CN107260600A - Multiple whitening and spot eliminating cream and preparation method thereof - Google Patents
Multiple whitening and spot eliminating cream and preparation method thereof Download PDFInfo
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- CN107260600A CN107260600A CN201710467388.XA CN201710467388A CN107260600A CN 107260600 A CN107260600 A CN 107260600A CN 201710467388 A CN201710467388 A CN 201710467388A CN 107260600 A CN107260600 A CN 107260600A
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- eliminating cream
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a kind of multiple whitening and spot eliminating cream and preparation method thereof, the multiple whitening and spot eliminating cream whitening spot-removing component is made up of ascorbic acid glucoside, tranexamic acid, 4 methoxysalicylic acid potassium and three flower extracts, and three flower extracts are the mixture of Flos persicae extract, Flos Nelumbinis extract and armour Flos Hibisci extract.Product of the present invention realizes comprehensive, profound, highly effective and safe anti-aging and freckle removing and whitening using plant extract and existing conventional whitening agent such as ascorbic acid glucoside, 4 methoxysalicylic acid potassium, the mode that tranexamic acid, niacinamide are mutually gathered.
Description
【Technical field】
The present invention relates to multiple whitening and spot eliminating cream and preparation method thereof, belong to cosmetic technical field.
【Background technology】
Generally, people mainly judge the age of a people according to the change of other side face.These changes, including form
Change (presence of wrinkle) and the change of tone (presence of color spot).With age, the color spot of face occurs senile
Color spot and chloasma hepaticum.In Japanese pharmaceutical part outer article, cosmeceutical be exactly brag about " by it is sun-proof prevent senile plaque expelling, freckle shape
Into " skin-lightening cosmetic of efficiency effect.Senile color spot is due to that skin is exposed under sunshine and formed, skin-lightening cosmetic
Effective object is exactly senile color spot.With people's nature beautiful to pursuing and the attitude of back to nature, containing natural products into
The cosmetics demand divided increasingly increases, pure natural product cosmetics mainstreaming.The whitening spot-removing class production sold in the market
Product largely can only range light spot product in fact.Because color spot formation mechenism is complicated, the whitening of the market overwhelming majority is caused to be dispelled
Spot class product efficacy is not enough, has quite a few consumer to have no actual effect after.
In ancient times, the effect of beauty is often reached with peach blossom prescription.According to popular legend, the daughter that Wu Tse-tien is most made a pet of is peaceful public
It is main to commonly use this beauty secret recipe, make skin as white as snow, it is smooth soft and moist.Peach blossom is recorded in《Prescriptions for Universal Relief》With promoting blood circulation skin makeup, eliminate
The beauty functions of blackspot, the beauties of A Dream of Red Mansions use the effect for reaching beautifying face and moistering lotion.Ubac princess, Southern Dynasties princess Song Liu Chu
Jade, the title for having the beauty of people of imperial lineage first.Extracting waste shrub althea flower is some, suddenly smashes mud such as, plus cold boiling water stirring, thin,tough silk bag twists juice, and first-class
Whitish honey, which is converted, to be mixed.Summer lotus, absorbs the elite of morning dew, converges the energy of burning sun, produces unlimited vitality, can be flesh
Skin continuously injects new energy and vigor, is for women to reverse the time, keep appearance here, rare anti-ageing beauty treatment
Good merchantable brand.
Modern scientific research shows that peach blossom is rich in kaempferol, carrotene, vitamin, amino acid；Lotus is rich in flavones, ammonia
Base acid, mineral matter, Vc；Shrub althea flower is rich in flavones, anthocyanin, Vc amino acid.Peach blossom, lotus flower, shrub althea flower skim the cream off milk, and three spend foster
Face, promotes collagen to produce, and increases skin elasticity, purifies skin, improves the low and deep colour of skin, more makes skin present after whitening soft
Sliding tender white good state.Midsummer rose of Sharon confusion human society, contains abundant vitamin C, amino acid, crude protein and calcium, magnesium, iron, zinc etc.
Trace element, by strengthening the immunity of skin, improving the health status of skin slows down skin aging.
【The content of the invention】
The invention aims to the defect for overcoming prior art, there is provided a kind of comprehensive, profound, highly effective and safe
Multiple whitening and spot eliminating cream.
It is another object of the present invention in order to provide the preparation method of the multiple whitening and spot eliminating cream.
