CN107320224A - Weaving base reinforcing degradable intraluminal stent and its preparation and application - Google Patents
Weaving base reinforcing degradable intraluminal stent and its preparation and application Download PDFInfo
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- CN107320224A CN107320224A CN201710435901.7A CN201710435901A CN107320224A CN 107320224 A CN107320224 A CN 107320224A CN 201710435901 A CN201710435901 A CN 201710435901A CN 107320224 A CN107320224 A CN 107320224A
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- silk thread
- braided
- axial
- weaving
- intraluminal stent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2002/821—Ostial stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2002/823—Stents, different from stent-grafts, adapted to cover an aneurysm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0069—Three-dimensional shapes cylindrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
- A61F2240/002—Designing or making customized prostheses
Abstract
The invention provides one kind weaving base reinforcing degradable intraluminal stent and its preparation and application.Described weaving base reinforcing degradable intraluminal stent, it is characterized in that, including the hollow tubular fabric being knitted to form by biodegradable Polymer wire line as braided silk through two-dimentional three-dimensional, axial silk thread is introduced between two groups of braided silks during braiding, axial silk thread is not involved in braiding, by Technology for Heating Processing so that axial silk thread melting, the intertwined point of two groups of biodegradable Polymer wire lines is adhesively fixed by the axial silk thread of melting, so as to obtain the weaving base reinforcing degradable intraluminal stent of dimensionally stable.The present invention can effectively solve machine braiding edge and be easy to loose, the shortcoming that structure is not fixed easily；The sliding between support intertwined point can be effectively prevented, the number of support unit length intertwined point when being radially compressed is improved, support radial support power is improved.
Description
Technical field
The present invention relates to one kind weaving base reinforcing degradable intraluminal stent and preparation method thereof, more particularly to one kind can
Mechanical expansion implantable braided support and its preparation for the stenosis disease such as blood vessel, food meatus, tracheae, bile duct, intestinal tube
Method.
Background technology
Support is the main method of current body lumen stenosis disease treatment, is the basis being molded in tube chamber balloon expandable
On grow up, provide effective support in diseased region, and prevent at a specified future date narrow again.Specifically, by radial compression shape
The intraluminal stent of state navigates to the diseased region of body lumen by induction system, and support is then discharged at once, auxiliary by sacculus
Help expansion or from swollen expansion diameter itself, directly contacted with wall of the lumen, wall of the lumen is provided using the radial support power of support
Effectively support, plays a part of expanding lesion cavity wall, so as to maintain tube chamber unobstructed.
Traditional intraluminal stent is that permanent material is prepared from, and inflammatory reaction at a specified future date can be caused in longer-term persistence body,
More firm metal material can cause chronic injury to cavity wall, while the compliance of diseased region and implantation support portions is also deposited
In significant difference.Biodegradable scaffold is that a class provides effective support within the lesion reparation phase for tube chamber, and in tube chamber healing
Automatic degraded afterwards is absorbed, and will not produce permanent damage to human body.This support can provide temporary axial direction and footpath
To rectification effect and more preferable physiology reparation, it is allowed to the reconstruct of tube chamber original position, treated again without limitation on operation or intervention.Due to
More suitable degradation time, degradable high polymer turns into the preferred material of current biodegradable stent.
According to processing mode, current degradable polymer tube chamber bare bracket can be divided mainly into laser engraving support and braiding branch
Frame.Laser engraving support refers to cut out specific structure shape by methods such as laser on existing polymer cylinder, formed with
Brace rod and the support that dowel is main body, are mainly used in coronary artery and peripheral vascular at present.In release process
In, the laser engraving support of compressive state is brought it about into plastic strain and fixed-type by balloon expandable, to support lesion
Tube chamber, but the pliability of support is poor, is easily caused that support is adherent bad, and the overdistension of sacculus easily causes the disintegration of support.
