CN100478037C - A fabric enhanced composite vascular prosthesis - Google Patents
A fabric enhanced composite vascular prosthesis Download PDFInfo
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- CN100478037C CN100478037C CNB2006101665686A CN200610166568A CN100478037C CN 100478037 C CN100478037 C CN 100478037C CN B2006101665686 A CNB2006101665686 A CN B2006101665686A CN 200610166568 A CN200610166568 A CN 200610166568A CN 100478037 C CN100478037 C CN 100478037C
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Abstract
The invention discloses a fabric reinforced composite artificial vessel to transplant into human body in the biological medical material manufacturing domain, which is composed of anticoagulant layer, reinforced fabric layer and elastic adhesive layer, wherein the reinforced fabric layer and elastic adhesive layer constitute the frame of artificial vessel; the reinforced fabric layer is buried in the elastic adhesive layer; the anticoagulant layer is set on the inner surface of artificial vessel frame of reinforced fabric layer and elastic adhesive layer, which forms blood flow channel; the anticoagulant layer and elastic adhesive layer are blending bulk of polyurethane or hyper-fine protein powder and polyurethane with grafted sulfuric group on the surface with micro-hole on the inner part.
Description
Technical field
The present invention relates to the enhanced composite vascular prosthesis of a kind of fabric, particularly a kind of can implant into body in and have an artificial blood vessel of good antithrombotic and biocompatibility.
Background technology
Medical circle can be treated the human common disease of the overwhelming majority, the property implanted in surgical operation medical material is used very extensive, and multiple implantation medical material has been obtained greatly degree solution patient's misery of good medical treatment effect clinically.The existing so far nearly 60 years history of the exploitation of artificial blood vessel and development.Succeed in developing polyvinyl (Vinyon " N ") artificial blood vessel first from nineteen fifty-two VoorheeS, and since being used for clinical achieving success in next year, people have researched and developed out the artificial blood vessel of various materials, multiple molding and different porosities successively.
The artificial blood vessel of prior art generally is to adopt the woven method system of knitting to form, and domestic existing woven blood vessel's organizational structure is broadly divided into tube wall fiber alignment two kinds of fluffy satin weaves of plain weave and fibrous structure closely.The former comprises woven real silk artificial blood vessel, weaving polyester artificial vascular and real silk and the interlacing artificial blood vessel of terylene, and the latter then is woven lint type dacron-made artificial blood vessel.Textile artificial blood vessel is owing to the vascular quality problem that the reason of processing and arrangement aspect, back causes has mainly showed: oozing of blood is serious, loosing-resistant poor performance, self-supporting structure are bad, easily subside, vertical and radial poor compliance or the like.Maximum diameter of hole and permeability resistance are to realize in the operation the not fundamental of oozing of blood and the cell growth of operation back.The permeability of fabric and the density of fabric, the structure of organizational structure and used yarn all has very big relation.The major issue that exists in the present domestic woven artificial blood vessel is that the impermeabilisation ability of fabric is also poor.Ideal artificial blood vessel should have the favorable tissue compatibility, antithrombotic, physical stability, anti-infection property and be convenient to surgeon's use.The subject matter that small-bore artificial blood vessel exists is that artificial blood vessel does not have antithrombotic fully, and blood flow is when inner chamber, because blood flow is little, flow velocity is slow, easily forms mural thrombus at artificial III tube chamber face, and blood clotting is hyperfunction thereupon, blood flow is slower, and the thrombosis layer thickens, and finally causes the artificial blood vessel obturation.
The research of many researcheres is in recent years just concentrating in the use of semiconductor fiber, particularly in the application of absorbable bicomponent fibre, surface modification and three-dimensional rack, mainly contains:
(1) artificial blood vessel of chamber face liner endotheliocyte
Thrombosis is the main cause of clinical failure after artificial graft's material implants.Though often be devoted to grow to material surface by the physicochemical property and the stimulation vascular endothelial cell that change material surface, plant the antithrombotic top layer that vascular endothelial cell can form blood vessel in the analog on the artificial blood vessel surface, can improve the blood compatibility of material, particularly improve the patency rate of small-bore artificial blood vessel.Adopt the artificial blood vessel patency rate of this method development higher, can reach 96%, but have two main problems: 1. Zhong Zhi endothelial cell activity is low, is not enough to form at material surface the endothelial layer of a fusion; 2. the time between cell seeding is implanted to operation is too short, and blood flow has washed away as yet the not endotheliocyte of sticking wall.Therefore there is very big difficulty technically.
