CN107281429A - A kind of gynemetrics's hip bath decoction and preparation method thereof - Google Patents

A kind of gynemetrics's hip bath decoction and preparation method thereof Download PDF

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CN107281429A
CN107281429A CN201710654925.1A CN201710654925A CN107281429A CN 107281429 A CN107281429 A CN 107281429A CN 201710654925 A CN201710654925 A CN 201710654925A CN 107281429 A CN107281429 A CN 107281429A
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parts
gynemetrics
microwave
chinese
hip bath
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于瑞霞
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Abstract

The invention belongs to gynecological and obstetrical nursing treatment technology field, more particularly to a kind of gynemetrics's hip bath decoction and preparation method thereof.It is made up of the component of following mass fraction：57 parts of fiveleaf akebia fruit, 35 parts of Fructus meliae toosendan, 57 parts of the coptis, 46 parts of armeniaca mume, 57 parts of the root of Dahurain angelica, 57 parts of fleabane flower, 35 parts of lopseed, 35 parts of laciniate blumea herb, 57 parts of folium artemisiae argyi, 46 parts of cassia twig, 46 parts of spearmint, 35 parts of notopterygium root, 35 parts of Galanga Galangal Seed, 35 parts of marine alga, 35 parts of the fruit of Chinese magnoliavine, 35 parts of Morinda officinalis, 46 parts of menthol, 46 parts of soybean, 57 parts of calcined and quenched CALAMINA, 35 parts of pine needle, 35 parts of the Chinese bulbul.The Chinese medical extract sheerly Chinese medicine preparation of the present invention, nontoxic and harmless to fetus and pregnant woman, gravidic women can also be used, and directly act on that vulva is local, anti-inflammatory anti-itch, and have no side effect good effect.

Description

A kind of gynemetrics's hip bath decoction and preparation method thereof
Technical field
The invention belongs to gynecological and obstetrical nursing treatment technology field, more particularly to a kind of gynemetrics's hip bath decoction and its preparation side Method.
Background technology
Gynaecological imflammation is the common disease of women, is primarily referred to as inflammation (vulvitis, vaginitis, the palace of female sex organ Neck inflammation, hysteritis, pelvic infecton, adnexitis, sexually transmitted disease etc.), the reproductive organs of women generally occurs different acute and slow Property inflammation, the inflammation that occurs after infection is attacked by various pathogenic bacteria.Inflammation is treated not in time, except may cause inflammation each Physiological site is mutually spread with outside cross-infection, can bring many complication, to immunologic function, metabolism and endocrine system System can all produce harmful effect, even result in the malignant change at some positions.If pregnant female, intrauterine infection, production can be caused The influence neonates such as road infection, cause the serious consequences such as miscarriage, premature labor, congenital development deformity, feeblemindedness.Gynaecology is treated at present Antibiotic therapy method being used the method for inflammation, it is bacterial resistance occurred that this cure is easily caused body, or even cultivates more Superbacteria.And Chinese medicine is that, by adjusting immunity of organism, adjusting bacterial metabolism, a variety of drug effects integrate collaboration to reach inhibiting bacteria and diminishing inflammation Purpose.Therefore, it is relatively good method that treatment gynaecological imflammation is suited the remedy to the case using Chinese medicine compound prescription, can reach treatment mesh , and safety, have no side effect.
The content of the invention
Present invention solves the technical problem that be current treatment gynaecological imflammation method more use antibiotic therapy method, it is this to control It is bacterial resistance occurred that therapy is easily caused body, or even cultivates superbacteria, and potentially danger is big.
To solve the above problems, the present invention provides a kind of gynemetrics's hip bath decoction, it is made up of the component of following mass fraction： 5-7 parts of fiveleaf akebia fruit, 3-5 parts of Fructus meliae toosendan, 5-7 parts of the coptis, 4-6 parts of armeniaca mume, 5-7 parts of the root of Dahurain angelica, 5-7 parts of fleabane flower, lopseed 3-5 Part, 3-5 parts of laciniate blumea herb, 5-7 parts of folium artemisiae argyi, 4-6 parts of cassia twig, 4-6 parts of spearmint, 3-5 parts of notopterygium root, 3-5 parts of Galanga Galangal Seed, marine alga 3-5 Part, 3-5 parts of the fruit of Chinese magnoliavine, 3-5 parts of Morinda officinalis, 4-6 parts of menthol, 4-6 parts of soybean, 5-7 parts of calcined and quenched CALAMINA, 3-5 parts of pine needle, hoary hair 3-5 parts of father-in-law.
