CN107279580A - A kind of feed addictive for improving immunity and its preparation method and application - Google Patents
A kind of feed addictive for improving immunity and its preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
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- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/748—Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a kind of feed addictive for improving immunity and its preparation method and application, the feed addictive is made up of the raw material below according to parts by weight：15 parts of spirulina, 8 16 parts of oat, 11 19 parts of Verbena officinalis, 15 25 parts of dandelion, 15 parts of frankincense, 37 parts of stir-baked RHIZOMA DIOSCOREAE, 13 21 parts of root of Chinese trichosanthes.The present invention is acted on conventional feed mutual cooperation, is not only ensured the normal nutrition demand of chicken, is improved immunity, and the effect of prevention and treatment bird flu is notable, cure rate is high, have no toxic side effect, particularly extremely notable to checken pest prevention effect.Feed addictive of the present invention can also improve production performance, and laying hen egg yield improves more than 10%, extends ovipository cycle 7 10 days, broiler growth more than 15% is delivered for sale in advance, have obvious effect in terms of improvement livestock products quality.Raw material of the present invention and preparation process are simple, and production cost is low, suitable for large-scale promotion and production.
Description
Technical field
The present invention relates to field of feed additive technology, specifically a kind of feed addictive for improving immunity and its preparation
Methods and applications.
Background technology
Bird flu (Bird Flu or Avian Influenza) is the abbreviation of Bird Flu, and it is by Flu-A
A kind of acute infectious disease caused by a kind of hypotype (also referred to as avian influenza virus) of virus, can also infect the mankind, by International Office of Epizootics
It is set to category A infectious disease, also known as fowl plague or European checken pest.Predominantly suffer from bird flu or carry the chicken of avian influenza virus, duck,
The poultry such as goose.Other birds, wild fowl or pig are also possible to turn into the infection sources.Mainly through respiratory infectious, pass through close contact sense
The birds of dye and its secretion, excreta, it is infected by the water of virus pollution etc..Existing therapeutic scheme due to without general vaccines,
Abuse of antibiotics, DeGrain, the death rate may be up to more than 50%, and pollute, and harmful components residual is exceeded.Feed adds
Plus agent is the raw material that modern feed industry is necessarily used, to reinforcing basal feed nutritive value, breeding performonce fo animals are improved, it is ensured that
There is obvious effect in terms of animal health, saving feed cost, improvement livestock products quality.Poultry is entered by feed addictive
Row prevention and treatment bird flu is a kind of extremely convenient method.But lack the feed addictive with above-mentioned effect at present.
The content of the invention
It is an object of the invention to provide a kind of feed addictive for improving immunity and its preparation method and application, to solve
The problem of being proposed in certainly above-mentioned background technology.
To achieve the above object, the present invention provides following technical scheme：
A kind of feed addictive for improving immunity, is made up of the raw material below according to parts by weight：1-5 parts of spirulina, swallow
8-16 parts of wheat, 11-19 parts of Verbena officinalis, 15-25 parts of dandelion, 1-5 parts of frankincense, 3-7 parts of stir-baked RHIZOMA DIOSCOREAE, 13-21 parts of root of Chinese trichosanthes.
It is used as further scheme of the invention：The feed addictive for improving immunity, by below according to parts by weight
Raw material is constituted：2-4 parts of spirulina, 10-14 parts of oat, 13-17 parts of Verbena officinalis, 18-22 parts of dandelion, 2-4 parts of frankincense, stir-baked RHIZOMA DIOSCOREAE
4-6 parts, 15-19 parts of root of Chinese trichosanthes.
It is used as further scheme of the invention：The feed addictive for improving immunity, by below according to parts by weight
Raw material is constituted：3 parts of spirulina, 12 parts of oat, 15 parts of Verbena officinalis, 20 parts of dandelion, 3 parts of frankincense, 5 parts of stir-baked RHIZOMA DIOSCOREAE, root of Chinese trichosanthes 17
Part.
