CN107296839A - A kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof - Google Patents

A kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof Download PDF

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Publication number
CN107296839A
CN107296839A CN201710333266.1A CN201710333266A CN107296839A CN 107296839 A CN107296839 A CN 107296839A CN 201710333266 A CN201710333266 A CN 201710333266A CN 107296839 A CN107296839 A CN 107296839A
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CN
China
Prior art keywords
parts
chrysanthemum
pharynx
rose
buccal tablet
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Pending
Application number
CN201710333266.1A
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Chinese (zh)
Inventor
史亚东
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ANHUI JUTAI CHUJU HERBAGE TECHNOLOGY Co Ltd
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ANHUI JUTAI CHUJU HERBAGE TECHNOLOGY Co Ltd
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Priority to CN201710333266.1A priority Critical patent/CN107296839A/en
Publication of CN107296839A publication Critical patent/CN107296839A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738—Rosa (rose)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention discloses a kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof, it is made up of the raw material of following parts by weight：33 37 parts of chrysanthemum, 14 17 parts of Momordica grosvenori, 56 parts of rose, 12 15 parts of the sterculia seed, 25 30 parts of sucrose, 46 parts of food starch, 1.0 1.2 parts of maltodextrin, 0.4 0.6 parts of potassium sorbate, 0.02 0.03 parts of magnesium stearate and pure appropriate amount of water；The selected high-quality chrysanthemum of the present invention, rose are raw material, collocation multiple auxiliary materials, with good clearing heat, relieving sore-throat, moistening lung for removing phlegm and antipyretic-antalgic function, pass through the enzymolysis processing to Momordica grosvenori and the sterculia seed, fully decompose nutritional ingredient therein, it is easy to absorption of human body, significant therapeutic effect is respectively provided with to pharyngeal uncomfortable, acpuei pharyngitis and chronic pharyngitis, simultaneously, the present invention is without any side effect, instant effect, taste is sweet, and stability is good.