Further optimization, is made up of the component of following mass fraction：It is 5-76 parts of fiveleaf akebia fruit, 4 parts of Fructus meliae toosendan, 6 parts of the coptis, green 5 parts of calyx plum, 6 parts of the root of Dahurain angelica, 6 parts of fleabane flower, 4 parts of lopseed, 4 parts of laciniate blumea herb, 6 parts of folium artemisiae argyi, 5 parts of cassia twig, 5 parts of spearmint, notopterygium root 4 Part, 4 parts of Galanga Galangal Seed, 4 parts of marine alga, 4 parts of the fruit of Chinese magnoliavine, 4 parts of Morinda officinalis, 5 parts of menthol, 5 parts of soybean, 6 parts of calcined and quenched CALAMINA, pine needle 4 Part, 4 parts of the Chinese bulbul.
Its preparation method is comprised the steps of：
(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 4-10 DEG C under the conditions of refrigerate 12-24h, then at -10~-18 DEG C Lower freezing 10-20h is standby；After freezing, volumetric expansion when being frozen using hydrone is directly destroyed the eucaryotic cell structure of Chinese medicine, carried High cellular damage rate, is that the microwave bulking of next step lays the first stone.
(2) temperature in microwave storehouse is set as 110-130 DEG C, microwave storehouse is preheated, and then puts into 1-2kg steps (1) Chinese medicine material after freezing processing, regulation microwave power is 450-600w, and operation 120-180s carries out microwave bulking；Then by temperature Degree is adjusted to 40-80 DEG C, and microwave power is 90-120w, dries 6-9min；Chinese medicine after freezing is directly carried out to microwave swollen Change, the strength for being directly changed into the distillation of gas moment from ice using hydrone completes puffing process, then without Chinese medicine is taken out, Directly be dried using microwave, open stirring in dry process, Chinese medicine during stirring uniform drying and because Microwave bulking, which is dried, to become fragile, and disintegrating slag is broken into naturally in whipping process, beneficial to the crushing in later stage.
(3) Chinese medicine after step (2) processing is put into ball mill and crushed；Further crush can cause medicinal material powder End is homogeneous, and various active ingredients are further separated out, beneficial to importing.
(4) the Chinese medicine material addition protease after crushing is weighed in proportion to be digested.Bioprotein after enzymolysis divides greatly Son has been cut into small molecular protein and polypeptide, it is to avoid allergic reaction caused by high molecular weight protein, at the same small molecular protein and Polypeptide is more easy to absorb, and works faster.
(5) according to 1:100~1:500 solid-liquid ratio soaks ultrafiltration after 12~24h in ethanol.Pole after being extracted through ethanol Property composition be readily dissolved in body fluid, be oriented to target location, instant effect；Macromolecular is further filtered in ultrafiltration, and what is left is biological small Molecule, works faster.
(6) filter residue after ultrafiltration is according to 1:3~1:5 solid-liquid ratio uses steam distillation after adding water, and collects condensed Liquid.The materials such as volatile essential oil are collected, are easy to hip bath liquid to penetrate keratoderma action.
(7) sealed after the liquid of step (5) and step (6) is mixed after microwave disinfection.Microwave disinfection is avoided Destruction of the high temperature sterilization to active ingredient, drug effect is more preferable.
Further, stage drying is used after step (2) microwave bulking, i.e., regulation temperature is 70-80 DEG C, work(first Rate 110-120w, dries 2-3min；Then regulation temperature is 50-70 DEG C, and power 100-110w dries 2-3min；Finally adjust Temperature is 40-50 DEG C, and power 90-100w dries 2-3min.
Further, the pulverization conditions of the step (3) are just to grind to shut down 3min after 15min using ball mill, then anti-mill 3min is shut down after 15min, so repeatedly 2 times.
Further, the protease in the step (4) is alkali protease, neutral proteinase, papain or pancreas One or more in protease.It is demonstrated experimentally that taking the effect of drugs after several protease hydrolyzeds of the above optimal, and pass through egg Medicine after white enzyme enzymolysis eliminates high molecular weight protein, can prevent because of drug-induced allergy.
Further, the molecular weight that milipore filter is retained in the step (5) is 15000-20000.It is demonstrated experimentally that molecular weight It is to retain the most molecular weight of active ingredient for 15000-20000, and it is rapid-action, effect is good.
Further, according to filter residue in the step (6)：Condensate liquid is 1:2 ratio collects the liquid of condensation.
Further, step (7) the microwave disinfection condition is 70 DEG C -105 DEG C, time 90-180 second.It can kill Farthest retain active ingredient on the basis of microorganism not to be destroyed.
Application method：Warm water hip bath 30min after medicine is mixed with water, decoction and water ratio 1：10~1：30.
Toxicity Analysis：
Fiveleaf akebia fruit：Bitter, it is mild-natured；Return liver, stomach；Function liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Control stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, Stomach warm-served food is stayed, polydipsia, also white dysentery, pain in the back, hypochondriac pain, hernia, cave warp, uterus tenesmus.Modern pharmacological research reports that it is to tumour Cell has inhibitory action.