Another object of the present invention is to provide a kind of preparation method for the feed addictive for improving immunity, including following step
Suddenly：
1) Chinese yam crushed, cross 100 mesh sieves, then the obtained stir-baked RHIZOMA DIOSCOREAEs of frying 30-50min are standby；
2) Verbena officinalis, root of Chinese trichosanthes crushed, cross 120-200 mesh sieves, add the volumetric concentration 65% of the two 12-14 times of quality
Ethanol, 4-5h is soaked at 68-70 DEG C, is then heated to 88-90 DEG C and stir process 1-1.2h, is filtered to take filtrate and produce mixing
Thing A；
3) oat, dandelion, frankincense are mixed, adds the deionized water of 10-12 times of three's mass, intense fire is boiled, slow fire
2.8-3h is decocted, filtrate is filtered to take, is mixed with spirulina, heating stirring handles 30-40min at 85-90 DEG C, produces mixture
B；
4) mixture A, mixture B are mixed with stir-baked RHIZOMA DIOSCOREAE, 25-30min, granulation, baking is stirred at a temperature of 70-75 DEG C
It is dry to produce feed addictive.
It is used as further scheme of the invention：Step 3) in, mixing speed is 350-400r/min.
It is used as further scheme of the invention：Step 4) in, mixing speed is 250-280r/min.
Another object of the present invention is to provide application of the feed addictive in poultry feed.
It is used as further scheme of the invention：Poultry is chicken.
Another object of the present invention is to provide application of the described feed addictive in preventing and treating bird flu feed is prepared.
It is used as further scheme of the invention：Bird flu is checken pest.
Spirulina, which has, mitigates cancer radiation, the toxicity of chemotherapy, the effects such as improving immunologic function, reduction blood fat.
Oat reduces blood pressure, reduces cholesterol, preventing and treating colorectal cancer, the medical value and health-care effect for preventing and treating heart disease.
Verbena officinalis is clearing heat and detoxicating, promoting blood circulation to remove blood stasis, inducing diuresis for removing edema.Control fever caused by exogenous pathogens, jaundice with damp-heat pathogen, oedema, dysentery, malaria,
Diphtheria, larynx numbness, gonorrhoea, Amenorrhea, abdominal mass, carbuncle sore tumefacting virus, noma.
The effects such as dandelion has diuresis, laxative, removing jaundice subcutaneous ulcer, cholagogic.Control heat toxin, it is carbuncle swells, sore, internal carbuncle, red eye, swell pain, wet
The puckery pain of heat, jaundice, dribbling urination, furuncle swelling toxin, acute mastitis, scrofula, toothache, hot eyes, pharyngalgia, lung carbuncle, acute appendicitis, jaundice with damp-heat pathogen, heat
Drench puckery pain.Control acute mastitis, adenolymphitis, scrofula, malignant boil carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis,
Acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infections etc..
Frankincense blood-activating and qi-promoting is relieved pain, detumescence and promoting granulation.Cure mainly chest impediment and cardialgia, gastral cavity pain, dysmenorrhoea Amenorrhea, postpartum stasis, disease
Lump in the abdomen is suffered from abdominal pain, arthralgia pain due to rheumatism, muscle arteries and veins contraction, traumatic injury, carbuncle swells sore.
Stir-baked RHIZOMA DIOSCOREAE have functions that invigorating the spleen, dehumidifying, tonifying Qi, beneficial lung, reinforce the kidney, strengthening the essence.
Root of Chinese trichosanthes clearing heat-fire, promotes the production of body fluid to quench thirst, apocenosis detumescence.Cure mainly：Control that pyreticosis is thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis,
Carbuncle swells, hemorrhoid impotence.
Compared with prior art, the beneficial effects of the invention are as follows：
The present invention is acted on conventional feed mutual cooperation, is not only ensured the normal nutrition demand of chicken, is improved immunity, and
Prevent and treat bird flu effect it is notable, cure rate is high, have no toxic side effect, particularly it is extremely notable to checken pest prevention effect,
With efficiently, have no toxic side effect, do not develop immunity to drugs, cure rate height, noresidue, without poisoning, free from environmental pollution, green safety ring
Protect, Abwehrkraft des Koepers can be increased, rapid, uneasy to recur, cheap advantage is acted on.
