CN107266598A - The functional sugar prepared based on nanometer technology and its application in field of medicaments - Google Patents
The functional sugar prepared based on nanometer technology and its application in field of medicaments Download PDFInfo
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- CN107266598A CN107266598A CN201710346352.6A CN201710346352A CN107266598A CN 107266598 A CN107266598 A CN 107266598A CN 201710346352 A CN201710346352 A CN 201710346352A CN 107266598 A CN107266598 A CN 107266598A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
- C08B37/009—Konjac gum or konjac mannan, i.e. beta-D-glucose and beta-D-mannose units linked by 1,4 bonds, e.g. from Amorphophallus species; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
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Abstract
The invention discloses a kind of method for producing nano functional sugar, include multiple steps, so that raw material pulverizing processing 60 180 minutes in pulverization cylinder, the velocity of rotation for controlling stirring rod simultaneously is 2,000 6000 revs/min, and by the FREQUENCY CONTROL of ultrasonic wave in 30k 90kHz or so, finally become more meticulous in airslide disintegrating mill 30 120 minutes；Final particle diameter of preparing is controlled in 10,000 20,000Da for the nano functional sugar in 20 40nm, and the molecular weight distribution of nano functional sugar.These nano functional sugar are applied in hypoglycemic product, can substantially reduce hypoglycemic after consumption, in 0.5g/kg to 2.0g/kg dosage range, blood sugar decreasing effect is lifted with dosage；Also, these nano functionals sugar is subjected to Sulfation modification, water-soluble good Sulfation derivative is obtained, described Sulfation derivative has anticoagulation, antithrombotic efficacy.
Description
Technical field
The present invention relates to a kind of nanometer refinement technology, further relate to using the functional sugar of technology preparation and its in medicine
Using.
Background technology
Nanometer (English：Nanometre) it is long measure, International System of Units symbol is nm.Original claims millimicron, is exactly 10-9
Rice (1/1000000000th meter), i.e., 10-6Millimeter (1/1000000th millimeters).As centimetre, decimeter with meter as, be length
Linear module.Equivalent to 4 times atom sizes, the length than single bacterium is also small.International common name is nanometer, letter
Write nm.
It is present scientific investigations showed that, the particle diameter of particle can influence the distribution of medicine in vivo, and the particulate that 5 μm of particle diameter ＜ can
Blood circulation can be entered with the particulate by lung, particle diameter ＜ 300nm, particle diameter ＜ 100nm particulate can enter marrow, nanometer
Medicine obtains oral, nasal-cavity administration, the bioavilability of Transdermal absorption medicine more easily by stomach, intestinal mucosa and nasal membrane
To raising.The nanosizing of particle can show many excellent performances, be embodied in quantum size effect, small size effect
Should, macro quanta tunnel effect, skin effect etc..
The preparation method of current nano-particle is generally divided into two major classes：Physical method and chemical method.Physical method is also known as
For comminuting method, it is cake mass to be crushed to solid material from large to small, i.e., nano-powder particle is made；Chemical method is also known as
Method for constructing, it is to pass through two stage nano materials of nucleation and growth by lower limit atom, ion, molecule.Using chemistry as base
The nano-powder manufacture method of plinth can obtain several nanometers of powder.But manufacturing cost is sometimes at a relatively high, and it is difficult amplification, particle diameter
Distribution is also more uneven.
At present, nanometer pulverization equipment mainly have multi-D swing high energy nanon ball-mill, multilayer classifying nano ball grinding machine,
High speed nano grinder, high speed shear ultrafine crusher, airslide disintegrating mill, ultrasonic wave nano grinder etc..
The main component of fine powder is SKGM, also known as konjaku glucomannan (KGM) after konjaku processing, and SKGM is
Know the maximum natural macromolecule amylose of viscosity in natural plant gum, polymerize by glucose and mannose and form heteroglycan.Mean molecule quantity
For 200,000-200 ten thousand, profile is white or cream is to light brown yellow powder, and it by molecular proportion is 1 to be：1.6 glucose and mannose
Residue is polymerized by β-(Isosorbide-5-Nitrae)-glycosidic bond, the side chain that there is β (1,3) glycosidic bond composition on some saccharide residue C-3, main
There is 1 side chain per 32-80 saccharide residue on chain, every side chain has on several to tens saccharide residues, main chain every about 19 sugar
There is an acetyl group combined with ester bond on residue.