Fructus meliae toosendan：Cold in nature, bitter is one kind of qi-activating drug, there is easypro liver promoting qi circulation and relieving pain, the drug effect of expelling parasite, for chest side of body, gastral cavity Abdominal distention and pain, colic, abdominal pain due to enterositosis.
The coptis：The Main Ingredients and Appearance of coptis itself is berberine, cures mainly heat-clearing and damp-drying drug, purging intense heat and detonicating.For damp and hot feeling of fullness, Acid regurgitation is vomitted, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache is quenched one's thirst, carbuncle swells malignant boil Sore；Eczema is controlled outside, wet sore, duct is suppurated.It is burning hot that prepared RHIZOMA COPTIDIS with vino is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach and stomach stop Vomit.Mutually tied for fever and chills, damp and hot middle resistance, feeling of fullness vomiting.The easypro liver anti-vomiting of cornel coptis.For liver-stomach disharmony, acid regurgitation is vomitted.
Armeniaca mume：It is slightly sour, it is puckery, it is nontoxic；Enter liver, lung two are passed through.Effect is relaxed liver, and stomach, resolving sputum；Cure mainly stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, appetite It is depressed, dizzy, scrofula.
The root of Dahurain angelica：Relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, clearing the nasal passage, eliminating dampness stops band, detumescence and apocenosis control headache, pain in the supra-orbital bone, dentalgia, Nasosinusitis, cold-dampness stomachache, intestines wind anal fistula, leukorrhea with reddish discharge, ulcer sores, skin itchy, mange.Dispelling wind and eliminating dampness, sensible analgesic, detumescence Apocenosis.
Fleabane flower：Can be clearing and activating the channels and collaterals and promoting blood circulation and removing blood stasis, expansion of cerebral vascular, reduction vascular resistence improve Brain circlulation, increase the heart Cerebral blood flow (CBF), improves immunologic function, cold in nature, slight bitter, Gan Wenxin, with the removing toxic substances that is slightly cold, dispelling wind and eliminating dampness, promoting blood circulation and removing blood stasis, work of stimulating the menstrual flow Effect of network, anti-inflammatory analgetic.
Lopseed：It is pungent, temperature；Return liver warp.Function dispelling wind and eliminating dampness, activating blood circulation and reducing swelling analgesic；Cure mainly arthralgia pain due to rheumatism, muscles contracture, Traumatic injury, sore swollen toxin.
Laciniate blumea herb：Pungent, hardship, slightly warm in nature.This medicine oral administration also can external application, with dispelling wind and eliminating dampness, clearing and activating the channels and collaterals effect. Clinically it is used for treating rheumatic ostealgia, headache, treating swelling and pain by traumatic injury, the disease such as eczema and venomous snake bite.
Folium artemisiae argyi：Pungent, hardship, it is warm-natured, it is nontoxic；Returns spleen, liver and kidney channel.Fragrant temperature dissipates, and can rise to drop.With warming channel for arresting bleeding, dissipate Cold analgesic, effect of wet down desinsection；Irregular menstruation is cured mainly, dysmenorrhoea, fertility, fetal irritability, trusted subordinate's crymodynia is spitted blood, bleeding from five sense organs or subcutaneous tissue, Spitting of blood, has blood in stool, uterine bleeding, gestation hemorrhage, diarrhea protracted dysentery, under band, eczema, mange, carbuncle swells, hemorrhoid.
Cassia twig：Can expelling cold and relieving exterior syndrome；Warming meridian；Activating YANG and prormoting functioning of QI.Main exterior syndrome due to wind-cold；Numbness and ache of cold dampness；Peripheral coldness；Amenorrhea abdomen Bitterly；Abdominal mass caking；The obstruction of qi in the chest；Palpitaition；Difficult urination.For anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, joint pain, phlegm and retained fluid stores Water, oedema, palpitaition, run quickly globefish.
Spearmint：It is pungent, sweet, tepor.Expelling wind and clearing away cold, cough-relieving, subdhing swelling and detoxicating.For catching a cold, cough, stomachache, abdominal distension, nerve Property headache；It is used for treating swelling and pain by traumatic injury, hot eyes erythralgia, children's boil outside.
Notopterygium root：It is pungent, bitter, warm-natured, dispellieg cold and dampness；Enter bladder, kidney channel.Effect dissipates exterior cold, wind-damp dispelling, sharp joint, analgesic；It is main Control and catch cold, have a headache lossless, geomantic omen edema, sore swollen toxin, impotence and seminal emission, enuresis frequent micturition, waist and knee crymodynia, deficiency of the kidney and dyspnea, five More diarrhea；External application curing vitiligo, alopecia areata.Relieving exterior syndrome and dispelling cold, expelling wind and eliminating dampness, analgesic, also for lossless, cold-dampness of catching cold, have a headache Numbness, upper limbs rheumatalgia pain.
