CN107279970A - It is a kind of to be used to dissolve thrombus, the health-care algae food beneficial to cardiovascular health - Google Patents

It is a kind of to be used to dissolve thrombus, the health-care algae food beneficial to cardiovascular health Download PDF

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Publication number
CN107279970A
CN107279970A CN201610198160.0A CN201610198160A CN107279970A CN 107279970 A CN107279970 A CN 107279970A CN 201610198160 A CN201610198160 A CN 201610198160A CN 107279970 A CN107279970 A CN 107279970A
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Prior art keywords
powder
health
lemon
garlic
sea
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CN201610198160.0A
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Inventor
黄建军
罗宁泰
张泽良
王婷
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Shandong University Weihai
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Shandong University Weihai
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Priority to CN201610198160.0A priority Critical patent/CN107279970A/en
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Preparation Of Fruits And Vegetables (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to medicine and healthy food products research and development technical field.The present invention relates to it is a kind of can with dredging vascellum, neutralizing thrombus, beneficial to health-care algae food formula of cardiovascular health and preparation method thereof.It is characterised by, by sea-tangle, ginger, garlic, onion, lemon, powder being fabricated to according to the processing technology that can retain its maximum active ingredient respectively, then according to 8:32:4:3:3 ratio is made capsulae enterosolubilis or uses direct compression of full-powder legal system piece agent.This tablet is alleviated outside atherosclerosis except that can lead to blood vessel, change thrombus, and also with reduction blood viscosity, improvement varication, limbs are weak, numbness in hands and feet is ice-cold, warm stomach of dispeling cold defaecation, cures tinea pedis, malicious wart, anti-oxidant, effect of anti-aging.Inventive formulation raw material is simple, reasonable mixture ratio, and edible safety is convenient, beneficial to absorbing, low manufacture cost, and process efficient is adapted to industrialized production.

Description

It is a kind of to be used to dissolve thrombus, the health-care algae food beneficial to cardiovascular health
Technical field
The present invention relates to medicine and healthy food products research and development technical field.Blood can be dredged the present invention relates to one kind Pipe, neutralizing thrombus, beneficial to marine alga diet therapy type Ricipe for health care food of cardiovascular health and preparation method thereof.
Background technology
Blood platelet will not adhere to complete blood vessel endothelium under normal circumstances.But thrombus shape can be made by taking care blood vessel internal membrane damage Into.Platelet aggregation can be activated after blood vessel is damaged to injured place, and VPV is slack-off, be retarded by silt and blood clotting is thrombus The important mechanisms of formation.In addition blood vessel is narrow because of factors such as atherosclerosis, be pressurized and bend, vascular bifurcation, valve etc. Reason cause blood flow disorder cause vortex when, haemocyte vortex in the holdup time it is long, promote thrombosis.For the shape of thrombus Seek the food that can prevent to have therapeutic efficiency concurrently into mechanism.Find that laminarin can reduce blood glucose, blood fat in numerous food And cholesterol, effective prevention of arterial hardening;Gingerol have to cardiovascular system cardiac stimulant, regulation vasomotoricity, antiplatelet, The effects such as reducing blood lipid, antiatherosclerosis, anti-oxidant and protection cardiac muscle;Allicin has platelet aggregation-against, expansion blood The effects such as managing, reduce blood pressure, preventing and treating miocardial infarction;Flavonoid substances and " fitoncidin " in onion, the efficiency with cardioprotection can To reduce the cholesterol in the danger of blood dyscrasia solidification, reduction blood, antithrombotic;Citric acid, vitamin C, lemon Lemon polyphenol etc., the effect with very strong suppression platelet aggregation.At present have on the market many vegetable beverages and using food as The health products of primary raw material, as ginger, sea-tangle, garlic, onion, lemon etc. have the food of health-care effect to body and many, but will Their edible food of putting together are less, and universal curative effect is not obvious, inconvenient eating.In the market, which also lacks one kind, to dredge Blood vessel, reduces blood viscosity, alleviates atherosclerosis, dissolves thrombus, the health food of green natural.