(2) autologous tissue's sheet transplantation type artificial blood vessel
Artificial blood tube chamber face also can obtain quick new intima through transplanting from body blood vessel fragment, has obtained good result in zoopery.Make it be embedded in the artificial blood vessel space through the syringe water injection pressure autogenous vein fragment of tissue, endotheliocyte is provided, form endothelial layer on this basis in vivo.Equipment and technology that the development of this kind artificial blood vessel needs are fairly simple, the patency rate of blood vessel is higher, but limited from the source of body blood vessel, and bigger to patient's injury, simultaneously must adopt heparin and collagen to overcome the formation of thrombosis, can not reach permanently effective purpose.
(3) composite artificial blood vessel
Nineteen eighty-two Wesolow Wesolow A. " Thorac Cardiovase Suregon " (1982 (30): 196～208). proposed in " The healing of arterial prostheses:the state of theart " literary composition of delivering on the magazine---plant the artificial blood vessel of absorbable fibre component, during transplanting, mesh is little, can reduce oozing of blood, after implanting, absorbable fibre is absorbed, and it is big that mesh becomes, and is beneficial to the formation of new intima.Employed fiber can be degraded in human body, helps improving the compatibility of artificial blood vessel and human body, but can not play antithrombotic effect.
(4) surface has antithrombotic artificial blood vessel
That use is dispelled is poly-, anticoagulant, thrombolytic agent handler hemopoietic inside pipe wall, make artificial blood vessel have one deck antithrombotic face, the main anticoagulant heparin that adopts solidifies, though heparin solidified surface energy short-term overcomes the interaction of blood and artificial blood vessel, the long-term anticoagulation that how to suit still remains further to be studied.
Have in view of that, provide a kind of impermeabilisation ability good and can prevent that the artificial blood vessel of thrombosis and neointimal hyperplasia is real in necessary.
Summary of the invention
For impermeabilisation the ability also poor and small-bore artificial blood vessel antithrombotic difference of the artificial blood vessel that solves prior art and the problem of neointimal hyperplasia, the invention provides a kind of artificial blood vessel with superperformance, its technical solution is:
Artificial blood vessel is by being made of anticoagulation layer, fabric enhancement layer and elastic bonding layer, wherein, fabric enhancement layer and elastic bonding layer constitute the skeleton of artificial blood vessel, the fabric enhanced layer packets is embedded among the elastic bonding layer, the anticoagulation layer sticks on the internal layer surface of the artificial blood vessel skeleton that fabric enhancement layer and elastic bonding layer constitute, form the passage of blood flow, anticoagulation layer and elastic bonding layer have the polyurethane of sulfonate group or particle diameter less than 50 microns the ultra-fine protein powder body and the mixture of polyurethane for surface grafting, and inner distribution micropore.When anticoagulation layer and elastic bonding layer are the mixture of ultra-fine protein powder body and polyurethane, the weight ratio of ultra-fine protein powder body and polyurethane is in the anticoagulation layer: 5: 95-80: 20, and the weight ratio of ultra-fine protein powder body of elastic bonding layer and polyurethane is: 5: 95～20: 80.Micropore size in anticoagulation layer and the elastic bonding layer is the 2-100 micron.Protein powder content changes in gradient in the elastic bonding layer.The ultra-fine protein powder body that contains in anticoagulation layer and the elastic bonding layer is gelatin, silkworm silk, Pilus Caprae seu Ovis or chitin.The fabric enhancement layer is the tubing of time processing molding, and tubing can adopt knitting, woven or non-woven method to make.The fabric enhancement layer adopts terylene, silkworm silk, spandex and polytetrafluoroethylene fibre material or blended material to make.The polyurethane and the ultra-fine protein powder body that constitute anticoagulation layer and elastic bonding layer are grafted with sulfonate group.
Owing to adopted technical scheme of the present invention, artificial blood vessel of the present invention can efficiently solve artificial blood vessel in use problem such as permeability resistance, blood compatibility and histocompatibility, antithrombotic, fatigue durability, can be used widely at medical field.
Description of drawings
Fig. 1 is the schematic cross-section of artificial blood vessel of the present invention:
Fig. 2 is an artificial blood vessel of the present invention partial cross section enlarged diagram.