Braided support is, by being intertwined to form network structure, tubular bracket to be obtained through thermal finalization by plurality of silk strands.Make
For a kind of self-expandable stent, by compressing and being limited in induction system, expansion state can be bounce back into during discharging,
With good compliance, it is easy to which, by tortuous pathological lumen, conveying is convenient, and elastic strain, aid in expanding without sacculus
.The radial support performance of braiding structure intraluminal stent is mainly by between fiber anti-bending strength, fiber flexing degree and intertwined point
Frictional force influence.Fiber flexing degree can effectively be increased by increasing count so that interweave in unit sizes
Point quantity increase.But be due to that intertwined point can slide after being compressed, make compression position local fiber flexing degree and
Intertwined point quantity declines, so as to reduce radial support performance.Volumes of the Zhang Peihua et al. (CN201110079141.3) in shaping
Knit parallel guide yarns on the inside of support tube wall through the relative aperture of inner core upper and lower ends, and the knotting of parallel guide yarns two ends is solid
Fixed, to improve the radial support power of support, but the retractility of support is restricted, and is unfavorable for clinical major diameter intraluminal stent and is situated between
Enter operation technique.Zhao Jiong hearts et al. (CN103142335A) utilize the thermodynamic behaviour of polymer, in the softening temperature of braided silk
Degree scope is heat-treated, and using molding to the effective fixation in intertwined point.Molding makes the braided silk in softening temperature overall
Compressed and occur irreversible transformation, silk thread section from circular or elliptical deformation be rectangular shape, to support form and mechanics
Performance has harmful effect, and clinical research shows that support square-section adds circulation of the blood flow in vascular wall and support intersection
Barrier, changes bloodstream form, easily to vascular wall formation mild method, so as to cause thrombus, smooth muscle cell activation etc. bad
Reaction.
The content of the invention
It is an object of the invention to provide a kind of weaving base reinforcing degradable intraluminal stent with good radial support power.
It is a further object of the present invention to provide a kind of weaving base reinforcing degradable tube chamber with good radial support power
The preparation method of support.
A further object of the present invention is to use the weaving base reinforcing degradable intraluminal stent with good radial support power
In inside of human body pipeline support, prevent inside of human body pipeline narrow or block.
To achieve the above objectives, the technical solution adopted by the present invention is as follows：
One kind weaving base reinforcing degradable intraluminal stent, it is characterised in that including by biodegradable Polymer wire line conduct
The hollow tubular fabric that braided silk is knitted to form through two-dimentional three-dimensional, axle is introduced during braiding between two groups of braided silks
To silk thread, axial silk thread is not involved in braiding, by Technology for Heating Processing so that axial silk thread melting, two groups of biodegradable Polymer wire lines
Intertwined point be adhesively fixed by the axial silk thread of melting, so as to obtain the weaving base reinforcing degradable tube chamber branch of dimensionally stable
Frame.
Preferably, a diameter of 0.1-0.5mm of described biodegradable Polymer wire line.
Preferably, the material of described biodegradable Polymer wire line is to possess the crystallization or hypocrystalline polymerization of definite melting point
Thing, including polylactide, PGA, polylactide-co-glycolide, polycaprolactone, PGA-caprolactone and poly- to dioxy ring
Hexanone etc..
Preferably, the internal diameter of described hollow tubular fabric is 1-50mm.
Preferably, the radical of described axial silk thread is less than or equal to the half of the total radical of braided silk.
Present invention also offers the preparation method of above-mentioned weaving base reinforcing degradable intraluminal stent, it is characterised in that
Including：
Step 1：Spool is made in two groups of braided silks needed for intertexture and is placed in the taking on yarn device of braider；By axial silk
Line is drawn by taking the through hole at the angle gear bolt center of yarn device, waits to be woven；
Step 2：Using two-dimentional three-dimensional weaving method, by two groups of braided silks in opposite direction with braid angle (braided wires
The angle of line and support axial direction) for 30 ° -80 ° shelf inner diameter identical tubular die surfaces with needed for that are interweaved and are wrapped in；
Axial silk thread is introduced during braiding between two groups of braided silks, is not involved in braiding；
Step 3：The braided fabric for carrying tubular die is placed in constant temperature thermal environment, temperature is between braided silk and axial direction
Between the fusing point of silk thread, axial silk thread melting attenuates tubular die stretching in the thermal environment, the axial continuous line segment shape of silk thread
State is destroyed, and the axial silk thread of the molten state at non-interwoven point is attached on mold outer surface and taken off with mould deformation from braided fabric
From the axial silk thread formation anchoring point of molten state at intertwined point, realization is adhesively fixed to two groups of silk threads, is placed in and cools down at room temperature
Afterwards, the weaving base reinforcing degradable intraluminal stent of dimensionally stable is obtained.
