink corresponding to the maximum closed container 3 of product flows out at first, and the ink in the small closed container 3 of other internal volumes is then successively
Outflow.
It it is a kind of showing for device for realizing many parts of spontaneous sequential flowings of liquid that the embodiment of the present invention two is provided referring to Fig. 3
It is intended to, the device includes pressurizer 1, closed container 3 and connecting tube 4, wherein, the quantity of closed container 3 and part of many parts of liquid
Number correspondence, closed container 3 is used to place each part liquid respectively, and the volume of multiple closed containers 3 is identical；The quantity of connecting tube 4
Number with many parts of liquid is corresponding, and the runner volume of multiple connecting tubes 4 is each unequal, and connection is converged in one end of multiple connecting tubes 4,
The other end is connected from different closed containers 3 respectively；Pressurizer 1 is used for what is constituted to multiple closed containers 3 and multiple connecting tubes 4
Inflating pressure in system.
In embodiment two, pressurizer 1 and closed container 3 are syringe, specifically, pressurization are used as using 20ml syringe
Three closed containers 3 are connected by device 1, three 5ml syringes as closed container 3 by gas-adding pipe 2 with pressurizer 1, gas-adding pipe
2 have intake valve 21 close to the position of closed container 3.Three closed containers 3 are fixed to 2ml position, and it is close at three
Close and 100 microlitres of blue ink a, red ink b and green ink c are injected separately into container 3.The end of closed container 3 and runner
Each unequal connecting tube 4 of volume is connected, wherein, the length of blue ink a correspondence connecting tubes 4 is 10cm, red ink b correspondences
The length of connecting tube 4 be 20cm, green ink c correspondence connecting tube 4 length be 40cm, three connecting tubes 4 by four-way pipe with
Microchannel 5 is connected, and the end of micro-tube 5 is connected with air bleeding valve (unmarked in figure).
After finishing device assembling, the air bleeding valve of the end of micro-tube 5 is closed, intake valve 21 is opened, by three closed containers 3
Keep flat, ink is not blocked the outlet of closed container 3.Pressurizer 1 is shifted onto 5ml positions and fixation by 20ml positions, close into
Air valve 21, closed container 3 is placed vertically, blocks ink initial inside the outlet of closed container 3, three closed containers 3
Pressure is equal.The slow air bleeding valve for opening the end of microchannel 5, it can be seen that result as shown in Figure 4, as shown in Figure 4, connecting tube
4 is longer, and the time that liquid (ink) enters microchannel 5 is more late, so as to form sequential flowing of many parts of liquid in microchannel 5.
In specific practical application, microchannel 5 can be PDMS chips, or can be the silica gel being made up of poromeric material
Pipe, when microchannel 5 is made up of poromeric material, then may not necessarily be communicated with air bleeding valve in end.Certainly, microchannel 5 also may be used
Think non-breathable pipeline or non-breathable chip, and be communicated with end air bleeding valve, the air bleeding valve of the end of microchannel 5 can be with
For permeability cell or the adjustable air bleeding valve of gas flux.
Present invention also offers a kind of method for realizing many parts of spontaneous sequential flowings of liquid, this method includes：
Multiple closed containers 3 with the number respective amount of many parts of liquid are taken, are located at respectively per portion liquid different close
Close in container 3；
Multiple connecting tubes 4 with the number respective amount of many parts of liquid are taken, when the volume of multiple closed containers 3 is different
When, multiple connecting tubes 4 are taken as that runner volume is equal, and when the volume all same of multiple closed containers 3, multiple connecting tubes 4 take
Each unequal for runner volume, connection is converged in one end of multiple connecting tubes 4, and the other end is connected from different closed containers 3 respectively；
The position of adjustment closed container 3 makes the liquid in each closed container 3 not block closed container 3 and connecting tube 4
Interface, inflating pressure in the system constituted to multiple closed containers 3 and multiple connecting tubes 4 is more than the internal pressure of system
External pressure；
The position of adjustment closed container 3 makes the liquid in each closed container 3 block closed container 3 and connecting tube again
4 interface；
By the turned on outside for converging connection end and system of connecting tube 4, the volume of each closed container 3 keeps constant, close
The gas pushed liquid closed in container 3 converges the flowing of connection end to connecting tube 4.