Galanga Galangal Seed：It is pungent；It is warm-natured；Returns spleen, lung channel.Function middle benefit gas eliminating dampness, eliminating dampness cold dispelling is amusing and helped digestion；It is cold for gastral cavity abdomen Bitterly, dyspepsia turgor, vomiting and diarrhea, drinking too much.Modern pharmacology proves that it has very strong active anticancer.
Marine alga：Taste into, it is cold in nature, it is nontoxic.Channel tropism：Lung spleen kidney；Liver stomach effect：Softening hard masses；Dissolving phlegm；Li Shui；Detumescence.Dissipating bind gas Carbuncle swells, the hollow ring of abdomen inner product block, distending pain, abdomen.12 kinds of oedema can be also descended, accumulation is sudden and violent routed between treating skin, stays depressed heat, diuresis.
The fruit of Chinese magnoliavine：Control the deficiency syndrome of the lung to breath with cough, thirst, spontaneous perspiration, night sweat, internal lesion caused by overexertion is thin thin, emission, protracted dysentery and diarrhea.It can increase The excited process of persistent erection pivot nervous system, can also strengthen process of inhibition, it is mutually balanced, and improve corticocerebral regulation and make With；Work ratio can be improved, is lessened fatigue.Gastric secretion, excited uterus can be adjusted, and promotes eyesight, hearing, skin sense is improved The resolving ability of receiver.For deficiency of vital energy Tianjin wound, the tired hidrosis of body, palpitaition of losing heart；Breathing with cough caused by insufficiency of lung-QI,deficiency of lung-QI or deficiency of both the lung and kidney, or Breath with cough with the passing of time, lung qi consumption wound；Insufficiency of heart yin, palpitation and severe palpitation, insomnia forgetfulness；The unconsolidation of the kidney-qi, seminal emission, frequent micturition, or speen-kidney dificiency, long Rush down more than.
Morinda officinalis：It is pungent, sweet, slightly warm in nature；Return kidney, Liver Channel, property is nontoxic.Function kidney-replenishing, strengthening the bones and muscles, wind-damp dispelling.For Impotence and seminal emission, uterus cold infertile, irregular menstruation, few abdomen crymodynia, arthralgia pain due to rheumatism, muscles and bones impotence.
Menthol：Anti-inflammatory, analgesic is antipruritic, can optionally stimulate the frigidoreceptor of human body skin or mucous membrane, produces cold Feel reflection and creeping chill, cause skin and mucosa vessel retraction.
Soybean：It is sweet, mild-natured, enter spleen, large intestine channel, with invigorating the spleen it is wide in, moisturize the water that disappears, clearing heat and detoxicating, QI invigorating effect； Cure mainly the thin thin, gestosis of infantile malnutrition due to digestive disturbances or intestinalparasites rush down dysentery, abdominal distension, sore and toxic, traumatism and bleeding etc..Soya bean can also anti-inflammation, to pharyngitis, knot Film inflammation, stomatitis, bacillary dysentery, enteritis are effective.Immunity of organism can be strengthened, vascular sclerosis is prevented, promote skeleton development, resistance iron deficiency Property anaemia, being capable of anti-oxidant and anti-aging effect.
Calcined and quenched CALAMINA：Odorless, taste micro-puckery.Function removing toxic substances removing nebula, the antipruritic sore of hygroscopic；Cure mainly red eye, swell pain, eyes-affinity Red rotten, the screen film triangular mass of mucous membrane growing from the inner corner of the eye, unhealing ulcer, pus is dripping, wet sore, pruitus.
Pine needle：It is bitter, puckery, temperature.Function expelling wind and activating blood flow, improving eyesight is calmed the nerves, removing toxic substances, antipruritic；Influenza is cured mainly, rheumatism is closed Section pain, treating swelling and pain by traumatic injury, yctalopia, high blood pressure, neurasthenia, external application treating chilblain.
The Chinese bulbul：Bitter, it is cold in nature；Return stomach, large intestine channel.With clearing heat and detoxicating, remove heat from the blood and relieve diarrhea, effect of removing dampness and destroying parasites； Cure mainly under heat toxin dysentery, nosebleed epistaxis, bleeding, band, pruritus vulvae, ulcerative carbuncle, scrofula.