Konjak glucomannan has an a variety of excellent characteristics, such as gelation, edibility, film forming, thus food,
Each production field such as medicine, chemical industry has extensive purposes.But KGM has the characteristics such as the low, poor fluidity of solubility, it is applied
It is subject to certain restrictions, is the further performance for improving KGM, expands its application, generally pass through Physical, chemical method and life
The means such as thing method are degraded to it.
Current nanometer pulverization technology is varied, but the nano-scale particle after crushing can not accurately control its molecule
After amount is, it is necessary to crush, then screening is measured, so as to obtain the product of needs.Substantial amounts of work has just been lost in this.Current people
Class causes most people's blood glucose more and more higher, it is necessary to carry out drug therapy because unsound eating habit and habits and customs, and
Drug therapy is substantially with adverse reaction, and drug price is also somewhat expensive.
Recent domestic is very active for the research of functional polysaccharide, and many developed countries produce a variety of polysaccharides
Product are set to specific health food, to prevent and treat the illnesss such as obesity, hyperglycaemia, high fat of blood, artery sclerosis and coronary heart disease.There is document report
Road, dietary fiber is significant to health, and it has the sensitiveness for improving nerve ending to insulin, adjusts diabetes
The blood sugar level of patient, increases quantity and the phagocytosis of macrophage, improves the physiological function such as human disease resistance therefore,
International diabetic tissue (1993) recommends the dietary fiber dietetic treatment of diabetes to the utmost.Kanjak mannan time glycan is a kind of excellent
Good water-soluble dietary fiber, kanjak mannan time glycan is applicable not only to healthy population, also suitable for diabetes patient's long-term taking,
It can be developed as the health food and medicine for preventing and treating diabetes.
Kanjak mannan time glycan can carry out a series of chemistry and change due to there is acetyl group and substantial amounts of hydroxyl in molecule
Property, various derivatives are made, so as to be greatly enriched the research and development and application of sweet dew time glycan.Improved by chemical modification sweet
Dew time glycan primary characteristic, makes it have more preferably action effect, it is often more important that new derivative can be made, develops more
Has the new product of glamour.
The content of the invention
The present invention can pass through control for of the prior art not enough there is provided a kind of method for producing nano functional sugar
The particle diameter of product after system refinement, so as to accurately control the molecular weight of product after dispersion and fining, obtains molecular weight distribution and concentrates
Nano functional sugar, the technical method is more convenient, environmental protection, cost reduction, more commercial competitiveness；And utilize the device and side
The sugared particle of the nano functional in molecular weight ranges is specified in method production, and after it is taken by defined dosage, blood sugar decreasing effect is bright
It is aobvious.
In order to solve the above-mentioned technical problem, the present invention is addressed by following technical proposals：One kind production nano functional
The method of sugar, including step one, by SKGM material pulverizing processing 60-180 minutes in pulverization cylinder, the rotation speed of stirring rod
Spend for 2000-6000 revs/min, by the FREQUENCY CONTROL of ultrasonic wave in 30k-90kHz；Step 2, starts discharge belt, will stir
The material that leaf rotation is brought up is delivered in aggregate bin；Step 3, starts pump and the material in aggregate bin is passed through into the first discharge nozzle
Airslide disintegrating mill is delivered to, and the first high-pressure pump is delivered to by the second discharge nozzle；Step 4, starts the first high-pressure pump, will
Material sprays into the material exported in airslide disintegrating mill and from the first discharge nozzle by the first air jet pipe and collided, and then stops first
High-pressure pump；Step 5, starts the second high-pressure pump, and material is sprayed into material in airslide disintegrating mill and internal by the second air jet pipe
Collide, then stop the second high-pressure pump；Step 6, starts the 3rd high-pressure pump, and material is sprayed into air-flow by the 3rd air jet pipe
Collided in pulverizer with internal material, then stop the 3rd high-pressure pump；Step 7, repeat step three to six, repetition time
30-120 minutes；Step 8, material transfer portion is by the material transportation collected from discharge nozzle to finished bin, and the material in finished bin is
Nano functional sugar.
