CN102160830B - Double-layer compound pipeline bracket and manufacturing method thereof - Google Patents
Double-layer compound pipeline bracket and manufacturing method thereof Download PDFInfo
- Publication number
- CN102160830B CN102160830B CN2011100782556A CN201110078255A CN102160830B CN 102160830 B CN102160830 B CN 102160830B CN 2011100782556 A CN2011100782556 A CN 2011100782556A CN 201110078255 A CN201110078255 A CN 201110078255A CN 102160830 B CN102160830 B CN 102160830B
- Authority
- CN
- China
- Prior art keywords
- support
- pipeline
- layer pipe
- layer
- inner layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Materials For Medical Uses (AREA)
- Laminated Bodies (AREA)
- Woven Fabrics (AREA)
Abstract
The invention relates to a double-layer compound pipeline bracket and a manufacturing method thereof, in particular to a double-layer compound pipeline bracket of which the inner-layer pipeline is a reticular pipeline knitted by poly(p-dioxanone) single filaments and the outer-layer pipeline of which is a reticular pipeline knitted by polyglycollide multi-filaments and a manufacturing method thereof. The double-layer compound pipeline bracket is formed by combining an inner-layer pipeline and an outer-layer pipeline, wherein the inner-layer pipeline is a reticular pipeline knitted by poly(p-dioxanone) fibers, and the outer-layer pipeline is a reticular pipeline knitted by polyglycollide fibers. The manufacturing method of the double-layer compound pipeline bracket comprises the following seven steps of: winding; knitting an inner-layer pipeline bracket; knitting an outer-layer pipeline bracket; taking down the brackets; axially stretching or compressing and fixing; thermally forming; and trimming. The compound pipeline bracket provided by the invention has better elastic recovery performance and mechanical stability, can not be damaged by stretching or compressing in a certain range, and has a stronger medicine carrying capability.
Description
Technical field
The present invention relates to a kind of two-layer compound pipeline support and manufacture method thereof, particularly relating to a kind of inner layer pipe is that the latticed pipeline of PPDO (PPDO) monofilament braiding, described outer layer pipe are two-layer compound pipeline support and the manufacture method thereof of the latticed pipeline of poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGLA) multifilament braiding.
Background technology
In vivo, a lot of pipe diameters all between 10-20mm, belongs to the pipeline of big caliber, such as esophagus, and urinary catheter, large artery trunks etc.Pathological changes when taking place in these pipelines, and majority needs the excision of row pathological changes and implements the pipeline reconstruction.Adopt the artificial material original position to rebuild the pipeline of pathological changes, can reduce operation wound, simplify the traditional treatment of operation technique.Many congenital or posteriority esophagel diseases all need the row esophagus to substitute art, and the esophagus pathological changes is most to be needed the excision of row pathological changes and implement esophageal reconstructions.The substitute of esophagus mainly divides two big classes: a class is its hetero-organization or the organ with self, and another kind of is artificial esophagus substitute.Adopt the artificial material original position to rebuild esophagus, can reduce operation wound, simplify operation technique, little to the digestion function effect, have important academic significance and practical value.Artificial esophagus is the main contents of artificial organ research and the major subjects of exploration always, the mankind have carried out a large amount of artificial esophagus experimentatioies since 20th century, successively attempt various materials and made artificial esophagus, as: macromolecular material and biomaterials such as trachea after treatment or blood vessel such as polyethylene, silicone rubber, silica gel terylene compound body, expanded PTFE, carbon fibre, and make the artificial esophagus of different shape, obtained some achievements.Macromolecular material can be easily by various process means load medicines, medicine is discharged or slow release fast, to promote the healing of local organization, in blood vessel, can prevent thrombosis, pre-preventing restenosis of blood vessel, be subjected to the extensive concern of material science and medical circle at present.
The support of pipelines of artificial material preparation has experienced several courses such as metal material, macromolecular material, biomaterial.The support of pipelines of metal material preparation has good mechanics support performance, but need to carry out the operation second time after the postoperative healing support taken out, and the biocompatibility of metal material and medicine carrying poor performance.Compare with metal material, the support of degradable biological material preparation has superior performance.The inner support of degradable high polymer material preparation has good biocompatibility, in the specific pathological process of human body, be degraded gradually at mechanics support and the drug release after-poppet finished local tube chamber, the long-term foreign body of having avoided prosthese to insert human body influences, and can keep narrow unobstructed the long period, improve patient's nutriture, simple to operate, patient is painful to be reduced, simultaneously can prevent tumor growth generation restenosis, delay patient's life.
