CN107281263A - A kind of composition and preparation method thereof, sachet and application - Google Patents
A kind of composition and preparation method thereof, sachet and application Download PDFInfo
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- CN107281263A CN107281263A CN201710048544.9A CN201710048544A CN107281263A CN 107281263 A CN107281263 A CN 107281263A CN 201710048544 A CN201710048544 A CN 201710048544A CN 107281263 A CN107281263 A CN 107281263A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 23
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 23
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 22
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229940116229 borneol Drugs 0.000 claims abstract description 22
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 22
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 22
- 240000004510 Agastache rugosa Species 0.000 claims abstract description 21
- 241000735527 Eupatorium Species 0.000 claims abstract description 21
- 235000004347 Perilla Nutrition 0.000 claims abstract description 21
- 239000003814 drug Substances 0.000 claims abstract description 17
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/009—Sachets, pouches characterised by the material or function of the envelope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
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Abstract
The invention discloses a kind of composition and preparation method thereof, sachet and application, described composition includes parts by weight of raw materials：3 ~ 10 parts of folium artemisiae argyi, 3 ~ 10 parts of wrinkled giant hyssop, 3 ~ 10 parts of cassia twig, 3 ~ 10 parts of purple perilla, 3 ~ 8 parts of eupatorium, 3 ~ 6 parts of borneol；The preparation method of described composition includes pre-treatment, extraction, post processing；The Chinese medicine sachet that described composition is prepared；Application of the described composition in preventing/treating cold in children.
Description
Technical field
The invention belongs to drug preparation technique field, and in particular to a kind of composition and preparation method thereof, sachet and application.
Background technology
Cold in children, is also named acute upper respiratory infection (acute upper res piratory infections), is
The most common disease of children, mainly invades nose, nasopharynx and pharyngeal, therefore conventional " acute nasopharyngitis " (flu), " acpuei pharyngitis "
" acute tonsillitis " etc. diagnoses noun, also can be collectively referred to as the infection of the upper respiratory tract, referred to as " upper sense ".Nasopharynx infection often may occur in which simultaneously
Disease is sent out, is related to adjacent organs such as larynx, tracheae, lung, oral cavity, nasal sinus, middle ear, eye and lymphonodi cervicales etc..Sometimes pharynx nasalis is primary
The symptom of disease has taken a turn for the better or disappeared, and its complication can delay or aggravate.In temperature Change too big season, cold in children occurs
Probability rise, have in addition falls ill repeatedly.Therefore, it is very necessary to develop a kind of product that can solve above-mentioned health problem
's.
The content of the invention
The first object of the present invention is to provide a kind of composition；Second purpose is the preparation of the composition described in offer
Method；3rd purpose is to provide the Chinese medicine sachet being made using described composition；4th purpose is the group described in offer
The application of compound.
The first object of the present invention is achieved in that described composition includes parts by weight of raw materials：3 ~ 10 parts of folium artemisiae argyi, the leaves of pulse plants
Fragrant 3 ~ 10 parts, 3 ~ 10 parts of cassia twig, 3 ~ 10 parts of purple perilla, 3 ~ 8 parts of eupatorium, 3 ~ 6 parts of borneol.
The second object of the present invention is achieved in that the preparation method of described composition, specifically includes following steps：
A, pre-treatment：Folium artemisiae argyi, wrinkled giant hyssop, cassia twig, purple perilla, eupatorium are pulverized and sieved respectively, is then well mixed and obtains mixture；
B, extraction：Again in the mixture add 3 ~ 10 times of mixture weight water carry out water extraction, then with 3 ~ 10 times amount 75% second
Alcoholic solution is precipitated, and extract solution is obtained after filtering；
C, post processing：By extract solution it is concentrated, dry, pulverize and sieve, add that borneol is well mixed to obtain objective composition.
The third object of the present invention is achieved in that the Chinese medicine sachet prepared using described composition, described
Chinese medicine sachet be with breathable fabric parcel composition made from sachet.
The fourth object of the present invention is achieved in that application of the described composition in preventing/treating cold in children.
