CN107260980A - A kind of hypoglycemic medicine and preparation method thereof - Google Patents
A kind of hypoglycemic medicine and preparation method thereof Download PDFInfo
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- CN107260980A CN107260980A CN201710309356.7A CN201710309356A CN107260980A CN 107260980 A CN107260980 A CN 107260980A CN 201710309356 A CN201710309356 A CN 201710309356A CN 107260980 A CN107260980 A CN 107260980A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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Abstract
A kind of hypoglycemic medicine, is made up of following raw materials：Grape, hawthorn, honey, barrenwort, Semen Cuscutae, Huangshan Gongju, the sophora bud, Fructus Aurantii, the leaf of bamboo, yeast.In the present invention, the glucose in glucose, hawthorn in grape, the glucose in honey are alcohol by microbe conversion, and glucose content is extremely low in liquid, and blood glucose rise is not resulted in after patients with diabetes mellitus.The nutritional ingredients such as tartaric acid, oxalic acid, citric acid in grape are retained, and have effects that tonneau urine, while being capable of invigorating qi and benefiting blood, Yin-nourishing and body fluid promoting, strengthening the muscles and bones.Glucose in hawthorn is converted into alcohol, and the drug ingedient such as brass class retains, not only with used in hypoglycemic, also with significant expansion blood vessel and antihypertensive effect, there is the function of enhancing cardiac muscle, arrhythmia, regulation blood fat and cholesterol level, the generation of diabetic complication can be prevented.
Description
Technical field
The invention belongs to endocrine therapy field, specifically a kind of hypoglycemic medicine and preparation method thereof.
Background technology
Diabetes are one group of metabolic diseases being characterized with hyperglycaemia.Hyperglycaemia be due to then defect of insulin secretion or
Its biological agent is damaged, or both have concurrently and cause.Long-standing hyperglycaemia during diabetes, cause various tissues, particularly eye,
Kidney, heart, blood vessel, the chronic lesion of nerve, dysfunction.Hypoglycemic is the preferred manner of drug therapy.Grape, hawthorn and honey
In there are multiple nutritional components, diabetic complication can be prevented, when because it is again containing substantial amounts of glucose, sugar is not suitable for
Urinate patient.
The content of the invention
The present invention provides a kind of hypoglycemic medicine and preparation method thereof, to solve defect of the prior art.
A kind of hypoglycemic medicine, is made up of following raw materials：Grape 1000-1500g, hawthorn 200-300g, honey 100-150g,
Barrenwort 10-15g, Semen Cuscutae 10-15g, Huangshan Gongju 5-10g, sophora bud 20-30g, Fructus Aurantii 5-10g, leaf of bamboo 2-10g, yeast 5-
10g。
A kind of hypoglycemic medicine as described above, is made up of following raw materials：It is grape 1000g, hawthorn 300g, honey 120g, excessive
Sheep leaves of pulse plants 10g, Semen Cuscutae 12g, Huangshan Gongju 10g, sophora bud 20g, Fructus Aurantii 7g, leaf of bamboo 2g, yeast 5g.
A kind of hypoglycemic medicine as described above, is made up of following raw materials：It is grape 1200g, hawthorn 200g, honey 150g, excessive
Sheep leaves of pulse plants 12g, Semen Cuscutae 15g, Huangshan Gongju 5g, sophora bud 26g, Fructus Aurantii 10g, leaf of bamboo 10g, yeast 7g.
A kind of hypoglycemic medicine as described above, is made up of following raw materials：It is grape 1500g, hawthorn 240g, honey 100g, excessive
Sheep leaves of pulse plants 15g, Semen Cuscutae 10g, Huangshan Gongju 8g, sophora bud 30g, Fructus Aurantii 5g, leaf of bamboo 4g, yeast 10g.
A kind of hypoglycemic medicine as described above, described yeast model F5, LaIVin 71B or LaIVin RA17.
A kind of preparation method of hypoglycemic medicine, comprises the steps 1. grape remove seed, hawthorn stoning, grape is crushed, plus
Enter into fermentation flask, stir, place 3-4h；2. 50g liquid is extracted in fermentation flask, yeast is incorporated in liquid, stirring
20-30min is stood after uniform, the liquid for adding yeast is added to fermentation flask fermentation 2-3d；Honey is added, continues the 1- that ferments
2d, is filtrated to get cerise liquid；3. barrenwort, Semen Cuscutae, Huangshan Gongju, the sophora bud, Fructus Aurantii, the leaf of bamboo are crushed, and step is 2.
