CN107308385A - A kind of pharmaceutical composition for treating synovitis - Google Patents

A kind of pharmaceutical composition for treating synovitis Download PDF

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Publication number
CN107308385A
CN107308385A CN201710508896.8A CN201710508896A CN107308385A CN 107308385 A CN107308385 A CN 107308385A CN 201710508896 A CN201710508896 A CN 201710508896A CN 107308385 A CN107308385 A CN 107308385A
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China
Prior art keywords
parts
synovitis
pharmaceutical composition
scorpio
tuber
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CN201710508896.8A
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Chinese (zh)
Inventor
蔡哲宇
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Guangzhou Wisdom Biotechnology Co Ltd
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Guangzhou Wisdom Biotechnology Co Ltd
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Priority to CN201710508896.8A priority Critical patent/CN107308385A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/646Arachnids, e.g. spiders, scorpions, ticks or mites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968Ophiopogon (Lilyturf)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/90Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
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  • Biotechnology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Insects & Arthropods (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of pharmaceutical composition for treating synovitis, it is made up of the raw material of following weight:10 20 parts of 10 20 parts of RHIZOMA COPTIDIS from Sichuan of China, 12 20 parts of smilax, 15 25 parts of RADIX ACONITI LATERALIS PREPARATA, 15 25 parts of the tuber of dwarf lilyturf, 10 15 parts of scorpio and the radix paeoniae rubrathe.The pharmaceutical composition for the treatment synovitis that the present invention is provided has promoting qi circulation and relieving pain, dispelling wind and eliminating dampness, hard bone strengthening tendons, eliminating evil dehumidifying and clearing and activating the channels and collaterals beneficial effect, and has special efficacy mainly for the synovitis of each joint part such as gonarthromeningitis, bursal synovitis.

