CN107279970A - It is a kind of to be used to dissolve thrombus, the health-care algae food beneficial to cardiovascular health - Google Patents
It is a kind of to be used to dissolve thrombus, the health-care algae food beneficial to cardiovascular health Download PDFInfo
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- CN107279970A CN107279970A CN201610198160.0A CN201610198160A CN107279970A CN 107279970 A CN107279970 A CN 107279970A CN 201610198160 A CN201610198160 A CN 201610198160A CN 107279970 A CN107279970 A CN 107279970A
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- 208000007536 Thrombosis Diseases 0.000 title claims abstract description 16
- 235000013305 food Nutrition 0.000 title claims abstract description 13
- 230000009286 beneficial effect Effects 0.000 title claims abstract description 9
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- 230000036996 cardiovascular health Effects 0.000 title claims abstract description 6
- 239000000843 powder Substances 0.000 claims abstract description 53
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 22
- 235000008397 ginger Nutrition 0.000 claims abstract description 22
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- 240000002234 Allium sativum Species 0.000 claims abstract description 18
- 235000004611 garlic Nutrition 0.000 claims abstract description 18
- 244000131522 Citrus pyriformis Species 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 15
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- 238000000034 method Methods 0.000 claims abstract description 9
- 238000012545 processing Methods 0.000 claims abstract description 8
- 241000294142 Vascellum Species 0.000 claims abstract description 7
- 230000003472 neutralizing effect Effects 0.000 claims abstract description 6
- 238000005516 engineering process Methods 0.000 claims abstract description 5
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- DBTMGCOVALSLOR-DEVYUCJPSA-N (2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](CO)O[C@H](O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-DEVYUCJPSA-N 0.000 description 4
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Preparation Of Fruits And Vegetables (AREA)
Abstract
The present invention relates to medicine and healthy food products research and development technical field.The present invention relates to it is a kind of can with dredging vascellum, neutralizing thrombus, beneficial to health-care algae food formula of cardiovascular health and preparation method thereof.It is characterised by, by sea-tangle, ginger, garlic, onion, lemon, powder being fabricated to according to the processing technology that can retain its maximum active ingredient respectively, then according to 8:32:4:3:3 ratio is made capsulae enterosolubilis or uses direct compression of full-powder legal system piece agent.This tablet is alleviated outside atherosclerosis except that can lead to blood vessel, change thrombus, and also with reduction blood viscosity, improvement varication, limbs are weak, numbness in hands and feet is ice-cold, warm stomach of dispeling cold defaecation, cures tinea pedis, malicious wart, anti-oxidant, effect of anti-aging.Inventive formulation raw material is simple, reasonable mixture ratio, and edible safety is convenient, beneficial to absorbing, low manufacture cost, and process efficient is adapted to industrialized production.
Description
Technical field
The present invention relates to medicine and healthy food products research and development technical field.Blood can be dredged the present invention relates to one kind
Pipe, neutralizing thrombus, beneficial to marine alga diet therapy type Ricipe for health care food of cardiovascular health and preparation method thereof.
Background technology
Blood platelet will not adhere to complete blood vessel endothelium under normal circumstances.But thrombus shape can be made by taking care blood vessel internal membrane damage
Into.Platelet aggregation can be activated after blood vessel is damaged to injured place, and VPV is slack-off, be retarded by silt and blood clotting is thrombus
The important mechanisms of formation.In addition blood vessel is narrow because of factors such as atherosclerosis, be pressurized and bend, vascular bifurcation, valve etc.
Reason cause blood flow disorder cause vortex when, haemocyte vortex in the holdup time it is long, promote thrombosis.For the shape of thrombus
Seek the food that can prevent to have therapeutic efficiency concurrently into mechanism.Find that laminarin can reduce blood glucose, blood fat in numerous food
And cholesterol, effective prevention of arterial hardening；Gingerol have to cardiovascular system cardiac stimulant, regulation vasomotoricity, antiplatelet,
The effects such as reducing blood lipid, antiatherosclerosis, anti-oxidant and protection cardiac muscle；Allicin has platelet aggregation-against, expansion blood
The effects such as managing, reduce blood pressure, preventing and treating miocardial infarction；Flavonoid substances and " fitoncidin " in onion, the efficiency with cardioprotection can
To reduce the cholesterol in the danger of blood dyscrasia solidification, reduction blood, antithrombotic；Citric acid, vitamin C, lemon
Lemon polyphenol etc., the effect with very strong suppression platelet aggregation.At present have on the market many vegetable beverages and using food as
The health products of primary raw material, as ginger, sea-tangle, garlic, onion, lemon etc. have the food of health-care effect to body and many, but will
Their edible food of putting together are less, and universal curative effect is not obvious, inconvenient eating.In the market, which also lacks one kind, to dredge
Blood vessel, reduces blood viscosity, alleviates atherosclerosis, dissolves thrombus, the health food of green natural.
