CN107281332A - One kind treats rheumatism Chinese medicine composition and preparation method thereof - Google Patents
One kind treats rheumatism Chinese medicine composition and preparation method thereof Download PDFInfo
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- CN107281332A CN107281332A CN201710711077.3A CN201710711077A CN107281332A CN 107281332 A CN107281332 A CN 107281332A CN 201710711077 A CN201710711077 A CN 201710711077A CN 107281332 A CN107281332 A CN 107281332A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/20—Aceraceae (Maple family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The present invention relates to technical field of traditional Chinese medicine, especially one kind treats rheumatism Chinese medicine composition and preparation method thereof, by china creeper root, maple leaves, dye meal flower are chosen and matched, sufficient raw, prepare simple, it is easy to use, short treating period so that can be taken effect at 35 days, it is relieved symptom within 15 days or so, effective percentage has reached 100%, and safety has no toxic side effect.
Description
Technical field
Rheumatism Chinese medicine composition and its preparation side are treated the present invention relates to technical field of traditional Chinese medicine, especially one kind
Method.
Background technology
Arthritis refers to generation in human synovial and its inflammatory disease of surrounding tissue, can be divided into tens of kinds.Clinical manifestation
For the red, swollen, hot of joint, pain, dysfunction and joint deformity, severe patient causes joint deformity, influence patients ' life quality.Close
Save the scorching cause of disease complicated, mainly have with the factor such as inflammation, autoimmune response, infection, metabolic disorder, wound, retrogression pathological changes
Close.Clinical common arthritis mainly includes following several：Rheumatism, rheumatoid arthritis, osteoarthritis, rigid spine
Inflammation, urarthritis, adjuvant arthritis, infectional arthritis, traumatic arthritis, psoriatic arthritis, enteropathic pass
Section is scorching, the joint manifestations of other systemic diseases include systemic loupus erythematosus, tumour, blood disease etc..
Rheumatic arthritis (rheumatoid arthritis) is a kind of common acute or chronic connective tissue inflammation,
Recurrent exerbation and heart can be involved, clinic is characterized with the migrans miserable, heavily write in joint and muscle, pain.Rheumatoid joint
Scorching (rheumatoid arthritis) is a kind of chronic generalized autoimmune disease being characterized with arthrosynovitis, sliding
The scorching persistently recurrent exerbation of film, can cause the destruction of intra-articular cartilage and bone, joint function disturbance, or even maimed person.Vasculitis lesion
Involve whole body each organ, therefore this disease is also known as rheumatoid disease.
At present, clinical treatment rheumatism, the means of rheumatoid arthritis mainly have：Physical treatment, mainly using various electricity
The method such as treatment and acupuncture, effect is not apparent；Drug therapy, is exactly mainly to take non-steroidal antiinflammatory drugs (NSAIDs), sugar
Cortin (Gs), the improvement state of an illness act on antirheumatic (DMARDs), autonomic drug, biological agent etc. slowly, and clinic display is often
Drug resistance can be produced, and is unable to radical curing of disease, and Western medicine toxic side effect is than larger.The conventional traditional Chinese medical science is often inclined to this sick understanding
The wet stasis of blood of chill is overweighted, it is unsatisfactory using the effect for the treatment of by Chinese herbs.
The content of the invention
In order to solve above-mentioned technical problem present in prior art, the present invention provides one kind and treats rheumatism Chinese traditional medicine composition
Thing and preparation method thereof.
It is achieved particular by following technical scheme：
One kind treats rheumatism Chinese medicine composition, and raw material is in parts by weight 1-3 parts of china creeper root, dye meal spends 3-7 parts, maple
1-5 parts of leaf.
It is preferred that, described raw material is in parts by weight 2 parts of china creeper root, dye meal spends 5 parts, 3 parts of maple leaves.
It is preferred that, described raw material is in parts by weight 1 part of china creeper root, dye meal spends 6 parts, 2 parts of maple leaves.
It is preferred that, described raw material is in parts by weight 3 parts of china creeper root, dye meal spends 4 parts, 4 parts of maple leaves.
The second purpose of the invention is also to provide above-mentioned treatment rheumatism Chinese medicine composition preparation method, including with
Lower step：
(1) china creeper root, dye meal flower, maple leaves are weighed, it is stand-by；
(2) china creeper root, dye meal flower, maple leaves are crushed respectively, sieved for subsequent use；
(3) china creeper root, dye meal flower, maple leaves are well mixed, add water, decoct, obtain decoction.
Described step, in addition to by adding water, decoct obtained decoction and be freeze-dried into after powder, add pharmacy
Acceptable auxiliary material prepares piece agent.
Described sieving was 5-100 mesh sieves.
Described step, in addition to add pharmaceutically acceptable auxiliary material into decoction and be prepared into syrup.
