CN103157132A - Artificial small vessel stent - Google Patents
Artificial small vessel stent Download PDFInfo
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- CN103157132A CN103157132A CN 201110414698 CN201110414698A CN103157132A CN 103157132 A CN103157132 A CN 103157132A CN 201110414698 CN201110414698 CN 201110414698 CN 201110414698 A CN201110414698 A CN 201110414698A CN 103157132 A CN103157132 A CN 103157132A
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Abstract
The invention discloses an artificial small vessel stent. The bionic concept is applied to building an artificial small vessel, the natural three-layer structure of blood vessels is mimicked, a medical-grade poly(p-dioxanone) suture line with good strength and elasticity is weaved into a netting tubular fabric as an intermediate elastic layer, blended chondroitin sulfate-collagen coating is used as an inner layer, a substrate fibrous layer is coated as an outer layer, and the above structure is reinforced by suture lines, and the stent is formed by combination. The degradable small vessel stent with physical and chemical, biomechanical properties similar to normal blood vessels and capable of matching with regenerated own vessel tissue is prepared.
Description
Technical field
The invention belongs to the medical tissue field of engineering technology, be specifically related to a kind of artificial minute vessel stent of three-layer composite structure.
Background technology
Organizational project is the emerging interdisciplinary field that grows up in the last thirty years, and its final purpose is to produce for recovering, keep or promote the product of human body damaged organ or organizational structure and function, such as organization engineering skin, bone, cartilage, tendon etc.
The tissue engineering blood vessel is as one of the product in tissue engineering field, and its development makes cardiovascular diseases's treatment full of hope, indicates that tissue engineering has stepped a great step by single organization's regeneration to complex tissue prefabricated.Its core is seed cell, can carries out the interaction of vascular stent material and cell and the intravascular stent of vital movement for seed cell, and its main research is the preparation of vascular stent material, screening and the cultivation of seed cell.In recent years, developing rapidly as the mankind seek and develop desirable tissue engineering blood vessel support of polymeric biomaterial and biotechnology provides new approach.About synthetic degradable macromolecule vascular stent material, most study is poly-acetic acid, polyurethane, polylactide and its copolymer both at home and abroad.Existing artificial blood vessel material all has unsatisfactory part, when substituting the little blood vessel of diameter＜5mm, usually causes vascular occlusion to make graft failure because thrombosis and new intima thicken.Be faced with at present following difficulty: 1) mechanical strength and elasticity: the fourth that implants at present can be born certain pressure of pulmonary circulation, but still needs further to improve for the holding capacity of body circulating pressure.As PGA, PLA material degradation time be 68 weeks, degradation time is too fast, causes engineering blood vessel soft, fragile, mechanical support power a little less than; 2) long-term patency rate: heavy caliber TEBV can keep certain long-term patency rate at present, but the long-term patency rate of small-bore TEBV is still undesirable; 3) the material hydrophilic poor cause the cell absorption affinity a little less than.As polyurethane material, its compliance is very good, and mechanical property is also fine, and document is also more aspect the research of engineering blood vessel.But this material degradation rate is relatively poor, cell thereon adhesive capacity and proliferation activity relatively poor, the focusing in the researchs that promote the polyurethane surface endothelialization of at present a lot of experiments.Desirable artificial blood vessel should be able to be reinvented along with the degraded of support in agglutination, forms one and has the neovascularity of same mechanical and biological property with host's tremulous pulse.
Summary of the invention
The objective of the invention is for the deficiencies in the prior art, design and a kind ofly reinvent along with the degraded of support in agglutination, can form the composite artificial minute vessel stent that has the neovascularity of same mechanical and biological property with host's tremulous pulse.
The technical solution adopted in the present invention is:
A kind of artificial minute vessel stent, it is characterized in that: described support is three-decker, the webmaster shape fabric that is woven into medical grade PPDO (PDS) suture is as middle elastic layer, and internal layer is blend chondroitin sulfate-collagenic coating, and skin is matrix fiber layer (SIS).
Described minute vessel stent is reinforced with medical grade PPDO suture, combined shaping.
The external diameter of described minute vessel stent is 3.5 4.5mm, and internal diameter is 3.2 3.8mm, thickness of pipe wall 0.3 1.3mm.
Compared with prior art, the invention has the advantages that:
1) the PDS fiber is applied to the patient as absorbable suture clinically, so non-toxic and safe, and its mechanical strength is high, physicochemical property is good, keep strength time long, the degraded and absorbed time is suitable, and woven performance is good, Bian weaves its monofilament structure with monfil can guarantee the mechanical property of materials, reduces simultaneously the foreign body reaction of tissue.SIS has suitable mechanical characteristic, domestic have the scholar directly with the small intestinal submucosa pipe as blood vessel graft, but it easily subsides, and low patency rate has limited further research and uses.With the inner support of PDS braiding webmaster as the artificial blood vessel, support fibrous layer, can guarantee to be implanted into body and provide enough mechanics supports after interior.