At present, sea-tangle, which is mainly, directly uses dry sea-tangle, and then cut-out soaking and water washing grinds to produce guarantor using colloid mill
Health food, this patent then using softening, it is lyophilized after make water sublimed, then grind and Kelp Powder is made is used, not only remove raw meat
Taste, improves mouthfeel and remains the laminarin that kelp Rich contains, with more preferable therapeutic effect.This patent is then taken ginger
Vacuum pressed drying and dehydrating is ground into powder and the method screened again after piece cryogenic freezing.Take utilizes garlic more on the market
The production technology of juice, we are ground into powder after then garlic is dehydrated, then preserve at utmost to protect under low temperature drying environment
Active ingredient is stayed, for future use.Onion is heated frequently with squeezing the juice or General low temperature is freezed, vacuum drying mode, these processing sides
Formula can make sulfide decompose or retain it is less, and this patent take it is broken, micro- cut, concentrate after vacuum drying mode, drug effect
Composition reaches maximum reservation.Lemon be usually consideration squeeze the juice infusion eat, it is then by Fresh Lemon vacuum that can so destroy us
Freeze-drying crushing is used.Finally, we are by Kelp Powder, ginger powder, garlic powder, onion powder, lemon powder in proportion 8:32:4:3:
Raw material is made tablet or capsulae enterosolubilis is made by 3 use direct compression of full-powder method simple to operation.This patent is used
Technique be can at utmost retain wherein treatment thrombus, dredging vascellum, alleviate atherosclerosis active ingredient work
Skill, thus health-care effect is notable.
This product manufacture craft is simple, and experiment effect is preferable, beneficial to carrying and instant, additive-free, edible safety.
The content of the invention
It is a kind of to be used for dredging vascellum, neutralizing thrombus it is an object of the invention to provide a kind of raw material is simple and easy to get, beneficial to the heart
The health-care algae food of vascular health and its formula and preparation method.
Present invention solves the technical problem that the technical scheme used for：This product using sea-tangle, fresh ginger, garlic, onion,
Lemon is raw material；Sea-tangle after cleaning is softened with 1% acetum while removing fishy smell, then water is rinsed, remove residual
Acetum, sea-tangle after softening is placed in clean container, is added the water of 2-3 times of volume, 4-6min is boiled, by the sea handled well
Band is put into freeze drying chamber, and vacuum drops to 10^-5Pa, and temperature is maintained at -40 DEG C, and freezing 8-12h makes sea-tangle fully charge, plus
Hot plate temperature is set as 95 DEG C of heating 4h, is then set to 80 DEG C of heating 3h, then is set to 60 DEG C of heating 1h, finally carries out at crushing
Reason, is then sieved with 60 mesh mesh screens；After fresh ginger is cut into slices at -23 DEG C low temperature pre-freeze 3h, then in -13 DEG C~15 DEG C of vacuum ring
Drying makes ice distil in border, and 18h is then dried under 30 DEG C~40 DEG C of drying temperature, drying pressure 6600Pa is less than to water content
5%, the method for being finally ground into powder and being screened with 60 mesh sieves is used；Taken off after fresh garlic will be cleaned with centrifuge
Water, is placed in baking oven in 30 DEG C or so constant temperature 30-36 hours, garlic then is ground into powder, will be sieved immediately with 60 mesh mesh screens
The powder selected at 4 DEG C or so and is preserved for future use in the environment of drying；The purple skin onion of selection high-quality, which is cleaned, does not remove the peel, and uses
Disintegrating machine is milled to 3mm particulates or so granule.It is viscous paste by raw material concentration, sets enrichment 45%.Fresh Lemon piece is put
Enter and freezed in -35 DEG C of freeze dryers, material center is reached -35 DEG C and continue to 0.5h.Material is moved on in heating plate,
Opening vavuum pump makes pressure reach 80pa, carries out lyophilization.Start heating system, using radiant heating, control material highest
48 DEG C of temperature, to keep the activity of active material.When plate temperature curve, material surface temperature curve, material center temperature curve
When parallel, then 1 h is maintained, freeze and crushed after terminating, sieved with 60 mesh mesh screens.
Capsulae enterosolubilis finally is made in the powder for having matched completion or convenient clothes are made using direct compression of full-powder method
With the controllable tablet of, dosage.
