CN102579170A - Thermoplastic degradable fiber woven stent and preparation method thereof - Google Patents
Thermoplastic degradable fiber woven stent and preparation method thereof Download PDFInfo
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- CN102579170A CN102579170A CN2012100302854A CN201210030285A CN102579170A CN 102579170 A CN102579170 A CN 102579170A CN 2012100302854 A CN2012100302854 A CN 2012100302854A CN 201210030285 A CN201210030285 A CN 201210030285A CN 102579170 A CN102579170 A CN 102579170A
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Abstract
The invention discloses a thermoplastic degradable fiber woven stent having a chitosan coating. The thermoplastic degradable fiber woven stent is prepared by the following steps: weaving degradable fiber into a tubular object with a net structure; bonding fibers in the tubular object at intersecting points via a thermal treatment or thermal press-bonding method, to prevent fiber looseness and endow the stent with high radial supporting force; coating the tubular object with a chitosan-acetic acid-water solution, and placing in anhydrous ethanol to form a chitosan coating; and removing ethanol in a vacuum drying oven. The obtained stent is high in radial supporting force, and can be completely degraded in vivo.
Description
Technical field
The present invention relates to a kind of thermoplasticity biodegradable fiber braided support and preparation method thereof, particularly relate to a kind of be used for that the inside of human body pipeline supports, prevents that the inside of human body pipeline is narrow or the support of the thermoplasticity biodegradable fiber braiding of stopping up and method for preparing.
Background technology
Because a variety of causes, inside of human body pipeline can take place narrow or stop up, and use metal rack to prevent and treat this type disease at present.But metal rack is difficult to take out, and brings some side effect.Preparing support with degradable high polymer material is one of approach that solves the metal rack side effect.But the support with the degradable high polymer material preparation runs into the hypodynamic problem of radial support at present.The radial support power that improves the degradable high polymer material support is to make the degradable macromolecule support have a key of practical value.
Summary of the invention
The purpose of this invention is to provide a kind of support with thermoplasticity biodegradable fiber braiding of good radial support power.
Another object of the present invention provides a kind of method for preparing of support of the thermoplasticity biodegradable fiber braiding with good radial support power.
Another purpose of the present invention is the support that the thermoplasticity biodegradable fiber with good radial support power weaves to be used for the inside of human body pipeline support, prevent and treat the narrow or obstruction of inside of human body pipeline.
A purpose more of the present invention provides a kind of method of applying the chitosan coating with porous and rough surface for above-mentioned support.
For reaching above purpose, the technical scheme that the present invention adopts is following:
A kind of thermoplasticity biodegradable fiber braided support of the present invention is the hollow tubular thing that is become by thermoplasticity biodegradable fiber interlacing, and fiber and fiber bond together in the cross point, does not take place loosely, and support has bigger radial support power.
As optimized technical scheme:
Aforesaid a kind of thermoplasticity biodegradable fiber braided support; The filament diameter of described thermoplasticity biodegradable fiber is 0.1-0.6mm, and described thermoplasticity biodegradable fiber is polylactide fiber, polyglycollide fibre, lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber and gathers the dioxanone fiber.
Aforesaid a kind of thermoplasticity biodegradable fiber braided support, there is the chitosan thin layer on described thermoplasticity biodegradable fiber braided support surface, and described chitosan thin layer surface is inferior light, has porous and more coarse characteristic.
The present invention also provides a kind of method for preparing of thermoplasticity biodegradable fiber braided support, may further comprise the steps:
(1) thermoplasticity biodegradable fiber interlacing is become the hollow tubular thing;
(2) external diameter is identical with the shelf inner diameter of final required preparation stainless steel tube inserts in the above-mentioned hollow tubular thing;
(3) the hollow tubular thing that the centre is inserted with stainless steel tube places more than the softening temperature of thermoplasticity biodegradable fiber, below the melt temperature;
(4) fiber and fiber form bonding in the cross point, do not take place loosely, and support has bigger radial support power;
(5) cool off, obtain the thermoplasticity biodegradable fiber braided support of dimensionally stable.