Chinese medicine composition prepared by the invention, its in use, it is after Chinese medicine composition is mixed, plus
Water is brewed into traditional Chinese herbal decoction, and controls water temperature to carry out immersion pin in the range of 35~45 DEG C, and is rubbed decoction using hand
Onto thigh；Can also be the medicine and 60- of the tablet, syrup or other preparation types that are prepared from the invention
70 DEG C of hot water mixing so that its effective ingredient content reaches after 20-40% that adjustment temperature is in the range of 35-45 DEG C
Immersion pin is carried out, and is rubbed decoction on thigh using hand.
In addition, the medicine of the invention can be used for orally, it is oral during, control effective ingredient contains
Measure as 0.02~0.1g/kg body weight, the wherein amount of effective ingredient is after china creeper root, dye meal flower, maple leaves mixing, to use
Water boiling and extraction comes out, and the powder meter being spray-dried.
The sufficient raw for the Chinese medicine composition that the invention is used, is prepared simply, easy to use, short treating period makes
Obtaining can take effect at 3-5 days, be relieved within 15 days or so symptom, and use it for 20 rheumathritis and rheumatoid arthritis
Patient carries out medication treatment processing, and its effective percentage has reached 100%, and safety has no toxic side effect.Ingredients symbol in the present invention
Close version in 2005《Pharmacopoeia of People's Republic of China》Chinese medicine process relevant regulations.
Embodiment
Limited with reference to specific embodiment technical scheme is further, but claimed
Scope is not only limited to made description.
Embodiment 1
Rheumatism Chinese medicine composition is treated, raw material is china creeper root 1g, dye meal flower 3g, maple leaves 1g.
Raw material is weighed, adds water and boils 1h, concoction is filtered out, temperature is placed on for 20 DEG C, air humidity is in the environment of 65%, old
Change 1h, produce.
Embodiment 2
Rheumatism Chinese medicine composition is treated, raw material is china creeper root 3g, dye meal flower 7g, maple leaves 5g.
Raw material is weighed, adds water and boils 2h, concoction is filtered out, temperature is placed on for 15 DEG C, air humidity is in the environment of 55%, old
Change 1.5h, produce.
Embodiment 3
Rheumatism Chinese medicine composition is treated, raw material is china creeper root 2g, dye meal flower 5g, maple leaves 3g.
Raw material is weighed, is crushed, sieving adds water and boils 1.5h, filters out concoction, and it is 23 DEG C to be placed on temperature, and air humidity is
In the environment of 60%, 1.3h is aged, is produced.
Embodiment 4
Rheumatism Chinese medicine composition is treated, raw material is china creeper root 1g, dye meal flower 6g, maple leaves 2g.
Raw material is weighed, is crushed, 100 mesh sieves is crossed, adds water and boil 1.6h, filter out concoction, it is 18 DEG C, air humidity to be placed on temperature
In the environment of 63%, 1h is aged, is produced.
Embodiment 5
Rheumatism Chinese medicine composition is treated, raw material is china creeper root 3g, dye meal flower 4g, maple leaves 4g.
Raw material is weighed, is crushed, 20 mesh sieves is crossed, adds water and boil 1h, filter out concoction, it is 20 DEG C to be placed on temperature, air humidity is
In the environment of 65%, 1h is aged, is produced.
Embodiment 6
Rheumatism Chinese medicine composition is treated, raw material is china creeper root 2g, dye meal flower 6g, maple leaves 4g.
Raw material is weighed, adds water and boils 1h, concoction is filtered out, temperature is placed on for 20 DEG C, air humidity is in the environment of 65%, old
Change 1h, be freeze-dried into powder, add pharmaceutically acceptable auxiliary material soluble starch and account for powder quality 1%, prepare piece agent；
Or alpha-lactose is added, prepare piece agent.
Concoction prepared by embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5 is admixed in mouse feed, is used
Handled in feeding mouse, and mouse growth process is observed, it is as a result as shown in table 1 below：
Table 1
| Addition is per kg feed additions | Feed 30 days and process mouse change | |
| Embodiment 1 | Active drug composition meter 1g | Sign has no any change, and mouse food-intake increased |
| Embodiment 2 | Active drug composition meter 2g | Sign has no any change, and mouse food-intake increased |
| Embodiment 3 | Active drug composition meter 3g | Sign has no any change, and mouse food-intake increased |
| Embodiment 4 | Active drug composition meter 4g | Sign has no any change, and mouse food-intake increased |
| Embodiment 5 | Active drug composition meter 5g | Sign has no any change, and mouse food-intake increased |
| Blank group | Plus the water with the isodose of embodiment 5 | Sign has no any change, and food-intake change is little |
Therefore, the drug ingedient has no toxic side effect, and has no any chronic toxicity.
