CN107375395A - 一种瞿麦鲜榨喷雾干燥颗粒饮片的制备工艺 - Google Patents
一种瞿麦鲜榨喷雾干燥颗粒饮片的制备工艺 Download PDFInfo
- Publication number
- CN107375395A CN107375395A CN201710738823.8A CN201710738823A CN107375395A CN 107375395 A CN107375395 A CN 107375395A CN 201710738823 A CN201710738823 A CN 201710738823A CN 107375395 A CN107375395 A CN 107375395A
- Authority
- CN
- China
- Prior art keywords
- squeezing
- concoction
- fringed pink
- spray
- crude slice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000013535 Dianthus superbus Nutrition 0.000 title claims abstract description 29
- 239000003814 drug Substances 0.000 title claims abstract description 20
- 238000005516 engineering process Methods 0.000 title claims abstract description 10
- 239000008187 granular material Substances 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 241001237097 Dianthus hyssopifolius Species 0.000 title claims abstract 8
- 239000000463 material Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000003756 stirring Methods 0.000 claims abstract description 9
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 5
- 230000014759 maintenance of location Effects 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000011122 softwood Substances 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 235000020985 whole grains Nutrition 0.000 claims description 4
- 244000025254 Cannabis sativa Species 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 244000183914 Dianthus superbus Species 0.000 abstract description 21
- 239000004480 active ingredient Substances 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 3
- 238000001914 filtration Methods 0.000 abstract description 3
- 238000002386 leaching Methods 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000003306 harvesting Methods 0.000 abstract description 2
- 239000002245 particle Substances 0.000 abstract description 2
- 230000000192 social effect Effects 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 4
- 238000000605 extraction Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000006837 decompression Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 240000006497 Dianthus caryophyllus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公布了一种瞿麦鲜榨喷雾干燥颗粒饮片的制备工艺。该工艺在瞿麦药材采收后，净选、淋洗，并趁鲜压榨，滤取药汁。药渣再加水搅拌，过滤压榨。所得药汁合并后减压浓缩，喷雾干燥，再制成颗粒。此法制备的瞿麦颗粒饮片，不仅流动性好，而且最大限度的同时保留了药材中的极性和非极性有效成分。饮片利于储运，方便调剂，质量可控，疗效可靠，对保障中医药临床疗效具有重要的意义。本法的推广实施，将有显著的社会意义和经济效益。
Description
技术领域
本发明属于中药材加工领域，尤其涉及中药瞿麦饮片的加工工艺。
背景技术
中药瞿麦为石竹科石竹属多年生草本的干燥全草，有清热、利尿、破血通经的功效。
常用的瞿麦饮片的加工方式为：采收后，除去杂质，晒干，直接打包储藏和运输。这些干燥的瞿麦卫生学指标不能达标，极易发生药材霉变，从而导致药材品质的下降和临床疗效的降低。此类草药饮片，体积庞大，易发生变质和被污染，质量很难保证，不利于调剂配方和确保其临床疗效。
目前，市场上也有瞿麦药材经过提取后制成的颗粒饮片销售。由于颗粒饮片制备过程中，提取不仅耗时耗能，而且因常用水做溶媒，药材中的非极性有效成分很难被提取出来。此外，由于提取用的瞿麦药材也是干燥并经过长时间储藏的，因此，其原料易污染和霉变的情况也是很难避免的。为了确保瞿麦药材的临床有效、质量稳定，一种新型的瞿麦饮片及其制备工艺亟待开发。
发明内容
本发明公布了 “一种瞿麦鲜榨喷雾干燥颗粒饮片的制备工艺”。本工艺可以最大限度的保留瞿麦药材中的极性和非极性有效成分，避免药材在现有的饮片加工和储运过程中引起的有效成分的丢失和药材品质的下降，减少药材受霉菌等的污染，对确保瞿麦饮片的质量稳定和临床安全有效具有重要的意义。
为了实现上述目的，本发明的技术方案为：
在瞿麦采收期采集其全草，洗净，切成1~2cm的段，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，留存0.1%~0.5%重量的初榨药汁备用，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得瞿麦药汁。将所得的药汁，于40~80℃减压浓缩，得到相对密度为1.02~1.10的浓缩液。将此浓缩液进行喷雾干燥，进风口温度设定为100~140℃,出风口温度设定为90~120℃，收集干燥物进行粉碎，过60~100目筛。将上述留存的初榨药汁与得到的喷干粉混合，酌情加入适量的淀粉和糊精，制备软材，制粒，干燥，整粒，包装即可。
在产品包装袋的标签上，印刷上品名、药用部位、种植地、生产商、生产日期、主要成分含量、性味归经、功能主治、用法用量、毒副作用及禁忌证等信息。袋内附上瞿麦的薄层鉴别图谱和/或高效液相特征图谱，作为产品的“身份证”。此外，在产品的包装袋上，印有二维码，通过扫描可以链接获取产品的原植物照片、药材照片、饮片照片、性状及显微鉴别特征等信息。
本发明的有益之处在于：
新鲜瞿麦药材净选洗涤后直接压榨、过滤、减压浓缩、喷雾干燥、制粒后，所得到的颗粒饮片，不仅流动性好，还能最大限度地保留药材中的有效成分。 这种饮片体积较之于传统饮片体积大大地减小，质量更加稳定，利于储运和临床调剂，具有十分显著的社会意义和经济意义。
具体实施方式
实施例1
将新鲜采集的瞿麦药材，净选，洗净，切成1cm的段，加入药材重量0.5倍量的水，搅拌15分钟，趁鲜压榨，留存此初榨药汁的0.1%备用。所得药渣加2倍量的自来水，搅拌20min，板框压滤机压榨取汁。所得药渣再用压榨机压榨，滤取药汁。将上述3次瞿麦药汁合并，用60目筛过滤，滤液减压浓缩，温度设定为60℃。在所得浓缩液相对密度为1.03时，转移到喷雾干燥塔进行喷雾干燥，进风口温度设定为140℃，出风口温度设定为110℃，收集干燥物，粉碎，过60目筛。将此喷干粉，与上述留存的初榨药汁混合制软材，制粒，干燥，整粒，装袋，1kg/袋，加入袋装抗氧化剂和干燥剂，真空封装，贴签即可。
实施例2
将新鲜采集的瞿麦药材，净选，洗净，切成2cm的段，加入药材重量1倍量的水，搅拌30分钟，趁鲜压榨，留存此初榨药汁的0.3%备用。所得药渣加5倍量的自来水，搅拌30min，板框压滤机压榨取汁。所得药渣再用压榨机压榨，滤取药汁。将上述3次瞿麦药汁合并，用100目筛过滤，滤液减压浓缩，温度设定为70℃。在所得浓缩液相对密度为1.05时，转移到喷雾干燥塔进行喷雾干燥，进风口温度设定为120℃，出风口温度设定为90℃，收集干燥物，粉碎，过60目筛。将此喷干粉，与上述留存的初榨药汁混合制软材，制粒，干燥，整粒，装袋，1kg/袋，加入袋装抗氧化剂和干燥剂，真空封装，贴签即可。
