CN107261109A

CN107261109A - It is a kind of to be used to treat pharmaceutical composition of diaper rash and preparation method thereof

Info

Publication number: CN107261109A
Application number: CN201710583826.9A
Authority: CN
Inventors: 华若延
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-07-18
Filing date: 2017-07-18
Publication date: 2017-10-20

Abstract

The present invention relates to a kind of pharmaceutical composition for being used to treat diaper rash and preparation method thereof, including honey and polymyxin class material, the mass ratio of wherein honey and polymyxin class material is 1:0.01‑0.05.Compared with the medicine of diaper rash of the prior art, preparation method of the invention is simple, can save responsible sterilization steps, and curative effect is significantly better than the existing product of prior art.

Description

It is a kind of to be used to treat pharmaceutical composition of diaper rash and preparation method thereof

Technical field

The present invention relates to biomedicine field, more particularly to a kind of pharmaceutical composition and its system for being used to treat diaper rash Preparation Method.

Background technology

Diaper rash refers in neonate's anal area, buttocks etc. rubefaction, easy secondary bacterial or candida albicans sense Dye, can occur skin ulcer when serious.The most frequently used therapeutic scheme is that duty is washed, and keeps drying and prickly-heat powder.But for urine The therapeutic effect of cloth rash is simultaneously bad.

Honey is a kind of complicated component, nutritious supersaturated sugar juice, with high osmotic pressure.Mature native honeybee Highly viscous state is presented in honey at normal temperatures, and water content is generally 17.4% or so, i.e., natural honey is that a kind of concentration is 82.6% Sugar juice, with hypertonic characteristic.It is anti-caused by the physical characteristic that the antimicrobial component contained in honey has in itself except honey Outside bacterium characteristic, the antibacterial material included in honey serves particularly important to wound healing.Main antibacterial group in honey Divide and be broadly divided into hydroperoxide kind and non-hydroperoxide kind.

Honey has a variety of pharmacological functions, the existing very long history of exploitation research of its medical value.Utilize the anti-of honey Bacterium characteristic promotes the phenomenon of wound healing and treatment other diseases to attract the interest of many scientific research persons.Zumla(1989)、J Multidigit scholar's Reporting of Overview such as eff rey (1996) and Mathew s (2002) honey is routed in treatment burn, wound, skin There is significant effect in terms of rotten, promotion dermatoplasty regeneration, gastroenteritis and gastric ulcer.

Honey is cheap, obtains convenient, has a variety of pharmacological effects again, the research and development in terms of medical science have larger Potentiality.But the problem of need to solving at present also has a lot, although academia has carried out substantial amounts of research in this aspect, but honey Anti-microbial property also ununified standard, its antimicrobial component and antibacterial mechanisms still without analyzing clear completely.

At present, if field of medical materials uses honey, it need to typically be sterilized through too high dose radiation exposure, but it is such Sterilising conditions only Large-scale professional mechanism just possesses, and the instrument cost used is high, and operation is also very complicated, therefore adds honey class The cost of medical material.But if sterilized without radiation exposure, the surface of a wound is likely to form wound infection, and treatment is not had on the contrary Effect.

The content of the invention

For problems of the prior art, the present invention is for a kind of pharmaceutical composition and its system for being used to treat diaper rash The mass ratio of Preparation Method, including honey and polymyxin class material, wherein honey and polymyxin class material is 1:0.01- 0.05。

Polymyxin class is the one group of basic polypeptide class antibiotic obtained from many Bacillus adhaerens nutrient solutions, belongs to narrow spectrum antibiosis Most gram negative bacillis are had powerful bactericidal action by element in clinic, be used for eye caused by sensitive bacterial, ear, skin, Mucosa infection and infection of burn.It has been investigated that, added in honey after a certain amount of polymyxin class material, for controlling There is excellent curative effect when treating diaper rash, it may be possible to because polymyxin class material is while infected wound is avoided, also effectively Inhibit the growth of bacterium in honey, and there is when treating diaper rash excellent technique effect, and other antibiotic and reach Less than such technique effect.

Further, described polymyxin class material is selected from polymyxin E and/or Polymyxin B sulfate.

Further, the mass ratio of described polymyxin E and Polymyxin B sulfate is 1:3.

Further, the mass ratio of honey and polymyxin class material is 1:0.02-0.04.

Further, pharmaceutical composition of the invention can also include pharmaceutically acceptable auxiliary material, to be configured to difference Formulation.

Nystatin is added in the natural honey wound dressing of the present invention, when dressing acts on wound, nystatin The growth of fungi in honey can be suppressed, so as to avoid wound from having new infection.While natural honey wound dressing of the present invention Preparation method is simple and easy to apply, eliminates the step of radiation exposure sterilizing is this to be difficult to carry out, additionally it is possible to reach effective antibacterial effect Really, remarkable in economical benefits.