Preferably, described braided silk is, with fixed and different fusing point semi-crystalline polymer, to compile with axial silk thread
The fusing point for knitting silk thread is higher than the fusing point of axial silk thread.
A kind of preparation method of enhanced intraluminal stent of base of weaving as described above, two groups of braided silks use same fibre
Material is tieed up, the axial silk thread of introducing is different from braided silk material, for another degradable biological less than braided silk fusing point
Material, and different melting points be higher than hot-fluid environmental treatment when temperature error scope.
A kind of weaving enhanced intraluminal stent of base involved in the present invention and preparation method thereof, number of spindle unit, braiding height, volume
Design can be oriented according to actual needs by knitting density, yarn diameter, stent diameter, stent length, support wall thickness etc., with
Close specific use environment.
Blood vessel, food meatus, tracheae, courage are used as present invention also offers above-mentioned weaving base reinforcing degradable intraluminal stent
Application in the mechanical expansion implantable braided support of the stenosis disease such as pipe, intestinal tube.
Compared with prior art, the invention has the advantages that：
(1) a kind of weaving enhanced intraluminal stent of base involved in the present invention and preparation method thereof, is compiled with reference to two-dimentional three-dimensional
Technology and high polymer material thermodynamic property are knitted, not introducing mechanical external force in hot-fluid processing procedure, this body structure is broken to material
Bad, the intertwined point of precise positioning braiding structure limits the sliding of intertwined point, realizes uniform, effective fixation of intertwined point, improves and spins
The radial support power of base intraluminal stent is knitted, and it is smaller on support pliability itself and retractility influence.
(2) intertwined point of weaving base reinforcing degradable two groups of biodegradable Polymer wire lines of intraluminal stent of the invention passes through
The axial silk thread of melting is adhesively fixed, and support two ends do not occur loosely, to make originally open port become have bigger radial direction
The close port of support force；Rack body position intertwined point does not slide, and support has larger radial support power.
(3) a kind of weaving enhanced intraluminal stent of base involved in the present invention and preparation method thereof, without to conventional open
The aftertreatment technology such as is welded, bonded in formula support two ends, by melting axial silk thread in hot-fluid environment, make support two ends each
Intertwined point is fixed respectively, forms semiclossed bracket edge, can effectively prevent support from dissipating side and off-line, and improve the radial direction of support
Support force.
(4) a kind of weaving enhanced intraluminal stent of base involved in the present invention and preparation method thereof, using FDA certifications
Degradable biological high polymer material, can be used for the mechanical expansion of the stenosis disease such as blood vessel, food meatus, tracheae, bile duct, intestinal tube
The preparation of implantable equipment.
(5) present invention introduces axial silk thread along weaving direction during braiding between two groups of degradable silk threads, but not
Braiding is participated in, using the Material Thermodynamics difference of braided silk and axial silk thread, by specific heat treatment environment by low melting point axle
Fused to silk thread, formed at intertwined point and two groups of silk threads are adhesively fixed, support two ends do not occur loosely, to make originally open
Port become the close port with bigger radial support power；Rack body position intertwined point does not slide, and support has
Larger radial support power.
(6) present invention makes braided support two ends and each intertwined point of main body section be melted axial silk thread accurately to bond
Fix together and uniformly, effectively.Machine braided support edge can effectively be solved and be easy to loose, what structure was not fixed easily lacks
Point；The sliding between support intertwined point can be effectively prevented, support unit sizes intertwined point when being radially compressed is improved
Number, improves support radial support power.
Brief description of the drawings
Fig. 1 is the structural representation of the weaving enhanced intraluminal stent of base.
Fig. 2 is enlarged drawing at A in Fig. 1；
In figure, 1 is braided silk, and 2 be the axial silk thread after melting.
