CN107227507B - Polylactide and poly (glycolide-lactide) composite fibre, preparation method, purposes and operation suture thread - Google Patents
Polylactide and poly (glycolide-lactide) composite fibre, preparation method, purposes and operation suture thread Download PDFInfo
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- CN107227507B CN107227507B CN201710359279.6A CN201710359279A CN107227507B CN 107227507 B CN107227507 B CN 107227507B CN 201710359279 A CN201710359279 A CN 201710359279A CN 107227507 B CN107227507 B CN 107227507B
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
- D01F8/14—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one polyester as constituent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/28—Formation of filaments, threads, or the like while mixing different spinning solutions or melts during the spinning operation; Spinnerette packs therefor
- D01D5/30—Conjugate filaments; Spinnerette packs therefor
- D01D5/34—Core-skin structure; Spinnerette packs therefor
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/44—Yarns or threads characterised by the purpose for which they are designed
- D02G3/448—Yarns or threads for use in medical applications
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- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2331/00—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products
- D10B2331/04—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products polyesters, e.g. polyethylene terephthalate [PET]
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- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2509/00—Medical; Hygiene
- D10B2509/04—Sutures
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- Textile Engineering (AREA)
- Mechanical Engineering (AREA)
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- Animal Behavior & Ethology (AREA)
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- Artificial Filaments (AREA)
Abstract
The invention discloses a kind of polylactides and poly (glycolide-lactide) composite fibre, preparation method, purposes and operation suture thread.The composite fibre includes polylactide fiber, poly (glycolide-lactide) composite fibre, and after forming composite fibre, polylactide fiber is the sandwich layer of composite fibre, and poly (glycolide-lactide) is the cortex of composite fibre.Calcium preparation method includes: the slice of the slice and poly (glycolide-lactide) that obtain polylactide respectively；Composite spinning is carried out for polylactide slice and polyglycolide slice, so that polylactide is in the sandwich layer of composite fibre, and poly (glycolide-lactide) wraps the cortex that polylactide forms composite fibre, obtains polylactide and poly- second hands over propyl ester composite fibre.The composite fibre can be used in operation suture thread.The operation suture thread is prepared via the composite fibre.The value range of the tensile strength of the composite fibre is 4.0~4.2CN/dtex, and the value range 20%~29% of elongation at break can satisfy the requirement of operation suture thread, meanwhile, it is cheap.
Description
Technical field
The present invention relates to composite fibre technology fields, more particularly to a kind of polylactide and the compound fibre of poly (glycolide-lactide)
Dimension, preparation method, purposes and operation suture thread.
Background technique
Polylactide is also polylactic acid, there is a hydroxyl and a carboxyl, multiple lactic acid molecules in single lactic acid molecules
Together ,-COOH the dehydrating condensation of-OH and other molecule ,-OH the dehydrating condensation of-COOH and other molecule, like this, they
Polymer is formd hand in hand, is called polylactic acid i.e. polylactide.Polylactide is obtained with the main polymerizable raw material of lactic acid
Polymer, raw material sources are abundant and can regenerate.The production process of polylactide is pollution-free, and product biological can drop
Solution, realizes circulation in nature, therefore be ideal Green Polymer Material.Poly (glycolide-lactide) is handed over by glycolide, third
Ester is by different ratio copolymerization gained, with good biocompatibility, and has to human body without prevention reaction and good drop
Xie Xing, catabolite CO2And H2O, it is especially suitable for the suture of internal wound, such as liver, spleen, stomach anastomosis operation, woman
Obstetrics, fascia suture and plastic surgery, ophthalmology, microsurgery and department of general surgery etc..
In the prior art, for the poly (glycolide-lactide) of operation suture thread due to micro- expensive, clinically, it is difficult to quilt
Ordinary consumer receives, and therefore, limits its extensive use.
Summary of the invention
In view of this, the present invention provides a kind of polylactides and poly (glycolide-lactide) composite fibre, preparation method, purposes
And operation suture thread, the cost of operation suture thread obtained can be made to reduce, can be improved the operation containing poly (glycolide-lactide)
The application range of suture, thus more suitable for practical.
In order to reach above-mentioned first purpose, the technology of polylactide provided by the invention and poly (glycolide-lactide) composite fibre
Scheme is as follows:
Polylactide provided by the invention and poly (glycolide-lactide) composite fibre include that polylactide fiber, poly (glycolide-lactide) are multiple
Condensating fiber,
After forming the composite fibre, the polylactide fiber is the sandwich layer of the composite fibre, and the poly- second third is handed over
Ester fiber is the cortex of the composite fibre.