The Chinese medical extract sheerly Chinese medicine preparation, nontoxic and harmless to fetus and pregnant woman, gravidic women of the present invention It can also be used, directly act on vulva part, anti-inflammatory anti-itch, have no side effect good effect.Wherein, fiveleaf akebia fruit, Fructus meliae toosendan, the coptis, Armeniaca mume has the effect of liver soothing and depression relief；The root of Dahurain angelica, fleabane flower, lopseed, laciniate blumea herb, which have, removes damp and hot effect；Golden cypress, radix glycyrrhizae, Radix cynanchi bungei, Poria cocos, pollen pini have the effect of nourishing yin and nourishing blood；Folium artemisiae argyi, cassia twig, spearmint, notopterygium root, Galanga Galangal Seed have the work of cold dispelling With marine alga, the fruit of Chinese magnoliavine, Morinda officinalis have the effect of tonifying spleen kidney, and menthol, soybean, calcined and quenched CALAMINA, pine needle, the Chinese bulbul, which have, to disappear Scorching antipruritic effect, alleviates the discomfort that episioitis is caused.By taking 200 patients as an example, treated using medicine of the present invention, Effectively, total effective rate is up to 99.5% to 199 patients.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention, Technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is the present invention one Divide embodiment, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making The every other embodiment obtained under the premise of creative work, belongs to the scope of protection of the invention.
Embodiment 1：
A kind of gynemetrics's hip bath decoction, it is for oral administration to be made up of the component of following mass fraction：5-76 parts of fiveleaf akebia fruit, Fructus meliae toosendan 4 Part, 6 parts of the coptis, 5 parts of armeniaca mume, 6 parts of the root of Dahurain angelica, 6 parts of fleabane flower, 4 parts of lopseed, 4 parts of laciniate blumea herb, 6 parts of folium artemisiae argyi, 5 parts of cassia twig, stay Blue fragrant 5 parts, 4 parts of notopterygium root, 4 parts of Galanga Galangal Seed, 4 parts of marine alga, 4 parts of the fruit of Chinese magnoliavine, 4 parts of Morinda officinalis, 5 parts of menthol, 5 parts of soybean, forge furnace Sweet 6 parts of stone, 4 parts of pine needle, 4 parts of the Chinese bulbul.
Preparation method is comprised the steps of：
(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 6 DEG C under the conditions of refrigerate 20h, at -15 DEG C freeze 15h it is standby With；After freezing, volumetric expansion when being frozen using hydrone directly destroys the eucaryotic cell structure of Chinese medicine, improves cellular damage rate, is The microwave bulking of next step lays the first stone.
(2) temperature in microwave storehouse is set as 120 DEG C, microwave storehouse is preheated, and is then put at 1kg steps (1) freezing Chinese medicine material after reason, regulation microwave power is 500w, and operation 160s carries out microwave bulking；Then it is 60 DEG C by temperature adjustment, Microwave power is 100w, dries 9min；Chinese medicine after freezing is directly subjected to microwave bulking, directly become from ice using hydrone Puffing process is completed for the strength that gas moment distils, then without Chinese medicine is taken out, is directly dried, done using microwave In dry process open stirring, Chinese medicine during stirring uniform drying and because microwave bulking dry become fragile, stirring During be broken into disintegrating slag naturally, beneficial to the crushing in later stage.
(3) Chinese medicine after step (2) processing is put into ball mill and crushed；Further crush can cause medicinal material powder End is homogeneous, and various active ingredients are further separated out, beneficial to importing.
(4) the Chinese medicine material addition protease after crushing is weighed in proportion to be digested.Bioprotein after enzymolysis divides greatly Son has been cut into small molecular protein and polypeptide, it is to avoid allergic reaction caused by high molecular weight protein, at the same small molecular protein and Polypeptide is more easy to absorb, and works faster.
(5) according to 1:300 solid-liquid ratio soaks ultrafiltration after 12~24h in ethanol.Polar component after being extracted through ethanol It is readily dissolved in body fluid, is oriented to target location, instant effect；Macromolecular is further filtered in ultrafiltration, and what is left is biological micromolecule, is risen Effect is faster.
(6) filter residue after ultrafiltration is according to 1:4 solid-liquid ratio uses steam distillation after adding water, and collects condensed liquid； Wherein according to filter residue：Condensate liquid is 1:2 ratio collects the liquid of condensation.
(7) sealed after the liquid of step (5) and step (6) is mixed after microwave disinfection, microwave disinfection is avoided Destruction of the high temperature sterilization to active ingredient, drug effect is more preferable.
Stage drying is used after step (2) microwave bulking, i.e., regulation temperature is 75 DEG C first, power 115w is dried 3min；Then regulation temperature is 60 DEG C, and power 105w dries 3min；Finally regulation temperature is 45 DEG C, and power 95w is dried 3min。
The pulverization conditions of the step (3) are just to grind to shut down 3min after 15min using ball mill, then are stopped after anti-mill 15min Machine 3min, repeatedly so 2 times.
During protease in the step (4) is alkali protease, neutral proteinase, papain or trypsase It is one or more of.It is demonstrated experimentally that taking the effect of drugs after several protease hydrolyzeds of the above optimal.