Supporter is a plastic conduit in traditional esophagus, puts the Guan Shixu general anesthesia, and short-term complication such as hemorrhage, perforation of esophagus etc. can be up to 5%-30%, and the mortality rate relevant with operation is up to 16%, and the postoperative restenosis rate can reach 7%-39%; Subsequently, multiple internal metal racks such as auto-expanding type " Z " type support (Gianturco support), auto-expanding type wire netting dress support (Wall stent), the metal net shaped support of balloon expandable (Strecker stent), the hot memory alloy stent of NiTi are applied to the treatment of esophagostenosis.These supports are inserted conveniently, patient's misery reduces, complication rate also reduces, it is narrow that China has also begun to use this therapy for treating late esophagus cancer in nineteen eighty-three, but placed stent in esophagus at that time mainly by carrying out under the surgery open chest surgery, wound is big, post-operative complication and mortality rate height, and indication is narrow; The metal stent in esophagus mainly contains rustless steel and Nitinol two big classes, and the latter has more superiority.The characteristics of Nitinol are to have unusual switching function, the corresponding variation namely taken place at a certain temperature, super-elasticity, wearability, corrosion resistance and excellent biological compatibility, its network structure unit has good vertical flexibility and radial support power, thereby can adapt to natural torsion and the biological wriggling of human body esophagus.Auto-expanding type " Z " type support (Gianturco support) is converted into the short cylindrical shape with the medical stainless steel silk of 0.01 inch of diameter in " Z " font mode, about the long 2cm of every joint, diameter 14-20mm, can connect into the more piece support with steel wire or fine rule according to lesion degree, its advantage is: tensile strength is good, good springiness, do not prolong during compression, but compliance is relatively poor; Auto-expanding type wire netting dress support (Wall stent) is woven into the webmaster shape with the medical stainless steel silk of many diameter 0.1-0.2mm, select for use the steel wire of different numbers, different-diameter to weave, can obtain density difference, different elastic support, the advantage of auto-expanding type wire netting dress support (Wall stent) is that longitudinal compliance is good, but elasticity is not as " Z " type support; The metal net shaped support of balloon expandable (Strecker stent) is to be woven into nettedly by the titanium silk of single 0.1-0.15mm or nitinol alloy wire, and this support need insert foley's tube again and carry out passive expansion after carrier pipe pushes narrow positions, could open fully.Other has a kind of Strecker support of self-inflated, is compressed in catheter surface, fixes with gelatin embedding again, and the outside is overlapped with a sheath pipe again, returns after delivering to narrow positions and removes the sheath pipe, and the gelatin of rack surface is met the secretions dissolving of esophagus inwall, and support is from swollen; The hot memory alloy stent of NiTi [5] the close helical form of diameter 0.35-0.65mm nitinol alloy wire coiled, two expands into double horn mouth shape.The arbitrarily molding less than 4 ℃ time of this support is wrapped in gastroscope or catheter surface, delivers to narrow positions, injects hot salt brine through conduit, and support is met heat and resiled, and general recovery temperature is 37 ℃-40 ℃.This framework's compatibility is good, is easy to discharge, and is usually used in the benign stricture of anastomotic stricture or short section; More than be the main kind by metal esophageal stents appear application in 1996, the subject matter of Cun Zaiing had at that time: esophageal stents appear can be placed not in place or slippage is difficult for taking out mostly; Can certain interception be arranged to growth of tumor by membrane support, but than the easier slippage of no membrane support, the someone has installed the support that colludes thorn, two expansion there is certain effect to preventing slippage, but makes the more difficult taking-up of support.
So far, the research of artificial esophagus has more than 50 year history, and the research that domestic and international each scholar adopts the kinds of artificial material to carry out artificial esophagus since half a century has obtained bigger achievement, but still has problems.The research in past is mainly the substitute that mechanical material is made, and then mainly concentrates on acellular support class artificial esophagus and engineered artificial esophagus two big classes in the recent period, and difficult point is still control and the histocompatibility of complication.Artificial esophagus will inevitably come off after keeping somewhere a period of time, newborn esophagostenosis can take place or fistula takes place.These are common complications of artificial esophagus animal experiment study, are that can artificial esophagus enter clinical key, and this also is the problem of the required solution of artificial esophagus researcher.
Summary of the invention
The purpose of this invention is to provide a kind of two-layer compound pipeline support and manufacture method thereof, it is that the latticed pipeline of PPDO (PPDO) monofilament braiding, described outer layer pipe are two-layer compound pipeline support and the manufacture method thereof of the latticed pipeline of poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGLA) multifilament braiding that a kind of inner layer pipe particularly is provided.Compound pipeline complex pipeline support of the present invention has better elastic recovery and mechanical stability, and stretching or compression all can not cause damage to it within limits; And has bigger medicine carrying ability.