Obtain cerise liquid mixing, carry out ultrasonic extraction 40-50min, be filtrated to get dark red liquid；4. 3. step is obtained
Dark red liquid add to simulation aging machine in, simulate ageing 12-24h, add water alcohol,diluted content and be reduced to 8-12%
（V/V）, obtain hypoglycemic medicine.
A kind of preparation method of hypoglycemic medicine as described above, described simulation aging machine includes open-topped tubular
Top cover is installed at shell, the top of shell, and supporting leg is installed in the bottom of shell, and motor, the output shaft of motor are installed in the bottom of shell
The vertical agitating shaft of connection, agitating shaft, agitating shaft is hollow, and several tracheaes are uniformly installed on the periphery top of agitating shaft, tracheae with
Agitating shaft is communicated, and several paddles and branch pipe are installed in the bottom of tracheae, and branch pipe is located between paddle, and branch pipe is connected with tracheae,
Several stomatas are opened up on branch pipe, swivel joint, swivel joint connection air inlet pipe are installed in the top of agitating shaft.
A kind of preparation method of hypoglycemic medicine as described above, described paddle is sheet, between paddle and tracheae
Angle be 30-60 °.
A kind of preparation method of hypoglycemic medicine as described above, in addition to the medicine that 4. assistant's step obtains step are added
Fining agent, clarifying reaction 1-2h, the hypoglycemic medicine clarified.
Ultrasonic power 400W, ultrasound in a kind of preparation method of hypoglycemic medicine as described above, described ultrasonic wave extraction
Temperature 60 C.
It is an advantage of the invention that：In the present invention, the glucose in glucose, hawthorn, the glucose in honey in grape
It is alcohol by microbe conversion, glucose content is extremely low in liquid（Less than 4.0g/L）, do not result in after patients with diabetes mellitus
Blood glucose rise, grape, the technology prejudice of hawthorn can not be used by overcoming diabetes patient.Tartaric acid, oxalic acid, citric acid in grape
It is retained etc. nutritional ingredient, there is tonneau urine, while being capable of invigorating qi and benefiting blood, Yin-nourishing and body fluid promoting, strengthening the muscles and bones.In hawthorn
Glucose be converted into alcohol, and the drug ingedient such as brass class retains, not only with used in hypoglycemic, also with significant expansion
Blood vessel and antihypertensive effect, the function of having enhancing cardiac muscle, arrhythmia, regulation blood fat and cholesterol level, can prevent glycosuria
The generation of sick complication.Fructose in Honey composition will not cause blood glucose rise, additionally it is possible to the mouthfeel of the regulation present invention, reduce various
The bitter taste of medicine and the bitterness sense of medicinal liquor.In every Chinese medicine after ultrasonically treated, cell membrane is crushed, and effective flavone component is released
Put, so as to be dissolved in alcohol, can more easily be absorbed by the body, flavone component there can be stimulation islet β cell pancreas islet
The effects such as element, the sensitiveness of increase insulin receptor, the absorption for suppressing glucose, improvement fatty acid metabolism, so as to realize hypoglycemic
Effect.Small side effects of the present invention, toxicity is low, it is adaptable to the long-term control to blood glucose.Under each Chinese medicine material also has in the present invention
State effect：Barrenwort：Tonifying kidney and strengthening yang；Dispelling wind and eliminating dampness；Strengthening tendons key bone；Semen Cuscutae：It is nourishing liver and kidney, astringent sperm contracting urine, improving eyesight；It is yellow
Mountain tribute chrysanthemum：Clear liver and improve vision, fall fire of getting rid of evils, refrigerant inducing diaphoresis；The sophora bud：Clearing heat-fire, cool blood；Fructus Aurantii：Regulating the flow of QI to ease the stomach, row is stagnant to disappear
It is swollen；The leaf of bamboo：Diuresis, clearing heat and relieving fidgetness is promoted the production of body fluid.
The present invention application method be：1-2 time daily, each 50-100ml is drunk in meal or after meal, avoids reference on an empty stomach.
（Hypoglycemia may be caused by drinking on an empty stomach）.
102 patients take, and the oldest is 70 years old, minimum 40 years old, diabetic duration 0-8, average course of disease 4.2
Year, it is type-II diabetes.Whole blood glucose reductions after 3 days are drunk, obvious effective rate is 100%.Blood glucose after 7 days is drunk to be able to maintain that surely
Fixed, wherein 86 people's fasting blood-glucoses are reduced to less than 6.1 mM/ls, obvious effective rate 84.3% was drunk after 21 days, 100 people's fasting bloods
Sugar is reduced to less than 6.1 mM/ls.Followed the trail of after 1 year and adhere to 45 that drink the present invention, fasting blood-glucose is kept at 6.1 millis
Below mol/L.