At present, sea-tangle, which is mainly, directly uses dry sea-tangle, and then cut-out soaking and water washing grinds to produce guarantor using colloid mill Health food, this patent then using softening, it is lyophilized after make water sublimed, then grind and Kelp Powder is made is used, not only remove raw meat Taste, improves mouthfeel and remains the laminarin that kelp Rich contains, with more preferable therapeutic effect.This patent is then taken ginger Vacuum pressed drying and dehydrating is ground into powder and the method screened again after piece cryogenic freezing.Take utilizes garlic more on the market The production technology of juice, we are ground into powder after then garlic is dehydrated, then preserve at utmost to protect under low temperature drying environment Active ingredient is stayed, for future use.Onion is heated frequently with squeezing the juice or General low temperature is freezed, vacuum drying mode, these processing sides Formula can make sulfide decompose or retain it is less, and this patent take it is broken, micro- cut, concentrate after vacuum drying mode, drug effect Composition reaches maximum reservation.Lemon be usually consideration squeeze the juice infusion eat, it is then by Fresh Lemon vacuum that can so destroy us Freeze-drying crushing is used.Finally, we are by Kelp Powder, ginger powder, garlic powder, onion powder, lemon powder in proportion 8:32:4:3: Raw material is made tablet or capsulae enterosolubilis is made by 3 use direct compression of full-powder method simple to operation.This patent is used Technique be can at utmost retain wherein treatment thrombus, dredging vascellum, alleviate atherosclerosis active ingredient work Skill, thus health-care effect is notable.
This product manufacture craft is simple, and experiment effect is preferable, beneficial to carrying and instant, additive-free, edible safety.
The content of the invention
It is a kind of to be used for dredging vascellum, neutralizing thrombus it is an object of the invention to provide a kind of raw material is simple and easy to get, beneficial to the heart The health-care algae food of vascular health and its formula and preparation method.
Present invention solves the technical problem that the technical scheme used for:This product using sea-tangle, fresh ginger, garlic, onion, Lemon is raw material;Sea-tangle after cleaning is softened with 1% acetum while removing fishy smell, then water is rinsed, remove residual Acetum, sea-tangle after softening is placed in clean container, is added the water of 2-3 times of volume, 4-6min is boiled, by the sea handled well Band is put into freeze drying chamber, and vacuum drops to 10^-5Pa, and temperature is maintained at -40 DEG C, and freezing 8-12h makes sea-tangle fully charge, plus Hot plate temperature is set as 95 DEG C of heating 4h, is then set to 80 DEG C of heating 3h, then is set to 60 DEG C of heating 1h, finally carries out at crushing Reason, is then sieved with 60 mesh mesh screens;After fresh ginger is cut into slices at -23 DEG C low temperature pre-freeze 3h, then in -13 DEG C~15 DEG C of vacuum ring Drying makes ice distil in border, and 18h is then dried under 30 DEG C~40 DEG C of drying temperature, drying pressure 6600Pa is less than to water content 5%, the method for being finally ground into powder and being screened with 60 mesh sieves is used;Taken off after fresh garlic will be cleaned with centrifuge Water, is placed in baking oven in 30 DEG C or so constant temperature 30-36 hours, garlic then is ground into powder, will be sieved immediately with 60 mesh mesh screens The powder selected at 4 DEG C or so and is preserved for future use in the environment of drying;The purple skin onion of selection high-quality, which is cleaned, does not remove the peel, and uses Disintegrating machine is milled to 3mm particulates or so granule.It is viscous paste by raw material concentration, sets enrichment 45%.Fresh Lemon piece is put Enter and freezed in -35 DEG C of freeze dryers, material center is reached -35 DEG C and continue to 0.5h.Material is moved on in heating plate, Opening vavuum pump makes pressure reach 80pa, carries out lyophilization.Start heating system, using radiant heating, control material highest 48 DEG C of temperature, to keep the activity of active material.When plate temperature curve, material surface temperature curve, material center temperature curve When parallel, then 1 h is maintained, freeze and crushed after terminating, sieved with 60 mesh mesh screens.
Capsulae enterosolubilis finally is made in the powder for having matched completion or convenient clothes are made using direct compression of full-powder method With the controllable tablet of, dosage.