Description

A kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof
Technical field
The present invention relates to a kind of Traditional Chinese medicine lozenge and preparation method thereof, and in particular to a kind of pharynx-clearing throat-benefiting buccal tablet and its making Method.
Background technology
Sore-throat is a kind of most common illness, and it is mainly in the cold season in 1 year, flu, tonsillitis, nasal sinus Inflammation, pertussis, sphagitis and virus infection even myocardial infarction can cause sore-throat；The traditional Chinese medical science thinks, chronic pharyngitis can be by Caused by fire excess from yin deficiency, phlegm resistance blood stasis, deficiency of Yin Tianjin are withered etc.；Chrysanthemum is clearing heat and detoxicating, wind-heat dissipating, at present, in treatment abscess of throat Western medicine is various in style, and big multi-component complex, preparation technology difficulty is big, although all with certain curative effect, but therapeutic effect is not thorough Recurrence is also easy to after bottom, healing, and therapeutic domain is narrow, and medicine time is long, it is impossible to reach the purpose treated both principal and secondary aspect of disease.
The content of the invention
In order to alleviate shortcomings and deficiencies of the prior art, it is an object of the invention to provide a kind of pharynx-clearing throat-benefiting buccal tablet and Its preparation method.
To achieve these goals, the present invention is adopted the following technical scheme that：
Pharynx-clearing throat-benefiting buccal tablet, is made up of the raw material of following parts by weight：33-37 parts of chrysanthemum, 14-17 parts of Momordica grosvenori, rose 5-6 Part, 12-15 parts of the sterculia seed, 25-30 parts of sucrose, 4-6 parts of food starch, 1.0-1.2 parts of maltodextrin, potassium sorbate 0.4-0.6 Part, 0.02-0.03 parts of magnesium stearate and pure appropriate amount of water.
Pharynx-clearing throat-benefiting buccal tablet, is made up of the raw material of following parts by weight：35 parts of chrysanthemum, 15 parts of Momordica grosvenori, 5 parts of rose, 13 parts of the sterculia seed, 28 parts of sucrose, 5 parts of food starch, 1.1 parts of maltodextrin, 0.5 part of potassium sorbate, 0.025 part of magnesium stearate and Pure appropriate amount of water.
The preparation method of pharynx-clearing throat-benefiting buccal tablet, including herein below：
（1）10-20 mesh is crushed to after chrysanthemum, rose are cleaned, is put into the extraction equipment with reflux cooler, is added pure Water purification is extracted, and amount of water is raw material chrysanthemum, 10-30 times of volume of rose quality, is warming up to 50 DEG C -100 DEG C, extraction 0.2h-2.0h；After extraction terminates, extract solution is filtered out；Extract solution is concentrated in vacuo through vacuum filter, and 50 DEG C of its thickening temperature- 70 DEG C, concentration volume to raw material chrysanthemum, 0.3-1.0 times of rose gross mass, acquisition chrysanthemum concrete；
（2）Momordica grosvenori, the sterculia seed are weighed, 10-15 times that its mixing total amount is added after cleaning measures pure water, and mixing mashing is mixed Add cellulase and pectase thereto again afterwards, it is 60ppm-80ppm to control cellulase concentration, pectin enzyme concentration is 40ppm-55ppm；Heating water bath digests 2-3 hours to 85-90 DEG C, filters to take filtrate, sterilize to obtain enzymolysis liquid, standby；
（3）By step（2）Enzymolysis liquid pour into step（1）In chrysanthemum concrete, stir and evenly mix, sucrose, mountain are then added thereto Potassium sorbate, magnesium stearate, stirring 15-20 minutes after, add food starch, maltodextrin, etc. other remaining constitutive materials, after Continuous stirring 30-40 minutes, wet granulation and drying after being 70%-80% ethanol wets with mass fraction, re-sieving, whole grain, by this Mixture tabletting, you can.
Described chrysanthemum can arbitrarily select Bo feverfew, tribute chrysanthemum, chrysanthemum indicum, chu chrysanthemum, FLOS CHRYSANTHEMI ALBA from Haizhou of China.
Described step（2）Cellulase concentration is 70ppm, and pectin enzyme concentration is 45ppm.
Beneficial effects of the present invention：
The selected high-quality chrysanthemum of the present invention, rose are raw material, multiple auxiliary materials of arranging in pairs or groups, with good clearing heat, relieving sore-throat, moistening lung for removing phlegm With antipyretic-antalgic function, by the enzymolysis processing to Momordica grosvenori and the sterculia seed, nutritional ingredient therein is fully decomposed, is easy to human body Absorb, significant therapeutic effect is respectively provided with to pharyngeal uncomfortable, acpuei pharyngitis and chronic pharyngitis, meanwhile, the present invention is without any pair Effect, instant effect, taste is sweet, and stability is good.
Embodiment
Embodiment 1：Pharynx-clearing throat-benefiting buccal tablet, by the raw material of following parts by weight（g）It is made：35 parts of chrysanthemum, 15 parts of Momordica grosvenori, 5 parts of rose, 13 parts of the sterculia seed, 28 parts of sucrose, 5 parts of food starch, 1.1 parts of maltodextrin, 0.5 part of potassium sorbate, stearic acid 0.025 part of magnesium and pure appropriate amount of water.
The preparation method of pharynx-clearing throat-benefiting buccal tablet, including herein below：
（1）20 mesh are crushed to after chrysanthemum, rose are cleaned, are put into the extraction equipment with reflux cooler, are added pure Water is extracted, and amount of water is raw material chrysanthemum, 20 times of volumes of rose quality, is warming up to 80 DEG C, extracts 1.0h；Extraction terminates Afterwards, extract solution is filtered out；Extract solution is concentrated in vacuo through vacuum filter, 60 DEG C of its thickening temperature, concentration volume to raw material chrysanthemum Flower, 0.5 times of rose gross mass, acquisition chrysanthemum concrete；
（2）Momordica grosvenori, the sterculia seed are weighed, 10 times of amount pure water of its mixing total amount are added after cleaning, mixing is beaten, after mixing again Cellulase and pectase are added thereto, it is 70ppm to control cellulase concentration, pectin enzyme concentration is 45ppm；Heating water bath To 85-90 DEG C, digest 2-3 hours, filter to take filtrate, sterilize to obtain enzymolysis liquid, standby；
（3）By step（2）Enzymolysis liquid pour into step（1）In chrysanthemum concrete, stir and evenly mix, sucrose, mountain are then added thereto Potassium sorbate, magnesium stearate, stirring 15 minutes after, add food starch, maltodextrin, etc. other remaining constitutive materials, continue Stirring 35 minutes, is wet granulation and drying, re-sieving, whole grain, by this mixture pressure after 75% ethanol wet with mass fraction Piece, you can.
Described chrysanthemum can arbitrarily select Bo feverfew, tribute chrysanthemum, chrysanthemum indicum, chu chrysanthemum, FLOS CHRYSANTHEMI ALBA from Haizhou of China.

