CN102552998A - Medicine-loaded coating and preparation method thereof - Google Patents
Medicine-loaded coating and preparation method thereof Download PDFInfo
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- CN102552998A CN102552998A CN2012100303325A CN201210030332A CN102552998A CN 102552998 A CN102552998 A CN 102552998A CN 2012100303325 A CN2012100303325 A CN 2012100303325A CN 201210030332 A CN201210030332 A CN 201210030332A CN 102552998 A CN102552998 A CN 102552998A
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Abstract
The invention relates to a medicine-loaded coating and a preparation method thereof, in particular to a coating for a thermoplastic degradable fibrous woven stent and a preparation method for the coating. The medicine-loaded coating is a medicine-loaded thin layer which is formed on a plurality of pores and a relatively rough chitosan thin-film layer of the surface of a stent. The method for preparing the degradable medicine-loaded coating comprises the following steps of: (1) coating a chitosan-acetic acid-aqueous solution on the surface of the degradable fibrous woven stent, putting into absolute ethanol, and removing ethanol to form a chitosan coating; (2) coating a medicine-loaded polycaprolactone water dispersion on the chitosan coating, and removing the moisture to form a medicine-loaded polycaprolactone coating; and (3) continuing to coat the medicine-loaded polycaprolactone water dispersion, and adding and adjusting the medicine loading capacity and medicine loading variety. The invention is characterized in that: the method is simple and convenient; and the medicine loading variety, coating thickness and medicine loading capacity are convenient to regulate and control.
Description
Technical field
The present invention relates to a kind of drug-carried coat and preparation method thereof; Particularly relate to coating of a kind of thermoplasticity biodegradable fiber braided support and preparation method thereof, specifically a kind of medicine carrying thin layer is formed at drug-carried coat on the more coarse chitosan thin layer of rack surface porous and surface and preparation method thereof.
Background technology
Support is a kind of inside of human body pipeline that is used to support, and has these line cloggings of control or narrow function.Rack surface is often imposed the coating that contains medicine, and to prevent growth and gathering or the bacterial reproduction of tissue at rack surface, the assurance human pipeline's is unobstructed.The method for preparing the support drug-carried coat that adopts at present does; Degradable high polymer material and medicine dissolution are formed the organic solvent solution of degradable high polymer material and medicine in organic solvent; Again this solution is coated on rack surface, treat organic solvent volatilization after, form drug-carried coat.Because organic solvent volatilizees easily, cause the organic solvent solution composition of degradable high polymer material and medicine to change easily, influence the quality of drug-carried coat; In addition, organic solvent also causes environmental pollution easily.
Summary of the invention
The purpose of this invention is to provide a kind of drug-carried coat and preparation method thereof; Coating of a kind of thermoplasticity biodegradable fiber braided support and preparation method thereof particularly is provided, and specifically a kind of medicine carrying thin layer is formed at drug-carried coat on the more coarse chitosan thin layer of rack surface porous and surface and preparation method thereof.
A kind of drug-carried coat of the present invention; Described drug-carried coat is meant the medicine carrying thin layer on the more coarse chitosan thin layer of porous and surface that is formed at rack surface; The thickness of described chitosan thin layer is 5～100 microns; Described chitosan thin layer porous surface and coarse helps combining of drug-carried coat and chitosan thin layer.
As optimized technical scheme:
Aforesaid a kind of drug-carried coat, described support are thermoplasticity biodegradable fiber braided supports.
Aforesaid a kind of drug-carried coat, the filament diameter of described thermoplasticity biodegradable fiber are the 0.1-0.6 millimeter.
Aforesaid a kind of drug-carried coat is characterized in that, described thermoplasticity biodegradable fiber is polylactide fiber, polyglycollide fibre, lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber or gathers the dioxanone fiber.
Aforesaid a kind of drug-carried coat, described medicine carrying thin layer is formed by medicament-carried nano-submicron particles aqueous dispersions, and the medicine carrying granule is a degradable high polymer material polycaprolactone medicine carrying granule, by water is disperseed.
A kind of drug-carried coat of the present invention provides a kind of can prevent and treat inside of human body pipeline obstruction and vegetative support degradable drug-carried coat.
Another object of the present invention provides a kind of method for preparing of drug-carried coat; Being a kind of method for preparing that adopts the support degradable drug-carried coat of medicine carrying particle aqueous dispersion formation, is a kind of method for preparing that the medicine carrying thin layer is formed at the drug-carried coat on the more coarse chitosan thin layer of rack surface porous and surface.