First, the present invention is as follows according to the constituent of percentage by weight:
Major ingredient(90%):Kelp Powder 14%, ginger powder 59%, garlic powder 7%, onion powder 5%, lemon powder 5%, auxiliary material(10%).
Filler:Amylum pregelatinisatum(5%-10%)(Mixed with laminarin);Adhesive:Water(Mixed with apple vinegar)Or starch Slurry(10%-20%);Disintegrant(1-6%):Sodium carboxymethyl starch(CMS-Na)/ gas-producing disintegrant;Lubricant:Superfine silica gel powder (0.1-0.3%)/ magnesium stearate(0.25-1%).
2nd, production technology of the present invention is carried out in accordance with the following steps
1. the processing of pair sea-tangle
(1)Dark brown is selected, blade is complete, and thickness is uniform and larger, the rotten sea-tangle of no disease and pests harm, nothing is soaked in 25 DEG C of clear water The silt of absorption is washed away after bubble 1h, the dirt and mucus on sea-tangle surface use clear water rinsed clean afterwards;
(2)Sea-tangle after cleaning is softened with 1% acetum while removing fishy smell, then water is rinsed, remove residual acetic acid Solution, sea-tangle after softening is placed in clean container, is added the water of 2-3 times of volume, is boiled 4-6min;
(3)The sea-tangle handled well is put into freeze drying chamber, vacuum in cryodesiccation chamber is dropped into 10^-5Pa, temperature is maintained at -40 DEG C, freezing 8-12h makes sea-tangle fully charge;
(4)Temperature of heating plate is set as 95 DEG C of heating 4h, is then set to 80 DEG C of heating 3h, then be set to 60 DEG C of heating 1h;
(5)Sea-tangle carries out pulverization process after drying, and is then sieved with 60 mesh mesh screens.
2. the processing to ginger
(1)Selection is fresh, without rotting, and free from insect pests, the stronger new ginger of the acid of no germination is not removed the peel and cleans ginger, cuts Into sheet, length, width, thickness are respectively 4.0~7.0cm, 2~3cm and 0.3~0.4cm, standby;
(2)The ginger splices handled well is put into freeze drying chamber, pre-freezing temperature -23 DEG C are set, pre-freeze time 3h, speed control exists It is per minute to decline 1~4 DEG C;
(3)Vacuum is extracted, the temperature of the indoor heating plate of freeze-drying is kept -13~15 DEG C (eutectic point of ginger is -12 DEG C), Make the water sublimed build-up ice;
(4)Adjust 30~40 DEG C of heating-up temperature, heating and keep drying pressure 6600Pa drying time 18h, until water content is less than 5%;
(5)Dried ginger splices is ground into powder, then sieved with 60 mesh mesh screens.
3. the processing of pair garlic
(1)Fresh, complete, unmetamorphosed garlic is selected for raw material, peeling cleaning;
(2)Garlic after cleaning is with using centrifuge dewatering;
(3)The garlic of dehydration is placed in baking oven in 30 DEG C or so constant temperature 30-36 hours;
(4)Dried garlic is ground into powder, immediately by the powder filtered out with 60 mesh mesh screens at 4 DEG C or so and dry Preserved for future use in environment.
4. the processing of pair onion
(1)From without the purple skin onion of rotten maturation that goes rotten, it is desirable to which epidermis is without machinery wound, pest and disease damage or phenomenon numb with cold.Clean not Peeling, 3mm particulates or so granule is milled to using disintegrating machine;
(2)Using scraper-type thickener, it is viscous paste by raw material concentration, sets enrichment 45%;
(3)Dried material is crushed through liquid-ring type pulverizer, it is rear to be sieved with 60 mesh mesh screens.
5th, to the processing of lemon
(1)Take Fresh Lemon to carry out disinfection after cleaning up to rinse and thinly slice;
(2)Fresh Lemon piece is put into -35 DEG C of freeze dryers and freezed, material center is reached -35 DEG C and is continued to 0.5h;
(3)Material is moved on in heating plate, opening vavuum pump makes pressure reach 80pa, carries out lyophilization;
(4)Start heating system, using radiant heating, 48 DEG C of control material maximum temperature, to keep the activity of active material. When plate temperature curve, material surface temperature curve, material center temperature curve are parallel, then 1 h is maintained, freeze and terminate;
(5)Sample after lyophilized is crushed, and is then sieved with 60 mesh mesh screens.