First, the present invention is as follows according to the constituent of percentage by weight：
Major ingredient（90%）：Kelp Powder 14%, ginger powder 59%, garlic powder 7%, onion powder 5%, lemon powder 5%, auxiliary material（10%）.
Filler：Amylum pregelatinisatum（5%-10%）（Mixed with laminarin）；Adhesive：Water（Mixed with apple vinegar）Or starch
Slurry（10%-20%）；Disintegrant（1-6%)：Sodium carboxymethyl starch（CMS-Na）/ gas-producing disintegrant；Lubricant：Superfine silica gel powder
（0.1-0.3%）/ magnesium stearate（0.25-1%）.
2nd, production technology of the present invention is carried out in accordance with the following steps
1. the processing of pair sea-tangle
（1）Dark brown is selected, blade is complete, and thickness is uniform and larger, the rotten sea-tangle of no disease and pests harm, nothing is soaked in 25 DEG C of clear water
The silt of absorption is washed away after bubble 1h, the dirt and mucus on sea-tangle surface use clear water rinsed clean afterwards；
（2）Sea-tangle after cleaning is softened with 1% acetum while removing fishy smell, then water is rinsed, remove residual acetic acid
Solution, sea-tangle after softening is placed in clean container, is added the water of 2-3 times of volume, is boiled 4-6min；
（3）The sea-tangle handled well is put into freeze drying chamber, vacuum in cryodesiccation chamber is dropped into 10^-5Pa, temperature is maintained at -40
DEG C, freezing 8-12h makes sea-tangle fully charge；
（4）Temperature of heating plate is set as 95 DEG C of heating 4h, is then set to 80 DEG C of heating 3h, then be set to 60 DEG C of heating 1h；
（5）Sea-tangle carries out pulverization process after drying, and is then sieved with 60 mesh mesh screens.
2. the processing to ginger
（1）Selection is fresh, without rotting, and free from insect pests, the stronger new ginger of the acid of no germination is not removed the peel and cleans ginger, cuts
Into sheet, length, width, thickness are respectively 4.0~7.0cm, 2~3cm and 0.3~0.4cm, standby；
（2）The ginger splices handled well is put into freeze drying chamber, pre-freezing temperature -23 DEG C are set, pre-freeze time 3h, speed control exists
It is per minute to decline 1~4 DEG C；
（3）Vacuum is extracted, the temperature of the indoor heating plate of freeze-drying is kept -13~15 DEG C (eutectic point of ginger is -12 DEG C),
Make the water sublimed build-up ice；
（4）Adjust 30~40 DEG C of heating-up temperature, heating and keep drying pressure 6600Pa drying time 18h, until water content is less than
5%；
（5）Dried ginger splices is ground into powder, then sieved with 60 mesh mesh screens.
3. the processing of pair garlic
（1）Fresh, complete, unmetamorphosed garlic is selected for raw material, peeling cleaning；
（2）Garlic after cleaning is with using centrifuge dewatering；
（3）The garlic of dehydration is placed in baking oven in 30 DEG C or so constant temperature 30-36 hours；
（4）Dried garlic is ground into powder, immediately by the powder filtered out with 60 mesh mesh screens at 4 DEG C or so and dry
Preserved for future use in environment.
4. the processing of pair onion
（1）From without the purple skin onion of rotten maturation that goes rotten, it is desirable to which epidermis is without machinery wound, pest and disease damage or phenomenon numb with cold.Clean not
Peeling, 3mm particulates or so granule is milled to using disintegrating machine；
（2）Using scraper-type thickener, it is viscous paste by raw material concentration, sets enrichment 45%；
（3）Dried material is crushed through liquid-ring type pulverizer, it is rear to be sieved with 60 mesh mesh screens.
5th, to the processing of lemon
（1）Take Fresh Lemon to carry out disinfection after cleaning up to rinse and thinly slice；
（2）Fresh Lemon piece is put into -35 DEG C of freeze dryers and freezed, material center is reached -35 DEG C and is continued to
0.5h；
（3）Material is moved on in heating plate, opening vavuum pump makes pressure reach 80pa, carries out lyophilization；
（4）Start heating system, using radiant heating, 48 DEG C of control material maximum temperature, to keep the activity of active material.
When plate temperature curve, material surface temperature curve, material center temperature curve are parallel, then 1 h is maintained, freeze and terminate；
（5）Sample after lyophilized is crushed, and is then sieved with 60 mesh mesh screens.