The specific embodiment
The present invention is described in further detail below in conjunction with accompanying drawing.
Fig. 1 is the schematic cross-section of artificial blood vessel of the present invention.Among the figure: 1 is that anticoagulation layer, 2 is that fabric enhancement layer, 3 is the elastic bonding layer, fabric enhancement layer 2 and elastic bonding layer 3 constitute the skeleton of artificial blood vessel, be embedded among the elastic bonding layer 3 with anticoagulation layer 1 fabric enhancement layer 2, anticoagulation layer 1 sticks on the internal layer surface of the artificial blood vessel skeleton that fabric enhancement layer 2 and elastic bonding layer 3 constitute, and forms the passage of blood flow.The present invention adopts the angle of three-decker from the simulation human vas.The human vas tube wall is divided into three layers of inner membrance, middle film and adventitias, so the artificial blood vessel of our design is the composition of simulation human vas, and internal layer adopts polyurethane to combine with the protein superfine powder and simulates a small amount of connective tissue of endothelium and outside thereof; Intermediate layer employing textile material is simulated smooth muscle and the elastic fiber in the human vas; The outer connective tissue that adopts polyurethane and protein superfine powder to simulate adventitia.
Fig. 2 is an artificial blood vessel of the present invention partial cross section enlarged diagram.Among the figure: 1 is that anticoagulation layer, 2 is that fabric enhancement layer, 3 is the elastic bonding layer, and 4 is ultra-fine protein powder body, and 5 is the micropore in the artificial blood vessel.Fabric enhancement layer 2 and elastic bonding layer 3 constitute the skeleton of artificial blood vessel, be embedded among the elastic bonding layer 3 with anticoagulation layer 1 fabric enhancement layer 2, anticoagulation layer 1 sticks on the internal layer surface of the artificial blood vessel skeleton that fabric enhancement layer 2 and elastic bonding layer 3 constitute, form the passage of blood flow, anticoagulation layer 1 and elastic bonding layer 3 are the mixture of polyurethane or ultra-fine protein powder body 4 and polyurethane, and inner distribution micropore 5.When anticoagulation layer 1 and elastic bonding layer 3 during for the mixture of ultra-fine protein powder body 4 and polyurethane wherein in the anticoagulation layer 1 weight ratio of ultra-fine protein powder body 4 and polyurethane be: 5: 95-80: 20, elastic bonding layer 3 ultra-fine protein powder body 4 with the weight ratio of polyurethane are: 5: 100～20: 80.Polyurethane and protein material all are and the best macromolecular material of human compatibility, and we carry out certain processing to protein superfine powder and polyurethane, make it to have anticoagulation function, so our artificial blood vessel of design have good anticoagulation function and biocompatibility.In anticoagulation layer 1, can adopt higher ultra-fine protein powder body 4 ratios and mainly be because the two function difference in whole composite vascular prosthesis in the reason of the lower ultra-fine protein powder body ratio of elastic bonding layer 3, adopting higher ultra-fine protein powder body ratio to help forming the cell inner membrance at the artificial blood vessel inwall in anticoagulation layer 1, is too many in order to be unlikely to that elastic bonding layer 3 intensity are reduced and adopt lower ultra-fine protein powder body ratio at elastic bonding layer 3.The existence of micropore 5 can make the growth of human body cell in artificial blood vessel inside, helps generating on artificial blood vessel of the present invention human body internal film tissue.The polyurethane of formation anticoagulation layer 1, elastic bonding layer 3 and ultra-fine protein powder body are through sulfonated processing, and surface grafting has sulfonate group, can effectively play the effect of anticoagulation, anti-tampon generation.
A kind of fabric of the present invention strengthens composite vascular prosthesis, adopt polyurethane, DMF and ultra-fine protein powder body to be mixed with certain density solution, at first has certain thickness tubulose polyurethane film anticoagulation layer 1 by dipping-percolation in certain die surface formation, again tubing is enclosed within on the mould that contains the anticoagulation layer, is fabric enhancement layer 2; Adopt tubulose polyurethane film manufacturing process as previously mentioned again, form elastic bonding layer 3, simultaneously fabric enhancement layer 2 is cemented in the inner skeleton that forms of artificial blood vessel at skin.Making the inner formation of artificial blood vessel aperture through the micropore processing then is the micropore of 2-100 micron, make polyurethane and protein superfine powder have sulfonate group through sulfonated modification again, strengthen composite vascular prosthesis after operations such as typing processing are made fabric of the present invention.