It is further real that following technical measures also can be used in polylactide provided by the invention and poly (glycolide-lactide) composite fibre
It is existing.
Preferably, the value range of the ratio of the cross-sectional area of the cross-sectional area of the sandwich layer and the cortex are as follows: (50
~70): (30~50).
Preferably, the sandwich layer and the cortex are concentric type structure from the cross section of the composite fibre.
Preferably, the value range of the tensile strength of the polylactide and poly (glycolide-lactide) composite fibre is 4.0CN/
The value range 20% of the elongation at break of dtex~4.2CN/dtex, the polylactide and poly (glycolide-lactide) composite fibre~
29%.
In order to reach above-mentioned second purpose, the preparation of polylactide provided by the invention and poly (glycolide-lactide) composite fibre
The technical solution of method is as follows:
The preparation method of polylactide provided by the invention and poly (glycolide-lactide) composite fibre the following steps are included:
The slice of the polylactide and the slice of the poly (glycolide-lactide) are obtained respectively；
Composite spinning is carried out for polylactide slice and polyglycolide slice, so that the polylactide is in institute
The sandwich layer of composite fibre is stated, and the poly (glycolide-lactide) wraps the cortex that the polylactide forms the composite fibre, obtains
Propyl ester composite fibre is handed over to the polylactide and poly- second.
The preparation method of polylactide provided by the invention and poly (glycolide-lactide) composite fibre also can be used following technology and arrange
It applies and further realizes.
Preferably, the method for obtaining polylactide slice the following steps are included:
The value range for choosing relative molecular mass is in 100,000~120,000 commercially available polylactide；
The commercially available polylactide obtains the polylactide slice, wherein the vacuum drying after vacuum drying
The value range of temperature be 105 DEG C~120 DEG C, the value range of the vacuum drying duration is 6h~8h.
Preferably, it is described obtain poly (glycolide-lactide) slice method the following steps are included:
Be (90~92) by the mass ratio of the material: the glycolide of (8~10), L- lactide account for total monomer the mass ratio of the material and are
0.01%~0.015% stannous octoate accounts for the laruyl alcohol that total monomer the mass ratio of the material is 0.01%~0.015% and is added to poly-
It closes in reaction kettle；
Close the polymerization reaction kettle；
After vacuumizing for the closed polymerization reaction kettle, N is passed through into the polymerization reaction kettle of vacuum2, so recycle 3
~5 times, each duration is 30min~35min, obtains the polymerization reaction kettle of reaction environment cleaning；
The polymerization reaction kettle of the reaction environment cleaning is heated and stirs, so that the temperature in the polymerization reaction kettle increases
To 160 DEG C~165 DEG C, and continue 40min~50min, obtains the first intermediate product；
The temperature of first intermediate product is set to be increased to 230 DEG C~235 DEG C with 5 DEG C/5min~8 DEG C/5min speed,
Obtain the second intermediate product；
When the intrinsic viscosity of second intermediate product reaches 1.6 ± 0.2dg/dL, the reaction of polymerization reaction kettle is terminated；
N is filled with into the polymerization reaction kettle for terminated reaction2Afterwards, second intermediate product is squeezed out；
Second intermediate product after extrusion successively through supercooling, pelletizing, drying, slice, the Vacuum Package the step of after,
The slice of the poly (glycolide-lactide) is made, wherein the operating environment of the step of the drying are as follows: the value range of temperature is 30 DEG C
~35 DEG C, the value range of dry duration is for 24 hours~36h.
Preferably, the process for carrying out composite spinning for polylactide slice and polyglycolide slice uses
Spin-draw one-step method realizes that the value range of draw ratio is 5 times~6 times.
Preferably, the process conditions for carrying out composite spinning for polylactide slice and polyglycolide slice
Include:
For the sandwich layer:
The temperature value range of component is 205 DEG C~216 DEG C,
The value range of screw pressure is 9.8MPa~10.5MPa,
The value range of spinning speed is 200m/min~400m/min；
For the cortex:
The temperature value range of component is 220 DEG C~240 DEG C,
The value range of screw pressure is 8.0MPa~9.0MPa,
The value range of spinning speed is 200m/min~400m/min；
The type of cooling is cooling for air, and blowing mode uses cross air blasting, and the value range for rate of drying is 3m/min~5m/
min。
Preferably, the method for the intrinsic viscosity of measurement second intermediate product the following steps are included:
Mass ratio is configured to solvent for 1: 1 phenol and tetrachloroethanes；
Second intermediate product is added in the solvent, being configured to the second intermediates content is 0.1g/dL's
Solution；
Under the conditions of 25 DEG C, the intrinsic viscosity of second intermediate product is measured using ubbelohde viscosity agent.