以上实施例，仅为说明本项发明的技术思想，不能凭此限定本发明的保护范围 凡是按照本发明提出的技术思想，在技术方案基础上所做的任何改动，均落入本发明保护的范围之内。
Claims (3)
1.一种瞿麦鲜榨喷雾干燥颗粒饮片的制备工艺，其特征在于：在瞿麦采收期采集其全草，洗净，切成1~2cm的段，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，留存0.1%~0.5%重量的初榨药汁备用，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得瞿麦药汁。
2.根据权利要求1所述的一种瞿麦鲜榨喷雾干燥颗粒饮片的制备工艺，其特征在于：将权利要求1中所得的药汁，于40~80℃减压浓缩，得到相对密度为1.02~1.10的浓缩液，对其进行喷雾干燥，进风口温度设定为100~140℃,出风口温度设定为90~120℃，收集干燥物进行粉碎，过60~100目筛。
3.根据权利要求1所述的一种瞿麦鲜榨喷雾干燥颗粒饮片的制备工艺，其特征在于：将权利要求1中留存的初榨药汁与权利要求2中得到的喷干粉混合，制备软材，制粒，干燥，整粒，包装即可。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738823.8A CN107375395A (zh) | 2017-08-25 | 2017-08-25 | 一种瞿麦鲜榨喷雾干燥颗粒饮片的制备工艺 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738823.8A CN107375395A (zh) | 2017-08-25 | 2017-08-25 | 一种瞿麦鲜榨喷雾干燥颗粒饮片的制备工艺 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107375395A true CN107375395A (zh) | 2017-11-24 |
Family
ID=60346003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710738823.8A Pending CN107375395A (zh) | 2017-08-25 | 2017-08-25 | 一种瞿麦鲜榨喷雾干燥颗粒饮片的制备工艺 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107375395A (zh) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213660A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种芦荟鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN105213452A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种蒲公英鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN105213551A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种白花蛇舌草鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN106109530A (zh) * | 2016-07-23 | 2016-11-16 | 徐漫 | 一种大青叶鲜榨喷雾干燥颗粒饮片及其制备工艺 |
-
2017
- 2017-08-25 CN CN201710738823.8A patent/CN107375395A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213660A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种芦荟鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN105213452A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种蒲公英鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN105213551A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种白花蛇舌草鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN106109530A (zh) * | 2016-07-23 | 2016-11-16 | 徐漫 | 一种大青叶鲜榨喷雾干燥颗粒饮片及其制备工艺 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107412303A (zh) | 一种佩兰鲜榨真空干燥粉末饮片的制备工艺 | |
| CN107281247A (zh) | 一种墨旱莲鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107281236A (zh) | 一种苦丁茶鲜榨喷雾干燥颗粒饮片及其制备工艺 | |
| CN107468751A (zh) | 一种连钱草鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107441223A (zh) | 一种鱼腥草鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375529A (zh) | 一种白英鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375389A (zh) | 一种茵陈鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107397787A (zh) | 一种广藿香鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375395A (zh) | 一种瞿麦鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375394A (zh) | 一种瞿麦鲜榨冷冻干燥粉末饮片的制备工艺 | |
| CN107468831A (zh) | 一种紫花地丁鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375349A (zh) | 一种木贼鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375370A (zh) | 一种芫荽鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107412434A (zh) | 一种龙葵鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107320568A (zh) | 一种龙葵鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107397774A (zh) | 一种芫荽鲜榨冷冻干燥粉末饮片的制备工艺 | |
| CN107412327A (zh) | 一种香薷鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375417A (zh) | 一种泽兰鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107334796A (zh) | 一种矮地茶鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375403A (zh) | 一种绞股蓝鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375379A (zh) | 一种大丁草鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107334790A (zh) | 一种凤尾草鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375410A (zh) | 一种鸡骨草鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN106109724A (zh) | 一种马鞭草鲜榨喷雾干燥粉末饮片及其制备工艺 | |
| CN107375543A (zh) | 一种败酱草鲜榨喷雾干燥颗粒饮片的制备工艺 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171124 |