The present invention also protects the preparation method of aforementioned pharmaceutical compositions, according to said ratio by honey and polymyxin class thing Matter is well mixed, and is heated to after 40-60 DEG C be incubated 3-5h, is cooled to room temperature, that is, obtains.

The present invention, which is found surprisingly that in honey, to be added after a certain amount of polymyxin class material, has excellent to treatment diaper rash Curative effect, compared with the medicine of diaper rash of the prior art, preparation method of the invention is simple, can save responsible Sterilization steps, and curative effect is significantly better than the existing product of prior art.

Embodiment

In order that the purpose of the present invention, technical scheme and beneficial effect are clearer, present invention specific examples below Illustrate, but the present invention is limited to absolutely not these examples.

Experimental example 1

In accordance with the following methods and prepared by the component proportion in table 1：

Wherein honey is by the natural honey that is taken at beekeeper.

Honey and different antibiotic are well mixed according to the proportioning in table 1,4h is incubated after being heated to 60 DEG C, is cooled to room Temperature, that is, obtain.

Table 1

Embodiment 2

It is the object of observation that selection, which is diagnosed as diaper rash infant 120, and the wherein age is 6 months to 1.5 years old, man 70, Female 50, is divided into 3 groups, every group each 40.3 groups of clinical data no significant differences, with comparativity.

3 groups of infants per half an hour, after once whetheing there is defecation, each defecation with warm water cleaning dried by inspection.Respectively with real A 1-10, embodiment 11-12 and embodiment 13-15 (control group) dabs affected part are applied, then wraps slightly loose cotton diaper, with Just skin is fully absorbed, and weather can expose buttocks when warm, daily to apply 3 times.3 groups are fed during treatment is observed, nurse identical, Efficacy evaluation is carried out after 3 days in medication.

Criterion of therapeutical effect：Effective is erythema range shorter, and color turns dark or turns light, and pain scratchiness disappears, at ulceration Without sepage；Effectively constant for erythema scope, flush degree and sufferings sense mitigate, and have a small amount of sepage；Invalid is that erythema scope is constant Or increase, diffusate increases, or even festers, and pain does not mitigate.

3 groups of clinical efficacy is compared as shown in table 2.

The Clinical efficacy comparison of table 2

	It is effective	Effectively	It is invalid	It is efficient
					Treatment group 1 (embodiment 1-10)	30	10	0	100%
Treatment group 2 (embodiment 11-12)	38	2	0	100%
					Treatment group 3 (embodiment 13-15)	20	10	10	75%

Wherein three groups infants do not occur adverse drug reaction.

The studies above result shows, three groups after the treatment and nursing by a course for the treatment of, treatment group 1 and treatment group 2 Total effective rate is 100%, hence it is evident that higher than the 75% for the treatment of group 3 (control group), it is seen then that many compared to other antibiotics Colistin class medicine has significantly excellent curative effect.And the notable effective percentage for the treatment of group 2 reaches 95%, is significantly higher than treatment group 1 Notable efficient (75%), it is seen then that using the combination of polymyxin E and Polymyxin B sulfate relative to single polymyxin class Medicine achieves more excellent curative effect.Difference has statistical significance, and with comparativity, P ＜ 0.05.As a result point out, institute There is the therapeutic effect of embodiment substantially and without adverse drug reaction, it is safe and reliable.

In summary, pharmaceutical composition of the invention is used to treat infant diaper rash, and treatment method is simple and without bad Reaction, can obviously improve infant illness, improve the quality of life of infant, shortens the hospital stays, so as to reduce medical expense, therefore is Effective, the preferred agents of infant diaper rash are treated, clinic is promoted the use of.

Although by referring to the preferred embodiments of the present invention, invention has been described, this area it is common It will be appreciated by the skilled person that various changes can be made to it in the form and details, without departing from appended right The spirit and scope of the present invention that claim is limited.

Claims

1. a kind of pharmaceutical composition for being used to treat diaper rash, it is characterised in that including honey and polymyxin class material, wherein The mass ratio of honey and polymyxin class material is 1:0.01-0.05.

2. pharmaceutical composition according to claim 1, it is characterised in that described polymyxin class material is selected from many slime moulds Plain E and/or Polymyxin B sulfate.

3. pharmaceutical composition according to claim 2, it is characterised in that described polymyxin E and the matter of Polymyxin B sulfate Amount is than being 1:3.

4. pharmaceutical composition according to claim 3, it is characterised in that the mass ratio of honey and polymyxin class material is 1:0.02-0.04。

5. the pharmaceutical composition according to any one of claim 1-4, it is characterised in that also including pharmaceutically acceptable Auxiliary material, to be configured to different formulations.

6. the preparation method of the pharmaceutical composition according to any one of claim 1-5, it is characterised in that match somebody with somebody according to above-mentioned It is more uniform than by honey and polymyxin class material mixing, it is heated to after 40-60 DEG C be incubated 3-5h, is cooled to room temperature, that is, obtains.