The molecular weight that milipore filter is retained in the step (5) is 18000.
Step (7) the microwave disinfection condition is 85 DEG C, 160 seconds time.Can be maximum on the basis of microorganism is killed The reservation active ingredient of degree is not destroyed.
Embodiment 2：
A kind of gynemetrics's hip bath decoction, it is for oral administration to be made up of the component of following mass fraction：5 parts of fiveleaf akebia fruit, 5 parts of Fructus meliae toosendan, 5 parts of the coptis, 6 parts of armeniaca mume, 5 parts of the root of Dahurain angelica, 7 parts of fleabane flower, 3 parts of lopseed, 5 parts of laciniate blumea herb, 5 parts of folium artemisiae argyi, 6 parts of cassia twig, stay orchid Fragrant 4 parts, 5 parts of notopterygium root, 3 parts of Galanga Galangal Seed, 5 parts of marine alga, 3 parts of the fruit of Chinese magnoliavine, 5 parts of Morinda officinalis, 4 parts of menthol, 6 parts of soybean, forge furnace are sweet 5 parts of stone, 5 parts of pine needle, 3 parts of the Chinese bulbul.
Preparation method is comprised the steps of：
(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 4 DEG C under the conditions of refrigerate 24h, at -10 DEG C freeze 20h it is standby With；After freezing, volumetric expansion when being frozen using hydrone directly destroys the eucaryotic cell structure of Chinese medicine, improves cellular damage rate, is The microwave bulking of next step lays the first stone.
(2) temperature in microwave storehouse is set as 110 DEG C, microwave storehouse is preheated, and is then put at 2kg steps (1) freezing Chinese medicine material after reason, regulation microwave power is 450w, and operation 180s carries out microwave bulking；Then it is 40 DEG C by temperature adjustment, Microwave power is 120w, dries 8min；Chinese medicine after freezing is directly subjected to microwave bulking, directly become from ice using hydrone Puffing process is completed for the strength that gas moment distils, then without Chinese medicine is taken out, is directly dried, done using microwave In dry process open stirring, Chinese medicine during stirring uniform drying and because microwave bulking dry become fragile, stirring During be broken into disintegrating slag naturally, beneficial to the crushing in later stage.
(3) Chinese medicine after step (2) processing is put into ball mill and crushed；Further crush can cause medicinal material powder End is homogeneous, and various active ingredients are further separated out, beneficial to importing.
(4) the Chinese medicine material addition protease after crushing is weighed in proportion to be digested.Bioprotein after enzymolysis divides greatly Son has been cut into small molecular protein and polypeptide, it is to avoid allergic reaction caused by high molecular weight protein, at the same small molecular protein and Polypeptide is more easy to absorb, and works faster.
(5) according to 1:100 solid-liquid ratio soaks ultrafiltration after 24h in ethanol.Polar component after being extracted through ethanol is easy to It is dissolved in body fluid, is oriented to target location, instant effect；Macromolecular is further filtered in ultrafiltration, and what is left is biological micromolecule, is worked more It hurry up.
(6) filter residue after ultrafiltration is according to 1:3 solid-liquid ratio uses steam distillation after adding water, and collects condensed liquid； Wherein according to filter residue：Condensate liquid is 1:2 ratio collects the liquid of condensation.
(7) sealed after the liquid of step (5) and step (6) is mixed after microwave disinfection, microwave disinfection is avoided Destruction of the high temperature sterilization to active ingredient, drug effect is more preferable.
Further, stage drying is used after step (2) microwave bulking, i.e., regulation temperature is 70 DEG C, power first 110w, dries 3min；Then regulation temperature is 50 DEG C, and power 110w dries 2min；Finally regulation temperature is 50 DEG C, power 90w, dries 3min.
Further, the pulverization conditions of the step (3) are just to grind to shut down 3min after 15min using ball mill, then anti-mill 3min is shut down after 15min, so repeatedly 2 times.
During protease in the step (4) is alkali protease, neutral proteinase, papain or trypsase It is one or more of.It is demonstrated experimentally that taking the effect of drugs after several protease hydrolyzeds of the above optimal.
The molecular weight that milipore filter is retained in the step (5) is 15000.
Step (7) the microwave disinfection condition is 105 DEG C, 90 seconds time.Can be maximum on the basis of microorganism is killed The reservation active ingredient of degree is not destroyed.
