CN107233746A - A kind of traditional Chinese medicine extraction crystallization apparatus - Google Patents
A kind of traditional Chinese medicine extraction crystallization apparatus Download PDFInfo
- Publication number
- CN107233746A CN107233746A CN201710587441.XA CN201710587441A CN107233746A CN 107233746 A CN107233746 A CN 107233746A CN 201710587441 A CN201710587441 A CN 201710587441A CN 107233746 A CN107233746 A CN 107233746A
- Authority
- CN
- China
- Prior art keywords
- tank
- heating
- cooling
- crystallizing
- crystallizing tank
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002425 crystallisation Methods 0.000 title claims abstract description 20
- 230000008025 crystallization Effects 0.000 title claims abstract description 20
- 239000003814 drug Substances 0.000 title claims abstract description 19
- 238000000605 extraction Methods 0.000 title claims abstract description 14
- 238000010438 heat treatment Methods 0.000 claims abstract description 51
- 238000001816 cooling Methods 0.000 claims abstract description 49
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000003507 refrigerant Substances 0.000 claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 17
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 17
- 238000007599 discharging Methods 0.000 claims description 18
- 239000007789 gas Substances 0.000 claims description 7
- 239000010410 layer Substances 0.000 claims 5
- 239000011229 interlayer Substances 0.000 claims 1
- 239000013078 crystal Substances 0.000 abstract description 18
- 238000001953 recrystallisation Methods 0.000 abstract description 7
- 238000009833 condensation Methods 0.000 abstract description 3
- 230000005494 condensation Effects 0.000 abstract description 3
- 239000012535 impurity Substances 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 239000002245 particle Substances 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 3
- 239000002699 waste material Substances 0.000 abstract description 3
- 230000012010 growth Effects 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0004—Crystallisation cooling by heat exchange
- B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
Landscapes
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention provides a kind of traditional Chinese medicine extraction crystallization apparatus, including the first heating tank, the first crystallizing tank, the second crystallizing tank；The water that steam in heating tank of the present invention enters in water tank, water tank by condensation can always be recycled as the refrigerant of the first crystallizing tank, save water resource, it is to avoid the waste of water resource；Present invention crystallization is divided into two steps, the first step is crystallization, second step is recrystallization, the refrigerant of first crystallizing tank is water, its cooling rate is slow so that the crystalline particle obtained by decoction is small, and impurity is also smaller, decoction after the first step is crystallized enters the second crystallizing tank, now liquor strength is relatively low, and the refrigerant of the second crystallizing tank is liquid nitrogen, so that decoction cooling rate is accelerated, just recrystallization can be completed, its crystalline rate is high, and the Chinese medicine crystal mass of production is good, and purity is high, epigranular, provides convenient for follow-up preparation process.
Description
Technical field
The present invention relates to Chinese medicine technical field of processing equipment, and in particular to a kind of traditional Chinese medicine extraction crystallization apparatus.
Background technology
During traditional Chinese medicine extraction, in order that its effect can preferably be played by obtaining active component, it usually needs to Chinese medicine
Extraction recrystallization is carried out, in order to which crystal size that the controllability and guarantee that improve crystallization process are obtained is more uniform, crystalline substance is practised more preferable
Or in order to obtain the crystal of specific crystal formation, it usually needs crystal seed is added, the quality of crystal seed is directly related to the matter of crystal
Amount, crystal seed suffers from certain requirement to purity, granularity and addition, and in order to obtain the measured crystal seed of matter, prior art is straight
It is connected on crystallizing tank and ultrasonic transducer is set, the formation of nucleus is stimulated by the disturbance of sound field, the supersaturation of solution is then utilized
The growth spent for crystal provides energy, but after substantial amounts of nucleus is produced, the degree of supersaturation in solution can not be enough
Nucleus provides the crystal growth having in the energy of growth, the growth course that can cause crystal soon, and some crystal growths are slower, make
It is uneven into obtained crystal size, while it is also possible to occurring the phenomenon of crystal caking and coalescence, therefore in growth course
Need that offer is a kind of can to provide the traditional Chinese medicine extraction crystallizer of high-quality crystal seed badly, to ensure to obtain the high crystalline substance of epigranular, purity
Body, is that follow-up Chinese medicine processing technology offers convenience.
The content of the invention
In order to solve problems of the prior art, the invention provides a kind of traditional Chinese medicine extraction crystallization apparatus.