6. integrated treatment：It is respectively 8 by ratio:32:4:3:3 Kelp Powder, ginger powder, garlic powder, onion powder, lemon powder mixing
Uniformly, raw material is then made by tablet using direct powder compression, or capsulae enterosolubilis is made in filling capsule.
Embodiment：
One kind of the present invention can be with dredging vascellum, neutralizing thrombus, beneficial to the marine alga diet therapy type health food of cardiovascular health
Formula and preparation method thereof.Including following examples, the following examples can further illustrate the present invention, but not in any way
The limitation present invention.
Embodiment 1
（1）Sea-tangle after cleaning is softened with 1% acetum while removing fishy smell, then water is rinsed, remove residual acetic acid
Solution, sea-tangle after softening is placed in clean container, is added the water of 2-3 times of volume, is boiled 4-6min, the sea-tangle handled well is put
Enter freeze drying chamber, vacuum drops to 10^-5Pa, and temperature is maintained at -40 DEG C, and freezing 8-12h makes sea-tangle fully charge, heating plate
Temperature is set as 95 DEG C of heating 4h, is then set to 80 DEG C of heating 3h, then be set to 60 DEG C of heating 1h；At -23 DEG C after fresh ginger is cut into slices
Lower low temperature pre-freeze 3h, then the drying sublimation in -13 DEG C~15 DEG C of vacuum environment, then in 30 DEG C~40 DEG C of drying temperature, dry
18h is dried under dry pressure 6600Pa to water content less than 5%；Centrifuge dewatering is used after fresh garlic will be cleaned, baking oven is placed in
In in 30 DEG C or so constant temperature 30-36 hours, garlic is then ground into powder, preserved at 4 DEG C or so and in the environment dried with
Standby rear use；The purple skin onion of selection high-quality, which is cleaned, is not removed the peel, and 3mm particulates or so granule is milled to using disintegrating machine.Raw material is concentrated
For viscous paste, enrichment 45% is set.Fresh Lemon piece is put into -35 DEG C of freeze dryers and freezed by [dean4], makes material
Center reaches -35 DEG C and continues to 0.5h.Material is moved on in heating plate, opening vavuum pump makes pressure reach 80pa, carries out
Lyophilization.Start heating system, using radiant heating, 48 DEG C of control material maximum temperature, to keep the work of active material
Property.When plate temperature curve, material surface temperature curve, material center temperature curve are parallel, then 1 h is maintained to freeze.Finally will be with
Upper five kinds of powder are sieved after crushing with 60 mesh mesh screens.
（2）Take major ingredient weight following Kelp Powder 800g, ginger powder 3200g, garlic powder 400g, onion powder obtained by above step
300g, lemon powder 300g are well mixed, and are subsequently filled into No. 0 capsulae enterosolubilis, every 0.5g.
Embodiment 2
（1）Sea-tangle after cleaning is softened with 1% acetum while removing fishy smell, then water is rinsed, remove residual acetic acid
Solution, sea-tangle after softening is placed in clean container, is added the water of 2-3 times of volume, is boiled 4-6min, the sea-tangle handled well is put
Enter freeze drying chamber, vacuum drops to 10^-5Pa, and temperature is maintained at -40 DEG C, and freezing 8-12h makes sea-tangle fully charge, heating plate
Temperature is set as 95 DEG C of heating 4h, is then set to 80 DEG C of heating 3h, then be set to 60 DEG C of heating 1h；At -23 DEG C after fresh ginger is cut into slices
Lower low temperature pre-freeze 3h, then the drying sublimation in -13 DEG C~15 DEG C of vacuum environment, then in 30 DEG C~40 DEG C of drying temperature, dry
18h is dried under dry pressure 6600Pa to water content less than 5%；Centrifuge dewatering is used after fresh garlic will be cleaned, baking oven is placed in
In in 30 DEG C or so constant temperature 30-36 hours, garlic is then ground into powder, preserved at 4 DEG C or so and in the environment dried with
Standby rear use；The purple skin onion of selection high-quality, which is cleaned, is not removed the peel, and 3mm particulates or so granule is milled to using disintegrating machine.Raw material is concentrated
For viscous paste, setting enrichment 45.94 %.After squeeze into vacuum drier, five sections of drying temperatures of setting are respectively 38 DEG C, 35
DEG C, 30 DEG C, 25 DEG C, 5 DEG C, set dry vacuum as 23.25 mbar；Fresh Lemon piece is put into -35 DEG C of freeze dryers
Row is lyophilized, material center is reached -35 DEG C and continues to 0.5h.Material is moved on in heating plate, opening vavuum pump makes pressure
80pa is reached, lyophilization is carried out.Start heating system, using radiant heating, 48 DEG C of control material maximum temperature, to keep
The activity of active material.When plate temperature curve, material surface temperature curve, material center temperature curve are parallel, then maintain 1 h
It is lyophilized.It will finally be sieved after five kinds of powder are crushed above with 60 mesh mesh screens.