Polylactide provided by the invention and poly (glycolide-lactide) composite fibre can be used in the purposes of operation suture thread.
Operation suture thread provided by the invention polylactide provided by the present invention and poly (glycolide-lactide) composite fibre system
At.
The polylactide and poly (glycolide-lactide) composite fibre being worth using preparation method provided by the invention stretch intensity
Value range is 4.0~4.2CN/dtex, and the value range 20%~29% of elongation at break can satisfy operation suture thread
It is required that therefore, the polylactide and poly (glycolide-lactide) composite fibre can be used in operation suture thread, which can be by
The polylactide is made with poly (glycolide-lactide) composite fibre.
Detailed description of the invention
By reading the following detailed description of the preferred embodiment, various other advantages and benefits are common for this field
Technical staff will become clear.The drawings are only for the purpose of illustrating a preferred embodiment, and is not considered as to the present invention
Limitation.And throughout the drawings, the same reference numbers will be used to refer to the same parts.In the accompanying drawings:
Fig. 1 is the structural representation of the cross section of polylactide provided in an embodiment of the present invention and poly (glycolide-lactide) composite fibre
Figure；
The step of Fig. 2 is the preparation method of polylactide provided in an embodiment of the present invention and poly (glycolide-lactide) composite fibre is flowed
Cheng Tu.
Specific embodiment
The present invention in order to solve the problems existing in the prior art, provide a kind of polylactide and poly (glycolide-lactide) composite fibre,
Preparation method, purposes and operation suture thread can be such that the cost of operation suture thread obtained reduces, can be improved containing poly-
The application range of the operation suture thread of second lactide, thus more suitable for practical.
It is of the invention to reach the technical means and efficacy that predetermined goal of the invention is taken further to illustrate, below in conjunction with
Attached drawing and preferred embodiment, to polylactide proposed according to the present invention and poly (glycolide-lactide) composite fibre, preparation method, use
Way and operation suture thread, specific embodiment, structure, feature and its effect, detailed description is as follows.In the following description, no
What same " embodiment " or " embodiment " referred to is not necessarily the same embodiment.In addition, the specific spy in one or more embodiments
Sign, structure or feature can be combined by any suitable form.
The terms "and/or", only a kind of incidence relation for describing affiliated partner, indicates that there may be three kinds of passes
System, it is specific to understand for example, A and/or B are as follows: it can simultaneously include A and B, can be with individualism A, it can also be with individualism
B can have above-mentioned three kinds of any case.
Referring to attached drawing 1, polylactide provided by the invention and poly (glycolide-lactide) composite fibre include polylactide fiber, gather
Second lactide composite fibre.After forming composite fibre, polylactide fiber is the sandwich layer 1 of composite fibre, poly (glycolide-lactide) fiber
For the cortex 2 of composite fibre.
Wherein, the value range of the ratio of the cross-sectional area of the cross-sectional area of sandwich layer 1 and cortex 2 are as follows: (50~70): (30
~50).It can keep the main mechanical properties and biodegradability of poly (glycolide-lactide) fiber substantially, and can reduce poly- second
The cost of lactide.
Wherein, from the cross section of composite fibre, sandwich layer 1 and cortex 2 are concentric type structure.In this case, by
In composite fibre isotropism, thereby it is ensured that the tensile strength of the composite fibre all directions and elongation at break uniformly,
Unanimously, it is unlikely to cause composite fibre to be broken due to different from by the contact angle between contactant.
Wherein, the value range of the tensile strength of polylactide and poly (glycolide-lactide) composite fibre be 4.0CN/dtex~
The value range 20%~29% of the elongation at break of 4.2CN/dtex, polylactide and poly (glycolide-lactide) composite fibre.
Referring to attached drawing 2, the preparation method of polylactide provided by the invention and poly (glycolide-lactide) composite fibre includes following
Step:
Step 1: obtaining the slice of polylactide and the slice of poly (glycolide-lactide) respectively；
Step 2: composite spinning is carried out for polylactide slice and polyglycolide slice, so that polylactide is in compound
The sandwich layer of fiber, and poly (glycolide-lactide) wraps the cortex that polylactide forms composite fibre, obtains polylactide and poly- second is handed over
Propyl ester composite fibre.