The nano functional sugar that a kind of profit is produced with the aforedescribed process, the particle diameter of the nano functional sugar is 20-40nm, molecule
Amount distribution is 10,000-20,000Da (dalton).Mannosan in this particle diameter and molecular weight ranges is referred to as sweet
Dew time glycan or nanometer sweet dew time glycan.
It is a kind of to be used for hypoglycemic method using above-mentioned nano functional sugar, it is 10,000-20 by the molecular weight distribution,
000Da nano functional sugar is applied in hypoglycemic product, can substantially reduce hypoglycemic after consumption, in 0.5g/kg extremely
In 2.0g/kg dosage range, blood sugar decreasing effect is lifted with dosage.
It is a kind of to prepare the application of liquaemin, heparan using above-mentioned nano functional sugar, be by the molecular weight distribution
10,000-20,000Da nano functional sugar carry out Sulfation modification, obtain water-soluble good Sulfation derivative, institute
The Sulfation derivative stated has anticoagulation, antithrombotic efficacy.Because KGM has the skeleton structure close with heparin, point
- OH in minor structure on C2, C3, C6 position, is respectively provided with stronger reactivity, is 10,000-20,000Da by molecular weight distribution
Nano functional sugar carry out hydroxypropylation and Sulfation modification successively, obtain water-soluble good KGM aldehydic acid propyl ester sodium sulphate
Salt (liquaemin), with the anticoagulation similar with heparin, antithrombotic efficacy is the important source material for preparing liquaemin, heparan.
SKGM is crushed to nano level particle by the present invention using nanometer pulverization device, controls the grain of these particles
Footpath, so that nano functional sugar of the molecular weight distribution in 10,000-20,000Da is obtained, after then being taken by prescribed dose,
With significant blood sugar decreasing effect；In addition by after its derivatization treatment, with anticoagulation, antithrombotic efficacy, be prepare liquaemin,
The important source material of heparan.
Brief description of the drawings
Fig. 1 is the pulverization cylinder structural representation of nanometer pulverization device used in the present invention.
Fig. 2 is the airslide disintegrating mill structural representation of nanometer pulverization device used in the present invention.
Fig. 3 is the Pneumatic crushing machine gaseous flow diagram of nanometer pulverization device used in the present invention.
Embodiment
The present invention is described in further detail with embodiment below in conjunction with the accompanying drawings：As shown in Figure 1 to Figure 3, one
The method for producing nano functional sugar, including step one are planted, by SKGM material pulverizing processing 60-180 points in pulverization cylinder 1
Clock, the velocity of rotation of stirring rod 13 is 2000-6000 revs/min, by the FREQUENCY CONTROL of ultrasonic wave in 30k-90kHz；Step 2, is opened
Dynamic discharge belt 15, paddle 131 is rotated the material brought up and is delivered in aggregate bin 31；Step 3, starting pump 3 will collect
Material in hopper 31 is delivered to airslide disintegrating mill 4 by the first discharge nozzle 321, and is delivered to by the second discharge nozzle 322
First high-pressure pump；Step 4, starts the first high-pressure pump, material is sprayed into airslide disintegrating mill 4 by the first air jet pipe 5 and from the
The material of one discharge nozzle 321 output collides, and then stops the first high-pressure pump；Step 5, starts the second high-pressure pump, material is led to
The material for crossing in the second air jet pipe 6 penetrating airslide disintegrating mill 4 and inside collides, and then stops the second high-pressure pump；Step 6, is opened
Dynamic 3rd high-pressure pump, material is sprayed into airslide disintegrating mill 4 by the 3rd air jet pipe 42 and internal material collides, Ran Houting
Only the 3rd high-pressure pump；Step 7, repeat step three to six, repetition time 30-120 minute；Step 8, material transfer portion will be from going out
The material transportation that expects pipe 41 is collected is to finished bin, and the material in finished bin is nano functional sugar.