Multiple whitening and spot eliminating cream, it is characterised in that including following weight percent composition：
A phases：
B phases：
B1 phases：
Propane diols 1.0-10.0%
Sodium Hyaluronate 0.1-1.0%
Xanthan gum 0.1-1.0%
C phases：
Polyacrylamide/polyethyleneglycol diacrylate 0.1-1.0%
D phases：
E phases：
Methylisothiazolinone 0.04-0.12%
Essence 0.01-0.10%.
The multiple whitening and spot eliminating cream of the present invention, it is characterised in that including following weight percent composition：A phases：
B phases：
B1 phases：
Propane diols 2.0%
Sodium Hyaluronate 0.2%
Xanthan gum 0.2%
C phases：
Polyacrylamide/polyethyleneglycol diacrylate 0.5%
D phases：
E phases：
Methylisothiazolinone 0.08%
Essence 0.05%.
Three flower extracts in the present invention are the mixing of Flos persicae extract, Flos Nelumbinis extract and armour Flos Hibisci extract
Thing.
Preferably, 0.1-1wt% containing Flos persicae extract in three flower extracts, Flos Nelumbinis extract 0.1-1wt%, the armour rose of Sharon
Flower extract 0.1-1wt%.The specific each component mass percent of three flower extracts is as follows：
Peach blossom (PRUNUS PERSICA) is rich in kaempferol, carrotene, vitamin, amino acid, with promoting blood circulation skin makeup, disappears
Except effect of blackspot, lotus flower (NELU BIUM SPECIOSUM) is rich in flavones, amino acid, mineral matter and Vc, the armour rose of Sharon
(HIBISCUS MILITARIS) flower is rich in flavones, anthocyanin and Vc amino acid.Flos persicae extract, Flos Nelumbinis extract and wooden a beautiful gem flower
Extract is mixed, promoting blood circulation to remove blood stasis, and three flower extracts can improve skin microcirculation with anti-oxidant, suppress color spot generation, remove skin
Toxin, nutrition skin.Moisturizing smoothing wrinkle, anti-aging, highlights skin.
The present invention (referred to as three spend beauty treatment side) is to the scavenging action of DPPH free radicals as shown in figure 1, three flower beauty treatment sides pair
The IC50 values 0.15% of DPPH 〃 radicals scavengings, and clearance rate gradually increases with the increase of three flower extract concentration,
Under 1.5% concentration, clearance rate reaches about 95%.
Scavenging action of the three flower beauty treatment sides to ABTS free radicals, as shown in Fig. 2 the IC50 that three flower beauty treatment sides are removed to ABTS
Value 0.07%, and under the concentration of three flower extracts about 0.3%, clearance rate reaches 100%.
The white-skinned face function effect of three flower beauty treatment sides is as shown in figure 3, three flower beauty treatment sides suppress the IC50 values of tyrosinase activity
0.8%.
Three flower beauty treatment sides are to the inhibitory action of B-16 melanin as shown in figure 4, three flower beauty treatment sides are in three flower extracts
Under 0.156% concentration, 35.6% is reached to the inhibiting rate that B16 melanin is generated.
Preferably, the addition of three flower extract of the invention is 0.1-8%；Preferably, three flower extract of the invention adds
Dosage is 0.1-6%；Preferably, the addition of three flower extract of the invention is 0.1-4%；Preferably, the flower of the present invention three is extracted
The addition of thing is 0.1-2%；Preferably, the addition of three flower extract of the invention is 1.5-10%；Preferably, the present invention three
The addition of flower extract is 4-10%；Preferably, the addition of three flower extract of the invention is 7-10%.
Ascorbic acid glucoside, 4- methoxysalicylic acid potassium, tranexamic acid, niacinamide, Ta Menshi are also added in the present invention
It is effect target with tyrosinase (TYR).In these whitening hosts, hindering of having can trigger black in melanocyte
The TYR activity that element is produced, also has using UV irradiations and causes melanocyte proliferation factor and inflammatory chemical mediator as the starting point
Whitening host, or even also having is suppressed in melanocyte for the purpose of melanin generation, but to suppress melanin in epidermis
It is dominant mechanism that diffusion and melanin, which are drained,.Ascorbic acid glucoside suppresses the life of melanin by hindering tyrosinase activity
Into：4- methoxysalicylic acids potassium promotes epidermis metabolism；Tranexamic acid anti-inflammatory effect (suppresses PGE2 to produce)；Niacinamide hinders
Melanosome is hindered to be transferred；These raw materials play a role simultaneously, the comprehensive formation for suppressing melanin, so that comprehensive, deep layer
It is secondary, highly effective and safe freckle removing and whitening.