There is good opsonic action to cold in children caused by a variety of different reasons.Particularly to children's recurrent exerbation, cureless
Cold symptoms, have effects that conditioning and righting.To following symptoms, with significant treatment or improvement result：Nasal obstruction, throat swell
Bitterly, fever and chills headache, receive poor, alliteration uncomfortable in chest, chest gastral cavity ruffian, vomiting and diarrhea.
The advanced water-filling of extraction process of the preparation method of the present invention is extracted, and ethanol solution precipitation process is then used again, can
Increase substantially product active ingredient concentration；Using folium artemisiae argyi, wrinkled giant hyssop as monarch drug in a prescription in the present composition, Papillary has fragrance
Change is turbid, wards off effect of dirty removing toxic substances.Folium artemisiae argyi is pungent, hardship, warm-natured, enters spleen, liver and kidney channel, and fragrance is pure and fresh, can dispel poison gas, except dirt,
There is rationale blood, by cold-dampness, Wen Jing, hemostasis, antiabortive work(；Wrinkled giant hyssop is pungent, slightly warm in nature, return lung, spleen, stomach, there is driving away summer heat inducing diaphoresis, changes
Effect of wet and stomach.We are with cassia twig, purple perilla, eupatorium altogether for ministerial drug, and cassia twig, purple perilla, the medicine of eupatorium three take its inducing diaphoresis to dispel with using
Wet, warming spleen and stomach for dispelling cold effect, cassia twig is pungent sweet, temperature, enters bladder, the heart, lung channel, can expelling cold and relieving exterior syndrome, warming meridian, activating YANG and prormoting functioning of QI；It is purple
Soviet Union is pungent, warm-natured.Return lung, the spleen channel, there is inducing sweat and dispelling exogenous evils, regulating the flow of QI to ease the stomach, effect of solving toxin of fish and crab；Eupatorium is pungent, puts down, enters spleen, stomach
Through with removing dampness by means of aromatics, appetizing of being amusing delivers effect of relieving summer-heat.Using borneol as adjuvant in prescription, the work(of its radiating of having one's ideas straightened out is taken
Effect, plays the curative effect of auxiliary monarch drug in a prescription cold dispelling, borneol is pungent, hardship, is slightly cold, Delicate fragrance a surname dissipate, and with inducing resuscitation of having one's ideas straightened out, heat-clearing dissipates poison is bright
Mesh moves back effect of screen.Full side's all medicines share, complements each other, has effects that obvious cold dispelling brings down a fever, delivers relieving summer-heat, can play
The effect of preventing/treating cold in children.
Embodiment
With reference to embodiment, the present invention is further illustrated, but the present invention is not any limitation as in any way,
Based on present invention teach that any conversion or replacement made, belong to protection scope of the present invention.
Composition of the present invention includes parts by weight of raw materials：3 ~ 10 parts of folium artemisiae argyi, 3 ~ 10 parts of wrinkled giant hyssop, 3 ~ 10 parts of cassia twig, purple
3 ~ 10 parts of Soviet Union, 3 ~ 8 parts of eupatorium, 3 ~ 6 parts of borneol.
Described composition includes parts by weight of raw materials：4 ~ 8 parts of folium artemisiae argyi, 4 ~ 8 parts of wrinkled giant hyssop, 4 ~ 8 parts of cassia twig, 4 ~ 8 parts of purple perilla, pendant
Blue 5 ~ 7 parts, 5 ~ 6 parts of borneol.
Described composition includes parts by weight of raw materials：5 ~ 7 parts of folium artemisiae argyi, 5 ~ 7 parts of wrinkled giant hyssop, 5 ~ 7 parts of cassia twig, 5 ~ 7 parts of purple perilla, pendant
Blue 5.5 ~ 6.5 parts, 5.5 ~ 6.5 parts of borneol.
The preparation method of described composition, specifically includes following steps：
A, pre-treatment：Folium artemisiae argyi, wrinkled giant hyssop, cassia twig, purple perilla, eupatorium are pulverized and sieved respectively, is then well mixed and obtains mixture；
B, extraction：Again in the mixture add 3 ~ 10 times of mixture weight water carry out water extraction, then with 3 ~ 10 times amount 75% second
Alcoholic solution is precipitated, and extract solution is obtained after filtering；
C, post processing：By extract solution it is concentrated, dry, pulverize and sieve, add that borneol is well mixed to obtain objective composition.