When the present invention carries out nano-milled, a kind of nanometer of preparation facilities is used, it includes pulverization cylinder 1, pulverization cylinder 1
The paddle 131 of spiral above and below being provided with stirring rod 13, stirring rod 13 is inside provided with, the bottom of pulverization cylinder 1 is provided with motor 11,
The output shaft 12 of motor 11 is connected with stirring rod 13, and the bottom of pulverization cylinder 1 is provided with feed pipe 14, and the top of pulverization cylinder 1 is provided with out
Expect conveyer belt 15, the annular on the top of paddle 131, the outer wall of pulverization cylinder 1 of discharge belt 15 is provided with three circles ultrasound
Ripple portion, often encloses ultrasonic wave portion and is provided with 7 supersonic generators 23, pulverization cylinder 1 is provided with cooling cylinder 2 outside, and the bottom of cooling cylinder 2 is set
It is equipped with water inlet pipe 21 and outlet pipe 22 is connected with upper side wall, the other end of discharge belt 15 is arranged on aggregate bin 31
Side, the lower section of aggregate bin 31 is connected with pump 3, and pump 3 is provided with discharging portion 32, and discharging portion 32 is provided with the first discharge nozzle 321 and second
Discharge nozzle 322, the first discharge nozzle 321 is connected with airslide disintegrating mill 4, and the side wall of airslide disintegrating mill 4 is provided with the first air jet pipe 5 and
Two air jet pipes 6, the top of airslide disintegrating mill 4 is provided with the 3rd air jet pipe 42, the first air jet pipe 5, the second air jet pipe 6 and the 3rd jet
The axis of pipe 42 intersects at a point, and the second discharge nozzle 322 is connected with the first high-pressure pump and the second high-pressure pump, the first high-pressure pump
Output end connects the first air jet pipe 5, and the output end of the second high-pressure pump connects the second air jet pipe 6, and the 3rd air jet pipe 42 is connected with the
Three high-pressure pumps, the bottom of airslide disintegrating mill 4 is provided with discharge nozzle 41, and discharge nozzle 41 is connected with material transfer portion, and material transfer portion connects
The first high-pressure pump, the second high-pressure pump and the 3rd high-pressure pump are connect, material transfer portion is also associated with setting in finished bin, airslide disintegrating mill 4
It is placed in baffle portion 45, baffle portion 45 and is provided with drainage inclined-plane 44, is provided between drainage inclined-plane 44 and the top of airslide disintegrating mill 4
The drainage cambered surface 43 of arc, the end of drainage cambered surface 43 is connected with the 3rd air jet pipe 42, and mill ball is provided with pulverization cylinder 1.
The nano functional sugar that a kind of profit is produced with the aforedescribed process, the particle diameter of the nano functional sugar is 20-40nm, molecule
Amount distribution is 10,000-20,000Da.Mannosan in this particle diameter and molecular weight ranges is referred to as sweet dew time glycan
Or nanometer sweet dew time glycan.
It is a kind of to be used for hypoglycemic method using above-mentioned nano functional sugar, it is 10,000-20 by the molecular weight distribution,
000Da nano functional sugar is applied in hypoglycemic product, can substantially reduce hypoglycemic after consumption, in 0.5g/kg extremely
In 2.0g/kg dosage range, blood sugar decreasing effect is lifted with dosage.
It is a kind of to prepare the application of liquaemin, heparan using above-mentioned nano functional sugar, be by the molecular weight distribution
10,000-20,000Da nano functional sugar carry out Sulfation modification, obtain water-soluble good Sulfation derivative, institute
The Sulfation derivative stated has anticoagulation, antithrombotic efficacy.Because KGM has the skeleton structure close with heparin, point
- OH in minor structure on C2, C3, C6 position, is respectively provided with stronger reactivity, is 10,000-20,000Da by molecular weight distribution
Nano functional sugar carry out hydroxypropylation and Sulfation modification successively, obtain water-soluble good KGM aldehydic acid propyl ester sodium sulphate
Salt (liquaemin), with the anticoagulation similar with heparin, antithrombotic efficacy.