The preparation method of the multiple whitening and spot eliminating cream of the present invention, it is characterised in that comprise the following steps：
(1) A phases each component is added in oil phase pot, stirred after being heated to 85 DEG C；
(2) B phases each component is added in aqueous phase pot, is warming up to 85 DEG C, added pre-dispersed good B1 phases, A phases are slowly taken out
Enter homogeneous 5 minutes in aqueous phase pot, stir, -0.04~-0.1Mpa vacuum heat-preservings 20 minutes, stirring cooling；
(3) when stirring is cooled to 65 DEG C, C phases, homogeneous 3min are added；
(4) when stirring is cooled to 40 DEG C, D, E phase is added, is stirred, 200 mesh filtering and dischargings.
The pH value of the multiple whitening and spot eliminating cream of the present invention is 5.5~7.5.
The present invention is relative to prior art, with advantages below：
Peach blossom in the present invention, lotus flower, shrub althea flower skims the cream off milk, three flower beauty treatments, promotes collagen to produce, increases skin
Elasticity, purifies skin, improves the low and deep colour of skin, more makes skin that soft and smooth tender white good state is presented after whitening, coordinates with tyrosinase
(TYR) it is the ascorbic acid glucoside of effect target, 4- methoxysalicylic acid potassium, tranexamic acid, niacinamide whitening host hinder
The TYR activity that melanin is produced can be triggered in melanocyte, start with from inactive intracellular TYR stability, suppress epidermis
Interior melanin diffusion, by multiple action so as to the safe and efficient effect for reaching whitening spot-removing.
Product of the present invention is using plant extract and existing conventional whitening agent such as ascorbic acid glucoside, 4- methoxysalicylic acids
Potassium, the mode that tranexamic acid, niacinamide are mutually gathered realizes comprehensive, profound, highly effective and safe anti-aging and freckle removing and whitening.
【Brief description of the drawings】
The chart that Fig. 1 influences for the application concentration of three flower extracts on DPPH free radical scavenging activities；
The chart that Fig. 2 influences for the application concentration of three flower extracts on ABTS free radical scavenging activities；
Fig. 3 is activity suppression figure of three flower extracts to tyrosinase；
Fig. 4 is three flower extracts and suppression comparison diagram of the ursin to melanin.
【Embodiment】
With reference to specific embodiment, the invention will be further described, and embodiment 1-3 each component mass percent is matched somebody with somebody
Than as shown in table 1：
Table 1：
Embodiment 1-3 preparation method is as follows：
(1) A phases each component is added in oil phase pot, mutually stirred after being heated to 85 DEG C；
(2), B phases each component is added in aqueous phase pot, 85 DEG C are warming up to, pre-dispersed good B1 phases is added, A phases is slowly taken out
Enter in aqueous phase pot, homogeneous 5 minutes stirs, -0.04~-0.1Mpa vacuum heat-preservings 20 minutes, stirring cooling；
(3) when stirring is cooled to 65 DEG C, C phases, homogeneous 3min are added；
(4) when stirring is cooled to 40 DEG C, D, E phase is added, is stirred, 200 mesh filtering and dischargings.
First, some testing performance indexes are done to embodiment 1-3 products, its test is as follows：
1. outward appearance：White lotion
2.pH values：5.5-7.5
3. heat-resistant stability investigates (48 DEG C × 24h)：It is qualified
4. cold-resistant study on the stability (- 15 DEG C × 24h)：It is qualified
2nd, embodiment properties of product evaluation test is as follows：
1st, skin irritation test：
2.5~3kg healthy rabbits 40 are selected, every rabbit back is symmetrical to select shaving 2.5cm at 202, it is right with itself
Carried out according to test method(s), apply 0.5g products of the present invention every time or bare substrate, twice daily, left side or right side are administered at random, observed
And record the reacting phenomenon of skin after 24h, 72h.
As a result show：Have no that rubefaction, dermexanthesis, water lump etc. are local after product 24h, 72h for applying 1-3 of the embodiment of the present invention
Stimulate the reaction.
2nd, efficacy assessments
90 volunteers are selected, are divided into 3 test control groups, every group of 30 people, group 1 to 3 corresponds to use embodiment respectively
1-3 product, product acts on face, daily morning and evening 1 time, and continuous to use one month, effect recording is in table 2.
Effect is described：
Effect is obvious：Whitening effect is excellent, and skin-tightening is flexible；
There is improvement：Whitening effect is general.
Effect is poor：Skin is varied less substantially.