Feed addictive of the present invention can also improve production performance, and laying hen egg yield improves more than 10%, extends ovipository cycle
7-10 days, broiler growth more than 15% was delivered for sale in advance, had obvious effect in terms of improvement livestock products quality.Raw material of the present invention
And preparation process is simple, production cost is low, suitable for large-scale promotion and production.
Embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
With reference to a kind of feed addictive of safe noresidue
Embodiment 1
In the embodiment of the present invention, a kind of feed addictive for improving immunity is made up of following raw material：Spirulina 1kg, swallow
Wheat 8kg, Verbena officinalis 11kg, dandelion 15kg, frankincense 1kg, stir-baked RHIZOMA DIOSCOREAE 3kg, root of Chinese trichosanthes 13kg.
Chinese yam is crushed, 100 mesh sieves are crossed, then the obtained stir-baked RHIZOMA DIOSCOREAEs of frying 30min are standby.Verbena officinalis, root of Chinese trichosanthes are crushed,
120 mesh sieves are crossed, the ethanol of volumetric concentration 65% of the two 12 times of quality is added, soaks 4h at 68 DEG C, be then heated to 88 DEG C simultaneously
Stir process 1h, filters to take filtrate and produces mixture A.Oat, dandelion, frankincense are mixed, going for 10 times of three's mass is added
Ionized water, intense fire is boiled, and is cooked by slow fire 2.8h, filters to take filtrate, is mixed with spirulina, with 350r/min stirring at 85 DEG C
Speed heating stirring handles 30min, produces mixture B.Mixture A, mixture B are mixed with stir-baked RHIZOMA DIOSCOREAE, in 70 DEG C of temperature
Under 25min, granulation, drying feed addictive are stirred with 250r/min mixing speed.
Embodiment 2
In the embodiment of the present invention, a kind of feed addictive for improving immunity is made up of following raw material：Spirulina 5kg, swallow
Wheat 16kg, Verbena officinalis 19kg, dandelion 25kg, frankincense 5kg, stir-baked RHIZOMA DIOSCOREAE 7kg, root of Chinese trichosanthes 21kg.
Chinese yam is crushed, 100 mesh sieves are crossed, then the obtained stir-baked RHIZOMA DIOSCOREAEs of frying 50min are standby.Verbena officinalis, root of Chinese trichosanthes are crushed,
200 mesh sieves are crossed, the ethanol of volumetric concentration 65% of the two 14 times of quality is added, soaks 5h at 70 DEG C, be then heated to 90 DEG C simultaneously
Stir process 1.2h, filters to take filtrate and produces mixture A.Oat, dandelion, frankincense are mixed, 12 times of three's mass is added
Deionized water, intense fire is boiled, and is cooked by slow fire 3h, filters to take filtrate, is mixed with spirulina, with 400r/min stirring at 90 DEG C
Speed heating stirring handles 40min, produces mixture B.Mixture A, mixture B are mixed with stir-baked RHIZOMA DIOSCOREAE, in 75 DEG C of temperature
Under 30min, granulation, drying feed addictive are stirred with 280r/min mixing speed.
Embodiment 3
In the embodiment of the present invention, a kind of feed addictive for improving immunity is made up of following raw material：Spirulina 2kg, swallow
Wheat 10kg, Verbena officinalis 13kg, dandelion 18kg, frankincense 2kg, stir-baked RHIZOMA DIOSCOREAE 4kg, root of Chinese trichosanthes 15kg.
Chinese yam is crushed, 100 mesh sieves are crossed, then the obtained stir-baked RHIZOMA DIOSCOREAEs of frying 40min are standby.Verbena officinalis, root of Chinese trichosanthes are crushed,
150 mesh sieves are crossed, the ethanol of volumetric concentration 65% of the two 13 times of quality is added, soaks 4.5h at 69 DEG C, be then heated to 89 DEG C
And stir process 1.1h, filter to take filtrate and produce mixture A.Oat, dandelion, frankincense are mixed, 11 times of three's mass is added
Deionized water, intense fire is boiled, is cooked by slow fire 2.9h, filters to take filtrate, mixed with spirulina, with 380r/min's at 88 DEG C
Mixing speed heating stirring handles 35min, produces mixture B.Mixture A, mixture B are mixed with stir-baked RHIZOMA DIOSCOREAE, at 72 DEG C
At a temperature of 28min, granulation, drying feed addictive are stirred with 260r/min mixing speed.