A kind of two-layer compound pipeline support of the present invention, combined by inside and outside two-layer pipeline, described inner layer pipe is the latticed pipeline of PPDO (PPDO) fibrage, and described outer layer pipe is the latticed pipeline of poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGLA) multifilament braiding;
Described PPDO (PPDO) fiber is monofilament;
Described poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGLA) fiber is multifilament;
Have certain clearance between described inner layer pipe and the described outer layer pipe, the gap is 0～0.5mm.
As optimized technical scheme:
Aforesaid a kind of two-layer compound pipeline support, described inner layer pipe and outer layer pipe are isometric; The mesh-density of described inner layer pipe is 40-48 hole/square centimeter, and the mesh-density of described outer layer pipe is 50-60 hole/square centimeter.Described inner layer pipe and outer layer pipe are isometric, two-layer pipeline is axially all having extension property preferably, and along with the stretching caliber of pipeline can diminish, the mesh-density of pipeline becomes sparse, along with the compression caliber of pipeline can become greatly, it is fine and close that the mesh-density of pipeline can become.The compound pipeline complex pipeline support is compared with the monolayer support of pipelines, and the lateral density of grid has increased, and namely the mesh of grid has diminished; Owing to double-deck Overlay, vertical density of grid has also increased again, and namely the space between the mesh has also diminished, and these not only are conducive to improve the radial support power of compound pipeline complex pipeline support, and have improved its medicine carrying.Be that when along the axial tension inner layer pipe, its caliber can dwindle, and the binding site between the outer layer pipe can reduce by the unordered mat in intertwined point, grid top separately between the two-layer pipeline; When along the axial compression outer layer pipe, its caliber can increase, and the binding site between the inner layer pipe can reduce, and two-layer like this pipeline will partly separate, and has produced a lot of spaces between the two-layer pipeline, and these spaces are conducive to above more liquid medicine is loaded in.
Aforesaid a kind of two-layer compound pipeline support, the diameter of described PPDO (PPDO) monfil is 0.2-0.4mm.
Aforesaid a kind of two-layer compound pipeline support, the diameter of described poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGLA) multifilament fiber is 0.15-0.2mm.
A kind of two-layer compound pipeline support of the present invention, its inner layer pipe and outer layer pipe are isometric, and the caliber of inner layer pipe combines by part grid intertwined point between the two-layer pipeline less than the caliber of outer layer pipe.Have certain space between the two-layer pipeline, the space after the thermal finalization between the two-layer pipeline is fixed.The mesh-density of compound pipeline complex pipeline has had better elastic recovery and mechanical stability greater than the mesh-density of monolayer support of pipelines through compound pipeline complex pipeline support after the thermal finalization, and stretching or compression all can not cause damage to it within limits.
The present invention also provides a kind of manufacture method of two-layer compound pipeline support, with metallic conduit as tube core, on braider, at first use PPDO (PPDO) braiding inner layer pipe support, after braiding is good, again with the inner layer pipe support as tube core, in its outside with described poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGLA) woven outer layer support of pipelines; The two-layer compound support that braiding is good is taken off from braider together with metal die, then from the two ends of pipeline along PPDO (PPDO) the support two ends of the internal layer that axially stretches respectively to the 1.05-1.1 of original length doubly, clamp PPDO (PPDO) pipeline and metal die with clip, make PPDO (PPDO) two ends be fixed on not resilience on the metal die; The above-mentioned double-skin duct support that fixes with clip is put into carries out thermal finalization in the baking oven, setting temperature is 80 °-85 °, and shaping time is 15-20 minute; Stereotypedly two-layer compound pipeline support is taken off to come above metal die after to be cooled, had one's hair trimmed in the two ends of compound pipeline complex pipeline, namely make successful double-layer composite pipe road support;
Wherein, described PPDO (PPDO) fiber is monofilament; Described poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGLA) fiber is multifilament.
The manufacture method of aforesaid a kind of two-layer compound pipeline support, the mesh-density of described inner layer pipe are 36-45 hole/square centimeter, and the mesh-density of described outer layer pipe is 45-55 hole/square centimeter.
The manufacture method of aforesaid a kind of two-layer compound pipeline support, the diameter of described PPDO (PPDO) monfil is 0.2-0.4mm; The diameter of described poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGLA) multifilament fiber is 0.15-0.2mm.