Aforesaid method for preparing; The filament number diameter of described thermoplasticity biodegradable fiber is 0.1-0.6mm, and described thermoplasticity biodegradable fiber is polylactide fiber, polyglycollide fibre, lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber or gathers the dioxanone fiber.
Aforesaid method for preparing adopts the method for mold pressing to increase the pressure of fiber intersection points when forming bonding, make fiber and fiber in the cross point good bond.
The present invention provides a kind of method for preparing thermoplasticity biodegradable fiber braided support again, may further comprise the steps:
(1) thermoplasticity biodegradable fiber interlacing is become the hollow tubular thing;
(2) external diameter is identical with the shelf inner diameter of final required preparation stainless steel tube inserts in the above-mentioned hollow tubular thing;
(3) the hollow tubular thing that the centre is inserted with stainless steel tube places more than the softening temperature of thermoplasticity biodegradable fiber, below the melt temperature;
(4) fiber and fiber form bonding in the cross point;
(5) cool off, obtain the thermoplasticity biodegradable fiber braided support of dimensionally stable;
(6) chitosan acetic acid-aqueous solution coated is surperficial in described thermoplasticity biodegradable fiber braided support; Immerse in the dehydrated alcohol again; Chitosan is separated out; With the acetic acid eluting, obtain the thermoplasticity biodegradable fiber braided support that thermoplasticity biodegradable fiber surface has porous and the more coarse chitosan coating in surface simultaneously.
(7) in 35-50 ℃ of vacuum drying oven dry 15-30 minute, remove the ethanol in the chitosan thin layer.
Aforesaid method for preparing, the mass concentration of chitosan is 2-4% in described chitosan-acetic acid-aqueous solution, the mass ratio of acetic acid and water is: 3-5: 100.
Aforesaid method for preparing, the temperature of described dehydrated alcohol are 20-30 ℃, and the support immersion time is 10-20 minute.
Aforesaid method for preparing; The filament number diameter of described thermoplasticity biodegradable fiber is 0.1-0.6mm, and described thermoplasticity biodegradable fiber is polylactide fiber, polyglycollide fibre, lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber, polycaprolactone fiber or gathers the dioxanone fiber.
Concrete implementation procedure:
Adopt the thermoplasticity biodegradable fiber of diameter 0.1-0.6mm, for example: polylactide fiber, polyglycollide fibre, lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber, gather the dioxanone cross fibers is woven into and have cancellated tube.Adopt the degradable high polymer braiding thermoplasticity biodegradable fiber support of fibre morphology, its reason is that the degradable high polymer of fibre morphology has higher bending modulus, and can give support has higher radial support power.The tube that the thermoplasticity biodegradable fiber is woven into is placed on the metal bar, and more than the softening point temperature of thermoplasticity biodegradable fiber, heat-treat below the melting temperature, heat treatment period is 5-15 minute.The thermoplasticity biodegradable fiber takes place softening more than softening point temperature, when melting temperature is following and shrinks, and the fiber of tube and the cross point of fiber can take place bonding.Also can adopt the method for mould pressing, make the cross point of fiber and fiber better bonding.Temperature is reduced to room temperature, and the thermoplasticity biodegradable fiber hardens again.After Overheating Treatment, bonding between fiber and the fiber, the support dimensionally stable of thermoplasticity biodegradable fiber braiding; Be not easy to get loose between fiber and fiber; Support has bigger radial support power, and can be when inserting the inside of human body pipeline diameter reduction, insert smoothly; Strut then, reach the effect of supporting the inside of human body pipeline.(wherein: the mass concentration of chitosan is 2-4% with chitosan-acetic acid-aqueous solution; The mass ratio of acetic acid and water is: 3-5: 100) coated and the heat treated rack surface of process; To prop up in the dehydrated alcohol that is placed on 20-30 ℃ 10-20 minute, acetic acid is by eluting again, and chitosan is separated out fast; Forming the surface is inferior light, has porous and than the thin layer of rough features, simultaneously with the acetic acid eluting.In 35-50 ℃ of vacuum drying oven dry 15-30 minute, remove the ethanol in the chitosan thin layer.