Table 2：Product clinical test results are as follows:
| Group | Effect is obvious | There is improvement | Effect is poor | Allergic reaction |
| 1 | 10 | 8 | 12 | Nothing |
| 2 | 23 | 6 | 1 | Nothing |
| 3 | 25 | 5 | 0 | Nothing |
Clinical test results show that product of the present invention is real in addition to the amount of effect component in embodiment 1 is few and effect is not notable
The product white-skinned face function for applying example 2 and 3 is notable, while without allergic phenomena.
It can be seen that, the active component contained by many natural plants can be obviously improved skin pigment spot, play light speckles, beautification and white
With the effect of skin-moisturizing, skin.Some plants contain higher tocopherol and flavonoid class, and tocopherols are good antioxidants,
Flavonoids has the ability of very strong elimination free radical, and can promote the ringing of capillary, and can promote capillary
Ringing, these all desalinate color spot, suppress the formation of melanin and have good effect, pass through the comprehensive resistance of multiple approach
The formation of disconnected melanin, so as to reach safe and efficient Whitening, spot effect.
Product of the present invention is by experimental data proportion optimizing, using pure plant extractive technique and existing conventional whitening
The mode that agent is combined, suppresses the modes such as melanin formation or transfer path by multiple approach and reaches that all-position safety is efficient
The purpose of whitening spot-removing.
Claims (4)
1. multiple whitening and spot eliminating cream, it is characterised in that including following weight percent composition：
A phases：
B phases：
B1 phases：
Propane diols 1.0-10.0%
Sodium Hyaluronate 0.1-1.0%
Xanthan gum 0.1-1.0%
C phases：
Polyacrylamide/polyethyleneglycol diacrylate 0.1-1.0%
D phases：
E phases：
Methylisothiazolinone 0.04-0.12%
Essence 0.01-0.10%.
2. multiple whitening and spot eliminating cream according to claim 1, it is characterised in that including following weight percent composition：
A phases：
B phases：
B1 phases：
Propane diols 2.0%
Sodium Hyaluronate 0.2%
Xanthan gum 0.2%
C phases：
Polyacrylamide/polyethyleneglycol diacrylate 0.5%
D phases：
E phases：
Methylisothiazolinone 0.08%
Essence 0.05%.
3. multiple whitening and spot eliminating cream according to claim 1 or 2, it is characterised in that three described flower extracts carry for peach blossom
Take the mixture of thing, Flos Nelumbinis extract and armour Flos Hibisci extract.
4. the preparation method of the multiple whitening and spot eliminating cream described in claim 3, it is characterised in that comprise the following steps：
(1) A phases each component is added in oil phase pot, stirred after being heated to 85 DEG C；
(2) B component is added in aqueous phase pot, is warming up to 85 DEG C, add pre-dispersed good B1 phases, A phases are slowly pumped into aqueous phase pot
In, homogeneous 5 minutes stirs, -0.04~-0.1Mpa vacuum heat-preservings 20 minutes, stirring cooling；
(3) when stirring is cooled to 65 DEG C, C phases, homogeneous 3min are added；
(4) when stirring is cooled to 40 DEG C, D, E phase is added, is stirred, 200 mesh filtering and dischargings.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710467388.XA CN107260600A (en) | 2017-06-20 | 2017-06-20 | Multiple whitening and spot eliminating cream and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710467388.XA CN107260600A (en) | 2017-06-20 | 2017-06-20 | Multiple whitening and spot eliminating cream and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107260600A true CN107260600A (en) | 2017-10-20 |
Family
ID=60068234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710467388.XA Pending CN107260600A (en) | 2017-06-20 | 2017-06-20 | Multiple whitening and spot eliminating cream and preparation method thereof |
Country Status (1)
| Country | Link |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109276529A (en) * | 2018-09-28 | 2019-01-29 | 康美时代（广东）发展有限公司 | A kind of lightening compositions and the whitening lotion comprising the composition |
| CN113662882A (en) * | 2021-10-09 | 2021-11-19 | 上海新高姿化妆品有限公司 | Whitening, spot-fading and tightening essence and preparation method thereof |
-
2017
- 2017-06-20 CN CN201710467388.XA patent/CN107260600A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109276529A (en) * | 2018-09-28 | 2019-01-29 | 康美时代（广东）发展有限公司 | A kind of lightening compositions and the whitening lotion comprising the composition |
| CN113662882A (en) * | 2021-10-09 | 2021-11-19 | 上海新高姿化妆品有限公司 | Whitening, spot-fading and tightening essence and preparation method thereof |
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