The present invention provides a kind of manufacture method of two-layer compound pipeline support again, concrete steps are: with metallic conduit as tube core, on braider, at first use PPDO (PPDO) monfil braiding inner layer pipe support, after braiding is good, again with the inner layer pipe support as tube core, in its outside with described poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGLA) multifilament woven outer layer support of pipelines; The two-layer compound support that braiding is good is taken off from braider together with metal die, then from the two ends of pipeline along axially compressing outer field PGLA support respectively to 0.9 times of original length, clamp poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGLA) pipeline and inner layer pipe respectively with clip, make its two ends be fixed on not resilience on the inner layer pipe; The above-mentioned double-layer scaffold that fixes with clip is put into carries out thermal finalization in the baking oven, setting temperature is 80 °-85 °, and shaping time is 15-20 minute; Stereotypedly two-layer compound pipeline support is taken off to come above metal die after to be cooled, had one's hair trimmed in the two ends of compound pipeline complex pipeline, namely make successful double-layer composite pipe road support;
Wherein, described PPDO (PPDO) fiber is monofilament; Described poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGLA) fiber is multifilament.
The manufacture method of aforesaid a kind of two-layer compound pipeline support, the mesh-density of described inner layer pipe are 15-20 hole/square centimeter, and the mesh-density of described outer layer pipe is 14-22 hole/square centimeter.
The manufacture method of aforesaid a kind of two-layer compound pipeline support, the diameter of described PPDO (PPDO) monfil is 0.2-0.4mm; The diameter of described poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGLA) multifilament fiber is 0.15-0.2mm.
Inner layer pipe and outer layer pipe by the made compound pipeline complex pipeline of method provided by the present invention are isometric, and the caliber of outer layer pipe combines by part grid intertwined point between the two-layer pipeline greater than the caliber of inner layer pipe.Have certain space between the two-layer pipeline, the space after the thermal finalization between the two-layer pipeline is fixed.The mesh-density of compound pipeline complex pipeline has had better elastic recovery and mechanical stability greater than the mesh-density of monolayer support of pipelines through compound pipeline complex pipeline support after the thermal finalization, and stretching or compression all can not cause damage to it within limits.
Beneficial effect
PPDO (PPDO) is a kind of monofilament, and this fiber has higher intensity, and is better with the support of pipelines mechanics support performance of its braiding, but because this fiber is a kind of monofilament, smooth surface is so the support of pipelines medicine carrying of its braiding is very poor; Poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGLA) is a kind of multifilament, support of pipelines medicine carrying with its braiding is good, but only the support of pipelines support force with this material braiding is but very little, two kinds of materials are combined, adopt the mode that coats to weave two-layer compound pipeline support, so not only improved the mechanical property of support of pipelines, simultaneously improve voidage between the double-layer scaffold in the mode that adopts axial tension inner layer pipe or axial compression outer layer pipe support after the braiding, improved the medicine carrying performance of support of pipelines so again greatly, thereby the compound pipeline complex pipeline support that forms has had the two-fold advantage of bigger mechanical property and good medicine carrying performance concurrently.
The specific embodiment
Below in conjunction with the specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used for explanation the present invention and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Embodiment 1
A kind of two-layer compound pipeline support is combined by inside and outside two-layer pipeline, and inner layer pipe is the latticed pipeline of PPDO fibrage, and outer layer pipe is the latticed pipeline of polyglycollide fibre braiding; The PPDO fiber is monofilament, and diameter is 0.2mm, and polyglycollide fibre is multifilament, diameter 0.15mm; Inner layer pipe and outer layer pipe are isometric.The manufacture method of this two-layer compound pipeline support is: as tube core, at first use PPDO fibrage inner layer pipe support with metallic conduit on braider, the mesh-density of inner layer pipe is 48 hole/square centimeters; After braiding is good, again with the inner layer pipe support as tube core, with polyglycollide fibre woven outer layer support of pipelines, the mesh-density of outer layer pipe is 60 hole/square centimeters in its outside; The two-layer compound pipeline support that braiding is good is taken off from braider together with metal die, then from the two ends of pipeline along the inner layer pipe support two ends that axially stretch respectively to 1.1 times of original length, clamp inner layer pipe support and metal die with clip, make inner layer pipe support two ends be fixed on not resilience on the metal die; The above-mentioned double-skin duct support that fixes with clip is put into carries out thermal finalization in the baking oven, setting temperature is 85 °, and shaping time is 20 minutes; Stereotypedly two-layer compound pipeline support is taken off to come above metal die after to be cooled, at this moment, have certain clearance between inner layer pipe and the described outer layer pipe, the gap is 0.5mm; Had one's hair trimmed in the two ends of compound pipeline complex pipeline, namely make successful double-layer composite pipe road support.The two-layer compound pipeline support that this making is successful carries out the medicine carrying experiment, and the carrying drug ratio of this pipeline reaches 86.04% after tested.Being the monolayer support of pipelines of the PPDO fibrage of 0.2mm with diameter, only is 50.32% through its carrying drug ratio of medicine carrying test back discovery.