Under prior art, the molecular weight of detection polysaccharide is a sufficiently complex cumbersome process, especially to passing through chemistry
Or the nano functional sugar that biological mode is obtained carries out detection molecules amount, even more one very difficult operation.There is provided in this programme
Device, the particle diameter overall distribution of the nano functional sugar product of production is similar to normal distribution.Entered multiple detection contrast hair
Existing, the particle diameter for the nano functional sugar that the present apparatus is produced by the above method is in the range of 20-40nm, meanwhile, corresponding point
Son amount is distributed between 10,000-20,000Da.The nano functional sugar of present apparatus production, its particle diameter and molecular weight are presented a kind of right
It should be related to.This just enormously simplify detection process, as long as the particle diameter of detection particle, so that when saving substantial amounts of work
Between.That is, the nano functional sugar produced by the present apparatus, as long as by size controlling in the range of 20-40nm, it becomes possible to ensure
Molecular weight distribution is between 10,000-20,000Da.
The present invention is 60-180 minutes by adjusting SKGM material pulverizing processing time in pulverization cylinder 1, then will be stirred
The velocity of rotation for mixing rod 13 is set as 2000-6000 revs/min, after preliminary crushing, then is transported to airslide disintegrating mill 4
The fine crushing of 30-120 minutes when inside entering behavior, it becomes possible to obtain SKGM particle of the particle diameter within 20-40nm, its point
Son amount is distributed between 10,000-20,000Da just.Mechanical force forces KGM meta system by uniform sequential cutting, makes
Macromolecular chain and hydrogen bond fracture originally obtains the relatively low functional sugar of molecular weight.
The experiment case study on implementation 1 of the present invention：
Experimental method：Kunming kind adult mice 100 (male and female half and half) is chosen, average weight is (25 ± 2.5) g, by female
Male half and half principle random selection 10 is only used as Normal group, and remaining 40 is raised after 2-3 months only with high lipid food, with small dose
Streptozotocin induced Diabetic is measured, fasting blood sugar includes experiment more than 15mmol/L person, mouse then is divided into 2 types at random
Diabetic model group, melbine administration group, sweet dew time glycan low dose group (0.5g/kg), sweet dew time glycan high dose group
(2.0g/kg), Normal group and diabetes B model group give equivalent distilled water.Experiment periods are 4 weeks, week about each group
Mouse empty stomach eye socket takes blood, surveys its blood-sugar content.
Specific result of the test is as shown in the table.
Influence of the sweet dew time glycan of table 1 to diabetes B mouse blood sugarmmol/L
△P<0.001, compared with blank group, * P<0.05, compared with model group
As shown in Table 1, preceding model and each administration group mouse blood sugar is administered apparently higher than blank group (P<0.001)；Diformazan is double
Guanidine administration group blood glucose declines substantially, and being administered to decline for the 1st week just has significant difference (P<0.05), continue within later 3 weeks to decline；It is sweet
Dew time glycan high dose administration group is with the extension of administration time, and significantly, be administered to decline in 4 weeks has conspicuousness poor to time-effect relationship
Different, change of blood sugar is not notable in 3 weeks before sweet dew time glycan low dosage administration group, and the 4th week blood glucose, which declines, has significant difference (P<
0.05).Melbine is, for clinical hypoglycemic drug, with obvious hypoglycemic effect, by contrast, to show sweet dew
Glycan has hypoglycemic effect, and hypoglycemic effect has obvious timeliness and dose-effect relationship.
The experiment case study on implementation 2 of the present invention：
Kunming kind adult mice 48 (male and female half and half) is chosen, average weight is (25 ± 2.5) g, by the principle of male and female half and half
At random, 4 groups, every group 12 are randomly divided into.According to 25ml/kg capacity gavages, physiological saline is given respectively, and method China makes 10mg/kg,
Sweet dew time polysaccharid derivative low dosage 10mg/kg, sweet dew time polysaccharid derivative high dose 1000g/kg, continuous gavage 30d.30th
1h after its administration, from the blood sampling of mouse intraocular corner of the eyes ball rear vein beard, the clotting time of each group mouse is determined according to capillary tube method：Take blood
5cm is reached to blood pillar height, is fractureed one section of capillary every 30s, checks for clotting strands, to the institute for blood clotting silk occur since being taken blood
It is the clotting time between lasting.