Wherein, in step 1, obtain polylactide slice method the following steps are included:
Step 1011: the value range for choosing relative molecular mass is in 100,000~120,000 commercially available polylactide；
Step 1012: commercially available polylactide obtains polylactide slice, wherein vacuum drying after vacuum drying
The value range of temperature is 105 DEG C~120 DEG C, and the value range of vacuum drying duration is 6h~8h.Wherein, vacuum is dry
When the value range of dry duration is 6h~8h, the moisture removal in polymer can be fallen, to prevent in spinning
Cause pyrohydrolysis in journey, its mechanical property is avoided to be lowered.
Wherein, in step 1, obtain the method for the slice of poly (glycolide-lactide) the following steps are included:
Step 1021: be (90~92) by the mass ratio of the material: the glycolide of (8~10), accounts for total monomer substance at L- lactide
Amount than for 0.01%~0.015% stannous octoate, account for the laruyl alcohol that total monomer the mass ratio of the material is 0.01%~0.015%
It is added into polymerization reaction kettle；
Step 1022: closing polymerization reaction kettle；
Step 1023: after vacuumizing for closed polymerization reaction kettle, being passed through N into the polymerization reaction kettle of vacuum2, so
Circulation 3~5 times, each duration are 30min~35min, obtain the polymerization reaction kettle of reaction environment cleaning；
Step 1024: the polymerization reaction kettle of environment cleaning is heated and be stirred to react, so that the temperature liter in polymerization reaction kettle
Up to 160 DEG C~165 DEG C, and continue 40min~50min, obtain the first intermediate product；
Step 1025: with 5 DEG C/5min~8 DEG C/5min speed make the first intermediate product temperature be increased to 230 DEG C~
235 DEG C, obtain the second intermediate product；
Step 1026: when the intrinsic viscosity of the second intermediate product reaches 1.6 ± 0.2dg/dL, terminating polymerization reaction kettle
Reaction；
Step 1027: N is filled with into the polymerization reaction kettle for terminated reaction2Afterwards, the second intermediate product is squeezed out；
Step 1028: the second intermediate product after extrusion successively through supercooling, pelletizing, drying, slice, Vacuum Package step
After rapid, the slice of poly (glycolide-lactide) being made, wherein the operating environment of dry step are as follows: the value range of temperature is 30 DEG C~
35 DEG C, the value range of dry duration is for 24 hours~36h.Wherein, the value range of vacuum drying duration is for 24 hours
When~36h, the moisture removal in polymer can be fallen, to prevent from causing pyrohydrolysis during the spinning process, avoid its power
Performance is learned to be lowered.
Wherein, the process for carrying out composite spinning for polylactide slice and polyglycolide slice uses spin-draw one
Footwork realizes that the value range of draw ratio is 5 times~6 times.
Wherein, include: for the process conditions of polylactide slice and polyglycolide slice progress composite spinning
For sandwich layer:
The temperature value range of component is 205 DEG C~216 DEG C,
The value range of screw pressure is 9.8MPa~10.5MPa,
The value range of spinning speed is 200m/min~400m/min；
For cortex:
The temperature value range of component is 220 DEG C~240 DEG C,
The value range of screw pressure is 8.0MPa~9.0MPa,
The value range of spinning speed is 200m/min~400m/min；
The type of cooling is cooling for air, and blowing mode uses cross air blasting, and the value range for rate of drying is 3m/min~5m/
min。
Wherein, in step 1026, measure the second intermediate product intrinsic viscosity method the following steps are included:
Step 10261: mass ratio is configured to solvent for 1: 1 phenol and tetrachloroethanes；
Step 10262: the second intermediate product being added in solvent, being configured to the second intermediates content is 0.1g/dL
Solution；
Step 10263: under the conditions of 25 DEG C, the intrinsic viscosity of the second intermediate product is measured using ubbelohde viscosity agent.
Polylactide provided by the invention and poly (glycolide-lactide) composite fibre can be used in the purposes of operation suture thread.
Operation suture thread provided by the invention polylactide provided by the present invention and poly (glycolide-lactide) composite fibre system
At.
The polylactide and poly (glycolide-lactide) composite fibre being worth using preparation method provided by the invention stretch intensity
Value range is 4.0~4.2CN/dtex, and the value range 20%~29% of elongation at break can satisfy operation suture thread
It is required that therefore, the polylactide and poly (glycolide-lactide) composite fibre can be used in operation suture thread, which can be by
The polylactide is made with poly (glycolide-lactide) composite fibre.