Embodiment 2
A kind of two-layer compound pipeline support is combined by inside and outside two-layer pipeline, and inner layer pipe is the latticed pipeline of PPDO fibrage, and outer layer pipe is the latticed pipeline of polyglycollide fibre braiding; The PPDO fiber is monofilament, and diameter is 0.3mm, and polyglycollide fibre is multifilament, diameter 0.18mm; Inner layer pipe and outer layer pipe are isometric.The manufacture method of this two-layer compound pipeline support is: as tube core, at first use PPDO fibrage inner layer pipe support with metallic conduit on braider, the mesh-density of inner layer pipe is 44 hole/square centimeters; After braiding is good, again with the inner layer pipe support as tube core, with polyglycollide fibre woven outer layer support of pipelines, the mesh-density of outer layer pipe is 55 hole/square centimeters in its outside; The two-layer compound pipeline support that braiding is good is taken off from braider together with metal die, then from the two ends of pipeline along the inner layer pipe support two ends that axially stretch respectively to 1.05 times of original length, clamp inner layer pipe support and metal die with clip, make inner layer pipe support two ends be fixed on not resilience on the metal die; The above-mentioned double-skin duct support that fixes with clip is put into carries out thermal finalization in the baking oven, setting temperature is 83 °, and shaping time is 18 minutes; Stereotypedly two-layer compound pipeline support is taken off to come above metal die after to be cooled, at this moment, have certain clearance between inner layer pipe and the described outer layer pipe, the gap is 0.4mm; Had one's hair trimmed in the two ends of compound pipeline complex pipeline, namely make successful double-layer composite pipe road support.The two-layer compound pipeline support that this making is successful carries out the medicine carrying experiment, the carrying drug ratio of this pipeline reaches 75.38% after tested, being the monolayer support of pipelines of the PPDO fibrage of 0.3mm with diameter, only is 43.34% through its carrying drug ratio of medicine carrying test back discovery.
Embodiment 3
A kind of two-layer compound pipeline support is combined by inside and outside two-layer pipeline, and inner layer pipe is the latticed pipeline of PPDO fibrage, and outer layer pipe is the latticed pipeline of polyglycollide fibre braiding; The PPDO fiber is monofilament, and diameter is 0.4mm, and polyglycollide fibre is multifilament, diameter 0.20mm; Inner layer pipe and outer layer pipe are isometric.The manufacture method of this two-layer compound pipeline support is: as tube core, at first use PPDO fibrage inner layer pipe support with metallic conduit on braider, the mesh-density of inner layer pipe is 40 hole/square centimeters; After braiding is good, again with the inner layer pipe support as tube core, with polyglycollide fibre woven outer layer support of pipelines, the mesh-density of outer layer pipe is 50 hole/square centimeters in its outside; The two-layer compound pipeline support that braiding is good is taken off from braider together with metal die, then from the two ends of pipeline along the inner layer pipe support two ends that axially stretch respectively to 1.00 times of original length, clamp inner layer pipe support and metal die with clip, make inner layer pipe support two ends be fixed on not resilience on the metal die; The above-mentioned double-skin duct support that fixes with clip is put into carries out thermal finalization in the baking oven, setting temperature is 80 °, and shaping time is 15 minutes; Stereotypedly two-layer compound pipeline support is taken off to come above metal die after to be cooled, at this moment, have certain clearance between inner layer pipe and the described outer layer pipe, the gap is 0.3mm; Had one's hair trimmed in the two ends of compound pipeline complex pipeline, namely make successful double-layer composite pipe road support.The two-layer compound pipeline support that this making is successful carries out the medicine carrying experiment, the carrying drug ratio of this pipeline reaches 61.22% after tested, being the monolayer support of pipelines of the PPDO fibrage of 0.4mm with diameter, only is 40.32% through its carrying drug ratio of medicine carrying test back discovery.