Embodiment
With reference to specific embodiment, the present invention is expanded on further.It should be understood that these embodiments are merely to illustrate the present invention
Rather than limitation the scope of the present invention.In addition, it is to be understood that after the content of the invention lectured has been read, people in the art
Member can make various changes or modifications to the present invention, and these equivalent form of values equally fall within the application appended claims and limited
Scope.
Embodiment 1
As depicted in figs. 1 and 2, a kind of weaving base reinforcing degradable intraluminal stent, including by biodegradable Polymer wire line
The hollow tubular fabric being knitted to form as braided silk 1 through two-dimentional three-dimensional, during braiding between two groups of braided silks 1
Axial silk thread 2 is introduced, axial silk thread 2 is not involved in braiding, by Technology for Heating Processing so that axial silk thread 2 is melted, two groups degradable
The intertwined point of macromolecule silk thread is adhesively fixed by the axial silk thread 2 of melting, so that the weaving base for obtaining dimensionally stable is enhanced
Degradable intraluminal stent.
The preparation method of described weaving base reinforcing degradable intraluminal stent is：
Step 1：Spool is made in two groups of braided silks needed for intertexture and is placed in taking for the two-dimentional spindle type braider of 48 ingots
On yarn device；Axial silk thread is drawn by taking the through hole at the angle gear bolt center of yarn device, waits to be woven；Described braided silk
For a diameter of 0.10mm polylactide-co-glycolide monofilament, every group 24.
Step 2：Using two-dimentional three-dimensional weaving method, by two groups of braided silks in opposite direction with braid angle (braided wires
Line and the angle of support axial direction) being interweaved for 30 ° and being wrapped in the shelf inner diameter identical tubular die surface with needed for forms
Internal diameter is 3mm hollow tubular fabric；Axial silk thread during braiding between weaving square is directed upwardly into two groups of braided silks,
It is not involved in braiding；Described axial silk thread is the axial silk thread of 8 polycaprolactones, is evenly distributed in hollow tubular fabric.It is described
Tubular die be polyfluortetraethylene pipe that external diameter is 3mm.
Step 3：The braided fabric for carrying tubular die is placed in into 80 DEG C of constant temperature forced air ovens in a tensioned state to be formed
Hot-air environment in shape 10min, temperature is between polylactide-co-glycolide and the fusing point of polycaprolactone, axial silk thread
Melting, tubular die stretching is attenuated, depart from braided fabric inner surface, axle to mold outer surface in 80 DEG C of hot-air environment
Destroyed to the continuous line segment state of silk thread, the axial silk thread of molten state at non-interwoven point is attached on mold outer surface with mould deformation
Depart from from braided fabric, the axial silk thread formation anchoring point of the molten state at intertwined point is realized to two groups of polylactide-co-glycolides
Braided silk is adhesively fixed.It is placed in after Slow cooling at room temperature, obtains the weaving base reinforcing degradable tube chamber of dimensionally stable
Support.The radial support power of this support is 200cN/mm.
Embodiment 2
As depicted in figs. 1 and 2, a kind of weaving base reinforcing degradable intraluminal stent, including by biodegradable Polymer wire line
The hollow tubular fabric being knitted to form as braided silk 1 through two-dimentional three-dimensional, during braiding between two groups of braided silks 1
Axial silk thread 2 is introduced, axial silk thread 2 is not involved in braiding, by Technology for Heating Processing so that axial silk thread 2 is melted, two groups degradable
The intertwined point of macromolecule silk thread is adhesively fixed by the axial silk thread 2 of melting, so that the weaving base for obtaining dimensionally stable is enhanced
Degradable intraluminal stent.
The preparation method of described weaving base reinforcing degradable intraluminal stent is：
Step 1：Spool is made in two groups of braided silks needed for intertexture and is placed in taking for the two-dimentional spindle type braider of 32 ingots
On yarn device；Axial silk thread is drawn by taking the through hole at the angle gear bolt center of yarn device, waits to be woven；Described braided silk
For a diameter of 0.25mm polylactide monofilament, every group 16.