Embodiment 4
In the embodiment of the present invention, a kind of feed addictive for improving immunity is made up of following raw material：Spirulina 4kg, swallow
Wheat 14kg, Verbena officinalis 17kg, dandelion 22kg, frankincense 4kg, stir-baked RHIZOMA DIOSCOREAE 6kg, root of Chinese trichosanthes 19kg.
Chinese yam is crushed, 100 mesh sieves are crossed, then the obtained stir-baked RHIZOMA DIOSCOREAEs of frying 40min are standby.Verbena officinalis, root of Chinese trichosanthes are crushed,
150 mesh sieves are crossed, the ethanol of volumetric concentration 65% of the two 13 times of quality is added, soaks 4.5h at 69 DEG C, be then heated to 89 DEG C
And stir process 1.1h, filter to take filtrate and produce mixture A.Oat, dandelion, frankincense are mixed, 11 times of three's mass is added
Deionized water, intense fire is boiled, is cooked by slow fire 2.9h, filters to take filtrate, mixed with spirulina, with 380r/min's at 88 DEG C
Mixing speed heating stirring handles 35min, produces mixture B.Mixture A, mixture B are mixed with stir-baked RHIZOMA DIOSCOREAE, at 72 DEG C
At a temperature of 28min, granulation, drying feed addictive are stirred with 260r/min mixing speed.
Embodiment 5
In the embodiment of the present invention, a kind of feed addictive for improving immunity is made up of following raw material：Spirulina 3kg, swallow
Wheat 12kg, Verbena officinalis 15kg, dandelion 20kg, frankincense 3kg, stir-baked RHIZOMA DIOSCOREAE 5kg, root of Chinese trichosanthes 17kg.
Chinese yam is crushed, 100 mesh sieves are crossed, then the obtained stir-baked RHIZOMA DIOSCOREAEs of frying 40min are standby.Verbena officinalis, root of Chinese trichosanthes are crushed,
150 mesh sieves are crossed, the ethanol of volumetric concentration 65% of the two 13 times of quality is added, soaks 4.5h at 69 DEG C, be then heated to 89 DEG C
And stir process 1.1h, filter to take filtrate and produce mixture A.Oat, dandelion, frankincense are mixed, 11 times of three's mass is added
Deionized water, intense fire is boiled, is cooked by slow fire 2.9h, filters to take filtrate, mixed with spirulina, with 380r/min's at 88 DEG C
Mixing speed heating stirring handles 35min, produces mixture B.Mixture A, mixture B are mixed with stir-baked RHIZOMA DIOSCOREAE, at 72 DEG C
At a temperature of 28min, granulation, drying feed addictive are stirred with 260r/min mixing speed.
Comparative example 1
In addition to oat, dandelion, frankincense is not contained, it is formulated and preparation process is consistent with embodiment 5.
Comparative example 2
Only contain oat, dandelion, frankincense, its preparation process is consistent with embodiment 5.
The toxicity test of embodiment 6
1 material and method
1.1 material
1.1.1 experimental animal Kunming hybridizes healthy mice, and 18~24g of body weight is purchased from Hunan Medical University's zoopery
Portion.
1.1.2 feed addictive made from the embodiment of the present invention 5.
1.2 method
1.2.1 acute toxicity test
60 small white mouses are taken using administration by gavage, six groups are randomly divided into, every group 10, male and female half and half, every small white mouse presses body
It is administered again and is：First group of given low is 10g/kg, and second group of given low is 20g/kg, and the 3rd group is 50g/kg, the 4th group
For 100g/kg, the 5th group is 150g/kg.Control group gavage distilled water 150g/kg.
1.2.2 chronic toxicity test
50 small white mouses are randomly divided into five groups, every group 10, male and female half and half (are separately fed), each group small white mouse gavages
Dosage is calculated by body weight per 20g, and first group is 0.3g, and second group is 0.4g, and the 3rd group is 0.6g, and the 4th group is 0.8g.Daily
Gavage once in the morning, and control group gavages 1.00g/ distilled water daily, daily observation small white mouse spirit, appetite, activity, fecaluria and
Death condition.When testing beginning, each group is weighed once, is then weighed once within every 15 days, and Germicidal efficacy is at the end of 45 days, all
Cut open inspection is slaughtered, takes 0.8g group control group small white mouses liver, the heart, stomach, kidney to do pathological examination.