Model case：
1st, Zhang, Henan people from Zhoukou City 52 years old, with type-II diabetes 3 years, takes Western medicine Or Metformin In Treating diabetes always,
Substantially, blood glucose is always between 12-15 mM/ls for stomach side effect reaction.Start in March, 2016 to take the present invention, after 2 days
Blood glucose is reduced to 8.5 mM/ls, takes after 7 days, and fasting blood-glucose is reduced to 5.8 mM/ls, adheres to taking the present invention.
Further consultation in March, 2017, fasting blood-glucose is always below 6.1 mM/ls.
2nd, Zheng, Henan people from Zhoukou City 47 years old, with type-II diabetes 6 years, passes through injection of insulin and ties up hypoglycemic, 2016
Year takes the present invention in 2 months, stops using insulin.Take after 7 days, fasting blood-glucose is always below 6.1 mM/ls.Adhere to
Take the present invention, further consultation in 2 months in 2017, fasting blood-glucose is always below 6.1 mM/ls.
3rd, Lee, Henan people from Shangqiu 65 years old, with type-II diabetes 7 years, is matched somebody with somebody by injection of insulin and acarbose tablet
Treatment is closed, effect is undesirable.Start in April, 2016 to take the present invention, blood glucose is reduced to 8.5 mM/ls after 7 days, takes 21
After it, fasting blood-glucose is reduced to 5.4 mM/ls, adheres to taking the present invention.In March, 2017 low further consultation, fasting blood-glucose exists always
Less than 6.1 mM/ls.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is the accompanying drawing used required in technology description to be briefly described, it should be apparent that, drawings in the following description are this hairs
Some bright embodiments, for those of ordinary skill in the art, without having to pay creative labor, can be with
Other accompanying drawings are obtained according to these accompanying drawings.
Fig. 1 is the structural representation of simulation aging machine in the present invention；Fig. 2 is the sectional structure signal along Fig. 1 line A-A
Figure.
Reference：The stomata of 1 shell, 2 supporting leg, 3 motor, 4 agitating shaft, 5 top cover, 6 tracheae, 7 paddle, 8 branch pipe 9
The air inlet pipe of 10 swivel joint 11.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical scheme be clearly and completely described, it is clear that described embodiment is a part of embodiment of the invention, rather than
Whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making creative work premise
Lower obtained every other embodiment, belongs to the scope of protection of the invention.
A kind of hypoglycemic medicine, is made up of following raw materials：Grape 1000-1500g, hawthorn 200-300g, honey 100-150g,
Barrenwort 10-15g, Semen Cuscutae 10-15g, Huangshan Gongju 5-10g, sophora bud 20-30g, Fructus Aurantii 5-10g, leaf of bamboo 2-10g, yeast 5-
10g。
Specifically, a kind of hypoglycemic medicine, is made up of following embodiment raw materials：
Embodiment 1：Grape 1000g, hawthorn 300g, honey 120g, barrenwort 10g, Semen Cuscutae 12g, Huangshan Gongju 10g, the sophora bud
20g, Fructus Aurantii 7g, leaf of bamboo 2g, yeast 5g.
Embodiment 2：Grape 1200g, hawthorn 200g, honey 150g, barrenwort 12g, Semen Cuscutae 15g, Huangshan Gongju 5g, Chinese scholartree
Rice 26g, Fructus Aurantii 10g, leaf of bamboo 10g, yeast 7g.
Embodiment 3：Grape 1500g, hawthorn 240g, honey 100g, barrenwort 15g, Semen Cuscutae 10g, Huangshan Gongju 8g, Chinese scholartree
Rice 30g, Fructus Aurantii 5g, leaf of bamboo 4g, yeast 10g.
Described yeast model F5, LaIVin 71B or LaIVin RA17.Above-mentioned yeast is applied to drink ahead of time
With F5 can start and complete alcoholic fermentation rapidly, and the fragrance with pepper can cover the taste of Chinese medicine；LaIVin 71B foams
Less, precipitate, with the fresh and pleasant fragrance of fragrance；LaIVin RA17 can fully and rapidly show the perfume (or spice) of grape
Gas, blocks the smell of Chinese medicine.