Embodiment 4
A kind of two-layer compound pipeline support is combined by inside and outside two-layer pipeline, and inner layer pipe is the latticed pipeline of PPDO fibrage, and outer layer pipe is the latticed pipeline of polyglycollide fibre braiding; The PPDO fiber is monofilament, and diameter is 0.2mm, and polyglycollide fibre is multifilament, diameter 0.15mm; Inner layer pipe and outer layer pipe are isometric.The manufacture method of this two-layer compound pipeline support is: as tube core, at first use PPDO fibrage inner layer pipe support with metallic conduit on braider, the mesh-density of inner layer pipe is 48 hole/square centimeters; After braiding is good, again with the inner layer pipe support as tube core, with polyglycollide fibre woven outer layer support of pipelines, the mesh-density of outer layer pipe is 60 hole/square centimeters in its outside; The two-layer compound pipeline support that braiding is good is taken off from braider together with metal die, then from the two ends of pipeline along axially compressing the outer layer pipe support respectively to 0.85 times of original length, clamp inner layer pipe support and metal die with clip, make inner layer pipe support two ends be fixed on not resilience on the metal die; The above-mentioned double-skin duct support that fixes with clip is put into carries out thermal finalization in the baking oven, setting temperature is 85 °, and shaping time is 20 minutes; Stereotypedly two-layer compound pipeline support is taken off to come above metal die after to be cooled, at this moment, have certain clearance between inner layer pipe and the described outer layer pipe, the gap is 0.5mm; Had one's hair trimmed in the two ends of compound pipeline complex pipeline, namely make successful double-layer composite pipe road support.The two-layer compound pipeline support that this making is successful carries out the medicine carrying experiment, and the carrying drug ratio of this pipeline reaches 87.23% after tested.Being the monolayer support of pipelines of the PPDO fibrage of 0.2mm with diameter, only is 52.33% through its carrying drug ratio of medicine carrying test back discovery.
Embodiment 5
A kind of two-layer compound pipeline support is combined by inside and outside two-layer pipeline, and inner layer pipe is the latticed pipeline of PPDO fibrage, and outer layer pipe is the latticed pipeline of polyglycollide fibre braiding; The PPDO fiber is monofilament, and diameter is 0.2mm, and polyglycollide fibre is multifilament, diameter 0.15mm; Inner layer pipe and outer layer pipe are isometric.The manufacture method of this two-layer compound pipeline support is: as tube core, at first use PPDO fibrage inner layer pipe support with metallic conduit on braider, the mesh-density of inner layer pipe is 48 hole/square centimeters; After braiding is good, again with the inner layer pipe support as tube core, with polyglycollide fibre woven outer layer support of pipelines, the mesh-density of outer layer pipe is 60 hole/square centimeters in its outside; The two-layer compound pipeline support that braiding is good is taken off from braider together with metal die, then from the two ends of pipeline along axially compressing the outer layer pipe support respectively to 0.87 times of original length, clamp inner layer pipe support and metal die with clip, make inner layer pipe support two ends be fixed on not resilience on the metal die; The above-mentioned double-skin duct support that fixes with clip is put into carries out thermal finalization in the baking oven, setting temperature is 85 °, and shaping time is 20 minutes; Stereotypedly two-layer compound pipeline support is taken off to come above metal die after to be cooled, at this moment, have certain clearance between inner layer pipe and the described outer layer pipe, the gap is 0.5mm; Had one's hair trimmed in the two ends of compound pipeline complex pipeline, namely make successful double-layer composite pipe road support.The two-layer compound pipeline support that this making is successful carries out the medicine carrying experiment, and the carrying drug ratio of this pipeline reaches 86.65% after tested.Being the monolayer support of pipelines of the PPDO fibrage of 0.2mm with diameter, only is 51.54% through its carrying drug ratio of medicine carrying test back discovery.
Embodiment 6
A kind of two-layer compound pipeline support is combined by inside and outside two-layer pipeline, and inner layer pipe is the latticed pipeline of PPDO fibrage, and outer layer pipe is the latticed pipeline of polyglycollide fibre braiding; The PPDO fiber is monofilament, and diameter is 0.2mm, and polyglycollide fibre is multifilament, diameter 0.15mm; Inner layer pipe and outer layer pipe are isometric.The manufacture method of this two-layer compound pipeline support is: as tube core, at first use PPDO fibrage inner layer pipe support with metallic conduit on braider, the mesh-density of inner layer pipe is 48 hole/square centimeters; After braiding is good, again with the inner layer pipe support as tube core, with polyglycollide fibre woven outer layer support of pipelines, the mesh-density of outer layer pipe is 60 hole/square centimeters in its outside; The two-layer compound pipeline support that braiding is good is taken off from braider together with metal die, then from the two ends of pipeline along axially compressing the outer layer pipe support respectively to 0.85 times of original length, clamp inner layer pipe support and metal die with clip, make inner layer pipe support two ends be fixed on not resilience on the metal die; The above-mentioned double-skin duct support that fixes with clip is put into carries out thermal finalization in the baking oven, setting temperature is 85 °, and shaping time is 20 minutes; Stereotypedly two-layer compound pipeline support is taken off to come above metal die after to be cooled, at this moment, have certain clearance between inner layer pipe and the described outer layer pipe, the gap is 0.5mm; Had one's hair trimmed in the two ends of compound pipeline complex pipeline, namely make successful double-layer composite pipe road support.The two-layer compound pipeline support that this making is successful carries out the medicine carrying experiment, and the carrying drug ratio of this pipeline reaches 85.65% after tested.Being the monolayer support of pipelines of the PPDO fibrage of 0.2mm with diameter, only is 50.95% through its carrying drug ratio of medicine carrying test back discovery.