Embodiment 1: selecting dacron is the fabric enhancement layer, the mixture of silk ultra-fine powder body and polyurethane is as anticoagulation layer and elastic bonding layer, wherein the weight ratio of silk ultra-fine powder body and polyurethane is in the anticoagulation layer: 60: 40, the weight ratio of ultra-fine protein powder body and polyurethane was in the elastic bonding layer: 5: 95.
At first terylene short fiber is processed into yarn on spinning frame, on tricot machine, is processed into diameter then and is 4 millimeters pipe dress fabric; It is 2 microns superfine powder that silkworm silk is processed into particle diameter; Polyurethane material is dissolved into certain density solution with DMF, in silkworm silk superfine powder and weight polyurethane than 60: 40 ratio and respectively the silkworm silk superfine powder is joined in the polyurethane solutions in silkworm silk superfine powder and the ratio of weight polyurethane than 5: 95.The mould that at first with diameter is 4 millimeters immerses silkworm silk superfine powder and the polyurethane solutions of weight polyurethane than 60: 40, and the oven dry back forms the anticoagulation layer at die surface; The pipe dress fabric that with diameter is 4 millimeters then is enclosed within same die surface again, immerse again in silkworm silk superfine powder and the polyurethane solutions of weight polyurethane than 5: 95, drying forms the elastic bonding layer, promptly make initial artificial blood vessel form, can be processed into final artificial blood vessel through microporeization, post processing such as sulfonated again.
Embodiment 2: selecting silk fabric is the fabric enhancement layer, the mixture of superfine wool powder body and polyurethane is as anticoagulation layer and elastic bonding layer, wherein the weight ratio of silk ultra-fine powder body and polyurethane is in the anticoagulation layer: 20: 80, the weight ratio of ultra-fine protein powder body and polyurethane changed in gradient in the elastic bonding layer.
The silkworm silk long filament is processed into diameter on loom be 5 millimeters pipe dress fabric; It is 10 microns, 1 micron superfine powder that Pilus Caprae seu Ovis is processed into particle diameter respectively; Polyurethane material is dissolved into certain density solution with DMF, is that 10 microns Pilus Caprae seu Ovis superfine powder joins polyurethane solutions in Pilus Caprae seu Ovis superfine powder and the ratio of weight polyurethane than 20: 80 with particle diameter, in Pilus Caprae seu Ovis superfine powder and the ratio of weight polyurethane than 5: 95,8: 92,10: 90,20: 80 respectively just particle diameter be that 1 micron Pilus Caprae seu Ovis superfine powder silkworm silk superfine powder joins in the polyurethane solutions.The mould that at first with diameter is 5 millimeters immerses silkworm silk superfine powder and the polyurethane solutions of weight polyurethane than 20: 80, and the oven dry back forms the anticoagulation layer at die surface; The pipe dress fabric that with diameter is 5 millimeters then is enclosed within same die surface again, immerse successively again in Pilus Caprae seu Ovis superfine powder and the polyurethane solutions of weight polyurethane than 5: 95,8: 92,10: 90,20: 80, drying, can become the elastic bonding layer of protein powder body distribution gradient and the protein powder body burden height on top layer successively, promptly make initial artificial blood vessel form, can be processed into final artificial blood vessel through microporeization, post processing such as sulfonated again.
Embodiment 3: selecting spandex fabric is the fabric enhancement layer, and polyurethane is as anticoagulation layer and elastic bonding layer.
Spandex continuous yarn is processed into diameter on loom be 5 millimeters pipe dress fabric; Polyurethane material is dissolved into certain density solution with DMF.The mould that at first with diameter is 5 millimeters immerses in the polyurethane solutions, and the oven dry back forms the anticoagulation layer at die surface; The pipe dress fabric that with diameter is 5 millimeters then is enclosed within same die surface again, immerses repeatedly in the polyurethane solutions again, and drying can be made into initial artificial blood vessel form, can be processed into final artificial blood vessel through microporeization, post processing such as sulfonated again.