A kind of preparation method of hypoglycemic medicine, comprises the steps 1. grape remove seed, hawthorn stoning, grape is crushed, plus
Enter into fermentation flask, stir, place 3-4h；2. 50g liquid is extracted in fermentation flask, yeast is incorporated in liquid, stirring
20-30min is stood after uniform, the liquid for adding yeast is added to fermentation flask fermentation 2-3d；Honey is added, continues the 1- that ferments
2d, is filtrated to get cerise liquid；3. barrenwort, Semen Cuscutae, Huangshan Gongju, the sophora bud, Fructus Aurantii, the leaf of bamboo are crushed, and step is 2.
Obtain the mixing of cerise liquid, carry out ultrasonic extraction 40-50min, be filtrated to get dark red liquid, it is ultrasonic power 400W, super
Sound temperature 60 C；4. the dark red liquid that 3. step obtains is added into simulation aging machine, simulates ageing 12-24h, then add
Water alcohol,diluted content is reduced to 8-12%（V/V）, obtain hypoglycemic medicine；In order to increase color and luster effect, 5. 4. step is obtained
Medicine add fining agent, clarifying reaction 1-2h, the hypoglycemic medicine clarified.After fining agent is handled, liquid medicine is improved
The clarity of agent, partial impurities are flocculated, and improve drug effect.
Simulating aging machine can use high-gravity rotating bed, or use more simple equipment, and example is simulated as mentioned
Aging machine includes the shell 1 of open-topped tubular, and top cover 5 is installed at the top of shell 1, and supporting leg 2 is installed in the bottom of shell 1,
Motor 3 is installed in the bottom of shell 1, and the output shaft of motor 3 connects vertical agitating shaft 4, agitating shaft 4, agitating shaft 4 and shell 1 it
Between connected by sealed bearings, prevent leakage, agitating shaft 4 is hollow, and several tracheaes 6 are uniformly installed on the periphery top of agitating shaft 4,
Tracheae 6 is hard, and tracheae 6 is communicated with agitating shaft 4, and several paddles 7 and branch pipe 8, described paddle are installed in the bottom of tracheae 6
7 be sheet, and the angle between paddle 7 and tracheae 6 is 30-60 °, the structure and liquid contact surface product it is moderate, stirring resistance compared with
It is small, while local turbulence can be increased, stirring efficiency is improved, branch pipe 8 is located between paddle 7, and branch pipe 8 is connected with tracheae 6, branch
Several stomatas 9 are opened up on pipe 8, swivel joint 10, the connection air inlet pipe 11 of swivel joint 10 are installed in the top of agitating shaft 4.Simulation is old
Wine machine is by the stirring to liquid, while being passed through gas, effectively facilitates fermentation, simulates ageing environment, reduce brewing time, improves
Mouthfeel.
Finally it should be noted that：The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
The present invention is described in detail with reference to the foregoing embodiments, it will be understood by those within the art that：It still may be used
To be modified to the technical scheme described in foregoing embodiments, or equivalent substitution is carried out to which part technical characteristic；
And these modification or replace, do not make appropriate technical solution essence depart from various embodiments of the present invention technical scheme spirit and
Scope.
Claims (10)
1. a kind of hypoglycemic medicine, it is characterised in that：It is made up of following raw materials：Grape 1000-1500g, hawthorn 200-300g, honey
100-150g, barrenwort 10-15g, Semen Cuscutae 10-15g, Huangshan Gongju 5-10g, sophora bud 20-30g, Fructus Aurantii 5-10g, leaf of bamboo 2-
10g, yeast 5-10g.
2. a kind of hypoglycemic medicine according to claim 1, it is characterised in that：It is made up of following raw materials：Grape 1000g, mountain
Short, bristly hair or beard 300g, honey 120g, barrenwort 10g, Semen Cuscutae 12g, Huangshan Gongju 10g, sophora bud 20g, Fructus Aurantii 7g, leaf of bamboo 2g, yeast 5g.
3. a kind of hypoglycemic medicine according to claim 1, it is characterised in that：It is made up of following raw materials：Grape 1200g, mountain
Short, bristly hair or beard 200g, honey 150g, barrenwort 12g, Semen Cuscutae 15g, Huangshan Gongju 5g, sophora bud 26g, Fructus Aurantii 10g, leaf of bamboo 10g, yeast
7g。
4. a kind of hypoglycemic medicine according to claim 1, it is characterised in that：It is made up of following raw materials：Grape 1500g, mountain
Short, bristly hair or beard 240g, honey 100g, barrenwort 15g, Semen Cuscutae 10g, Huangshan Gongju 8g, sophora bud 30g, Fructus Aurantii 5g, leaf of bamboo 4g, yeast 10g.