Step 2：Using two-dimentional three-dimensional weaving method, by two groups of braided silks in opposite direction with braid angle (braided wires
Line and the angle of support axial direction) being interweaved for 50 ° and being wrapped in the shelf inner diameter identical tubular die surface with needed for forms
Internal diameter is 8mm hollow tubular fabric；Axial silk thread during braiding between weaving square is directed upwardly into two groups of braided silks,
It is not involved in braiding；Described axial silk thread is the axial silk thread of 8 polycaprolactones, is evenly distributed in hollow tubular fabric.It is described
Tubular die be polyfluortetraethylene pipe that external diameter is 8mm.
Step 3：The braided fabric for carrying tubular die is placed in into 80 DEG C of constant temperature forced air ovens in a tensioned state to be formed
Hot-air environment in shape 15min, temperature is between polylactide and the fusing point of polycaprolactone, and low melting point polycaprolactone melts
Melt, tubular die stretching attenuates in 80 DEG C of hot-air environment, departs from braided fabric inner surface to mold outer surface, gathers oneself
The continuous line segment state of lactone be destroyed, the molten state polycaprolactone at non-interwoven point be attached on mold outer surface with mould deformation from
Depart from braided fabric, the molten state polycaprolactone formation anchoring point at intertwined point is realized to two groups of polylactide braided silks
Be adhesively fixed.It is placed in after Slow cooling at room temperature, obtains the weaving base reinforcing degradable intraluminal stent of dimensionally stable.It is this
The radial support power of support is 350cN/mm.
Embodiment 3
As depicted in figs. 1 and 2, a kind of weaving base reinforcing degradable intraluminal stent, including by biodegradable Polymer wire line
The hollow tubular fabric being knitted to form as braided silk 1 through two-dimentional three-dimensional, during braiding between two groups of braided silks 1
Axial silk thread 2 is introduced, axial silk thread 2 is not involved in braiding, by Technology for Heating Processing so that axial silk thread 2 is melted, two groups degradable
The intertwined point of macromolecule silk thread is adhesively fixed by the axial silk thread 2 of melting, so that the weaving base for obtaining dimensionally stable is enhanced
Degradable intraluminal stent.
The preparation method of described weaving base reinforcing degradable intraluminal stent is：
Step 1：Spool is made in two groups of braided silks needed for intertexture and is placed in taking for the two-dimentional spindle type braider of 48 ingots
On yarn device；Axial silk thread is drawn by taking the through hole at the angle gear bolt center of yarn device, waits to be woven；Described braided silk
For a diameter of 0.25mm polylactide monofilament, every group 24.
Step 2：Using two-dimentional three-dimensional weaving method, by two groups of braided silks in opposite direction with braid angle (braided wires
Line and the angle of support axial direction) being interweaved for 80 ° and being wrapped in the shelf inner diameter identical tubular die surface with needed for forms
Internal diameter is 8mm hollow tubular fabric；Axial silk thread during braiding between weaving square is directed upwardly into two groups of braided silks,
It is not involved in braiding；Described axial silk thread is 4 PPDO silk threads, is evenly distributed in hollow tubular fabric.Institute
The tubular die stated is the polyfluortetraethylene pipe that external diameter is 8mm.
Step 3：The braided fabric for carrying tubular die is placed in into 110 DEG C of constant temperature forced air ovens in a tensioned state to be formed
Hot-air environment in shape 15min, temperature gathers low melting point between polylactide and the fusing point of PPDO
Lanthanum Isopropoxide is melted, and tubular die stretching attenuates in 110 DEG C of hot-air environment, departs to mold outer surface and weaves
Web inner surface, the continuous line segment state of PPDO is destroyed, the molten state PPDO at non-interwoven point
It is attached on mold outer surface with mould deformation from braided fabric to depart from, the molten state PPDO at intertwined point is formed
Two groups of polylactide braided silks are adhesively fixed for anchoring point, realization.It is placed in after Slow cooling at room temperature, obtains dimensionally stable
Weaving base reinforcing degradable intraluminal stent.The radial support power of this support is 300cN/mm.