In addition, the mouse that this researcher also raises embodiment 5 was at the 31st day, the concoction prepared using embodiment 5
Direct gavage mouse, every mouse stomach 300ml, and mouse is observed, have no that mouse has any death, and in gavage 5h
Afterwards, mouse is fed intake, mouse feed is normal, it is seen then that the pharmaceutical composition there are no any toxic side effect.
Clinical practice：
Liu XX, man, 38 years old.Suffer from rheumatic arthritis, Long-term Hormone prednisone, it continuously takes 5 years, rheumatoid
The factor 271, erythrocyte sedimentation rate 69；Pin is soaked using the Chinese medicine composition progress of the invention and is orally administered 15 days, and it is taken action and normal
People is as good as, and Rheumatoid factors are 38, and erythrocyte sedimentation rate is 18.
Leaf XX, man, 48 years old.Suffering from rheumatic arthritis has 3 years medical histories, and since in March, 2016, its is increasingly severe, lies
In bed, stand up to be required for people to help, in the process, methotrexate (MTX) and Voltarol are taken always, is not substantially taken effect.2016
Year, August started to take the Chinese medicine composition of the invention after 13 days, and it has significantly been alleviated, and can substantially leave the bed away
Dynamic, action is returned to normal, and in continuous use to after 20 days, it, which can leave the bed, freely walks, painless.
Claims (8)
1. one kind treats rheumatism Chinese medicine composition, it is characterised in that raw material is in parts by weight 1-3 parts of china creeper root, dye meal flower
3-7 parts, 1-5 parts of maple leaves.
2. treatment rheumatism Chinese medicine composition as claimed in claim 1, it is characterised in that described raw material is in parts by weight
2 parts of china creeper root, dye meal spend 5 parts, 3 parts of maple leaves.
3. treatment rheumatism Chinese medicine composition as claimed in claim 1, it is characterised in that described raw material is in parts by weight
1 part of china creeper root, dye meal spend 6 parts, 2 parts of maple leaves.
4. treatment rheumatism Chinese medicine composition as claimed in claim 1, it is characterised in that described raw material is in parts by weight
3 parts of china creeper root, dye meal spend 4 parts, 4 parts of maple leaves.
5. the treatment rheumatism Chinese medicine composition preparation method as described in claim any one of 1-4, it is characterised in that including with
Lower step：
(1) china creeper root, dye meal flower, maple leaves are weighed, it is stand-by；
(2) china creeper root, dye meal flower, maple leaves are crushed respectively, sieved for subsequent use；
(3) china creeper root, dye meal flower, maple leaves are well mixed, add water, decoct, obtain decoction.
6. rheumatism Chinese medicine composition preparation method is treated as claimed in claim 5, it is characterised in that described step, in addition to
By adding water, decoct obtained decoction and be freeze-dried into after powder, add pharmaceutically acceptable auxiliary material and prepare piece agent.
7. rheumatism Chinese medicine composition preparation method is treated as claimed in claim 5, it is characterised in that described sieving was 5-
100 mesh sieves.
8. rheumatism Chinese medicine composition preparation method is treated as claimed in claim 5, it is characterised in that described step, in addition to
Pharmaceutically acceptable auxiliary material is added into decoction and is prepared into syrup.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710711077.3A CN107281332A (en) | 2017-08-18 | 2017-08-18 | One kind treats rheumatism Chinese medicine composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710711077.3A CN107281332A (en) | 2017-08-18 | 2017-08-18 | One kind treats rheumatism Chinese medicine composition and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN107281332A true CN107281332A (en) | 2017-10-24 |
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ID=60106296
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710711077.3A Pending CN107281332A (en) | 2017-08-18 | 2017-08-18 | One kind treats rheumatism Chinese medicine composition and preparation method thereof |
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| Country | Link |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5426323A (en) * | 1977-07-26 | 1979-02-27 | Koshiro Chiyuuji Shiyouten Kk | Antiinflammatory agent |
| CN103919854A (en) * | 2014-04-18 | 2014-07-16 | 温先敏 | Application of butterflybush flower and extract thereof to preparation of medicament |
| CN105412693A (en) * | 2015-12-01 | 2016-03-23 | 黑龙江江恒医药科技有限公司 | Spur pain relief capsules and preparation method thereof |
-
2017
- 2017-08-18 CN CN201710711077.3A patent/CN107281332A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5426323A (en) * | 1977-07-26 | 1979-02-27 | Koshiro Chiyuuji Shiyouten Kk | Antiinflammatory agent |
| CN103919854A (en) * | 2014-04-18 | 2014-07-16 | 温先敏 | Application of butterflybush flower and extract thereof to preparation of medicament |
| CN105412693A (en) * | 2015-12-01 | 2016-03-23 | 黑龙江江恒医药科技有限公司 | Spur pain relief capsules and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 黄汉儒: "《广西民族医药验方汇编》", 31 July 1993, 广西民族出版社 * |
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Application publication date: 20171024 |