5. a kind of hypoglycemic medicine according to claim 1, it is characterised in that：Described yeast model F5, LaIVin
71B or LaIVin RA17.
6. a kind of preparation method of hypoglycemic medicine according to claim 1, it is characterised in that：Comprise the steps 1. Portugal
Grape remove seed, hawthorn stoning, grape is crushed, adds into fermentation flask, stirs, 3-4h is placed；2. extracted in fermentation flask
50g liquid, yeast is incorporated in liquid, 20-30min is stood after stirring, and the liquid for adding yeast is added to fermentation flask
Ferment 2-3d；Honey is added, continues the 1-2d that ferments, is filtrated to get cerise liquid；3. by barrenwort, Semen Cuscutae, Huang Shangong
Chrysanthemum, the sophora bud, Fructus Aurantii, the leaf of bamboo are crushed, and the cerise liquid that obtains of step 2. is mixed, and carries out ultrasonic extraction 40-50min, filtering
Obtain dark red liquid；4. the dark red liquid that 3. step obtains is added into simulation aging machine, simulates ageing 12-24h,
Add water alcohol,diluted content and be reduced to 8-12%（V/V）, obtain hypoglycemic medicine.
7. a kind of preparation method of hypoglycemic medicine according to claim 6, it is characterised in that：Described simulation aging machine bag
Include the shell of open-topped tubular（1）, shell（1）Top install top cover（5）, shell（1）Bottom install supporting leg
（2）, shell（1）Bottom install motor（3）, motor（3）Output shaft connect vertical agitating shaft（4）, agitating shaft（4）, stir
Mix axle（4）For hollow, agitating shaft（4）Periphery top several tracheaes are uniformly installed（6）, tracheae（6）With agitating shaft（4）Communicate,
Tracheae（6）Bottom several paddles are installed（7）And branch pipe（8）, branch pipe（8）Positioned at paddle（7）Between, branch pipe（8）With gas
Pipe（6）Connection, branch pipe（8）On open up several stomatas（9）, agitating shaft（4）Top install swivel joint（10）, swivel joint
（10）Connect air inlet pipe（11）.
8. a kind of preparation method of hypoglycemic medicine according to claim 6, it is characterised in that：Described paddle（7）For
Sheet, paddle（7）With tracheae（6）Between angle be 30-60 °.
9. a kind of preparation method of hypoglycemic medicine according to claim 6, it is characterised in that：Also including assistant's step will walk
The rapid medicine 4. obtained adds fining agent, clarifying reaction 1-2h, the hypoglycemic medicine clarified.
10. a kind of preparation method of hypoglycemic medicine according to claim 6, it is characterised in that：Described ultrasonic wave extraction
60 DEG C of middle ultrasonic power 400W, ultrasonic temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710309356.7A CN107260980A (en) | 2017-05-04 | 2017-05-04 | A kind of hypoglycemic medicine and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710309356.7A CN107260980A (en) | 2017-05-04 | 2017-05-04 | A kind of hypoglycemic medicine and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN107260980A true CN107260980A (en) | 2017-10-20 |
Family
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| CN201710309356.7A Pending CN107260980A (en) | 2017-05-04 | 2017-05-04 | A kind of hypoglycemic medicine and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1119543A (en) * | 1995-07-27 | 1996-04-03 | 刘小兵 | Multifunctional nutrient oral liquor |
| CN104544415A (en) * | 2015-01-23 | 2015-04-29 | 安徽大学 | Selenium-enriched blueberry drink and preparation method thereof |
| CN105296313A (en) * | 2015-12-02 | 2016-02-03 | 青岛浩大海洋保健食品有限公司 | Compound and fermented ginseng health drink and production process thereof |
| CN206014920U (en) * | 2016-09-20 | 2017-03-15 | 济宁学院 | Biomass ferment consersion unit |
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2017
- 2017-05-04 CN CN201710309356.7A patent/CN107260980A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1119543A (en) * | 1995-07-27 | 1996-04-03 | 刘小兵 | Multifunctional nutrient oral liquor |
| CN104544415A (en) * | 2015-01-23 | 2015-04-29 | 安徽大学 | Selenium-enriched blueberry drink and preparation method thereof |
| CN105296313A (en) * | 2015-12-02 | 2016-02-03 | 青岛浩大海洋保健食品有限公司 | Compound and fermented ginseng health drink and production process thereof |
| CN206014920U (en) * | 2016-09-20 | 2017-03-15 | 济宁学院 | Biomass ferment consersion unit |
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