2 result of the tests
2.1 the acute toxicity tests
Test result indicates that, do not cause mice dying yet when feed addictive gavage of the present invention is by 150g/kg dosage.Respectively
The no abnormality seen compared with control group small white mouse such as experimental group small white mouse spirit, appetite, activity.The internal organ of each group small white mouse after cut open inspection
Organ no abnormality seen phenomenon compared with control group, histopathologic examination's also no abnormality seen lesion, it was demonstrated that small white mouse is to the present invention
More than the maximal tolerance dose stomach 150g/kg of feed addictive, can be considered nontoxic level.
2.2 chronic toxicity test results
2.2.1 clinical observation gavage each test group small white mouse spirit of feed addictive of the present invention, appetite, activity, hair color,
Fecaluria was observed through 45 days, was showed no obvious abnormal response, but the weightening of small white mouse is obvious, the significant difference compared with control group
(0.05 ＞ P ＞ 0.01).
2.2.2 cut open after viewing test observes 45 days, by whole small white mouse cut open inspections, as a result each group small white mouse internal organs are not sent out
Existing pathological change.
2.2.3 pathologic examination does disease to the liver of 0.8g dosage groups and control group small white mouse, kidney, stomach, the heart, spleen tissue
Histological observation is managed, pathological change is not as a result found.
3 brief summaries
Experiment proves that the maximal tolerance dose of feed addictive gavage small white mouse of the present invention, in more than 150g/kg, can be considered nothing
Malicious level.0.2~0.8g/20g dosage each groups are gavaged daily, were observed through 45 days, all health, poisoning or the phenomena of mortality are found no
And weightening is obvious, cut open inspection and histological observation do not show any abnormalities change.It is substantially nontoxic so as to confirm that the present invention is gavaged, safely may be used
Lean on.
Embodiment 7
Experiment of preventive effects：Using 7 Japanese instar chickling 900, wherein 100 are only used as control group isolation and support, using common
Feed；100 are only used as blank group, using normal diet；Another 700 experiment isolated rearings, are randomly divided into 7 groups, every group 100
Only, the feed addictive+normal diet prepared using embodiment 1-5 and comparative example 1-2, the addition of feed addictive is common
The 0.8% of feed.Feeding manner is free choice feeding, free water, after 24h, takes the chick intramuscular injection in test group and control group to connect
Influenza A virus liquid after dilution is planted, 120h death conditions are recorded, result of the test refers to table 1 below.
Therapeutic effect is tested：Using 7 Japanese instar chickling 800, the influenza A virus liquid after 800 eye droppings inoculation dilutions,
Feeding manner is free choice feeding and free water, infects after 12h, wherein 100 are only used as control group, uses normal diet；Another 700
Only it is test group, is randomly divided into 7 groups, every group 100, the feed addictive prepared using embodiment 1~5 and comparative example 1~2+
Normal diet, the addition of feed addictive is the 1% of normal diet, the death condition of continuous record 120h each groups, experiment knot
Fruit refers to table 1 below.
Each treatment group of table 1 prevents and treats the result of checken pest
Conclusion：As shown in Table 1, the feed addictive that prepared by embodiment 1-5 has good prophylactic-therapeutic effect to checken pest, protects
Rate and survival rate are more than 96%, and the protective rate and survival rate of feed addictive prepared by comparative example 1-2 are below 45%.
Can be seen that the present invention from the comparison of comparative example 1-2 and embodiment 5 can be effectively prevented and treated under the synergy of each raw material
Flu-A.
Meanwhile, the feed addictive also prepared using 1-5 of the embodiment of the present invention carries out Flu-A disease to poultry such as duck, geese
The preventing and treating experiment of poison, as a result finds, feed addictive prepared by embodiment 1-5 has preferably preventing and treating work(to the Flu-A of duck
Effect, protective rate and survival rate are more than 90%, and the Flu-A prophylactic-therapeutic effect to goose is general, and protective rate and survival rate exist
More than 75%.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
It may be appreciated other embodiment.