6. integrated treatment:It is respectively 8 by ratio:32:4:3:3 Kelp Powder, ginger powder, garlic powder, onion powder, lemon powder mixing Uniformly, raw material is then made by tablet using direct powder compression, or capsulae enterosolubilis is made in filling capsule.
Embodiment:
One kind of the present invention can be with dredging vascellum, neutralizing thrombus, beneficial to the marine alga diet therapy type health food of cardiovascular health Formula and preparation method thereof.Including following examples, the following examples can further illustrate the present invention, but not in any way The limitation present invention.
Embodiment 1
(1)Sea-tangle after cleaning is softened with 1% acetum while removing fishy smell, then water is rinsed, remove residual acetic acid Solution, sea-tangle after softening is placed in clean container, is added the water of 2-3 times of volume, is boiled 4-6min, the sea-tangle handled well is put Enter freeze drying chamber, vacuum drops to 10^-5Pa, and temperature is maintained at -40 DEG C, and freezing 8-12h makes sea-tangle fully charge, heating plate Temperature is set as 95 DEG C of heating 4h, is then set to 80 DEG C of heating 3h, then be set to 60 DEG C of heating 1h;At -23 DEG C after fresh ginger is cut into slices Lower low temperature pre-freeze 3h, then the drying sublimation in -13 DEG C~15 DEG C of vacuum environment, then in 30 DEG C~40 DEG C of drying temperature, dry 18h is dried under dry pressure 6600Pa to water content less than 5%;Centrifuge dewatering is used after fresh garlic will be cleaned, baking oven is placed in In in 30 DEG C or so constant temperature 30-36 hours, garlic is then ground into powder, preserved at 4 DEG C or so and in the environment dried with Standby rear use;The purple skin onion of selection high-quality, which is cleaned, is not removed the peel, and 3mm particulates or so granule is milled to using disintegrating machine.Raw material is concentrated For viscous paste, enrichment 45% is set.Fresh Lemon piece is put into -35 DEG C of freeze dryers and freezed by [dean4], makes material Center reaches -35 DEG C and continues to 0.5h.Material is moved on in heating plate, opening vavuum pump makes pressure reach 80pa, carries out Lyophilization.Start heating system, using radiant heating, 48 DEG C of control material maximum temperature, to keep the work of active material Property.When plate temperature curve, material surface temperature curve, material center temperature curve are parallel, then 1 h is maintained to freeze.Finally will be with Upper five kinds of powder are sieved after crushing with 60 mesh mesh screens.
(2)Take major ingredient weight following Kelp Powder 800g, ginger powder 3200g, garlic powder 400g, onion powder obtained by above step 300g, lemon powder 300g are well mixed, and are subsequently filled into No. 0 capsulae enterosolubilis, every 0.5g.