（2）Take the major ingredient weight as obtained by above step as follows：Kelp Powder 720g, ginger powder 2880g, garlic powder 360g, ocean
Green onion powder 270g, lemon powder 270g.Required auxiliary material weight is as follows：Amylum pregelatinisatum（Mixed with laminarin）350g, K30 type PVP
（PVP）70g, sodium carboxymethyl starch（CMS-Na）70g, superfine silica gel powder 10g.
（3）60 mesh sieves are crossed after auxiliary material in addition to superfine silica gel powder is crushed, then it were mixed to 60 mesh sieve with major ingredient three times, then
It will be added thereto after crushing by the superfine silica gel powder of 60 mesh sieves, circular flat, every 0.5g be made through tablet press machine.
Claims (3)
1. a kind of raw material is simple and easy to get, with dredging vascellum, dissolve thrombus, the health-care algae food beneficial to cardiovascular health, its
It is sea-tangle, ginger, garlic, onion, lemon to be characterised by main component, and active component major ingredient by weight percentage accounts for 90%, sea-tangle
Powder 14%, ginger powder 59%, garlic powder 7%, onion powder 5%, lemon powder 5%, auxiliary material accounts for 10%, capsulae enterosolubilis is made or by complete
Direct powder compression is pressed into tablet.
2. a kind of raw material according to claim 1 is simple and easy to get, the health-care algae food with dredging vascellum, neutralizing thrombus
Product, the health food is Kelp Powder, ginger powder, garlic powder, onion powder, lemon powder ratio are divided into 8:32:4:3:3, it is straight using full powder
Connect pressed disc method and tablet is made in raw material, or enteric glue is made in filling capsule.
3. a kind of raw material according to claim 1 is simple and easy to get, the health-care algae food with dredging vascellum, neutralizing thrombus
Product, its processing technology be sea-tangle then using softening, it is lyophilized after make water sublimed：Vacuum pressed is dried de- after ginger slice cryogenic freezing
Water is ground into powder and the method screened again：Be ground into powder after garlic dehydration, then preserve under low temperature drying environment with
At utmost retain active ingredient；Onion take it is broken, micro- cut, concentrate after vacuum drying mode；Lemon is used fresh lemon
Lemon vacuum freeze drying is crushed and is used.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610198160.0A CN107279970A (en) | 2016-04-01 | 2016-04-01 | It is a kind of to be used to dissolve thrombus, the health-care algae food beneficial to cardiovascular health |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610198160.0A CN107279970A (en) | 2016-04-01 | 2016-04-01 | It is a kind of to be used to dissolve thrombus, the health-care algae food beneficial to cardiovascular health |
Publications (1)
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|---|---|
| CN107279970A true CN107279970A (en) | 2017-10-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610198160.0A Pending CN107279970A (en) | 2016-04-01 | 2016-04-01 | It is a kind of to be used to dissolve thrombus, the health-care algae food beneficial to cardiovascular health |
Country Status (1)
| Country | Link |
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| CN (1) | CN107279970A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048153A (en) * | 2009-11-10 | 2011-05-11 | 天津市百奥生物技术有限公司 | Health-care food with effect of reducing fat and preparation method thereof |
| CN103652895A (en) * | 2013-12-05 | 2014-03-26 | 倪俊 | Health-care capsule for alleviating arteriosclerosis |
-
2016
- 2016-04-01 CN CN201610198160.0A patent/CN107279970A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048153A (en) * | 2009-11-10 | 2011-05-11 | 天津市百奥生物技术有限公司 | Health-care food with effect of reducing fat and preparation method thereof |
| CN103652895A (en) * | 2013-12-05 | 2014-03-26 | 倪俊 | Health-care capsule for alleviating arteriosclerosis |
Non-Patent Citations (5)
| Title |
|---|
| 康景隆: "《食品冷藏链技术》", 28 February 2005 * |
| 沈月新: "《常见水产品安全食用问答》", 31 March 2009 * |
| 王金花等: "《产品质量卫生安全新工艺新配方与无公害生产加工核心技术 质量检验检疫新标准实务全书》", 31 October 2004 * |
| 陈栓虎等: "《农副产品综合利用和深加工技术 蔬菜类》", 31 March 2003 * |
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Application publication date: 20171024 |