Technical proposal that the invention solves the above-mentioned problems is：A kind of traditional Chinese medicine extraction crystallization apparatus, including the first heating tank,
One crystallizing tank, the second crystallizing tank, the first heating tank are provided with heating tank charging aperture, air inlet and heating tank gas outlet, and first adds
The gas outlet of hot tank is connected with the exhaust tube of vavuum pump, the escape pipe of vavuum pump is connected with the entrance of condenser, and condenser goes out
Mouth is connected with water tank, and the outlet pipe of water tank is connected with the refrigerant inlet of the first crystallizing tank, and the outlet pipe is provided with the 3rd conveying
Pump, the refrigerant exit of the first crystallizing tank is connected with the water inlet pipe of water tank, and the first heating tank is additionally provided with heating tank discharging opening, described to add
Hot tank discharging opening is connected with one end of the first charging line, the first charging of the other end of the first charging line and the first cooling tank
Mouthful it is connected, first charging line is provided with the first delivery pump, first is additionally provided with the first crystallizing tank and enters outlet pipe and the
One discharging opening, first discharging opening is connected with one end of the second charging line, the other end other end of the second charging line with
Second discharging opening of the second cooling tank is connected, and second charging line is provided with the second delivery pump, the second crystallizing tank and also set
There is second to enter outlet pipe, liquid nitrogen entrance and liquid nitrogen outlet；
First is additionally provided with first crystallizing tank and carries brilliant pipeline, first carries brilliant pipeline provided with the first valve, the second crystallizing tank
Brilliant pipeline is carried provided with second, second carries brilliant pipeline provided with the second valve；
Heater is provided with inside first heating tank, the heater includes installed part and two groups of heating components, institute
Stating heating group valency includes connector and some heating plates being uniformly arranged on connector, and the quantity of the heating plate is 4-5
Individual, installed part is connected with heating tank tank bottom, and connector is connected with installed part；
First crystallizing tank, which is provided with the first cooling sandwith layer, the first cooling sandwith layer, is provided with the first cooling coil, and described first is cold
But coil pipe, which spirals, is arranged in the first cooling sandwith layer, and one end of the first cooling coil is connected with refrigerant inlet, the other end and refrigerant
Outlet is connected；
Second crystallizing tank, which is provided with the second cooling sandwith layer, the second cooling sandwith layer, is provided with the second cooling coil, and described second is cold
But coil pipe, which spirals, is arranged in the second cooling sandwith layer, and one end of the second cooling coil is connected with liquid nitrogen entrance, the other end and liquid nitrogen
Outlet is connected.
The present invention has beneficial effect：
The water that steam in heating tank of the present invention enters in water tank, water tank by condensation as the first crystallizing tank refrigerant,
It can always be recycled, save water resource, it is to avoid the waste of water resource；Present invention crystallization is divided into two steps, and the first step is
Crystallization, second step is recrystallization, and the refrigerant of the first crystallizing tank is water, and its cooling rate is slow so that the crystalline particle obtained by decoction
Small, impurity is also smaller, and the decoction after the first step is crystallized enters the second crystallizing tank, and now liquor strength is relatively low, the second crystallization
The refrigerant of tank is liquid nitrogen, so that decoction cooling rate is accelerated, and just can complete recrystallization, and its crystalline rate is high, in production
Medicine crystal mass is good, and purity is high, and epigranular provides convenient for follow-up preparation process.
Brief description of the drawings
Fig. 1 is schematic structural view of the invention；
Fig. 2 is the first cooling sandwith layer structural representation；
Fig. 3 is the second cooling sandwith layer structural representation；
In figure：The heating tanks of 1- first, the crystallizing tanks of 2- first, the crystallizing tanks of 3- second, 4- heating tank charging apertures, 5- air inlets,
6- heating tanks gas outlet, 7- vavuum pumps, 8- exhaust tubes, 9- escape pipes, 10- condensers, 11- water tanks, 12- outlet pipes, 13- refrigerants
Entrance, the delivery pumps of 14- the 3rd, 15- refrigerant exits, 16- water inlet pipes, 17- heating tank discharging openings, the charging lines of 18- first, 19-
First charging aperture, the delivery pumps of 20- first, 21- first enters outlet pipe, the discharging openings of 22- first, the charging lines of 23- second, 24-
Second discharging opening, the delivery pumps of 25- second, 26- second enters outlet pipe, and 27- liquid nitrogen entrances, 28- liquid nitrogen outlet, 29- first is carried
Brilliant pipeline, the valves of 30- first, 31- second carries brilliant pipeline, the valves of 32- second, 33- installed parts, 34- connectors, 35- heating plates,
The cooling sandwith layers of 36- first, the cooling coils of 37- first, the cooling sandwith layers of 38- second, the cooling coils of 39- second.