Beneficial effect
1, support of the present invention has good radial support ability, can support the inside of human body pipeline effectively, prevent the narrow or obstruction of inside of human body pipeline.
2, support of the present invention can be degraded after accomplishing its effect fully, no longer rests in the human body.
3, support of the present invention has the chitosan coating, can eliminate or alleviate the stimulation of scaffold degradation product to body.
4, to have chitosan coating surface porous coarse for support of the present invention, helps the adhesion of additional coatings.
The specific embodiment
Below in conjunction with the specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in the restriction scope of the present invention.Should be understood that in addition those skilled in the art can do various changes or modification to the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
A kind of thermoplasticity biodegradable fiber braided support of the present invention is the hollow tubular thing that is become by thermoplasticity biodegradable fiber interlacing, and fiber and fiber bond together in the cross point, does not take place loosely, and support has bigger radial support power.
Aforesaid a kind of thermoplasticity biodegradable fiber braided support; The filament diameter of described thermoplasticity biodegradable fiber is 0.1-0.6mm, and described thermoplasticity biodegradable fiber is polylactide fiber, polyglycollide fibre, lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber or gathers the dioxanone fiber.
Aforesaid a kind of thermoplasticity biodegradable fiber braided support, there is the chitosan thin layer on described thermoplasticity biodegradable fiber braided support surface, and described chitosan thin layer surface is inferior light, has porous and more coarse characteristic.
Embodiment 1
Be that become internal diameter with Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber interlacing be the cancellated tube of having of 6mm for the lactide of 0.2mm with diameter; Again this tube is enclosed within on the metal bar that external diameter is 6mm; Place 80 ℃ of baking ovens after 5 minutes; Fiber bonds in the cross point each other, cools off, takes off, and obtains fiber loose tube does not take place.
Coated chitosan-acetic acid on the heat treated above-mentioned tube of process surface-aqueous solution; The mass concentration of chitosan is 2% in chitosan-acetic acid-aqueous solution; The mass ratio of acetic acid and water is 3: 100; Being coated with complexor is every centimetre of tube 0.023 gram, has chitosan-acetic acid-aqueous solution tubulose thing to place 20 ℃ of dehydrated alcohol coated then, shakes after 10 minutes and takes out; Place 20 ℃ of fresh dehydrated alcohol again, shake after 10 minutes and take out, with thorough eluting acetic acid; In 35 ℃ of vacuum drying ovens dry 30 minutes again, remove ethanol, promptly obtain having the lactide and the Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber support of chitosan coating.The radial support power of the every cm of this support is 195 lis of cattle.
Embodiment 2
With diameter is that gathering of 0.3mm the dioxanone cross fibers to be woven into internal diameter be the cancellated tube of having of 6mm; Again this tube is enclosed within on the metal bar that external diameter is 6mm; Place 110 ℃ of baking ovens after 10 minutes, use the mould pressing of internal diameter as 6.5mm, fiber bonds in the cross point each other; Cool off again, take off, obtain fiber loose tubulose does not take place.
Through hot pressing above-mentioned tube surface coated chitosan acetic acid-aqueous solution; The mass concentration of chitosan is 2% in chitosan-acetic acid-aqueous solution; The mass ratio of acetic acid and water is 3: 100; Being coated with complexor is every centimetre of tube 0.035 gram, has chitosan acetic acid-aqueous solution tubulose thing to place 20 ℃ of dehydrated alcohol coated then, shakes after 5 minutes and takes out; Place 20 ℃ of fresh dehydrated alcohol again, shake after 5 minutes and take out, with thorough eluting acetic acid; In 40 ℃ of vacuum drying ovens dry 20 minutes again, remove ethanol, promptly obtain having gathering of chitosan coating to the dioxanone fibrous framework.The radial support power of the every cm of this support is 239 lis of cattle.