Embodiment 3：
A kind of gynemetrics's hip bath decoction, it is for oral administration to be made up of the component of following mass fraction：7 parts of fiveleaf akebia fruit, 3 parts of Fructus meliae toosendan, 7 parts of the coptis, 4 parts of armeniaca mume, 7 parts of the root of Dahurain angelica, 5 parts of fleabane flower, 5 parts of lopseed, 3 parts of laciniate blumea herb, 7 parts of folium artemisiae argyi, 4 parts of cassia twig, stay orchid Fragrant 6 parts, 3 parts of notopterygium root, 5 parts of Galanga Galangal Seed, 3 parts of marine alga, 5 parts of the fruit of Chinese magnoliavine, 3 parts of Morinda officinalis, 6 parts of menthol, 4 parts of soybean, forge furnace are sweet 7 parts of stone, 3 parts of pine needle, 5 parts of the Chinese bulbul.
The preparation method of endo-medicine is comprised the steps of：
(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 10 DEG C under the conditions of refrigerate 12h, freeze 10h at -18 DEG C It is standby；After freezing, volumetric expansion when being frozen using hydrone directly destroys the eucaryotic cell structure of Chinese medicine, improves cellular damage rate, Laid the first stone for the microwave bulking of next step.
(2) temperature in microwave storehouse is set as 130 DEG C, microwave storehouse is preheated, and is then put at 1kg steps (1) freezing Chinese medicine material after reason, regulation microwave power is 600w, and operation 120s carries out microwave bulking；Then it is 80 DEG C by temperature adjustment, Microwave power is 90w, dries 7min；Chinese medicine after freezing is directly subjected to microwave bulking, directly become from ice using hydrone Puffing process is completed for the strength that gas moment distils, then without Chinese medicine is taken out, is directly dried, done using microwave In dry process open stirring, Chinese medicine during stirring uniform drying and because microwave bulking dry become fragile, stirring During be broken into disintegrating slag naturally, beneficial to the crushing in later stage.
(3) Chinese medicine after step (2) processing is put into ball mill and crushed；Further crush can cause medicinal material powder End is homogeneous, and various active ingredients are further separated out, beneficial to importing.
(4) the Chinese medicine material addition protease after crushing is weighed in proportion to be digested.Bioprotein after enzymolysis divides greatly Son has been cut into small molecular protein and polypeptide, it is to avoid allergic reaction caused by high molecular weight protein, at the same small molecular protein and Polypeptide is more easy to absorb, and works faster.
(5) according to 1:500 solid-liquid ratio soaks ultrafiltration after 12h in ethanol.Polar component after being extracted through ethanol is easy to It is dissolved in body fluid, is oriented to target location, instant effect；Macromolecular is further filtered in ultrafiltration, and what is left is biological micromolecule, is worked more It hurry up.
(6) filter residue after ultrafiltration is according to 1:5 solid-liquid ratio uses steam distillation after adding water, and collects condensed liquid； Wherein according to filter residue：Condensate liquid is 1:2 ratio collects the liquid of condensation.
(7) sealed after the liquid of step (5) and step (6) is mixed after microwave disinfection, microwave disinfection is avoided Destruction of the high temperature sterilization to active ingredient, drug effect is more preferable.
Stage drying is used after step (2) microwave bulking, i.e., regulation temperature is 80 DEG C first, power 110w is dried 2min；Then regulation temperature is 70 DEG C, and power 100w dries 3min；Finally regulation temperature is 50 DEG C, and power 100w is dried 2min。
The pulverization conditions of the step (3) are just to grind to shut down 3min after 15min using ball mill, then are stopped after anti-mill 15min Machine 3min, repeatedly so 2 times.
During protease in the step (4) is alkali protease, neutral proteinase, papain or trypsase It is one or more of.It is demonstrated experimentally that taking the effect of drugs after several protease hydrolyzeds of the above optimal.
The molecular weight that milipore filter is retained in the step (5) is 20000.
Step (7) the microwave disinfection condition is 105 DEG C, 90 seconds time.Can be maximum on the basis of microorganism is killed The reservation active ingredient of degree is not destroyed.

Claims (8)

1. a kind of gynemetrics's hip bath decoction, it is characterised in that be made up of the component of following mass fraction：5-7 parts of fiveleaf akebia fruit, melia toosendan Sub- 3-5 parts, 5-7 parts of the coptis, 4-6 parts of armeniaca mume, 5-7 parts of the root of Dahurain angelica, 5-7 parts of fleabane flower, 3-5 parts of lopseed, 3-5 parts of laciniate blumea herb, 5-7 parts of folium artemisiae argyi, 4-6 parts of cassia twig, 4-6 parts of spearmint, 3-5 parts of notopterygium root, 3-5 parts of Galanga Galangal Seed, 3-5 parts of marine alga, 3-5 parts of the fruit of Chinese magnoliavine, 3-5 parts of Morinda officinalis, 4-6 parts of menthol, 4-6 parts of soybean, 5-7 parts of calcined and quenched CALAMINA, 3-5 parts of pine needle, 3-5 parts of the Chinese bulbul.