Embodiment
Below in conjunction with the accompanying drawings and embodiment the present invention is further illustrated.
As illustrated, a kind of traditional Chinese medicine extraction crystallization apparatus, including the first heating tank, the first crystallizing tank, the second crystallizing tank, the
One heating tank is provided with heating tank charging aperture, air inlet and heating tank gas outlet, the heating tank gas outlet of the first heating tank with it is true
The exhaust tube of empty pump is connected, and the escape pipe of vavuum pump is connected with the entrance of condenser, and the outlet of condenser is connected with water tank, water tank
Outlet pipe be connected with the refrigerant inlet of the first crystallizing tank, the outlet pipe be provided with the 3rd delivery pump, the first crystallizing tank it is cold
Matchmaker outlet is connected with the water inlet pipe of water tank, and the first heating tank is additionally provided with heating tank discharging opening, the heating tank discharging opening and first
One end of charging line is connected, and the other end of the first charging line is connected with the first charging aperture of the first cooling tank, and described first
Charging line is provided with the first delivery pump, and first is additionally provided with the first crystallizing tank and enters outlet pipe and the first discharging opening, and described the
One discharging opening is connected with one end of the second charging line, the other end other end of the second charging line and the second of the second cooling tank
Discharging opening is connected, and second charging line is provided with the second delivery pump, be additionally provided with the second crystallizing tank second enter outlet pipe,
Liquid nitrogen entrance and liquid nitrogen outlet；
First is additionally provided with first crystallizing tank and carries brilliant pipeline, first carries brilliant pipeline provided with the first valve, the second crystallizing tank
Brilliant pipeline is carried provided with second, second carries brilliant pipeline provided with the second valve；
Heater is provided with inside first heating tank, the heater includes installed part and two groups of heating components, institute
Stating heating group valency includes connector and some heating plates being uniformly arranged on connector, and the quantity of the heating plate is 4-5
Individual, installed part is connected with heating tank tank bottom, and connector is connected with installed part；
First crystallizing tank, which is provided with the first cooling sandwith layer, the first cooling sandwith layer, is provided with the first cooling coil, and described first is cold
But coil pipe, which spirals, is arranged in the first cooling sandwith layer, and one end of the first cooling coil is connected with refrigerant inlet, the other end and refrigerant
Outlet is connected；
Second crystallizing tank, which is provided with the second cooling sandwith layer, the second cooling sandwith layer, is provided with the second cooling coil, and described second is cold
But coil pipe, which spirals, is arranged in the second cooling sandwith layer, and one end of the second cooling coil is connected with liquid nitrogen entrance, the other end and liquid nitrogen
Outlet is connected.
The water that steam in heating tank of the present invention enters in water tank, water tank by condensation as the first crystallizing tank refrigerant,
It can always be recycled, save water resource, it is to avoid the waste of water resource；Present invention crystallization is divided into two steps, and the first step is
Crystallization, second step is recrystallization, and the refrigerant of the first crystallizing tank is water, and its cooling rate is slow so that the crystalline particle obtained by decoction
Small, impurity is also smaller, and the decoction after the first step is crystallized enters the second crystallizing tank, and now liquor strength is relatively low, the second crystallization
The refrigerant of tank is liquid nitrogen, so that decoction cooling rate is accelerated, and just can complete recrystallization, and its crystalline rate is high, in production
Medicine crystal mass is good, and purity is high, and epigranular provides convenient for follow-up preparation process.