Claims (10)
1. a kind of feed addictive for improving immunity, it is characterised in that be made up of the raw material below according to parts by weight：Spirulina
1-5 parts, 8-16 parts of oat, 11-19 parts of Verbena officinalis, 15-25 parts of dandelion, 1-5 parts of frankincense, 3-7 parts of stir-baked RHIZOMA DIOSCOREAE, root of Chinese trichosanthes 13-
21 parts.
2. the feed addictive according to claim 1 for improving immunity, it is characterised in that by below according to parts by weight
Raw material is constituted：2-4 parts of spirulina, 10-14 parts of oat, 13-17 parts of Verbena officinalis, 18-22 parts of dandelion, 2-4 parts of frankincense, stir-baked RHIZOMA DIOSCOREAE
4-6 parts, 15-19 parts of root of Chinese trichosanthes.
3. the feed addictive according to claim 1 for improving immunity, it is characterised in that by below according to parts by weight
Raw material is constituted：3 parts of spirulina, 12 parts of oat, 15 parts of Verbena officinalis, 20 parts of dandelion, 3 parts of frankincense, 5 parts of stir-baked RHIZOMA DIOSCOREAE, root of Chinese trichosanthes 17
Part.
4. a kind of preparation method of the feed addictive of raising immunity as described in claim 1-3 is any, it is characterised in that
Comprise the following steps：
1) Chinese yam crushed, cross 100 mesh sieves, then the obtained stir-baked RHIZOMA DIOSCOREAEs of frying 30-50min are standby；
2) Verbena officinalis, root of Chinese trichosanthes crushed, cross 120-200 mesh sieves, add the second of volumetric concentration 65% of the two 12-14 times of quality
Alcohol, 4-5h is soaked at 68-70 DEG C, is then heated to 88-90 DEG C and stir process 1-1.2h, is filtered to take filtrate and produce mixture
A；
3) oat, dandelion, frankincense are mixed, adds the deionized water of 10-12 times of three's mass, intense fire is boiled, is cooked by slow fire
2.8-3h, filters to take filtrate, is mixed with spirulina, and heating stirring handles 30-40min at 85-90 DEG C, produces mixture B；
4) mixture A, mixture B are mixed with stir-baked RHIZOMA DIOSCOREAE, 25-30min is stirred at a temperature of 70-75 DEG C, granulation, drying are
Obtain feed addictive.
5. the preparation method of the feed addictive according to claim 4 for improving immunity, it is characterised in that step 3)
In, mixing speed is 350-400r/min.
6. the preparation method of the feed addictive according to claim 4 for improving immunity, it is characterised in that step 4)
In, mixing speed is 250-280r/min.
7. application of the feed addictive as described in claim 1-3 is any in poultry feed.
8. application of the feed addictive according to claim 7 in poultry feed, it is characterised in that poultry is chicken.
9. application of the feed addictive in preventing and treating bird flu feed is prepared as described in claim 1-3 is any.
10. application of the feed addictive according to claim 9 in preventing and treating bird flu feed is prepared, it is characterised in that
Bird flu is checken pest.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710634705.2A CN107279580A (en) | 2017-07-29 | 2017-07-29 | A kind of feed addictive for improving immunity and its preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710634705.2A CN107279580A (en) | 2017-07-29 | 2017-07-29 | A kind of feed addictive for improving immunity and its preparation method and application |
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| CN107279580A true CN107279580A (en) | 2017-10-24 |
Family
ID=60103750
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| CN201710634705.2A Pending CN107279580A (en) | 2017-07-29 | 2017-07-29 | A kind of feed addictive for improving immunity and its preparation method and application |
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| EP1312370A1 (en) * | 2001-11-16 | 2003-05-21 | Iijima Corporation | Composition comprising dried whole egg for treating hepatitis |
| CN101564480A (en) * | 2008-04-22 | 2009-10-28 | 许云生 | Medicine for preventing fowl plague |
| CN105770034A (en) * | 2016-05-20 | 2016-07-20 | 李登 | Chinese herbal preparation for treating femoral head necrosis and preparing method and application thereof |
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