Embodiment 1
The section of cortex and sandwich layer (using poly (glycolide-lactide) as the skin of composite fibre, using polylactide as the core of composite fibre)
Product area ratio is 70:30, spare poly (glycolide-lactide)/polylactide is dried in vacuo respectively, poly (glycolide-lactide) is 35
Be dried in vacuo 26 hours at DEG C, polylactide chip drying condition are as follows: be dried in vacuo 8 hours at 105 DEG C.Vacuum degree-
0.09MPa, composite fibre use spin-draw one-step method, draw ratio be 5 times.Filament number is 2.2-2.5dtex
(100D/48f).Spinning process condition are as follows: sandwich layer component temperature range is 205-216 DEG C, screw pressure 9.8MPa, spinning speed
Degree is 240m/min, and cortex component temperature range is 220-240 DEG C, screw pressure 8.0MPa, spinning speed 240m/min,
Air is cooling, and side-blown airspeed is 3m/min, and poly (glycolide-lactide)/polylactide composite fibre can be obtained.
Poly (glycolide-lactide)/polylactide composite fibre performance parameter are as follows: tensile strength reaches 4.2CN/dtex, and fracture is stretched
Long 25%, good hand touch, more at low cost than PGLA 30%, also it is able to satisfy the requirement of operation suture thread.
Embodiment 2~20
Although preferred embodiments of the present invention have been described, it is created once a person skilled in the art knows basic
Property concept, then additional changes and modifications may be made to these embodiments.So it includes excellent that the following claims are intended to be interpreted as
It selects embodiment and falls into all change and modification of the scope of the invention.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
Mind and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to include these modifications and variations.
Claims (11)
1. the preparation method of a kind of polylactide and poly (glycolide-lactide) composite fibre, which comprises the following steps:
The slice of the polylactide and the slice of the poly (glycolide-lactide) are obtained respectively；
Composite spinning is carried out for polylactide slice and polyglycolide slice, so that the polylactide is in described multiple
The sandwich layer of condensating fiber, and the poly (glycolide-lactide) wraps the cortex that the polylactide forms the composite fibre, obtains institute
It states polylactide and poly- second hands over propyl ester composite fibre；
The method for obtaining polylactide slice the following steps are included:
The value range for choosing relative molecular mass is in 100,000~120,000 commercially available polylactide；
The commercially available polylactide obtains the polylactide slice, wherein the vacuum drying temperature after vacuum drying
The value range of degree is 105 DEG C~120 DEG C, and the value range of the vacuum drying duration is 6h~8h.
2. the preparation method of polylactide according to claim 1 and poly (glycolide-lactide) composite fibre, which is characterized in that institute
It states polylactide and poly (glycolide-lactide) composite fibre includes polylactide fiber, poly (glycolide-lactide) composite fibre,
After forming the composite fibre, the polylactide fiber is the sandwich layer of the composite fibre, and the poly (glycolide-lactide) is fine
Dimension is the cortex of the composite fibre.
3. the preparation method of polylactide according to claim 2 and poly (glycolide-lactide) composite fibre, which is characterized in that institute
State the value range of the ratio of the cross-sectional area of sandwich layer and the cross-sectional area of the cortex are as follows: (50~70): (30~50).
4. the preparation method of polylactide according to claim 2 and poly (glycolide-lactide) composite fibre, which is characterized in that from
The cross section of the composite fibre is observed, and the sandwich layer and the cortex are concentric type structure.
5. the preparation method of polylactide according to claim 2 and poly (glycolide-lactide) composite fibre, which is characterized in that institute
The value range for stating the tensile strength of polylactide and poly (glycolide-lactide) composite fibre is 4.0c N/dtex~4.2c N/dtex,
The value range 20%~29% of the elongation at break of the polylactide and poly (glycolide-lactide) composite fibre.