In specific practical application, if to be taken as volume different for multiple closed containers 3, then can be by adjusting each
Volume fraction between closed container 3 adjusts the order for converging connection end that liquid flows to connecting tube 4；If multiple closed
It is identical that container 3 is taken as volume, then can flow to company by adjusting the length ratio between each connecting tube 4 to adjust liquid
The order for converging connection end of adapter 4.
In the method for what the present invention was provided realize many parts of spontaneous sequential flowings of liquid, first to closed container 3 and connecting tube 4
Inflating pressure in the system of composition, makes the internal pressure of system be more than external pressure, is then stopped respectively by the closure of liquid
The gas of a part of High Voltage, finally by the turned on outside for converging connection end and system of connecting tube 4, makes closed container 3 with connecting
Pressure difference is formed between adapter 4, then liquid neous flow in the presence of gases at high pressure, and due to each volume of closed container 3
When different, the runner volume of each connecting tube 4 is equal, or during each 3 volume all same of closed container, each connection
The runner volume of pipe 4 is each unequal, so the time for converging connection end that each part liquid reaches connecting tube 4 is different, so as to realize
The sequential flowing of many parts of liquid.In summary, the method that the present invention is provided can realize the spontaneous sequential flowing of many parts of liquid, because
This needs once-through operation that successively order addition of the plurality of reagents to sample can be achieved, and reaches saving working time, improves work
The purpose of efficiency.
The foregoing description of the disclosed embodiments, enables professional and technical personnel in the field to realize or using the present invention.
A variety of modifications to embodiment will be apparent for those skilled in the art, as defined herein general
Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, the present invention will not
It can be restricted to embodiment illustrated herein, and be to fit to consistent with features of novelty with principles disclosed herein most wide
Scope.
Claims (10)
1. a kind of method for realizing many parts of spontaneous sequential flowings of liquid, it is characterised in that including：
Multiple closed containers (3) with the number respective amount of many parts of liquid are taken, are located at respectively not per a liquid
In the same closed container (3)；
Multiple connecting tubes (4) with the number respective amount of many parts of liquid are taken, when the volume of multiple closed containers (3)
When different, multiple connecting tubes (4) are taken as that runner volume is equal, when the volume of multiple closed containers (3) is equal
When identical, multiple connecting tubes (4) are taken as that runner volume is each unequal, and connection is converged in one end of multiple connecting tubes (4),
The other end is connected from the different closed containers (3) respectively；
Adjusting the position of the closed container (3), the liquid in each described closed container (3) is not blocked described close
The interface of container (3) and the connecting tube (4) is closed, is constituted to multiple closed containers (3) and multiple connecting tubes (4)
Inflating pressure in system, makes the internal pressure of the system be more than external pressure；
Adjusting the position of the closed container (3) again, the liquid in each described closed container (3) is blocked described
Closed container (3) and the interface of the connecting tube (4)；
The connecting tube (4) is converged into connection end and the turned on outside of the system, the volume of each closed container (3)
Keep constant, liquid described in the gas push in the closed container (3) flows to the connection end of converging of the connecting tube (4).
2. according to the method described in claim 1, it is characterised in that it is different that multiple closed containers (3) are taken as volume,
The connecting tube (4) is flowed to by adjusting the volume fraction between each described closed container (3) to adjust the liquid
Converge the order at connection end.
3. according to the method described in claim 1, it is characterised in that it is identical that multiple closed containers (3) are taken as volume, passes through
Adjust the length ratio between each described connecting tube (4) to adjust that the liquid flows to the connecting tube (4) converges company
The order of go side.