Embodiment 3
With diameter is that to be woven into internal diameter be the cancellated tube of having of 8mm for the polylactide cross fibers of 0.6mm; Again this tube is enclosed within on the metal bar that external diameter is 8mm; Place 80 ℃ of baking ovens after 15 minutes; Fiber bonds in the cross point each other, cools off, takes off, and obtains fiber loose tubular bracket does not take place.The radial support power of the every cm of this support is 335 lis of cattle.
Embodiment 4
With diameter is that to become internal diameter be the cancellated tube of having of 8mm for the polyglycollide fibre interlacing of 0.4mm; Again this tube is enclosed within on the metal bar that external diameter is 8mm; Place 80 ℃ of baking ovens after 15 minutes; Fiber bonds in the cross point each other, cools off, takes off, and obtains fiber loose tube does not take place.
Coated chitosan-acetic acid on the heat treated above-mentioned tube of process surface-aqueous solution; The mass concentration of chitosan is 4% in chitosan-acetic acid-aqueous solution; The mass ratio of acetic acid and water is 5: 100; Being coated with complexor is every centimetre of tube 0.030 gram, has chitosan-acetic acid-aqueous solution tubulose thing to place 30 ℃ of dehydrated alcohol coated then, shakes after 5 minutes and takes out; Place 30 ℃ of fresh dehydrated alcohol again, shake after 5 minutes and take out, with thorough eluting acetic acid; In 50 ℃ of vacuum drying ovens dry 15 minutes again, remove ethanol, promptly obtain having the polyglycollide fibre support of chitosan coating.The radial support power of the every cm of this support is 355 lis of cattle.
Embodiment 5
Be that become internal diameter with Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber interlacing be the cancellated tube of having of 3mm for the lactide of 0.1mm with diameter; Again this tube is enclosed within on the metal bar that external diameter is 3mm; Place 80 ℃ of baking ovens after 5 minutes; Fiber bonds in the cross point each other, cools off, takes off, and obtains fiber loose tubular bracket does not take place.The radial support power of the every cm of this support is 150 lis of cattle.
Claims (10)
1. thermoplasticity biodegradable fiber braided support is characterized in that: described thermoplasticity biodegradable fiber braided support is the hollow tubular thing that is become by thermoplasticity biodegradable fiber interlacing, and fiber and fiber bond together in the cross point.
2. a kind of thermoplasticity biodegradable fiber braided support according to claim 1; It is characterized in that; The filament diameter of described thermoplasticity biodegradable fiber is 0.1-0.6mm, and described thermoplasticity biodegradable fiber is polylactide fiber, polyglycollide fibre, lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber, polycaprolactone fiber or gathers the dioxanone fiber.
3. a kind of thermoplasticity biodegradable fiber braided support according to claim 1; It is characterized in that; There is the chitosan thin layer on described thermoplasticity biodegradable fiber braided support surface, and described chitosan thin layer surface is inferior light, has porous and more coarse characteristic.
4. method for preparing thermoplasticity biodegradable fiber braided support according to claim 1 is characterized in that may further comprise the steps:
(1) thermoplasticity biodegradable fiber interlacing is become the hollow tubular thing;
(2) external diameter is identical with the shelf inner diameter of final required preparation stainless steel tube inserts in the above-mentioned hollow tubular thing;
(3) the hollow tubular thing that the centre is inserted with stainless steel tube places more than the softening temperature of thermoplasticity biodegradable fiber, below the melt temperature;
(4) fiber and fiber form bonding in the cross point;
(5) cool off, obtain the thermoplasticity biodegradable fiber braided support of dimensionally stable.