Claims (5)

1. a kind of pharynx-clearing throat-benefiting buccal tablet, it is characterised in that：It is made up of the raw material of following parts by weight：33-37 parts of chrysanthemum, Momordica grosvenori 14-17 parts, 5-6 parts of rose, 12-15 parts of the sterculia seed, 25-30 parts of sucrose, 4-6 parts of food starch, maltodextrin 1.0-1.2 Part, 0.4-0.6 parts of potassium sorbate, 0.02-0.03 parts of magnesium stearate and pure appropriate amount of water.
2. pharynx-clearing throat-benefiting buccal tablet according to claim 1, it is characterised in that：It is made up of the raw material of following parts by weight：Chrysanthemum Spend 35 parts, 15 parts of Momordica grosvenori, 5 parts of rose, 13 parts of the sterculia seed, 28 parts of sucrose, 5 parts of food starch, 1.1 parts of maltodextrin, mountain 0.5 part of potassium sorbate, 0.025 part of magnesium stearate and pure appropriate amount of water.
3. a kind of preparation method of pharynx-clearing throat-benefiting buccal tablet as claimed in claim 1, it is characterised in that：Including herein below：
（1）10-20 mesh is crushed to after chrysanthemum, rose are cleaned, is put into the extraction equipment with reflux cooler, is added pure Water purification is extracted, and amount of water is raw material chrysanthemum, 10-30 times of volume of rose quality, is warming up to 50 DEG C -100 DEG C, extraction 0.2h-2.0h；After extraction terminates, extract solution is filtered out；Extract solution is concentrated in vacuo through vacuum filter, and 50 DEG C of its thickening temperature- 70 DEG C, concentration volume to raw material chrysanthemum, 0.3-1.0 times of rose gross mass, acquisition chrysanthemum concrete；
（2）Momordica grosvenori, the sterculia seed are weighed, 10-15 times that its mixing total amount is added after cleaning measures pure water, and mixing mashing is mixed Add cellulase and pectase thereto again afterwards, it is 60ppm-80ppm to control cellulase concentration, pectin enzyme concentration is 40ppm-55ppm；Heating water bath digests 2-3 hours to 85-90 DEG C, filters to take filtrate, sterilize to obtain enzymolysis liquid, standby；
（3）By step（2）Enzymolysis liquid pour into step（1）In chrysanthemum concrete, stir and evenly mix, sucrose, mountain are then added thereto Potassium sorbate, magnesium stearate, stirring 15-20 minutes after, add food starch, maltodextrin, etc. other remaining constitutive materials, after Continuous stirring 30-40 minutes, wet granulation and drying after being 70%-80% ethanol wets with mass fraction, re-sieving, whole grain, by this Mixture tabletting, you can.
4. pharynx-clearing throat-benefiting buccal tablet according to claim 1, it is characterised in that described chrysanthemum can be arbitrarily white from Bo Chrysanthemum, tribute chrysanthemum, chrysanthemum indicum, chu chrysanthemum, FLOS CHRYSANTHEMI ALBA from Haizhou of China.
5. the preparation method of pharynx-clearing throat-benefiting buccal tablet according to claim 2, it is characterised in that described step（2）In Cellulase concentration is 70ppm, and pectin enzyme concentration is 45ppm.
CN201710333266.1A 2017-05-12 2017-05-12 A kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof Pending CN107296839A (en)

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CN201710333266.1A CN107296839A (en) 2017-05-12 2017-05-12 A kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof

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CN201710333266.1A CN107296839A (en) 2017-05-12 2017-05-12 A kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111840341A (en) * 2020-08-13 2020-10-30 广州市香雪制药股份有限公司 Sterculia Lychnophora extract and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101690584A (en) * 2009-09-07 2010-04-07 北京同仁堂健康药业股份有限公司 Functional food and medicine for clearing throat and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101690584A (en) * 2009-09-07 2010-04-07 北京同仁堂健康药业股份有限公司 Functional food and medicine for clearing throat and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
黄秋云: "《左海药膳探骊》", 30 June 2013 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111840341A (en) * 2020-08-13 2020-10-30 广州市香雪制药股份有限公司 Sterculia Lychnophora extract and preparation method thereof

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Application publication date: 20171027

RJ01 Rejection of invention patent application after publication