Claims (8)
1, the enhanced composite vascular prosthesis of a kind of fabric, it is characterized in that: artificial blood vessel is by anticoagulation layer (1), fabric enhancement layer (2) and elastic bonding layer (3) constitute, wherein, fabric enhancement layer (2) and elastic bonding layer (3) constitute the skeleton of artificial blood vessel, fabric enhancement layer (2) is embedded among the elastic bonding layer (3), anticoagulation layer (1) sticks on the internal layer surface of the artificial blood vessel skeleton that fabric enhancement layer (2) and elastic bonding layer (3) constitute, form the passage of blood flow, anticoagulation layer (1) and elastic bonding layer (3) have the polyurethane of sulfonate group or particle diameter less than 50 microns the ultra-fine protein powder body (4) and the mixture of polyurethane for surface grafting, and inner distribution micropore (5).
2, the enhanced composite vascular prosthesis of a kind of fabric according to claim 1, it is characterized in that: when anticoagulation layer (1) and elastic bonding layer (3) during for the mixture of ultra-fine protein powder body (4) and polyurethane, the weight ratio of ultra-fine protein powder body and polyurethane is in the anticoagulation layer (1): 5: 95～80: 20, the weight ratio of ultra-fine protein powder body of elastic bonding layer (3) and polyurethane was: 5: 95-20: 80.
3, the enhanced composite vascular prosthesis of a kind of fabric according to claim 1 is characterized in that: micropore (5) aperture in anticoagulation layer (1) and the elastic bonding layer (3) is 2 one 100 microns.
4, the enhanced composite vascular prosthesis of a kind of fabric according to claim 1 is characterized in that: ultra-fine protein powder (4) content changes in gradient in the elastic bonding layer (3).
5, the enhanced composite vascular prosthesis of a kind of fabric according to claim 1 is characterized in that: the ultra-fine protein powder body (4) that contains in anticoagulation layer (1) and the elastic bonding layer (3) is gelatin, silkworm silk, Pilus Caprae seu Ovis or chitin.
6, the enhanced composite vascular prosthesis of a kind of fabric according to claim 1, it is characterized in that: fabric enhancement layer (2) is the tubing of time processing molding, tubing adopts knitting, woven or non-woven method to make.
7, the enhanced composite vascular prosthesis of a kind of fabric according to claim 1 is characterized in that: fabric enhancement layer (2) adopts terylene, silkworm silk, spandex and polytetrafluoroethylene fibre material or blended material to make.
8, the enhanced composite vascular prosthesis of a kind of fabric according to claim 1 is characterized in that: the polyurethane and the ultra-fine protein powder body (4) that constitute anticoagulation layer (1) and elastic bonding layer (3) are grafted with sulfonate group.
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| CNB2006101665686A CN100478037C (en) | 2006-12-30 | 2006-12-30 | A fabric enhanced composite vascular prosthesis |
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| CNB2006101665686A CN100478037C (en) | 2006-12-30 | 2006-12-30 | A fabric enhanced composite vascular prosthesis |
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| CN100478037C true CN100478037C (en) | 2009-04-15 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101270196B (en) * | 2007-12-29 | 2011-06-01 | 武汉科技学院 | Process for preparing hygroscopic vapor transmission polyurethane membrane |
| CN102296415A (en) * | 2011-07-21 | 2011-12-28 | 天津波柔婷针纺织品有限公司 | Method for weaving artificial blood vessel |
| CN107475851B (en) * | 2017-10-10 | 2019-12-31 | 东华大学 | Friction unlocking rotation type radial shrinkage and expansion pipe fabric and preparation method and application thereof |
| CN111760073B (en) * | 2020-05-18 | 2021-12-31 | 武汉杨森生物技术有限公司 | Tectorial membrane implantation medical instrument and preparation method thereof |
| CN112439094A (en) * | 2020-12-01 | 2021-03-05 | 紫水晶(山西)再生医学科技有限公司 | Artificial blood vessel based on bioactive glass material and preparation method thereof |
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Address after: 430073 Textile Road, Hongshan District, Hubei, China, No. 1, No. Patentee after: Wuhan Textile University Patentee after: Ouyang Chenxi Address before: 430073 Textile Road, Hongshan District, Hubei, China, No. 1, No. Patentee before: Wuhan University of Science and Technology Patentee before: Ouyang Chenxi |
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Application publication date: 20070801 Assignee: Wuhan Yang Sen Biotechnology Co., Ltd. Assignor: Wuhan Textile University|Ouyang Chenxi Contract record no.: 2012420000175 Denomination of invention: A fabric enhanced composite vascular prosthesis Granted publication date: 20090415 License type: Exclusive License Record date: 20121105 |
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