Influence of the sweet dew time polysaccharid derivative of table 2 to clotting time of mice
| Group | Dosage (mg/kg) | Number of animals | Clotting time (s) |
| Physiological saline | 0 | 12 | 222.1±72.3 |
| The order of method China | 10 | 12 | 295.6±80.3* |
| Product low dose group | 10 | 12 | 258.7±66.1 |
| Product high dose group | 1000 | 12 | 310.5±53.7* |
Compared with physiological saline group, * P<0.05
As shown in Table 2, compared with physiological saline group, the clotting time of sweet dew time polysaccharid derivative low dosage and high dose has
Extended, and increased with the increase of dosage；The clotting time of product high dose group mouse otherness compared with control group shows
Write, P ＜ 0.05；The order of method China is, for clinical anticoagulation medicine, with preventing and treating thrombotic disease, by contrast, to show
Sweet dew time polysaccharid derivative has anticoagulant function.And anticoagulation has obvious timeliness and dose-effect relationship.
Protection scope of the present invention includes but is not limited to embodiment of above, and protection scope of the present invention is with claims
It is defined, any replacement being readily apparent that to those skilled in the art that this technology is made, deformation, improvement each fall within the present invention's
Protection domain.
Claims (4)
1. a kind of method for producing nano functional sugar, it is characterised in that：Including step one, by SKGM material in pulverization cylinder
（1）Interior pulverizing processing 60-180 minutes, stirring rod（13）Velocity of rotation be 2000-6000 revs/min, by the frequency control of ultrasonic wave
System is in 30k-90kHz；Step 2, starts discharge belt（15）, by paddle（131）Rotate the material brought up and be delivered to collection
Hopper（31）It is interior；Step 3, starts pump（3）By aggregate bin（31）Interior material passes through the first discharge nozzle（321）It is delivered to air-flow
Pulverizer（4）, and pass through the second discharge nozzle（322）It is delivered to the first high-pressure pump；Step 4, starts the first high-pressure pump, by thing
Material passes through the first air jet pipe（5）Spray into airslide disintegrating mill（4）It is interior and from the first discharge nozzle（321）The material of output collides, so
After stop the first high-pressure pump；Step 5, starts the second high-pressure pump, material is passed through into the second air jet pipe（6）Spray into airslide disintegrating mill
（4）Interior and internal material collides, and then stops the second high-pressure pump；Step 6, starts the 3rd high-pressure pump, and material is passed through into the
Three air jet pipes（42）Spray into airslide disintegrating mill（4）Interior and internal material collides, and then stops the 3rd high-pressure pump；Step 7,
Repeat step three to six, repetition time 30-120 minute；Step 8, material transfer portion will be from discharge nozzle（41）The material fortune of collection
The material transported in finished bin, finished bin is nano functional sugar.
2. a kind of nano functional sugar of the method production described in utilization claim 1, it is characterised in that：The nano functional sugar
Particle diameter is 20-40nm, and range of molecular weight distributions is 10,000-20,000Da.
3. the sugared application in field of medicaments of nano functional described in a kind of usage right requirement 2, it is characterised in that：By the molecule
The nano functional sugar that amount is distributed as 10,000-20,000Da is applied in hypoglycemic product, and drop can be substantially reduced after consumption
Blood glucose, in 0.5g/kg to 2.0g/kg dosage range, blood sugar decreasing effect is lifted with dosage.
4. the nano functional sugar described in a kind of usage right requirement 2 is preparing the application of liquaemin, heparan, it is characterised in that：
The molecular weight distribution is subjected to Sulfation modification for 10,000-20,000Da nano functional sugar, obtains water-soluble good
Sulfation derivative, described Sulfation derivative has anticoagulation, antithrombotic efficacy.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107754383A (en) * | 2017-11-30 | 2018-03-06 | 江苏飞视文化发展有限公司 | A kind of advertising is with glue folliculus machine |
| CN107936135A (en) * | 2017-12-14 | 2018-04-20 | 宁波拜尔玛生物科技有限公司 | A kind of preparation method and applications of high-purity sweet dew time glycan |
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| CN107936135B (en) * | 2017-12-14 | 2020-05-26 | 宁波拜尔玛生物科技有限公司 | Preparation method and application of high-purity mannan |
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