Claims (9)
1. one kind weaving base reinforcing degradable intraluminal stent, it is characterised in that including being used as volume by biodegradable Polymer wire line
The hollow tubular fabric that silk thread is knitted to form through two-dimentional three-dimensional is knitted, is introduced axially between two groups of braided silks during braiding
Silk thread, axial silk thread is not involved in braiding, by Technology for Heating Processing so that the melting of axial silk thread, two groups of biodegradable Polymer wire lines
Intertwined point is adhesively fixed by the axial silk thread of melting, so as to obtain the weaving base reinforcing degradable tube chamber branch of dimensionally stable
Frame.
2. base reinforcing degradable intraluminal stent of weaving as claimed in claim 1, it is characterised in that described degradable high score
A diameter of 0.1-0.5mm of sub- silk thread.
3. base reinforcing degradable intraluminal stent of weaving as claimed in claim 1, it is characterised in that described degradable high score
The material of sub- silk thread is crystallization or the semi-crystalline polymer for possessing definite melting point.
4. base reinforcing degradable intraluminal stent of weaving as claimed in claim 1, it is characterised in that described degradable high score
The material of sub- silk thread is polylactide, PGA, polylactide-co-glycolide, polycaprolactone, PGA-caprolactone and gathered
At least one of Lanthanum Isopropoxide.
5. base reinforcing degradable intraluminal stent of weaving as claimed in claim 1, it is characterised in that described hollow tubular is knitted
The internal diameter of thing is 1-50mm.
6. base reinforcing degradable intraluminal stent of weaving as claimed in claim 1, it is characterised in that described axial silk thread
Radical is less than or equal to the half of the total radical of braided silk.
7. the preparation method of the weaving base reinforcing degradable intraluminal stent any one of claim 1-6, its feature exists
In, including：
Step 1：Spool is made in two groups of braided silks needed for intertexture and is placed in the taking on yarn device of braider；Axial silk thread is led to
The through hole for crossing the angle gear bolt center for taking yarn device is drawn, and waits to be woven；
Step 2：Using two-dimentional three-dimensional weaving method, by two groups of braided silks in opposite direction with braid angle (braided silk with
The angle of support axial direction) for 30 ° -80 ° shelf inner diameter identical tubular die surfaces with needed for that are interweaved and are wrapped in；Axially
Silk thread is introduced during braiding between two groups of braided silks, is not involved in braiding；
Step 3：The braided fabric for carrying tubular die is placed in constant temperature thermal environment, temperature is between braided silk and axial silk thread
Fusing point between, the melting of axial silk thread attenuates tubular die stretching in the thermal environment, the axial continuous line segment state quilt of silk thread
The axial silk thread of molten state at destruction, non-interwoven point is attached on mold outer surface and departed from mould deformation from braided fabric, hands over
The axial silk thread formation anchoring point of molten state at knitting, realization is adhesively fixed to two groups of silk threads, is placed in after cooling at room temperature, obtains
To the weaving base reinforcing degradable intraluminal stent of dimensionally stable.
8. the preparation method for base reinforcing degradable intraluminal stent of weaving as claimed in claim 7, it is characterised in that described
Braided silk is that, with fixed and different fusing point semi-crystalline polymer, the fusing point of braided silk is higher than axial silk with axial silk thread
The fusing point of line.
9. mechanical expansion implantable of the base reinforcing degradable intraluminal stent as stenosis disease of weaving described in claim 1
Application in braided support.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710435901.7A CN107320224B (en) | 2017-06-09 | 2017-06-09 | Weaving base reinforcing degradable intraluminal stent and its preparation and application |
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| CN108066048A (en) * | 2017-12-20 | 2018-05-25 | 东华大学 | It is thermally bonded degradable intraluminal stent of composite construction and its preparation method and application |
| CN109770982A (en) * | 2019-02-20 | 2019-05-21 | 东华大学 | A kind of hollow porous part absorbable suture and preparation method |
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| CN114259607A (en) * | 2021-12-28 | 2022-04-01 | 宇航 | Preparation method of stent |
| CN115153953A (en) * | 2022-09-08 | 2022-10-11 | 深圳市华和创微医疗科技有限公司 | Three-dimensional braided stent and manufacturing method |
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