Embodiment 2
(1)Sea-tangle after cleaning is softened with 1% acetum while removing fishy smell, then water is rinsed, remove residual acetic acid Solution, sea-tangle after softening is placed in clean container, is added the water of 2-3 times of volume, is boiled 4-6min, the sea-tangle handled well is put Enter freeze drying chamber, vacuum drops to 10^-5Pa, and temperature is maintained at -40 DEG C, and freezing 8-12h makes sea-tangle fully charge, heating plate Temperature is set as 95 DEG C of heating 4h, is then set to 80 DEG C of heating 3h, then be set to 60 DEG C of heating 1h;At -23 DEG C after fresh ginger is cut into slices Lower low temperature pre-freeze 3h, then the drying sublimation in -13 DEG C~15 DEG C of vacuum environment, then in 30 DEG C~40 DEG C of drying temperature, dry 18h is dried under dry pressure 6600Pa to water content less than 5%;Centrifuge dewatering is used after fresh garlic will be cleaned, baking oven is placed in In in 30 DEG C or so constant temperature 30-36 hours, garlic is then ground into powder, preserved at 4 DEG C or so and in the environment dried with Standby rear use;The purple skin onion of selection high-quality, which is cleaned, is not removed the peel, and 3mm particulates or so granule is milled to using disintegrating machine.Raw material is concentrated For viscous paste, setting enrichment 45.94 %.After squeeze into vacuum drier, five sections of drying temperatures of setting are respectively 38 DEG C, 35 DEG C, 30 DEG C, 25 DEG C, 5 DEG C, set dry vacuum as 23.25 mbar;Fresh Lemon piece is put into -35 DEG C of freeze dryers Row is lyophilized, material center is reached -35 DEG C and continues to 0.5h.Material is moved on in heating plate, opening vavuum pump makes pressure 80pa is reached, lyophilization is carried out.Start heating system, using radiant heating, 48 DEG C of control material maximum temperature, to keep The activity of active material.When plate temperature curve, material surface temperature curve, material center temperature curve are parallel, then maintain 1 h It is lyophilized.It will finally be sieved after five kinds of powder are crushed above with 60 mesh mesh screens.
(2)Take the major ingredient weight as obtained by above step as follows:Kelp Powder 720g, ginger powder 2880g, garlic powder 360g, ocean Green onion powder 270g, lemon powder 270g.Required auxiliary material weight is as follows:Amylum pregelatinisatum(Mixed with laminarin)350g, K30 type PVP (PVP)70g, sodium carboxymethyl starch(CMS-Na)70g, superfine silica gel powder 10g.
(3)60 mesh sieves are crossed after auxiliary material in addition to superfine silica gel powder is crushed, then it were mixed to 60 mesh sieve with major ingredient three times, then It will be added thereto after crushing by the superfine silica gel powder of 60 mesh sieves, circular flat, every 0.5g be made through tablet press machine.

Claims (3)

1. a kind of raw material is simple and easy to get, with dredging vascellum, dissolve thrombus, the health-care algae food beneficial to cardiovascular health, its It is sea-tangle, ginger, garlic, onion, lemon to be characterised by main component, and active component major ingredient by weight percentage accounts for 90%, sea-tangle Powder 14%, ginger powder 59%, garlic powder 7%, onion powder 5%, lemon powder 5%, auxiliary material accounts for 10%, capsulae enterosolubilis is made or by complete Direct powder compression is pressed into tablet.
2. a kind of raw material according to claim 1 is simple and easy to get, the health-care algae food with dredging vascellum, neutralizing thrombus Product, the health food is Kelp Powder, ginger powder, garlic powder, onion powder, lemon powder ratio are divided into 8:32:4:3:3, it is straight using full powder Connect pressed disc method and tablet is made in raw material, or enteric glue is made in filling capsule.
3. a kind of raw material according to claim 1 is simple and easy to get, the health-care algae food with dredging vascellum, neutralizing thrombus Product, its processing technology be sea-tangle then using softening, it is lyophilized after make water sublimed:Vacuum pressed is dried de- after ginger slice cryogenic freezing Water is ground into powder and the method screened again:Be ground into powder after garlic dehydration, then preserve under low temperature drying environment with At utmost retain active ingredient;Onion take it is broken, micro- cut, concentrate after vacuum drying mode;Lemon is used fresh lemon Lemon vacuum freeze drying is crushed and is used.
CN201610198160.0A 2016-04-01 2016-04-01 It is a kind of to be used to dissolve thrombus, the health-care algae food beneficial to cardiovascular health Pending CN107279970A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102048153A (en) * 2009-11-10 2011-05-11 天津市百奥生物技术有限公司 Health-care food with effect of reducing fat and preparation method thereof
CN103652895A (en) * 2013-12-05 2014-03-26 倪俊 Health-care capsule for alleviating arteriosclerosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102048153A (en) * 2009-11-10 2011-05-11 天津市百奥生物技术有限公司 Health-care food with effect of reducing fat and preparation method thereof
CN103652895A (en) * 2013-12-05 2014-03-26 倪俊 Health-care capsule for alleviating arteriosclerosis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
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Application publication date: 20171024