The extraction time that described water is extracted is 18 ~ 30 hours.
The Extracting temperature that described water is extracted is 40 ~ 50 DEG C.
Described sieving was 20 mesh sieves.
Described concentration is to be concentrated into the g/ml of relative density 1.9 ~ 2.0.
The Chinese medicine sachet that described composition is prepared, described Chinese medicine sachet is to wrap up composition system with breathable fabric
The sachet obtained.
Application of the described composition in preventing/treating cold in children.
With reference to embodiment 1 ~ 10, the invention will be further described.
Embodiment 1
Composition includes parts by weight of raw materials：3 parts of folium artemisiae argyi, 3 parts of wrinkled giant hyssop, 3 parts of cassia twig, 3 parts of purple perilla, 3 parts of eupatorium, 3 parts of borneol.
Embodiment 2
Composition includes parts by weight of raw materials：10 parts of folium artemisiae argyi, 10 parts of wrinkled giant hyssop, 10 parts of cassia twig, 10 parts of purple perilla, 8 parts of eupatorium, 6 parts of borneol.
Embodiment 3
Composition includes parts by weight of raw materials：4 parts of folium artemisiae argyi, 4 parts of wrinkled giant hyssop, 4 parts of cassia twig, 4 parts of purple perilla, 5 parts of eupatorium, 5 parts of borneol.
Embodiment 4
Composition includes parts by weight of raw materials：8 parts of folium artemisiae argyi, 8 parts of wrinkled giant hyssop, 8 parts of cassia twig, 8 parts of purple perilla, 7 parts of eupatorium, 6 parts of borneol.
Embodiment 5
Composition includes parts by weight of raw materials：5 parts of folium artemisiae argyi, 5 parts of wrinkled giant hyssop, 5 parts of cassia twig, 5 parts of purple perilla, 5.5 parts of eupatorium, 5.5 parts of borneol.
Embodiment 6
Composition includes parts by weight of raw materials：7 parts of folium artemisiae argyi, 7 parts of wrinkled giant hyssop, 7 parts of cassia twig, 7 parts of purple perilla, 6.5 parts of eupatorium, 6.5 parts of borneol.
Embodiment 7
The preparation method of described composition, specifically includes following steps：
A, pre-treatment：Folium artemisiae argyi, wrinkled giant hyssop, cassia twig, purple perilla, eupatorium are pulverized and sieved respectively, is then well mixed and obtains mixture；
B, extraction：Again in the mixture add 3 times of mixture weight water carry out water extraction, then with 3 times measure 75% ethanol solutions
Precipitation, extract solution is obtained after filtering；
C, post processing：By extract solution it is concentrated, dry, pulverize and sieve, add that borneol is well mixed to obtain objective composition.
Embodiment 8
The preparation method of described composition, specifically includes following steps：
A, pre-treatment：Folium artemisiae argyi, wrinkled giant hyssop, cassia twig, purple perilla, eupatorium are pulverized and sieved respectively, is then well mixed and obtains mixture；
B, extraction：Again in the mixture add 6.5 times of mixture weight water carry out water extraction, then with 6.5 times measure 75% ethanol
Solution is precipitated, and extract solution is obtained after filtering；
C, post processing：By extract solution it is concentrated, dry, pulverize and sieve, add that borneol is well mixed to obtain objective composition.
Embodiment 9
The preparation method of described composition, specifically includes following steps：
A, pre-treatment：Folium artemisiae argyi, wrinkled giant hyssop, cassia twig, purple perilla, eupatorium are pulverized and sieved respectively, is then well mixed and obtains mixture；
B, extraction：The water for adding 10 times of mixture weight in the mixture again carries out water extraction, then molten with 75% ethanol of 10 times of amounts
Extract solution is obtained after liquid precipitate, filtering；
C, post processing：By extract solution it is concentrated, dry, pulverize and sieve, add that borneol is well mixed to obtain objective composition.