2) the present invention weaves webmaster as artificial blood vessel's inner support with PDS, support the SIS fibrous layer, use the continuous sewn reinforcement of PDS suture between two-layer, at last at rack inner wall chondroitin sulfate-collagenic coating, make three-decker become as a whole, the mechanical property of support be can increase, and SIS layer and the disengagement under blood flow impacts of PDS layer of support prevented.Adopt simultaneously this law to build intravascular stent, use at last the blend collagenic coating, make inner surface of tube wall smooth, avoid the exposure of reinforced suture in blood, this is the very important factor of small-caliber vascular graft embolism occurred.
3) glutaraldehyde can make the connection that forms the covalent bond take glutaraldehyde as intermediary between collagen protein triple helix structure, also can form similar covalent bonds between collagen molecules simultaneously, in this increase collagen molecules of glutaraldehyde and intermolecular covalently bound effect, make the structure of collagen protein tend towards stability, increased the mechanical property of collagen protein.The chondroitin sulfate of introducing during simultaneously chemical crosslinking does not change collagen in vivo to the inducing action of tissue growth, and can improve the anticoagulant performance of support.
4) braiding property intravascular stent has good elasticity, tension force and compliance, and its biomechanical property has incomparable property, yet the easy running of fiber has limited its further application.We adopt the three-decker of imitating natural blood vessel, the compound blend chitosan-collagen of webmaster internal layer, and skin is coated with the matrix fiber layer, efficiently solves the running problem of webmaster.
5) the present invention is applied to biomimetic concept the structure of artificial minute vessel, imitate the three-decker of natural blood vessel, utilization has good intensity and elastic medical grade PPDO (PDS) suture is woven into webmaster shape fabric as middle elastic layer, internal layer blend chondroitin sulfate-collagenic coating, outer coated matrix fiber layer (SIS), suture is reinforced, combined shaping.
Description of drawings:
Fig. 1 is structural representation of the present invention.
The specific embodiment:
Below in conjunction with accompanying drawing, the present invention is further explained explanation.
A kind of artificial minute vessel stent as shown in Figure 1, comprise three layers, utilization has intensity and elastic medical grade PPDO (PDS) suture is woven into webmaster shape fabric as middle elastic layer (2), internal layer (3) blend chondroitin sulfate-collagenic coating (Coll), outer (1) coated matrix fiber layer (SIS), reinforce again combined shaping with described suture; Prepare have the physics and chemistry similar to normal blood vessels, biomechanical property and the degradability small-caliber vascular stent that can be complementary with the native blood vessel tissue regeneration, the external diameter of minute vessel stent is 3.5 4.5mm, internal diameter is 3.2 3.8mm, thickness of pipe wall 0.3 1.3mm.
Claims (3)
1. artificial minute vessel stent, it is characterized in that: described support is three-decker, the webmaster shape fabric that is woven into medical grade PPDO suture is as middle elastic layer (2), and internal layer is blend chondroitin sulfate-collagenic coating (3), and skin is matrix fiber layer (1).
2. composite artificial minute vessel stent as claimed in claim 1, it is characterized in that: described minute vessel stent is reinforced with medical grade PPDO suture, combined shaping.
3. composite artificial minute vessel stent as claimed in claim 1, it is characterized in that: the external diameter of described minute vessel stent is 3.5 4.5mm, internal diameter is 3.2 3.8mm, thickness of pipe wall 0.3 1.3mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110414698 CN103157132A (en) | 2011-12-13 | 2011-12-13 | Artificial small vessel stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110414698 CN103157132A (en) | 2011-12-13 | 2011-12-13 | Artificial small vessel stent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103157132A true CN103157132A (en) | 2013-06-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110414698 Withdrawn CN103157132A (en) | 2011-12-13 | 2011-12-13 | Artificial small vessel stent |
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| CN (1) | CN103157132A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104826169A (en) * | 2015-04-21 | 2015-08-12 | 湖南大学 | New artificial blood vessel |
| CN115025295A (en) * | 2022-05-27 | 2022-09-09 | 上海大学 | Intravascular stent covering film with coagulation promoting and long-term antibacterial effects and preparation method thereof |
| WO2022184183A1 (en) * | 2021-03-05 | 2022-09-09 | 上海交通大学医学院附属新华医院 | Preparation method for absorbable vascular stent coating for infant narrow blood vessel |
-
2011
- 2011-12-13 CN CN 201110414698 patent/CN103157132A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104826169A (en) * | 2015-04-21 | 2015-08-12 | 湖南大学 | New artificial blood vessel |
| WO2022184183A1 (en) * | 2021-03-05 | 2022-09-09 | 上海交通大学医学院附属新华医院 | Preparation method for absorbable vascular stent coating for infant narrow blood vessel |
| US11986575B2 (en) | 2021-03-05 | 2024-05-21 | Xinhua Hospital Affiliated To Shanghai Jiaotong University School Of Medicine | Preparation method of absorbable vascular stent coating for angiostenosis in infant |
| CN115025295A (en) * | 2022-05-27 | 2022-09-09 | 上海大学 | Intravascular stent covering film with coagulation promoting and long-term antibacterial effects and preparation method thereof |
| CN115025295B (en) * | 2022-05-27 | 2023-02-28 | 上海大学 | Intravascular stent tectorial membrane with coagulation promoting and long-term antibacterial effects and preparation method thereof |
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Application publication date: 20130619 |