Claims (4)
1. a kind of traditional Chinese medicine extraction crystallization apparatus, it is characterised in that including the first heating tank, the first crystallizing tank, the second crystallizing tank,
One heating tank is provided with heating tank charging aperture, air inlet and heating tank gas outlet, the gas outlet of the first heating tank and vavuum pump
Exhaust tube is connected, and the escape pipe of vavuum pump is connected with the entrance of condenser, and the outlet of condenser is connected with water tank, the water outlet of water tank
Pipe is connected with the refrigerant inlet of the first crystallizing tank, and the outlet pipe is provided with the 3rd delivery pump, the refrigerant exit of the first crystallizing tank
It is connected with the water inlet pipe of water tank, the first heating tank is additionally provided with heating tank discharging opening, the heating tank discharging opening and the first feed pipe
The one end in road is connected, and the other end of the first charging line is connected with the first charging aperture of the first cooling tank, first feed pipe
Road is provided with the first delivery pump, and first is additionally provided with the first crystallizing tank and enters outlet pipe and the first discharging opening, first discharging
Mouth is connected with one end of the second charging line, the other end other end of the second charging line and the second discharging opening of the second cooling tank
It is connected, second charging line is provided with the second delivery pump, is additionally provided with second on the second crystallizing tank and enters outlet pipe, liquid nitrogen
Mouth and liquid nitrogen outlet.
2. a kind of traditional Chinese medicine extraction crystallization apparatus as claimed in claim 1, it is characterised in that be additionally provided with first on the first crystallizing tank
Brilliant pipeline is carried, first carries brilliant pipeline provided with the first valve, and the second crystallizing tank carries brilliant pipeline provided with second, and second carries brilliant pipeline
It is provided with the second valve.
3. a kind of traditional Chinese medicine extraction crystallization apparatus as claimed in claim 1, it is characterised in that provided with heating inside the first heating tank
Device, the heater includes installed part and two groups of heating components, and the heating group valency includes connector and uniformly set
Some heating plates on connector are put, the quantity of the heating plate is 4-5, and installed part is connected with heating tank tank bottom, connection
Part is connected with installed part.
4. a kind of traditional Chinese medicine extraction crystallization apparatus as claimed in claim 1, it is characterised in that the first crystallizing tank is provided with the first cooling
The first cooling coil is provided with interlayer, the first cooling sandwith layer, first cooling coil, which spirals, to be arranged in the first cooling sandwith layer,
One end of first cooling coil is connected with refrigerant inlet, and the other end is connected with refrigerant exit；
Second crystallizing tank, which is provided with the second cooling sandwith layer, the second cooling sandwith layer, is provided with the second cooling coil, second cooler pan
Pipe dish rotation is arranged in the second cooling sandwith layer, and one end of the second cooling coil is connected with liquid nitrogen entrance, and the other end is exported with liquid nitrogen
It is connected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710587441.XA CN107233746A (en) | 2017-07-18 | 2017-07-18 | A kind of traditional Chinese medicine extraction crystallization apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710587441.XA CN107233746A (en) | 2017-07-18 | 2017-07-18 | A kind of traditional Chinese medicine extraction crystallization apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107233746A true CN107233746A (en) | 2017-10-10 |
Family
ID=59990675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710587441.XA Pending CN107233746A (en) | 2017-07-18 | 2017-07-18 | A kind of traditional Chinese medicine extraction crystallization apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107233746A (en) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040147769A1 (en) * | 2002-01-08 | 2004-07-29 | Davis John Henry | Oil extraction process and apparatus therefor |
| US20110061205A1 (en) * | 2008-06-18 | 2011-03-17 | Gea Messo Gmbh | Method and device for continuously producing a crystallite having a constant particle size distribution |
| CN202554955U (en) * | 2012-04-13 | 2012-11-28 | 四川省三星堆制药有限公司 | Closed type Chinese medicine extracting concentration device |