Embodiment 10：Efficacy validation is tested
Subjects：Using the method for chester sampling, extract certain kindergarten it is small, in, the children of the top class in a kindergarten be subjects, Zong Gongxuan
451 people are taken, wherein in the people of test group 243, boy student is 169 people, and female is 74 people, and the people of control group 208, boy student is 132 people, and schoolgirl 76
People；Compare between group through the age, gender comparison, there was no significant difference.
Test method：Test group is worn use Chinese medicine sachet daily, and a sachet is changed per 10d, 20d is continuously worn；Control
Group does not wear Chinese medicine sachet, observes 20d；Flu number of the infected is counted respectively.
Evaluation method：The flu incidence of disease of statistical test group and control group, then calculates protective rate by following equation respectively
And efficiency index,
The % of protective rate=(the control group incidence of disease test group incidence of disease)/control group incidence of disease × 100；
Efficiency index=control group the incidence of disease/test group incidence of disease, is effective more than 2.
Result of the test is shown in Table 1 ~ 2.
The test group cold in children situation of table 1（Example）
The control group children of table 2 flu situation（Example）
%=51.0% of protective rate=71/139 × 100, efficiency index=139/68=2.04, effect is effective.
From table 1, table 2, test group number of the infected is 68 people, and control group number of the infected is 139 people, is computed, and is protected
Rate is 51.0%, and efficiency index is 2.04, shows that the incidence of disease of flu can effectively be reduced by wearing present composition Chinese medicine sachet.
Claims (10)
1. a kind of composition, it is characterised in that described composition includes parts by weight of raw materials：3 ~ 10 parts of folium artemisiae argyi, 3 ~ 10 parts of wrinkled giant hyssop,
3 ~ 10 parts of cassia twig, 3 ~ 10 parts of purple perilla, 3 ~ 8 parts of eupatorium, 3 ~ 6 parts of borneol.
2. composition according to claim 1, it is characterised in that described composition includes parts by weight of raw materials：Folium artemisiae argyi 4 ~ 8
Part, 4 ~ 8 parts of wrinkled giant hyssop, 4 ~ 8 parts of cassia twig, 4 ~ 8 parts of purple perilla, 5 ~ 7 parts of eupatorium, 5 ~ 6 parts of borneol.
3. composition according to claim 1, it is characterised in that described composition includes parts by weight of raw materials：Folium artemisiae argyi 5 ~ 7
Part, 5 ~ 7 parts of wrinkled giant hyssop, 5 ~ 7 parts of cassia twig, 5 ~ 7 parts of purple perilla, 5.5 ~ 6.5 parts of eupatorium, 5.5 ~ 6.5 parts of borneol.
4. the preparation method of a kind of composition as described in claim 1 ~ 3 is any, it is characterised in that specifically include following steps：
A, pre-treatment：Folium artemisiae argyi, wrinkled giant hyssop, cassia twig, purple perilla, eupatorium are pulverized and sieved respectively, is then well mixed and obtains mixture；
B, extraction：Again in the mixture add 3 ~ 10 times of mixture weight water carry out water extraction, then with 3 ~ 10 times amount 75% second
Alcoholic solution is precipitated, and extract solution is obtained after filtering；
C, post processing：By extract solution it is concentrated, dry, pulverize and sieve, add that borneol is well mixed to obtain objective composition.
5. the preparation method of composition according to claim 4, it is characterised in that the extraction time that described water is extracted is
18 ~ 30 hours.
6. the preparation method of composition according to claim 4, it is characterised in that the Extracting temperature that described water is extracted is
40~50℃。
7. the preparation method of composition according to claim 4, it is characterised in that described sieving was 20 mesh sieves.
8. the preparation method of composition according to claim 4, it is characterised in that described concentration be concentrated into it is relatively close
Spend 1.9 ~ 2.0 g/ml.
9. the Chinese medicine sachet that one kind is prepared using the composition as described in claim 1 ~ 3 is any, described Chinese medicine sachet
It is with sachet made from breathable fabric parcel composition.
10. a kind of application of the composition in preventing/treating cold in children as described in claim 1 ~ 3 is any.
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| CN108210830A (en) * | 2018-03-29 | 2018-06-29 | 德阳爱可依生物科技有限公司 | A kind of Chinese medicine composition and its application |
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Application publication date: 20171024 |