Claims (10)
1. two-layer compound pipeline support, it is characterized in that: described two-layer compound pipeline support is combined by inside and outside two-layer pipeline, described inner layer pipe is the latticed pipeline of PPDO fibrage, and described outer layer pipe is the latticed pipeline of polyglycollide fibre braiding;
Described PPDO fiber is monofilament;
Described polyglycollide fibre is multifilament;
Have certain clearance between described inner layer pipe and the described outer layer pipe, the gap is 0～0.5mm.
2. a kind of two-layer compound pipeline support according to claim 1 is characterized in that described inner layer pipe and outer layer pipe are isometric; The mesh-density of described inner layer pipe is 40-48 hole/square centimeter, and the mesh-density of described outer layer pipe is 50-60 hole/square centimeter.
3. a kind of two-layer compound pipeline support according to claim 1 is characterized in that the diameter of described polydioxanone monofilament fiber is 0.2-0.4mm.
4. a kind of two-layer compound pipeline support according to claim 1 is characterized in that, described poly-Acetic acid, hydroxy-, bimol. cyclic ester multifilament fiber diameter 0.15-0.2mm.
5. the manufacture method of a two-layer compound pipeline support, it is characterized in that: with metallic conduit as tube core, on braider, at first use PPDO fibrage inner layer pipe support, after braiding is good, again with the inner layer pipe support as tube core, in its outside with polyglycollide fibre woven outer layer support of pipelines; The two-layer compound support that braiding is good is taken off from braider together with metal die, then from the two ends of pipeline along axially stretch respectively inner layer pipe support two ends to the 1.05-1.1 of original length doubly, clamp inner layer pipe support and metal die with clip, make inner layer pipe support two ends be fixed on not resilience on the metal die; The above-mentioned double-skin duct support that fixes with clip is put into carries out thermal finalization in the baking oven, setting temperature is 80 ℃-85 ℃, and shaping time is 15-20 minute; Stereotypedly two-layer compound pipeline support is taken off to come above metal die after to be cooled, had one's hair trimmed in the two ends of compound pipeline complex pipeline, namely make successful double-layer composite pipe road support.
6. the manufacture method of a kind of two-layer compound pipeline support according to claim 5 is characterized in that, the mesh-density of described inner layer pipe support is 36-45 hole/square centimeter, and the mesh-density of described outer layer pipe support is 45-55 hole/square centimeter.
7. the manufacture method of a kind of two-layer compound pipeline support according to claim 5 is characterized in that, described PPDO fiber is monfil, and diameter is 0.2-0.4mm; Described polyglycollide fibre is multifilament fiber, and diameter is 0.15-0.2mm.
8. the manufacture method of a two-layer compound pipeline support, it is characterized in that: with metallic conduit as tube core, on braider, at first use PPDO fibrage inner layer pipe support, after braiding is good, again with the inner layer pipe support as tube core, in its outside with polyglycollide fibre woven outer layer support of pipelines; The two-layer compound support that braiding is good is taken off from braider together with metal die, then from the two ends of pipeline along axially compress respectively the outer layer pipe support to the 0.85-0.9 of original length doubly, clamp outer layer pipe support and inner layer pipe respectively with clip, make its two ends be fixed on not resilience on the metal die; The above-mentioned double-layer scaffold that fixes with clip is put into carries out thermal finalization in the baking oven, setting temperature is 80 ℃-85 ℃, and shaping time is 15-20 minute; Stereotypedly two-layer compound pipeline support is taken off to come above metal die after to be cooled, had one's hair trimmed in the two ends of compound pipeline complex pipeline, namely make successful double-layer composite pipe road support; Wherein, described PPDO fiber is monofilament; Described polyglycollide fibre is multifilament.
