CN107281247A - 一种墨旱莲鲜榨喷雾干燥颗粒饮片的制备工艺 - Google Patents
一种墨旱莲鲜榨喷雾干燥颗粒饮片的制备工艺 Download PDFInfo
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Abstract
本发明公布了一种墨旱莲鲜榨喷雾干燥颗粒饮片的制备工艺。该工艺在墨旱莲药材采收后，净选、淋洗，并趁鲜压榨，滤取药汁。药渣再加水搅拌，过滤压榨。所得药汁合并后减压浓缩，喷雾干燥，制粒。此法制备的墨旱莲颗粒饮片，最大限度的保留了药材中的极性和非极性有效成分。饮片利于储运，方便调剂，质量可控，疗效可靠，对保障中医药临床疗效具有重要的意义。本法的推广实施，将有显著的社会意义和经济效益。
Description
技术领域
本发明属于中药材加工领域，尤其涉及中药墨旱莲饮片的加工工艺。
背景技术
中药墨旱莲，为菊科植物鳢肠Eclipta prostrata L. 的干燥地上部分。花开时采割，晒干。
本品味甘、酸，性寒，归肾、肝经。具有滋补肝肾，凉血止血的功能。主要用于肝肾阴虚，牙齿松动，须发早白，眩晕耳鸣，腰膝酸软，阴虚血热吐血、衄血、尿血，血痢，崩漏下血，外伤出血。
常用的墨旱莲饮片的加工方式为：割取地上部分，切碎，晒干入药；或者经整理、晒干后，直接打包储藏和运输。这些干燥的墨旱莲药材运送到中药饮片厂后，需要清洗、切段，并重新晒干。现有工艺耗时费力，工序重复，增加了饮片的生产成本。在此过程中不仅会导致其中的水溶性有效成分的大量流失，而且闷润工序如在高温季节进行，极易发生药材霉变，从而导致药材品质的下降和临床疗效的降低。此类草药饮片，体积庞大，容易污染和霉变，质量很难保证，不利于调剂配方和确保其临床疗效。
目前，市场上也有墨旱莲药材经过提取后制成的颗粒饮片销售。由于颗粒饮片制备过程中，提取不仅耗时耗能，而且因常用水做溶媒，药材中的非极性有效成分很难被提取出来。此外，由于提取用的墨旱莲药材也是干燥并经过长时间储藏的，因此，有效成分的损失也是很大的。为了确保墨旱莲药材的临床有效、质量稳定，一种新型的墨旱莲饮片亟待开发。
发明内容
本发明公布了 “一种墨旱莲鲜榨喷雾干燥颗粒饮片的制备工艺”。本工艺可以最大限度的保留墨旱莲药材中的极性和非极性有效成分，避免药材在现有的饮片加工和储运过程中引起的有效成分的丢失和药材品质的下降，减少药材受霉菌等的污染，对确保墨旱莲饮片的质量稳定和临床安全有效具有重要的意义。
为了实现上述目的，本发明的技术方案为：
在墨旱莲采收期采集其地上部分，洗净，切成1~2cm的段，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，留存0.1%~0.5%重量的初榨药汁备用，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得到墨旱莲药汁。将所得的药汁，于40~75℃减压浓缩，得到相对密度为1.02~1.10的浓缩液，将此浓缩液转移至喷雾干燥塔喷雾干燥，进风口温度为90~140℃，出风口温度为70~110℃，收集干燥物，粉碎后过60~100目筛。将前述留存的初榨药汁，与喷干粉混合均匀，制备软材，制粒，干燥后整粒，收集颗粒，包装即可。
在产品包装袋的标签上，印刷上品名、药用部位、种植地、生产商、生产日期、主要成分含量、性味归经、功能主治、用法用量、毒副作用及禁忌证等信息。袋内附上墨旱莲的薄层鉴别图谱和/或高效液相特征图谱，作为产品的“身份证”。此外，在产品的包装袋上，印有二维码，通过扫描可以链接获取产品的原植物照片、药材照片、饮片照片、性状及显微鉴别特征等信息。
本发明的有益之处在于：
新鲜墨旱莲药材净选洗涤后直接切段压榨、过滤、减压浓缩、喷雾干燥、制粒所得到的颗粒饮片，可以最大限度地保留药材中的有效成分。 这种饮片体积较之于传统饮片体积大大地减小，流动性好，质量更加稳定，便于储运和临床调剂，具有十分显著的社会意义和经济意义。
具体实施方式
实施例1
将新鲜采集的墨旱莲药材，洗净，切成1cm的段，加入药材重量0.5倍量的水，搅拌15分钟，趁鲜压榨，留存此初榨药汁0.1%备用。所得药渣加2倍量的自来水，搅拌20min，板框压滤机压取药汁。所得药渣再用压榨机压榨，滤取药汁。将上述3次压榨得到的墨旱莲药汁合并，过100目筛。滤液减压浓缩，温度设定为60℃。在浓缩所得浓缩液相对密度为1.02时，进行喷雾干燥，进风口温度为140℃，出风口温度为110℃。收集喷雾干燥物，粉碎，过60目筛。将上述初榨药汁于喷干粉混合均匀，制备软材，制粒，干燥，整粒后装袋，1kg/袋，加入袋装干燥剂和抗氧化剂，真空封口，贴签即可。
实施例2