Description

A kind of pharmaceutical composition for treating synovitis
Technical field
The present invention relates to the drug therapy field of orthopaedics disease, more particularly, to a kind of drug regimen for treating synovitis Thing.
Background technology
Gonarthromeningitis is a kind of sterile type inflammation, is due to sprain of knee joint and a variety of intraarticular damages and causes 's.The dysfunction of synovial membrane can cause joint fluid normally can not generate and absorb, and knee joint will produce hydrops.The form of synovial membrane Change can also attack knee cartilage, and treatment not in time can cause knee joint osseous arthritis, there is the very big crisis that disables.
Gonarthromeningitis not the limitation of has age but can all occur in any age level.Come for young man Say, they generally have a larger amount of exercise, thus during exercise easily because knee joint catch a packet, reverse, hyperkinesia Afterwards, occurs swelling, pain, activity is difficult, walk lamely on foot, local skin temperature is high, skin turgor is nervous or arthrocentesiS bleeding Situations such as property liquid.
At present in terms of doctor trained in Western medicine, mainly there are oral drugs, joint cavity injection medicine for the therapy for treating gonarthromeningitis Thing and flushing, operation etc..Although oral western medicine medicine can slow down slight illness to a certain extent, often index is not effected a permanent cure, and secondary Effect is more.The treatment cost of joint cavity injection medicine and flushing, operation etc. is larger, and risk is higher.Treat and slide in terms of the traditional Chinese medical science The scorching therapy of film mainly has external application therapy, napratherapy etc., and tcm therapy is based on expectant treatment, according to theory of traditional Chinese medical science, passes through Adjust the vital organs of the human body in body, stimulate circulation, and then reach the purpose for the treatment of.But external application therapy and napratherapy work Time it is longer, and need to for a long time adhere to, easily be recurred again if giving up halfway.
The content of the invention
To overcome existing technological deficiency, use Chinese herbal medicine preparation, treatment time short and curative effect the invention provides one kind The pharmaceutical composition of significant treatment synovitis.
To realize the purpose of the present invention, it is achieved using following technical scheme:
A kind of pharmaceutical composition for treating synovitis, it is made up of the raw material of following weight:10-20 parts of RHIZOMA COPTIDIS from Sichuan of China, soil 10-20 parts of 12-20 parts of Poria cocos, 5-15 parts of RADIX ACONITI LATERALIS PREPARATA, 15-25 parts of the tuber of dwarf lilyturf, 10-15 parts of scorpio and the radix paeoniae rubrathe.
Preferably, it is made up of the raw material of following weight:13-17 parts of RHIZOMA COPTIDIS from Sichuan of China, 15-17 parts of smilax, system 12-18 parts of 7-13 parts of monkshood, 18-23 parts of the tuber of dwarf lilyturf, 11-14 parts of scorpio and the radix paeoniae rubrathe.
Preferably, it is made up of the raw material of following weight:15 parts of RHIZOMA COPTIDIS from Sichuan of China, 16 parts of smilax, RADIX ACONITI LATERALIS PREPARATA 10 15 parts of part, 20 parts of the tuber of dwarf lilyturf, 13 parts of scorpio and the radix paeoniae rubrathe.
In the present invention, the pharmacology of each material component and effect are as follows:
RHIZOMA COPTIDIS from Sichuan of China:Nature and flavor:Bitter cold.Channel tropism:Enter the heart, liver, courage, spleen, stomach, large intestine footpath.Function:Heat-clearing and damp-drying drug, removing toxic substances.Cure mainly:The heart Heated is contained, dysphoria with smothery sensation coma or dysphoria and insomnia, red eye, swell pain, hygropyretic vomiting, rush down dysentery, the disease such as ulcerative carbuncle pyogenic infections.
Smilax:Nature and flavor:It is sweet, light, flat.Channel tropism:Enter liver, stomach, kidney channel.Function:Dampness removing heat, removing toxic substances.Cure mainly:Syphilis is disliked Sore, carbuncle turgescence canker, muscles and bones contraction, mercury poisoning.
RADIX ACONITI LATERALIS PREPARATA:Nature and flavor and channel tropism:It is pungent, sweet, big heat;It is poisonous.The thoughts of returning home, kidney, the spleen channel.Function is with curing mainly:Recuperating depleted yang, is mended Fire is supporing yang, by wind-cold damp pathogen.Collapsed for yang depletion, cold weak pulse of limb, impotence, Gong Leng, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold sensation of the genitalia oedema, Deficiency of yang diseases caused by external factors, numbness and ache of cold dampness.
The tuber of dwarf lilyturf:Nature and flavor:Sweet, slight bitter, it is slightly cold.Channel tropism:Enter lung, the heart, stomach.Function:Moistening lung clears away heart-fire, reinforcing stomach reg fluid.It is main Control:The hot hemoptysis of labor, cough caused by dryness phlegm glues, restlessness and thirst, the disease such as withered constipation in Tianjin.
Scorpio:Function is cured mainly:Wind-dispelling, only convulsion, dredging collateral, detoxify.Control infantile convulsion and take out and pluck, epilepsy, apoplexy, hemiplegia, mouth eye It is crooked, antimigraine, arthralgia pain due to rheumatism, lockjaw, scrofula, rubella sore swells.
The radix paeoniae rubrathe:Nature and flavor:Acid, it is bitter, be slightly cold.Channel tropism:Enter Liver Channel.Function:It is clear to let out irascibility, blood-stasis-dissipating blood-circulation-promoting, analgesic.Cure mainly:Month Through uncomfortable, stasis of blood, Amenorrhea note of the ancient Chinese lump in the abdomen, carbuncle sore tumefacting virus, painful swelling of joints, pain in chest and hypochondrium.
Compared with prior art, the invention has the advantages that:The present invention uses dispelling wind and eliminating pain, and hard bone strengthening tendons is dispelled The principle of heresy dehumidifying, takes RHIZOMA COPTIDIS from Sichuan of China and the anti-inflammatory of smilax toxic removing, town to be supported through analgesia, RADIX ACONITI LATERALIS PREPARATA and the invigorating the spleen of tuber of dwarf lilyturf tonifying lung, nourishing liver Kidney, scorpio and radix paeoniae rubrathe work are delayed between warp, each medicine through dredging collateral, promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain, expelling wind and clearing away cold, dispelling wind and eliminating dampness, analgesic therapy It is beneficial each other evident, and then draw evil outgoing, reach the purpose for the treatment of synovitis.Shown according to clinical test results, medicine group of the invention Compound is mainly for gonarthromeningitis, the equal special efficacy of synovitis of each joint part of bursal synovitis.
Embodiment
To make the object, technical solutions and advantages of the present invention clearer, with reference to specific embodiment to of the invention real The mode of applying is described in more detail.
Embodiment 1
A kind of pharmaceutical composition for treating synovitis, it is made up of the raw material of following weight:15 parts of RHIZOMA COPTIDIS from Sichuan of China, smilax 15 parts of 16 parts, 10 parts of RADIX ACONITI LATERALIS PREPARATA, 20 parts of the tuber of dwarf lilyturf, 13 parts of scorpio and the radix paeoniae rubrathe.
The raw material components of above-mentioned weight are weighed, the preparation method of honeyed bolus are routinely prepared by aforementioned pharmaceutical compositions It is prepared into honeyed bolus.
Embodiment 2
A kind of pharmaceutical composition for treating synovitis, it is made up of the raw material of following weight:10 parts of RHIZOMA COPTIDIS from Sichuan of China, smilax 10 parts of 12 parts, 5 parts of RADIX ACONITI LATERALIS PREPARATA, 15 parts of the tuber of dwarf lilyturf, 10 parts of scorpio and the radix paeoniae rubrathe.
Its preparation method be the same as Example 1.
Embodiment 3
A kind of pharmaceutical composition for treating synovitis, it is made up of the raw material of following weight:20 parts of RHIZOMA COPTIDIS from Sichuan of China, smilax 20 parts of 20 parts, 15 parts of RADIX ACONITI LATERALIS PREPARATA, 25 parts of the tuber of dwarf lilyturf, 15 parts of scorpio and the radix paeoniae rubrathe.
Its preparation method be the same as Example 1.
The pharmaceutical composition of the present invention can constitute the pharmaceutical preparations such as decoction, pill, electuary, take daily, and 2 week was One course for the treatment of.Present invention is generally directed to acute and chronic arthrosynovitis, bursal synovitis, the traditional Chinese medical science claims hydrops articuli, and shoulder cutting edge of a knife or a sword, elbow joint bone are wide The synovitis of each joint part such as joint has a special efficacy, pharmaceutical composition of the invention, the pain relief after 1 hour of taking medicine, Symptom is obviously improved after one week of medication, after 1 course for the treatment of of pharmaceutical composition for taking the present invention, efficient up to 100%.
The clinical test results of embodiment 4:
The patient 117 for clinically suffering from synovitis is randomly selected, wherein man 56, female 61.Age 8-14 Sui 14,15- 39 years old 22,40-59 Sui 66,60-70 Sui 15.40 are sprained, tourism, which is climbed the mountain, strains 32, without the obvious cause of disease 15. Single knee is fallen ill 12, and double knees are fallen ill 18.Clinical manifestation has knee joint bulge full, swelling and pain, hence it is evident that tenderness, floats kneecap Experiment is positive, and local skin temperature increases, inconvenient walking, joint stuffiness.The course of disease is most short 21 days, most long 5 years, wherein ill more than 3 years Person has 36, and ill more than 1 year and less than 3 years persons have 58, and ill less than 1 year has 23.Knee joint is pointed out in the inspection of CR pieces Slight regression person 18, remaining joint is without obvious osseous abnomalit.
117 patients are divided into 3 groups, every group of 39 people, wherein, first group of patient takes honeyed bolus made from embodiment 1, Second group of patient takes honeyed bolus made from embodiment 2, and the 3rd group of patient takes honeyed bolus made from embodiment 3.Wherein all patients One course for the treatment of of pharmaceutical composition using the present invention is effective, has 78 patients to take two courses for the treatment of of pharmaceutical composition of the present invention After fully recover, other 39 after with the present invention 3 to 4 courses for the treatment of of pharmaceutical composition after, all cured through follow-up.Through clinical trial With patient's readme, the therapeutic effect of honeyed bolus is compared with the therapeutic effect for being better than embodiment 2 and embodiment 3 made from embodiment 1.
Model case:Mrs Wang, 53 years old, people from Guangzhou Guangdong, it is invalid through multi-treatment to suffer within 2012 arthrosynovitis, by People introduces the state of an illness after 1 course for the treatment of of pharmaceutical composition for taking the present invention and has been clearly better, and is fully recovered after rear 3 courses for the treatment of of continual cure, Follow-up is not recurred after 1 year.