2. gynemetrics's hip bath decoction as claimed in claim 1, it is characterised in that be made up of the component of following mass fraction：August 5-76 parts of letter, 4 parts of Fructus meliae toosendan, 6 parts of the coptis, 5 parts of armeniaca mume, 6 parts of the root of Dahurain angelica, 6 parts of fleabane flower, 4 parts of lopseed, 4 parts of laciniate blumea herb, Chinese mugwort 6 parts of leaf, 5 parts of cassia twig, 5 parts of spearmint, 4 parts of notopterygium root, 4 parts of Galanga Galangal Seed, 4 parts of marine alga, 4 parts of the fruit of Chinese magnoliavine, 4 parts of Morinda officinalis, menthol 5 Part, 5 parts of soybean, 6 parts of calcined and quenched CALAMINA, 4 parts of pine needle, 4 parts of the Chinese bulbul.
3. a kind of preparation method of gynemetrics's hip bath decoction as claimed in claim 1, it is characterised in that endo-medicine is by following step Rapid composition：
(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 4-10 DEG C under the conditions of refrigerate 12-24h, it is cold at -10~-18 DEG C Freeze 10-20h standby；
(2) temperature in microwave storehouse is set as 110-130 DEG C, microwave storehouse is preheated, and then puts into 1-2kg steps (1) freezing Chinese medicine material after processing, regulation microwave power is 450-600w, and operation 120-180s carries out microwave bulking；Then temperature is adjusted Save as 40-80 DEG C, microwave power is 90-120w, dry 6-9min；
(3) Chinese medicine after step (2) processing is put into ball mill and crushed；
(4) the Chinese medicine material addition protease after crushing is weighed in proportion to be digested；
(5) according to 1:100~1:500 solid-liquid ratio soaks ultrafiltration after 12~24h in ethanol；
(6) filter residue after ultrafiltration is according to 1:3~1:5 solid-liquid ratio uses steam distillation after adding water, and collects condensed liquid；
(7) sealed after the liquid of step (5) and step (6) is mixed after microwave disinfection.
4. the preparation method of gynemetrics's hip bath decoction as claimed in claim 3, it is characterised in that：Step (2) microwave is swollen Stage drying is used after change, i.e., regulation temperature is 70-80 DEG C first, power 110-120w dries 2-3min；Then temperature is adjusted For 50-70 DEG C, power 100-110w dries 2-3min；Finally regulation temperature is 40-50 DEG C, and power 90-100w dries 2- 3min。
5. the preparation method of gynemetrics's hip bath decoction as claimed in claim 3, it is characterised in that：The crushing of the step (3) Condition is just to grind to shut down 3min after 15Min using ball mill, then shuts down 3min after anti-mill 15min, so repeatedly 2 times.
6. the preparation method of gynemetrics's hip bath decoction as claimed in claim 3, it is characterised in that：Egg in the step (4) White enzyme is the one or more in alkali protease, neutral proteinase, papain or trypsase.
7. the preparation method of gynemetrics's hip bath decoction as claimed in claim 3, it is characterised in that：Ultrafiltration in the step (5) The molecular weight of film retention is 15000-20000.
8. the preparation method of gynemetrics's hip bath decoction as claimed in claim 3, it is characterised in that：In the step (6) according to Filter residue：Condensate liquid is 1:2 ratio collects the liquid of condensation.
CN201710654925.1A 2017-08-03 2017-08-03 A kind of gynemetrics's hip bath decoction and preparation method thereof Withdrawn CN107281429A (en)

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Publication number Priority date Publication date Assignee Title
CN101152503A (en) * 2007-09-14 2008-04-02 江秀华 Lotion for treating gynecology inflammation
CN102233033A (en) * 2011-03-25 2011-11-09 刘明璇 External application lotion for treating gynecological cervical erosion and gynecological inflammations, and preparation method thereof
CN102949501A (en) * 2011-08-25 2013-03-06 彭军 External washing lotion for treating gynecological inflammation
CN104367687A (en) * 2014-11-18 2015-02-25 郭秀珍 Lotion for treating kysthitis
CN106177687A (en) * 2016-08-23 2016-12-07 刘洪玲 For external medicine composition treating gynecological inflammation and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101152503A (en) * 2007-09-14 2008-04-02 江秀华 Lotion for treating gynecology inflammation
CN102233033A (en) * 2011-03-25 2011-11-09 刘明璇 External application lotion for treating gynecological cervical erosion and gynecological inflammations, and preparation method thereof
CN102949501A (en) * 2011-08-25 2013-03-06 彭军 External washing lotion for treating gynecological inflammation
CN104367687A (en) * 2014-11-18 2015-02-25 郭秀珍 Lotion for treating kysthitis
CN106177687A (en) * 2016-08-23 2016-12-07 刘洪玲 For external medicine composition treating gynecological inflammation and preparation method thereof

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Application publication date: 20171024