| CN203816269U (en) * | 2014-03-31 | 2014-09-10 | 四川川大华西药业股份有限公司 | Device for extracting traditional Chinese medicine hippophae rhamnoides extract namely total flavones of hippophae rhamnoides |
| CN204093083U (en) * | 2014-10-08 | 2015-01-14 | 富阳思博工业设计有限公司 | A kind of energy-conservation interior external heating type Chinese medicine extracting tank |
| CN204428853U (en) * | 2015-02-03 | 2015-07-01 | 温州正展机械有限公司 | A kind of new medicine concentrator |
| CN106267879A (en) * | 2016-09-20 | 2017-01-04 | 苏州浩波科技股份有限公司 | The most controlled a kind of acesulfame potassium crystallization apparatus |
| CN206121215U (en) * | 2016-09-20 | 2017-04-26 | 苏州浩波科技股份有限公司 | Controllable ann matches sweet crystallization device in succession |
| CN206315290U (en) * | 2016-08-24 | 2017-07-11 | 谢凤妮 | A kind of Chinese medicine extract isolates and purifies system |
| CN206950705U (en) * | 2017-07-18 | 2018-02-02 | 汇森生物设备镇江有限公司 | A kind of traditional Chinese medicine extraction crystallization apparatus |
-
2017
- 2017-07-18 CN CN201710587441.XA patent/CN107233746A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040147769A1 (en) * | 2002-01-08 | 2004-07-29 | Davis John Henry | Oil extraction process and apparatus therefor |
| US20110061205A1 (en) * | 2008-06-18 | 2011-03-17 | Gea Messo Gmbh | Method and device for continuously producing a crystallite having a constant particle size distribution |
| CN202554955U (en) * | 2012-04-13 | 2012-11-28 | 四川省三星堆制药有限公司 | Closed type Chinese medicine extracting concentration device |
| CN203816269U (en) * | 2014-03-31 | 2014-09-10 | 四川川大华西药业股份有限公司 | Device for extracting traditional Chinese medicine hippophae rhamnoides extract namely total flavones of hippophae rhamnoides |
| CN204093083U (en) * | 2014-10-08 | 2015-01-14 | 富阳思博工业设计有限公司 | A kind of energy-conservation interior external heating type Chinese medicine extracting tank |
| CN204428853U (en) * | 2015-02-03 | 2015-07-01 | 温州正展机械有限公司 | A kind of new medicine concentrator |
| CN206315290U (en) * | 2016-08-24 | 2017-07-11 | 谢凤妮 | A kind of Chinese medicine extract isolates and purifies system |
| CN106267879A (en) * | 2016-09-20 | 2017-01-04 | 苏州浩波科技股份有限公司 | The most controlled a kind of acesulfame potassium crystallization apparatus |
| CN206121215U (en) * | 2016-09-20 | 2017-04-26 | 苏州浩波科技股份有限公司 | Controllable ann matches sweet crystallization device in succession |
| CN206950705U (en) * | 2017-07-18 | 2018-02-02 | 汇森生物设备镇江有限公司 | A kind of traditional Chinese medicine extraction crystallization apparatus |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104692575B (en) | Crystallization treatment method and device of high salt wastewater | |
| CN206950705U (en) | A kind of traditional Chinese medicine extraction crystallization apparatus | |
| CN106267879A (en) | The most controlled a kind of acesulfame potassium crystallization apparatus | |
| CN209286707U (en) | Device for evaporative crystallization | |
| CN206666417U (en) | A kind of continuous oscillation stream membrane crystallization device of antierythrite | |
| CN108726578A (en) | Ferrous sulfate continuous crystallisation technique in a kind of production of sulfate process titanium dioxide | |
| CN202155070U (en) | External-circulation evaporation crystallizer | |
| CN107233746A (en) | A kind of traditional Chinese medicine extraction crystallization apparatus | |
| CN206950704U (en) | A kind of concentrator in Chinese medicine preparation process | |
| CN204841004U (en) | Continuous crystallization equipment of phosphate | |
| CN203196371U (en) | Continuous potassium dihydrogen phosphate crystallization device | |
| CN207412792U (en) | A kind of valaciclovir hydrochlordide production crystallizing tank | |
| CN207307241U (en) | A kind of continuous vacuum evaporation crystallizer | |
| US3424221A (en) | Apparatus and method for continuous crystallization by evaporation | |
| CN203989945U (en) | A kind of continuous crystalizer | |
| CN104587699B (en) | A kind of glucose decrease temperature crystalline equipment and glucose decrease temperature crystalline technique | |
| CN206980161U (en) | A kind of chemical industry highly effective and safe crystallization apparatus | |
| CN106040028B (en) | Molasses heat dilution control system automatically | |
| CN106040027B (en) | Molasses heat dilution device | |
| US2587293A (en) | Sugar crystallizing process | |
| CN109045745A (en) | A kind of band promotes the continuous vacuum equipment of crystallisation by cooling of water conservancy diversion | |
| CN206103397U (en) | Adipic acid purification crystallization device | |
| CN205235452U (en) | Crystallization kettle | |
| CN202410227U (en) | Continuous type crystallizing system | |
| CN2915834Y (en) | Crystallizer for salt cake separation using freeze method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171010 |