Claims (3)

1. a kind of pharmaceutical composition for treating synovitis, it is characterised in that it is made up of the raw material of following weight:River is yellow 10-20 parts of 10-20 parts of company, 12-20 parts of smilax, 5-15 parts of RADIX ACONITI LATERALIS PREPARATA, 15-25 parts of the tuber of dwarf lilyturf, 10-15 parts of scorpio and the radix paeoniae rubrathe.
2. a kind of pharmaceutical composition for treating synovitis according to claim 1, it is characterised in that it is by following parts by weight The raw material composition of proportioning:13-17 parts of RHIZOMA COPTIDIS from Sichuan of China, 15-17 parts of smilax, 7-13 parts of RADIX ACONITI LATERALIS PREPARATA, 18-23 parts of the tuber of dwarf lilyturf, scorpio 11- 14 parts and 12-18 parts of the radix paeoniae rubrathe.
3. a kind of pharmaceutical composition for treating synovitis according to claim 2, it is characterised in that it is by following parts by weight The raw material composition of proportioning:15 parts of RHIZOMA COPTIDIS from Sichuan of China, 16 parts of smilax, 10 parts of RADIX ACONITI LATERALIS PREPARATA, 20 parts of the tuber of dwarf lilyturf, 13 parts of scorpio and the radix paeoniae rubrathe 15 Part.
CN201710508896.8A 2017-06-28 2017-06-28 A kind of pharmaceutical composition for treating synovitis Withdrawn CN107308385A (en)

Priority Applications (1)

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CN201710508896.8A CN107308385A (en) 2017-06-28 2017-06-28 A kind of pharmaceutical composition for treating synovitis

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Application Number Priority Date Filing Date Title
CN201710508896.8A CN107308385A (en) 2017-06-28 2017-06-28 A kind of pharmaceutical composition for treating synovitis

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103169822A (en) * 2013-04-17 2013-06-26 宁夏张氏回医正骨医院 Synovitis hui-nationality ointment and preparation method thereof
CN105535371A (en) * 2016-02-02 2016-05-04 杨存恒 Traditional Chinese medicine for treating gonarthromeningitis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103169822A (en) * 2013-04-17 2013-06-26 宁夏张氏回医正骨医院 Synovitis hui-nationality ointment and preparation method thereof
CN105535371A (en) * 2016-02-02 2016-05-04 杨存恒 Traditional Chinese medicine for treating gonarthromeningitis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
郭吉平等: "蠲水汤治疗慢性膝关节滑膜炎的体会", 《内蒙古中医药》 *

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