6. the preparation method of polylactide according to claim 1 and poly (glycolide-lactide) composite fibre, which is characterized in that institute
State obtain poly (glycolide-lactide) slice method the following steps are included:
Be (90~92) by the mass ratio of the material: the glycolide of (8~10), L- lactide account for total monomer the mass ratio of the material and are
0.01%~0.015% stannous octoate accounts for the laruyl alcohol that total monomer the mass ratio of the material is 0.01%~0.015% and is added to poly-
It closes in reaction kettle；
Close the polymerization reaction kettle；
After vacuumizing for the closed polymerization reaction kettle, N is passed through into the polymerization reaction kettle of vacuum2, so recycle 3~5
Secondary, each duration is 30min~35min, obtains the polymerization reaction kettle of reaction environment cleaning；
The polymerization reaction kettle for heating and stirring the reaction environment cleaning, so that the temperature in the polymerization reaction kettle is increased to
160 DEG C~165 DEG C, and continue 40min~50min, obtain the first intermediate product；
So that the temperature of first intermediate product is increased to 230 DEG C~235 DEG C with 5 DEG C/5min~8 DEG C/5min speed, obtains
Second intermediate product；
When the intrinsic viscosity of second intermediate product reaches 1.6 ± 0.2dg/dL, the reaction of polymerization reaction kettle is terminated；
N is filled with into the polymerization reaction kettle for terminated reaction2Afterwards, second intermediate product is squeezed out；
Second intermediate product after extrusion successively through supercooling, pelletizing, drying, slice, the Vacuum Package the step of after, be made
The slice of the poly (glycolide-lactide), wherein the operating environment of the step of the drying are as follows: the value range of temperature is 30 DEG C~35
DEG C, the value range of dry duration is for 24 hours~36h.
7. the preparation method of polylactide according to claim 1 and poly (glycolide-lactide) composite fibre, which is characterized in that institute
It is real using spin-draw one-step method to state the process for carrying out composite spinning for polylactide slice and polyglycolide slice
Existing, the value range of draw ratio is 5 times~6 times.
8. the preparation method of polylactide according to claim 7 and poly (glycolide-lactide) composite fibre, which is characterized in that institute
Stating the process conditions for carrying out composite spinning for polylactide slice and polyglycolide slice includes:
For the sandwich layer:
The temperature value range of component is 205 DEG C~216 DEG C,
The value range of screw pressure is 9.8MPa~10.5MPa,
The value range of spinning speed is 200m/min~400m/min；
For the cortex:
The temperature value range of component is 220 DEG C~240 DEG C,
The value range of screw pressure is 8.0MPa~9.0MPa,
The value range of spinning speed is 200m/min~400m/min；
The type of cooling is cooling for air, and blowing mode uses cross air blasting, and the value range for rate of drying is 3m/min~5m/min.
9. the preparation method of polylactide according to claim 6 and poly (glycolide-lactide) composite fibre, which is characterized in that survey
The method of the intrinsic viscosity of fixed second intermediate product the following steps are included:
Mass ratio is configured to solvent for 1: 1 phenol and tetrachloroethanes；
Second intermediate product is added in the solvent, the solution that the second intermediates content is 0.1g/dL is configured to；
Under the conditions of 25 DEG C, the intrinsic viscosity of second intermediate product is measured using ubbelohde viscosity agent.
10. any polylactide and poly (glycolide-lactide) composite fibre are used for the use of operation suture thread in claim 1~9
On the way.
11. a kind of operation suture thread, which is characterized in that handed over by the polylactide any in claim 1~9 with poly- second third
Ester composite fibre is made.
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| CN109234843B (en) * | 2018-07-10 | 2021-07-06 | 中国纺织科学研究院有限公司 | Polylactide and poly (p-dioxanone) composite fiber, preparation method and application thereof and surgical suture |
| CN110552082A (en) * | 2019-09-11 | 2019-12-10 | 中国纺织科学研究院有限公司 | colored polylactide and polycaprolactone composite fiber and preparation method thereof |
| CN111926409A (en) * | 2020-07-06 | 2020-11-13 | 中国纺织科学研究院有限公司 | Preparation method, application and suture line of purple poly (glycolide-lactide) master batch and fiber |
| CN111945247A (en) * | 2020-07-06 | 2020-11-17 | 中国纺织科学研究院有限公司 | Purple bright and clean polylactide and poly (glycolide-lactide) composite fiber, preparation method and application thereof and surgical suture |
| CN111979625A (en) * | 2020-08-25 | 2020-11-24 | 湖南尚珂伊针纺有限公司 | Chemical fiber composite fiber and processing method thereof |
| CN114177343A (en) * | 2021-11-12 | 2022-03-15 | 长春圣博玛生物材料有限公司 | Suture, preparation method and medical braided fabric |
| CN115110177A (en) * | 2022-07-28 | 2022-09-27 | 陈凌卉 | Polylactic acid-based antibacterial polyester gauze and preparation method and application thereof |
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