将新鲜采集的墨旱莲药材，洗净，切成2cm的段，加入药材重量1倍量的水，搅拌30分钟，趁鲜压榨，留存此初榨药汁0.5%备用。所得药渣加5倍量的自来水，搅拌30min，板框压滤机压取药汁。所得药渣再用压榨机压榨，滤取药汁。将上述3次压榨得到的墨旱莲药汁合并，过80目筛。滤液减压浓缩，温度设定为70℃。在浓缩所得浓缩液相对密度为1.05时，进行喷雾干燥，进风口温度为120℃，出风口温度为90℃。收集喷雾干燥物，粉碎，过60目筛。将上述初榨药汁于喷干粉混合均匀，制备软材，制粒，干燥，整粒后装袋，1kg/袋，加入袋装干燥剂和抗氧化剂，真空封口，贴签即可。
以上实施例，仅为说明本项发明的技术思想，不能凭此限定本发明的保护范围 凡是按照本发明提出的技术思想，在技术方案基础上所做的任何改动，均落入本发明保护的范围之内。
Claims (2)
1.一种墨旱莲鲜榨喷雾干燥颗粒饮片的制备工艺，其特征在于：在墨旱莲采收期采集其地上部分，洗净，切成1~2cm的段，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，留存0.1%~0.5%重量的初榨药汁备用，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得到墨旱莲药汁。
2.根据权利要求1所述的一种墨旱莲鲜榨喷雾干燥颗粒饮片的制备工艺，其特征在于：将权利要求2中所得的药汁，于40~75℃减压浓缩，得到相对密度为1.02~1.10的浓缩液，将此浓缩液转移至喷雾干燥塔喷雾干燥，进风口温度为90~140℃，出风口温度为70~110℃，收集干燥物，粉碎后过60~100目筛，得墨旱莲喷干粉，将其与将权利要求1中留存的初榨药汁混合均匀，制备软材，制粒，干燥后整粒，收集颗粒，包装即可。
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Cited By (8)
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| CN108524568A (zh) * | 2018-07-06 | 2018-09-14 | 徐自升 | 人参鲜提喷雾干燥颗粒饮片 |
| CN108524619A (zh) * | 2018-07-06 | 2018-09-14 | 徐自升 | 白芍鲜提喷雾干燥颗粒饮片 |
| CN108567808A (zh) * | 2018-07-06 | 2018-09-25 | 徐自升 | 党参鲜提喷雾干燥颗粒饮片 |
| CN108578567A (zh) * | 2018-07-06 | 2018-09-28 | 徐自升 | 麦冬鲜提喷雾干燥颗粒饮片 |
| CN108619211A (zh) * | 2018-07-06 | 2018-10-09 | 徐自升 | 桔梗鲜提喷雾干燥颗粒饮片 |
| CN108619221A (zh) * | 2018-07-06 | 2018-10-09 | 徐自升 | 黄芪鲜提喷雾干燥颗粒饮片 |
| CN108619304A (zh) * | 2018-07-06 | 2018-10-09 | 徐自升 | 地黄鲜提喷雾干燥颗粒饮片 |
| CN109568365A (zh) * | 2018-08-16 | 2019-04-05 | 广东方制药有限公司 | 一种墨旱莲配方颗粒的制备方法 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524568A (zh) * | 2018-07-06 | 2018-09-14 | 徐自升 | 人参鲜提喷雾干燥颗粒饮片 |
| CN108524619A (zh) * | 2018-07-06 | 2018-09-14 | 徐自升 | 白芍鲜提喷雾干燥颗粒饮片 |
| CN108567808A (zh) * | 2018-07-06 | 2018-09-25 | 徐自升 | 党参鲜提喷雾干燥颗粒饮片 |
| CN108578567A (zh) * | 2018-07-06 | 2018-09-28 | 徐自升 | 麦冬鲜提喷雾干燥颗粒饮片 |
| CN108619211A (zh) * | 2018-07-06 | 2018-10-09 | 徐自升 | 桔梗鲜提喷雾干燥颗粒饮片 |
| CN108619221A (zh) * | 2018-07-06 | 2018-10-09 | 徐自升 | 黄芪鲜提喷雾干燥颗粒饮片 |
| CN108619304A (zh) * | 2018-07-06 | 2018-10-09 | 徐自升 | 地黄鲜提喷雾干燥颗粒饮片 |
| CN109568365A (zh) * | 2018-08-16 | 2019-04-05 | 广东方制药有限公司 | 一种墨旱莲配方颗粒的制备方法 |
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