A kind of method for preparing of drug-carried coat may further comprise the steps:
(1) chitosan acetic acid-aqueous solution is coated on rack surface, immerses in the dehydrated alcohol again and take out support after 3～10 minutes, rack surface promptly forms porous and the chitosan thin layer on surface more coarse (preferably needing clearer and more definite qualification); Ethanol in the chitosan thin layer can place 35-60 ℃ vacuum drying oven to dry.
(2) medicament-carried nano-submicron particles aqueous dispersions is coated on the above-mentioned chitosan thin layer, removes moisture, medicament-carried nano-submicron particles is assembled, and promptly forms the medicine carrying thin layer;
(3) through repetitive coatings medicament-carried nano-submicron particles aqueous dispersions, further improve and regulate the drug loading of support, finally obtain described drug-carried coat.
The method for preparing of aforesaid a kind of drug-carried coat, the mass concentration of chitosan is 2-4% in described chitosan acetic acid-aqueous solution, the mass ratio of acetic acid and water is: 3-5: 100.
The method for preparing of aforesaid a kind of drug-carried coat, described support are thermoplasticity biodegradable fiber braided supports, and the filament diameter of described thermoplasticity biodegradable fiber is the 0.1-0.6 millimeter.
The method for preparing of aforesaid a kind of drug-carried coat, described thermoplasticity biodegradable fiber are polylactide fiber, polyglycollide fibre, lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber or gather the dioxanone fiber.
The method for preparing of aforesaid a kind of drug-carried coat is characterized in that, medicament-carried nano-submicron particles is a degradable high polymer material polycaprolactone medicine carrying granule in described medicament-carried nano-submicron particles aqueous dispersions, by water is disperseed.
At the stent surface coated chitosan acetic acid-aqueous solution of thermoplasticity biodegradable fiber (for example, polylactide fiber, polyglycollide fibre, lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber and gather, diameter is the 0.1-0.6 millimeter) braiding (wherein to the dioxanone fiber; The mass concentration of chitosan is 2-4%, and the mass ratio of acetic acid and water is: 3-5: 100), will prop up in the dehydrated alcohol that is placed on 20-30 ℃ 10-20 minute again; With the acetic acid eluting; Chitosan is separated out fast, forms porous and the more coarse chitosan thin layer in surface at rack surface, will prop up to be placed in the vacuum drying oven again; Descended dry 15-30 minute at 35-50 ℃, remove the ethanol in the chitosan thin layer.On the chitosan thin layer, apply medicament-carried nano-submicron particles aqueous dispersions, the medicine carrying granule is a degradable high polymer material polycaprolactone medicine carrying granule, by water is disperseed.Be placed in 40-60 ℃ the vacuum drying oven 20-40 minute with what apply medicament-carried nano-submicron particles aqueous dispersions, the water evaporation forms the polycaprolactone drug-carried coat.
Can the above-mentioned medicament-carried nano of repetitive coatings-submicron particles aqueous dispersions, the process of oven dry, increase and the drug loading of adjustment support; Medicine in each medicament-carried nano-submicron particles aqueous dispersions that applies can be different, contain the drug-carried coat of medicine more than 2 kinds or 2 kinds with formation.
Beneficial effect
1, chitosan coating of the present invention has elimination or alleviates the stimulation of scaffold degradation product to body.
2, chitosan coating surface porous of the present invention is coarse, helps the adhesion of drug-carried coat.
3, degradable drug-carried coat of the present invention has the medicament slow release ability, the cycle that can prolong drug discharges.
4, degradable drug-carried coat of the present invention has and can in human body, degrade fully.
5, employing medicament-carried nano of the present invention-submicron particles aqueous dispersions does not contain organic solvent as coating liquid, can avoid contaminated environment.
6, the present invention can form the drug-carried coat that contains medicine more than 2 kinds or 2 kinds with the medicament-carried nano that is loaded with different pharmaceutical-the submicron particles aqueous dispersions applies respectively, drying.
7, method of the present invention can increase and adjust the drug loading of support easily.
The specific embodiment
Below in conjunction with the specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in the restriction scope of the present invention.Should be understood that in addition those skilled in the art can do various changes or modification to the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
A kind of drug-carried coat of the present invention; Described drug-carried coat is meant the medicine carrying thin layer on the chitosan thin layer on the porous that is formed at rack surface and surface more coarse (preferably needing clearer and more definite qualification); Described chitosan thin layer porous surface and coarse helps combining of drug-carried coat and chitosan thin layer.
Aforesaid a kind of drug-carried coat, described support are thermoplasticity biodegradable fiber braided supports.
Aforesaid a kind of drug-carried coat, the filament diameter of described thermoplasticity biodegradable fiber are 0.1～0.6 millimeter.
Aforesaid a kind of drug-carried coat, described thermoplasticity biodegradable fiber are polylactide fiber, polyglycollide fibre, lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber or gather the dioxanone fiber.
Aforesaid a kind of drug-carried coat, described medicine carrying thin layer is formed by medicament-carried nano-submicron particles aqueous dispersions, and the medicine carrying granule is a degradable high polymer material polycaprolactone medicine carrying granule, by water is disperseed.
Embodiment 1
Be that the internal diameter that the lactide of 0.2mm becomes with Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber interlacing is 6mm at diameter; Length is 45mm, has on the cancellated tube, and (mass concentration of chitosan is 2% to apply chitosan-acetic acid-aqueous solution; The mass ratio of acetic acid and water is: 3: 100); Coated weight is 0.08 gram, will be coated with chitosan acetic acid-aqueous solution tubulose thing then and place 20 ℃ of dehydrated alcohol, shakes after 10 minutes and takes out; Place 20 ℃ of fresh dehydrated alcohol again, shake after 10 minutes and take out, with thorough eluting acetic acid; In 35 ℃ of vacuum drying ovens dry 30 minutes again, remove ethanol, promptly obtain having the lactide and the Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber support of chitosan coating, the amount of chitosan is 1.6mg.
(potency of azithromycin is 2.15mg/g on above-mentioned lactide with chitosan coating and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber support, to apply azithromycin-polycaprolactone nanometer-submicron particles aqueous dispersions; Polycaprolactone content is 3.58mg/g); Coated weight is 0.107g, and dry 40 minutes removal moisture in 40 ℃ of vacuum drying ovens promptly forms the polycaprolactone coating that is loaded with azithromycin again; The amount of azithromycin is 0.23mg, and the amount of polycaprolactone is 0.38mg.
Embodiment 2
Have chitosan coating and the polycaprolactone that is loaded with azithromycin that in embodiment 1, obtain are received on the lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber support of coating; Apply paclitaxel-polycaprolactone nanometer-submicron particles aqueous dispersions (content of taxol is 0.60mg/g, and polycaprolactone content is 3.00mg/g) once more, coated weight is 0.095g; Drying was removed moisture in 40 minutes in 40 ℃ of vacuum drying ovens again; In the rack surface coating, increase paclitaxel 0.057mg and polycaprolactone 0.29mg, in the final polycaprolactone coating that is loaded with azithromycin and paclitaxel that forms, the amount of azithromycin is 0.23mg; The amount of paclitaxel is 0.057mg, and the amount of polycaprolactone is 0.67mg.
Embodiment 3
Have chitosan coating and the polycaprolactone that is loaded with azithromycin that in embodiment 1, obtain are received on the lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber support of coating; (potency of azithromycin is 2.15mg/g to apply azithromycin-polycaprolactone nanometer-submicron particles aqueous dispersions once more; Polycaprolactone content is 3.58mg/g), coated weight is 0.098g, drier 20 minutes removal moisture in 60 ℃ of vacuum drying ovens; In the rack surface coating, increase azithromycin 0.21mg and polycaprolactone 0.35mg; In the final polycaprolactone coating that is loaded with azithromycin that forms, the amount of azithromycin is 0.44mg, and the amount of polycaprolactone is 0.73mg.
Embodiment 4
At diameter is that the internal diameter that the polyglycollide fibre interlacing of 0.10mm becomes is 3mm; Length is 20mm, has on the cancellated tube, and (mass concentration of chitosan is 2% to apply chitosan-acetic acid-aqueous solution; The mass ratio of acetic acid and water is: 3: 100); Coated weight is 0.03 gram, will be coated with chitosan acetic acid-aqueous solution tubulose thing then and place 30 ℃ of dehydrated alcohol, shakes after 5 minutes and takes out; Place 20 ℃ of fresh dehydrated alcohol again, shake after 5 minutes and take out, with thorough eluting acetic acid; In 50 ℃ of vacuum drying ovens dry 15 minutes again, remove ethanol, promptly obtain having the lactide and the Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber support of chitosan coating, the amount of chitosan is 0.6mg.
(potency of azithromycin is 2.15mg/g on above-mentioned polyglycollide fibre support with chitosan coating, to apply azithromycin-polycaprolactone nanometer-submicron particles aqueous dispersions; Polycaprolactone content is 3.58mg/g); Coated weight is 0.026g, and dry 40 minutes removal moisture in 40 ℃ of vacuum drying ovens promptly forms the polycaprolactone coating that is loaded with azithromycin again; The amount of azithromycin is 0.0056mg, and the amount of polycaprolactone is 0.087mg.
Embodiment 5
At diameter is that the internal diameter that the polylactide cross fibers of 0.25mm is woven into is 6mm; Length is 50mm, has on the cancellated tube, and (mass concentration of chitosan is 2% to apply chitosan-acetic acid-aqueous solution; The mass ratio of acetic acid and water is: 3: 100); Coated weight is 0.10 gram, will be coated with chitosan acetic acid-aqueous solution tubulose thing then and place 20 ℃ of dehydrated alcohol, shakes after 10 minutes and takes out; Place 20 ℃ of fresh dehydrated alcohol again, shake after 10 minutes and take out, with thorough eluting acetic acid; In 35 ℃ of vacuum drying ovens dry 30 minutes again, remove ethanol, promptly obtain having the lactide and the Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber support of chitosan coating, the amount of chitosan is 2.0mg.
(content of taxol is 0.60mg/g on above-mentioned polylactide fibrous framework with chitosan coating, to apply paclitaxel-polycaprolactone nanometer-submicron particles aqueous dispersions; Polycaprolactone content is 3.00mg/g); Coated weight is 0.12g, and dry 40 minutes removal moisture in 40 ℃ of vacuum drying ovens promptly forms the polycaprolactone coating that is loaded with paclitaxel again; The amount of paclitaxel is 0.072mg, and the amount of polycaprolactone is 0.36mg.
Embodiment 6
At diameter is that the internal diameter that gathering of 0.6mm the dioxanone cross fibers is woven into is 14mm, and length is 40mm, has on the cancellated tube; Apply chitosan-acetic acid-aqueous solution (mass concentration of chitosan is 4%, and the mass ratio of acetic acid and water is: 5: 100), coated weight is 0.25 gram; To be coated with chitosan acetic acid-aqueous solution tubulose thing then and place 30 ℃ of dehydrated alcohol, and shake after 10 minutes and take out; Place fresh dehydrated alcohol again, shake after 10 minutes and take out, with thorough eluting acetic acid; In 50 ℃ of vacuum drying ovens dry 15 minutes again, remove ethanol, what promptly obtain having the chitosan coating gathers to the dioxanone fibrous framework chitosan amount 10.0mg.
(content of taxol is 0.60mg/g on above-mentioned polylactide fibrous framework with chitosan coating, to apply paclitaxel-polycaprolactone nanometer-submicron particles aqueous dispersions; Polycaprolactone content is 3.00mg/g); Coated weight is 0.40g, and dry 40 minutes removal moisture in 40 ℃ of vacuum drying ovens promptly forms the polycaprolactone coating that is loaded with paclitaxel again; The amount of paclitaxel is 0.24mg, and the amount of polycaprolactone is 1.2mg.
Claims (10)
1. drug-carried coat is characterized in that: described drug-carried coat is meant the medicine carrying thin layer on the porous that is formed at rack surface and the more coarse chitosan thin layer in surface.
2. a kind of drug-carried coat according to claim 1 is characterized in that, described support is a thermoplasticity biodegradable fiber braided support.
3. a kind of drug-carried coat according to claim 2 is characterized in that, the filament diameter of described thermoplasticity biodegradable fiber is 0.1～0.6 millimeter.
4. according to claim 2 or 3 described a kind of drug-carried coats, it is characterized in that described thermoplasticity biodegradable fiber is polylactide fiber, polyglycollide fibre, lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber or gathers the dioxanone fiber.
5. a kind of drug-carried coat according to claim 1 is characterized in that, described medicine carrying thin layer is formed by medicament-carried nano-submicron particles aqueous dispersions, and the medicine carrying granule is a degradable high polymer material polycaprolactone medicine carrying granule, by water is disperseed.
6. the method for preparing of a kind of drug-carried coat according to claim 1, its characteristic may further comprise the steps:
(1) chitosan acetic acid-aqueous solution is coated on rack surface; Immerse again in the dehydrated alcohol and take out support after 10-20 minute; Rack surface promptly forms the more coarse chitosan thin layer of porous and surface, and the ethanol in the chitosan thin layer places 35-50 ℃ vacuum drying oven to dry;
(2) medicament-carried nano-submicron particles aqueous dispersions is coated on the above-mentioned chitosan thin layer, removes moisture, medicament-carried nano-submicron particles is assembled, and promptly forms the medicine carrying thin layer;
(3) through repetitive coatings medicament-carried nano-submicron particles aqueous dispersions, further improve and regulate the drug loading of support, finally obtain described drug-carried coat.
7. the method for preparing of a kind of drug-carried coat according to claim 6 is characterized in that, the mass concentration of chitosan is 2.0～4.0% in described chitosan acetic acid-aqueous solution, and the mass ratio of acetic acid and water is: 3～5: 100.
8. the method for preparing of a kind of drug-carried coat according to claim 6 is characterized in that, adopts vacuum drying oven to remove moisture, and temperature is 40-60 ℃, and the time is 20-40 minute.
9. the method for preparing of a kind of drug-carried coat according to claim 6 is characterized in that, described support is a thermoplasticity biodegradable fiber braided support, and the filament diameter of described thermoplasticity biodegradable fiber is 0.1～0.6 millimeter; Medicament-carried nano-submicron particles is a degradable high polymer material polycaprolactone medicine carrying granule in described medicament-carried nano-submicron particles aqueous dispersions, by water is disperseed.
10. the method for preparing of a kind of drug-carried coat according to claim 9 is characterized in that, described thermoplasticity biodegradable fiber is polylactide fiber, polyglycollide fibre, lactide and Acetic acid, hydroxy-, bimol. cyclic ester copolyester fiber or gathers the dioxanone fiber.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012100303325A CN102552998A (en) | 2012-02-10 | 2012-02-10 | Medicine-loaded coating and preparation method thereof |
| CN201210224355.XA CN102727946B (en) | 2012-02-10 | 2012-06-29 | Drug loaded coating and its preparation method |
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| CN2012100303325A CN102552998A (en) | 2012-02-10 | 2012-02-10 | Medicine-loaded coating and preparation method thereof |
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| CN201210224355.XA Active CN102727946B (en) | 2012-02-10 | 2012-06-29 | Drug loaded coating and its preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233129A (en) * | 2017-08-01 | 2017-10-10 | 有研医疗器械（北京）有限公司 | One kind coating stem cell bone fracture device and its application method |
| CN107497035A (en) * | 2017-09-30 | 2017-12-22 | 上海威宁整形制品有限公司 | Skin dilator with VEGF sustained release PCL coatings and preparation method thereof |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106879587B (en) * | 2017-01-20 | 2020-05-22 | 华南理工大学 | Herbicide-loaded nano drug-loaded slow-release film and preparation method thereof |
| CN112546306A (en) * | 2020-12-25 | 2021-03-26 | 常州大学 | Multilayer medicine-carrying PLGA wire material, preparation method and application |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7279174B2 (en) * | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
| CN101130114A (en) * | 2007-09-06 | 2008-02-27 | 复旦大学 | Biological compatibility surface coating of implantation type medical instruments and coating method thereof |
| CN101480506A (en) * | 2008-03-03 | 2009-07-15 | 唐华 | Degradable artificial trachea stent and production method thereof |
| CN101889985B (en) * | 2010-07-08 | 2011-11-23 | 东华大学 | Medicament-carrying nano microspheres and preparation method thereof |
| CN101947333B (en) * | 2010-08-27 | 2014-06-25 | 安泰科技股份有限公司 | Biodegradable medicament-loaded polymer scaffold and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233129A (en) * | 2017-08-01 | 2017-10-10 | 有研医疗器械（北京）有限公司 | One kind coating stem cell bone fracture device and its application method |
| CN107233129B (en) * | 2017-08-01 | 2019-06-21 | 有研医疗器械（北京）有限公司 | A kind of coating stem cell bone fracture device and its application method |
| CN107497035A (en) * | 2017-09-30 | 2017-12-22 | 上海威宁整形制品有限公司 | Skin dilator with VEGF sustained release PCL coatings and preparation method thereof |
| CN107497035B (en) * | 2017-09-30 | 2020-12-08 | 上海威宁整形制品有限公司 | Skin dilator with VEGF (vascular endothelial growth factor) slow-release PCL (polycaprolactone) coating and manufacturing method thereof |
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| CN102727946B (en) | 2014-02-26 |
| CN102727946A (en) | 2012-10-17 |
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Open date: 20120711 |