5. method for preparing according to claim 4; It is characterized in that; The filament number diameter of described thermoplasticity biodegradable fiber is 0.1-0.6mm, and described thermoplasticity biodegradable fiber is polylactide fiber, polyglycollide fibre, lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber and gathers the dioxanone fiber.
6. method for preparing according to claim 4 is characterized in that, adopts the method for mold pressing to increase the pressure of fiber intersection points when forming bonding, make fiber and fiber in the cross point good bond.
7. method for preparing according to the described thermoplasticity biodegradable fiber of claim 1～3 braided support is characterized in that may further comprise the steps:
(1) thermoplasticity biodegradable fiber interlacing is become the hollow tubular thing;
(2) external diameter is identical with the shelf inner diameter of final required preparation stainless steel tube inserts in the above-mentioned hollow tubular thing;
(3) the hollow tubular thing that the centre is inserted with stainless steel tube places more than the softening temperature of thermoplasticity biodegradable fiber, below the melt temperature;
(4) fiber and fiber form bonding in the cross point, do not take place loosely, and support has bigger radial support power;
(5) cool off, obtain the thermoplasticity biodegradable fiber braided support of dimensionally stable;
(6) chitosan acetic acid-aqueous solution coated is surperficial in described thermoplasticity biodegradable fiber braided support; Immerse in the dehydrated alcohol again; Chitosan is separated out; With the acetic acid eluting, obtain the thermoplasticity biodegradable fiber braided support that thermoplasticity biodegradable fiber surface has porous and the more coarse chitosan coating in surface simultaneously.
(7) dry in vacuum drying oven, remove the ethanol in the chitosan thin layer.
8. method for preparing according to claim 7 is characterized in that, the mass concentration of chitosan is 2-4% in described chitosan-acetic acid-aqueous solution, and the mass ratio of acetic acid and water is: 3～5: 100.
9. method for preparing according to claim 7 is characterized in that, the temperature of described dehydrated alcohol is 20-30 ℃, and the support immersion time is 10-20 minute; The temperature of described vacuum drying oven is 35-50 ℃, and be 15-30 minute drying time.
10. method for preparing according to claim 7; It is characterized in that; The filament number diameter of described thermoplasticity biodegradable fiber is 0.1-0.6mm, and described thermoplasticity biodegradable fiber is polylactide fiber, polyglycollide fibre, lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber or gathers the dioxanone fiber.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012100302854A CN102579170A (en) | 2012-02-10 | 2012-02-10 | Thermoplastic degradable fiber woven stent and preparation method thereof |
| CN201310046623.8A CN103142335B (en) | 2012-02-10 | 2013-02-05 | A kind of thermoplastic degradable fiber woven stent and preparation method thereof |
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| CN2012100302854A CN102579170A (en) | 2012-02-10 | 2012-02-10 | Thermoplastic degradable fiber woven stent and preparation method thereof |
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| CN201310046623.8A Active CN103142335B (en) | 2012-02-10 | 2013-02-05 | A kind of thermoplastic degradable fiber woven stent and preparation method thereof |
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| SE9102448D0 (en) * | 1990-08-28 | 1991-08-26 | Meadox Medicals Inc | RAVEL RESISTANT, SELF-SUPPORTING WOVEN GRAFT |
| JP2009160080A (en) * | 2007-12-28 | 2009-07-23 | Gunze Ltd | Biological duct stent |
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| CN102579170A (en) * | 2012-02-10 | 2012-07-18 | 东华大学 | Thermoplastic degradable fiber woven stent and preparation method thereof |
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2012
- 2012-02-10 CN CN2012100302854A patent/CN102579170A/en active Pending
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- 2013-02-05 CN CN201310046623.8A patent/CN103142335B/en active Active
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Also Published As
| Publication number | Publication date |
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| CN103142335A (en) | 2013-06-12 |
| CN103142335B (en) | 2015-08-12 |
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Application publication date: 20120718 |