4. a kind of device for realizing many parts of spontaneous sequential flowings of liquid, it is characterised in that including：
With multiple closed containers (3) of the number respective amount of many parts of liquid, the closed container (3) is used to place respectively
Each part liquid；
With multiple connecting tubes (4) of the number respective amount of many parts of liquid, company is converged in one end of multiple connecting tubes (4)
Logical, the other end is connected from the different closed containers (3) respectively, and the volume of multiple closed containers (3) is different, and
The multiple connecting tube (4) runner volumes are equal, or multiple closed containers (3) volume all same, and multiple institutes
State connecting tube (4) runner volume each unequal；
Pressurizer (1), the pressurizer (1) is used for what is constituted to multiple closed containers (3) and multiple connecting tubes (4)
Inflating pressure in system.
5. device according to claim 4, it is characterised in that converging for the connecting tube (4) connects end and microchannel (5)
One end connection, the other end of the microchannel (5) is communicated with air bleeding valve.
6. device according to claim 5, it is characterised in that the air bleeding valve is permeability cell or the adjustable row of gas flux
Air valve.
7. device according to claim 4, it is characterised in that converging for the connecting tube (4) connects end and microchannel (5)
One end connection, the microchannel (5) is the silicone tube that is made up of poromeric material.
8. device according to claim 5, it is characterised in that the microchannel (5) is PDMS chips.
9. device according to claim 5, it is characterised in that the microchannel (5) is non-breathable pipeline or non-
Gas chip.
10. the device according to any one in claim 4~9, it is characterised in that the closed container (3) and/or institute
Pressurizer (1) is stated for syringe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710500139.6A CN107328949B (en) | 2017-06-27 | 2017-06-27 | A kind of method and device for realizing the more parts of spontaneous sequential flowings of liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710500139.6A CN107328949B (en) | 2017-06-27 | 2017-06-27 | A kind of method and device for realizing the more parts of spontaneous sequential flowings of liquid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107328949A true CN107328949A (en) | 2017-11-07 |
| CN107328949B CN107328949B (en) | 2019-05-03 |
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| CN201710500139.6A Expired - Fee Related CN107328949B (en) | 2017-06-27 | 2017-06-27 | A kind of method and device for realizing the more parts of spontaneous sequential flowings of liquid |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103537329A (en) * | 2012-07-11 | 2014-01-29 | 三星电子株式会社 | Microfluidic structure, microfluidic device having the same and method of controlling the microfluidic device |
| CN104211216A (en) * | 2014-08-28 | 2014-12-17 | 马鞍山市桓泰环保设备有限公司 | Multifunctional automatic chemical waste liquid treatment device and control method thereof |
| CN104251875A (en) * | 2009-05-29 | 2014-12-31 | 生命技术公司 | Method for controlling fluid flow in fluidics circuit, and fluid control device |
| US20160187240A1 (en) * | 2004-07-02 | 2016-06-30 | University Of Chicago | Microfluidic system |
| CN106179549A (en) * | 2016-08-15 | 2016-12-07 | 南京大学 | A kind of micro-fluidic chip and application thereof |
-
2017
- 2017-06-27 CN CN201710500139.6A patent/CN107328949B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160187240A1 (en) * | 2004-07-02 | 2016-06-30 | University Of Chicago | Microfluidic system |
| CN104251875A (en) * | 2009-05-29 | 2014-12-31 | 生命技术公司 | Method for controlling fluid flow in fluidics circuit, and fluid control device |
| CN103537329A (en) * | 2012-07-11 | 2014-01-29 | 三星电子株式会社 | Microfluidic structure, microfluidic device having the same and method of controlling the microfluidic device |
| CN104211216A (en) * | 2014-08-28 | 2014-12-17 | 马鞍山市桓泰环保设备有限公司 | Multifunctional automatic chemical waste liquid treatment device and control method thereof |
| CN106179549A (en) * | 2016-08-15 | 2016-12-07 | 南京大学 | A kind of micro-fluidic chip and application thereof |
Non-Patent Citations (5)
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| CN107328949B (en) | 2019-05-03 |
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Granted publication date: 20190503 |