9. the manufacture method of a kind of two-layer compound pipeline support according to claim 8 is characterized in that, the mesh-density of described inner layer pipe support is 35-46 hole/square centimeter, and the mesh-density of described outer layer pipe support is 42-53 hole/square centimeter.
10. the manufacture method of a kind of two-layer compound pipeline support according to claim 8 is characterized in that, the diameter of described polydioxanone monofilament fiber is 0.2-0.4mm; The diameter of described poly-Acetic acid, hydroxy-, bimol. cyclic ester multifilament fiber is 0.15-0.2mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100782556A CN102160830B (en) | 2011-03-30 | 2011-03-30 | Double-layer compound pipeline bracket and manufacturing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100782556A CN102160830B (en) | 2011-03-30 | 2011-03-30 | Double-layer compound pipeline bracket and manufacturing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102160830A CN102160830A (en) | 2011-08-24 |
| CN102160830B true CN102160830B (en) | 2013-07-10 |
Family
ID=44462459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100782556A Active CN102160830B (en) | 2011-03-30 | 2011-03-30 | Double-layer compound pipeline bracket and manufacturing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102160830B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656838A (en) * | 2013-12-31 | 2014-03-26 | 易生科技(北京)有限公司 | Guide pipe of special ball bag structure |
| CN113599035A (en) * | 2021-09-02 | 2021-11-05 | 东莞颠覆产品设计有限公司 | Support and application |
| CN115553972B (en) * | 2022-10-19 | 2023-10-20 | 常州乐奥医疗科技股份有限公司 | Biliary tract stent manufacturing method and biliary tract stent |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496754A (en) * | 2008-01-29 | 2009-08-05 | 太雄医疗器株式会社 | Biodegradable double stent |
| CN101496753A (en) * | 2008-01-29 | 2009-08-05 | 太雄医疗器株式会社 | Double-tube type stent |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8114147B2 (en) * | 2008-06-16 | 2012-02-14 | Boston Scientific Scimed, Inc. | Continuous double layered stent for migration resistance |
-
2011
- 2011-03-30 CN CN2011100782556A patent/CN102160830B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496754A (en) * | 2008-01-29 | 2009-08-05 | 太雄医疗器株式会社 | Biodegradable double stent |
| CN101496753A (en) * | 2008-01-29 | 2009-08-05 | 太雄医疗器株式会社 | Double-tube type stent |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102160830A (en) | 2011-08-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20210282915A1 (en) | Composite lumen with reinforcing textile and matrix | |
| JP6537656B2 (en) | Warp knitted fabric and medical materials | |
| CN102973341B (en) | Braided self-expanding type tube cavity support and manufacturing method thereof | |
| US3463158A (en) | Polyglycolic acid prosthetic devices | |
| CN101428155B (en) | Composite artificial minute vessel stent and preparation method thereof | |
| US7582108B2 (en) | Tubular implant | |
| AU2013231444B2 (en) | Improved absorbable cap for bladder enlargement in patients with low compliance or for the replacement of a vast portion of bladder following bilharzia | |
| CN103142335B (en) | A kind of thermoplastic degradable fiber woven stent and preparation method thereof | |
| CN104689379B (en) | A kind of Weaving type is integrally formed blood vessel covered stent and preparation method thereof | |
| CN104168856B (en) | Replace the improved reinforcing PGA absorbability sticking patch of a wall of urinary bladder part after partial cystectomy | |
| CN107320224B (en) | Weaving base reinforcing degradable intraluminal stent and its preparation and application | |
| CN101234041A (en) | Atrial septal defect plugging device knitted by degradable material | |
| CN104720941A (en) | Vessel stent and production method thereof | |
| CN102160830B (en) | Double-layer compound pipeline bracket and manufacturing method thereof | |
| CN109771085B (en) | Three-dimensional hernia repair patch with anti-curling property and preparation method thereof | |
| CN202637199U (en) | Spiral degradable esophageal stent | |
| Aibibu et al. | An overview of braiding structure in medical textile: fiber-based implants and tissue engineering | |
| CN101234042B (en) | Method for knitting degradable heart atrial septal defect plugging device | |
| JP6506403B2 (en) | Resorbable and biocompatible PGA implant for implant after excision of IPP plaques | |
| CN201342120Y (en) | Composite artificial small blood vessel support | |
| CN103157132A (en) | Artificial small vessel stent | |
| CN202982316U (en) | Self-expanding type knitted tube bracket | |
| CN201591650U (en) | Degradable developable patent ductus arteriosus closer | |
| CN201453450U (en) | Mesh fabric for medical hernia patches | |
| CN104922736A (en) | Graphene heart stent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |