CN107308484A - A kind of ultra-thin medical aerogel dressing and preparation method thereof - Google Patents

A kind of ultra-thin medical aerogel dressing and preparation method thereof Download PDF

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Publication number
CN107308484A
CN107308484A CN201710397297.3A CN201710397297A CN107308484A CN 107308484 A CN107308484 A CN 107308484A CN 201710397297 A CN201710397297 A CN 201710397297A CN 107308484 A CN107308484 A CN 107308484A
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China
Prior art keywords
ultra
alginate
aerogel dressing
preparation
dry film
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CN201710397297.3A
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CN107308484B (en
Inventor
舒泉水
孙复钱
张鹏
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Institute of Applied Chemistry Jiangxi Academy of Sciences
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Institute of Applied Chemistry Jiangxi Academy of Sciences
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Abstract

A kind of ultra-thin medical aerogel dressing and preparation method thereof, the aerogel dressing, which is constituted, is：Deionized water 45 75%；Glycerine 5 20%；Polyvinyl alcohol 2 15%；Alginate 8 30%；Nano Silver or silver ion 0 1%.Preparation technology is that above-mentioned raw materials are thoroughly mixed after dissolving, the one-step shaping using electrostatic spinning technique combination heat cross-linking method, eliminates reverse mould when making medical aquogel and the cumbersome technique of crosslinking.Preparation method is comprised the steps of：（1）Polyvinyl alcohol and alginate are weighed according to the above ratio, and 5 15% mixed solution is dissolved into deionized water；（2）Dry film is made using electrostatic spinning heat cross-linking technique in above-mentioned solution；（3）Again mixed solution is made into its ratio for constituting reclaimed water, glycerine and Nano Silver；（4）The mixed solution of 34 times of dry film weights is added step by the method through spraying or soaking（2）Dry film among, that is, it is 0.5mm or so the uniform aerogel dressing material of thickness to be fabricated to thickness.

Description

A kind of ultra-thin medical aerogel dressing and preparation method thereof
Technical field
The present invention relates to a kind of ultra-thin medical aerogel dressing and preparation method thereof, belong to medical and health technical field.
Background technology
Medical hydrogel dressings are a kind of moist dressings, and product contains more than 60% moisture, can not only absorb wound and ooze The body fluid gone out, but moisture can be provided again when wound is dried, with Moist healing environment is provided for wound, shorten wound healing Time, accelerating wound healing, while adhesion wound, the features such as not resulting in secondary damage during replacing.Suitable for burn wound, The skin blemish surface of a wound caused by various tomography thickness skin donor wounds, all kinds of operative incisions and other many reasons.With water absorption rate Height, absorption speed is fast, the features such as transparent easy observation wound.
The manufacturer of aerogel dressing has much both at home and abroad at present, raw material used and production technology also incomplete phase Together, mainly there are UV photocuring processes, electron beam irradiation cross-linking method, high temperature esterification cross-linking method, freeze-drying etc..These methods are all By way of mould pour mask, then carry out above-mentioned cross-linking method to realize.These methods not only complex process, cost of manufacture is very Height, also can not make the aerogel dressing product of large area.
The content of the invention
The purpose of the present invention is, for problem present in the preparation of existing aerogel dressing, to disclose a kind of ultra-thin medical water Gel dressing and preparation method thereof.
Realize that technical scheme is as follows, a kind of ultra-thin medical aerogel dressing, the component of the dressing presses quality Meter, includes deionized water 45-75%；Glycerine 5-20%；Polyvinyl alcohol 2-15%；Alginate 8-30%；Nano Silver or silver ion 0-1%。
A kind of preparation method of ultra-thin medical aerogel dressing, methods described step is as follows：
（1）Polyvinyl alcohol and alginate are weighed by the component of the dressing, the mixed of mass ratio 5-15% is dissolved into deionized water Close solution；
（2）Dry film is made using electrostatic spinning heat cross-linking technique in above-mentioned solution；
（3）Again mixed solution is made into its ratio for constituting reclaimed water, glycerine and Nano Silver；
（4）Method through spraying or soaking adds the mixed solution of 3-4 times of dry film weight among dry film, that is, is fabricated to thickness For the uniform aerogel dressing material of 0.5mm or so thickness.
The alginate is the one or more of sodium alginate or other soluble alginates.
When the addition of the Nano Silver or silver ion is 0%, what is be fabricated to is not anti-bacterial hydrogel.
The preparation method of polyvinyl alcohol and the alginate mixed solution is first to allow poly- second in proportion in whipping process After enol is completely dissolved in deionized water, alginate is added until being completely dissolved.
The beneficial effects of the present invention are present invention obviates reverse mould when making medical aquogel and the cumbersome work being crosslinked Skill, the one-step shaping using electrostatic spinning technique combination heat cross-linking method, realizes the aerogel dressing of large area in technique The production of coiled material, significantly simplify the production technology of aerogel dressing, reduces production cost.The present invention is not by die size Limitation, the aerogel dressing of large area can be produced, and form coiled material.The present invention utilizes electrostatic spinning technique, can make Ultra-thin aerogel dressing thick 0.5mm, and thickness is homogeneous, solves the insurmountable difficulty of other hydrogel manufacturing process Topic.
Embodiment
Embodiment 1
1st, the preparation of polyvinyl alcohol and alginate mixed solution
8 grams of polyvinyl alcohol are added in whipping process in 200 grams of deionized water, 10 grams are added to after being completely dissolved Sodium alginate continues to stir to being completely dissolved.
2nd, dry film is made in electrostatic spinning heat cross-linking technique
The mixed solution of above-mentioned polyvinyl alcohol and sodium alginate is fabricated directly into poly- second using electrostatic spinning heat cross-linking equipment The ventilative dry film of the crosslinking of enol and sodium alginate.
3rd, prepared by ultra-thin hydrogel
10 grams of glycerine and 72 grams of deionized waters are mixed, are uniformly sprayed in above-mentioned dry film.After dry film imbibition balance, i.e. shape Into ultra-thin hydrogel sheet.
Embodiment 2
1st, the preparation of polyvinyl alcohol and alginate mixed solution
5 grams of polyvinyl alcohol are added in whipping process in 200 grams of deionized water, 13 grams are added to after being completely dissolved Sodium alginate continues to stir to being completely dissolved.
2nd, dry film is made in electrostatic spinning heat cross-linking technique
The mixed solution of above-mentioned polyvinyl alcohol and sodium alginate is fabricated directly into poly- second using electrostatic spinning heat cross-linking equipment The ventilative dry film of the crosslinking of enol and sodium alginate.
3rd, prepared by ultra-thin hydrogel
10 grams of glycerine, 2 grams of 4000ppm silver-colored solution and 70 grams of deionized waters are mixed, are uniformly sprayed in above-mentioned dry film. After dry film imbibition balance, that is, form ultra-thin argentiferous hydrogel sheet.

Claims (5)

1. a kind of ultra-thin medical aerogel dressing, it is characterised in that the component of the dressing by mass, includes deionized water 45-75%；Glycerine 5-20%；Polyvinyl alcohol 2-15%；Alginate 8-30%；Nano Silver or silver ion 0-1%.
2. a kind of preparation method of ultra-thin medical aerogel dressing, it is characterised in that methods described step is as follows：
（1）Polyvinyl alcohol and alginate are weighed by the component of the dressing, the mixed of mass ratio 5-15% is dissolved into deionized water Close solution；
（2）Dry film is made using electrostatic spinning heat cross-linking technique in above-mentioned solution；
（3）Again mixed solution is made into its ratio for constituting reclaimed water, glycerine and Nano Silver；
（4）Method through spraying or soaking adds the mixed solution of 3-4 times of dry film weight among dry film, that is, is fabricated to thickness For the uniform aerogel dressing material of 0.5mm or so thickness.
3. a kind of ultra-thin medical aerogel dressing according to claim 1, it is characterised in that the alginate is marine alga The one or more of sour sodium or other soluble alginates.
4. a kind of ultra-thin medical aerogel dressing according to claim 1, it is characterised in that the Nano Silver or silver ion Addition when being 0%, what is be fabricated to is not anti-bacterial hydrogel.
5. a kind of preparation method of ultra-thin medical aerogel dressing according to claim 2, it is characterised in that the poly- second The preparation method of enol and alginate mixed solution is first to allow polyvinyl alcohol in proportion in whipping process in deionized water After being completely dissolved, alginate is added until being completely dissolved.
CN201710397297.3A 2017-05-31 2017-05-31 Ultrathin medical hydrogel dressing and preparation method thereof Active CN107308484B (en)

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Application Number Priority Date Filing Date Title
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CN107308484B CN107308484B (en) 2020-08-14

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111068103A (en) * 2020-02-06 2020-04-28 牡丹江医学院 Long-acting antibacterial gel dressing for operation wound and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101011597A (en) * 2007-01-26 2007-08-08 东南大学 Nano fibrous frame material with sodium alginate as matrix and its preparing method
CN101445636A (en) * 2009-01-04 2009-06-03 武汉理工大学 A sodium alginate and polyvinyl alcohol compound sponges material and preparation method thereof
US20120141558A1 (en) * 2006-03-28 2012-06-07 University Of Washington Alginate-based nanofibers and related scaffolds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120141558A1 (en) * 2006-03-28 2012-06-07 University Of Washington Alginate-based nanofibers and related scaffolds
CN101011597A (en) * 2007-01-26 2007-08-08 东南大学 Nano fibrous frame material with sodium alginate as matrix and its preparing method
CN101445636A (en) * 2009-01-04 2009-06-03 武汉理工大学 A sodium alginate and polyvinyl alcohol compound sponges material and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111068103A (en) * 2020-02-06 2020-04-28 牡丹江医学院 Long-acting antibacterial gel dressing for operation wound and preparation method thereof
CN111068103B (en) * 2020-02-06 2020-12-18 牡丹江医学院 Long-acting antibacterial gel dressing for operation wound and preparation method thereof

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