CN107653516B - Poly (glycolide-lactide-co-glycolide-co-trimethylene carbonate) composite fiber, preparation method thereof, application thereof and surgical suture - Google Patents
Poly (glycolide-lactide-co-glycolide-co-trimethylene carbonate) composite fiber, preparation method thereof, application thereof and surgical suture Download PDFInfo
- Publication number
- CN107653516B CN107653516B CN201710915226.8A CN201710915226A CN107653516B CN 107653516 B CN107653516 B CN 107653516B CN 201710915226 A CN201710915226 A CN 201710915226A CN 107653516 B CN107653516 B CN 107653516B
- Authority
- CN
- China
- Prior art keywords
- glycolide
- poly
- lactide
- trimethylene carbonate
- composite fiber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
- D01F8/14—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one polyester as constituent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/105—Polyesters not covered by A61L17/12
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/28—Formation of filaments, threads, or the like while mixing different spinning solutions or melts during the spinning operation; Spinnerette packs therefor
- D01D5/30—Conjugate filaments; Spinnerette packs therefor
- D01D5/34—Core-skin structure; Spinnerette packs therefor
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Textile Engineering (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Mechanical Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a poly (lactide-co-glycolide) and glycolide-trimethylene carbonate copolymer composite fiber, a preparation method and application thereof and an operation suture. The composite fiber comprises glycolide-trimethylene carbonate copolymer and poly (lactide-co-glycolide) composite fiber, wherein after the composite fiber is formed, the poly (lactide-co-glycolide) fiber is a core layer of the composite fiber, and the glycolide-trimethylene carbonate copolymer is a skin layer of the composite fiber. The preparation method comprises the following steps: respectively obtaining glycolide-trimethylene carbonate copolymer slices and poly (glycolide-lactide) slices; and performing composite spinning on the slices to enable the poly (lactide-co-glycolide) to be positioned in a core layer of the composite fiber, and the poly (lactide-co-trimethylene carbonate) copolymer wraps the poly (lactide-co-glycolide) to form a skin layer of the composite fiber, so as to obtain the copolymer composite fiber. The composite fiber can be used for surgical suture. The surgical suture is prepared by the composite fiber. The composite fiber can meet the requirement of an operation suture line and has low manufacturing cost.
Description
Technical Field
The invention relates to the technical field of composite fibers, in particular to a poly (lactide-co-glycolide) and glycolide-trimethylene carbonate copolymer composite fiber, a preparation method, an application and an operation suture line thereof.
Background
The production process of the polylactide polymer is pollution-free, and the product can be biodegraded to realize the circulation in nature, so the polylactide polymer is an ideal green polymer material. The poly (glycolide-CO-lactide) (PGLA) is prepared by copolymerizing glycolide and lactide according to different proportions, has good biocompatibility, no inhibition reaction on human body and good degradability, and the degradation product is CO2And H2O, particularly suitable for suturing wounds in vivo, such as liver, spleen, gastrointestinal anastomosis, obstetrics and gynecology, fascia suture and plastic surgery, ophthalmology, microsurgery and general surgery, has been widely used as a surgical suture in daily operations, and also in various drug systems for resisting cancer, diminishing inflammation, promoting tissue regeneration and the like.
In the prior art, the degradation time of the poly (glycolide-lactide) used for the biodegradable material is short, and clinically, the long growth time is needed for the operation composition of a plurality of muscle tissues, and the traditional poly (glycolide-lactide) suture line cannot meet the requirements, so that the wide application of the poly (glycolide-lactide) suture line is limited. On the other hand, the glycolide-trimethylene carbonate copolymer surgical suture commonly used in the market at present has a long degradation time, but the price of the fiber is expensive, which greatly increases the treatment cost of patients.
Disclosure of Invention
In view of this, the present invention provides a poly (glycolide-co-trimethylene carbonate) composite fiber, a preparation method, a use thereof, and a surgical suture, which can reduce the cost of the prepared surgical suture, and can increase the application range of the surgical suture containing poly (glycolide-co-glycolide), thereby being more practical.
In order to achieve the first object, the technical scheme of the poly (glycolide-co-trimethylene carbonate) composite fiber provided by the invention is as follows:
the poly (lactide-co-glycolide) and glycolide-trimethylene carbonate copolymer composite fiber provided by the invention comprises poly (lactide-co-glycolide) fiber and glycolide-trimethylene carbonate copolymer fiber,
after the composite fiber is formed, the poly (lactide-co-glycolide) fiber is a core layer of the composite fiber, and the poly (glycolide-co-trimethylene carbonate) fiber is a skin layer of the composite fiber.
The poly (glycolide-co-lactide) and glycolide-trimethylene carbonate copolymer composite fiber provided by the invention can be further realized by adopting the following technical measures.
Preferably, the ratio of the cross-sectional area of the core layer to the cross-sectional area of the skin layer has a value range of: (15-50) and (85-50).
Preferably, the core layer and the skin layer have a concentric structure when viewed in a cross section of the composite fiber.
Preferably, the tensile strength of the poly (glycolide-co-trimethylene carbonate) composite fiber ranges from 4.4CN/dtex to 4.6CN/dtex, and the elongation at break of the poly (glycolide-co-trimethylene carbonate) composite fiber ranges from 22% to 27%.
In order to achieve the second object, the technical scheme of the preparation method of the poly (glycolide-co-trimethylene carbonate) composite fiber provided by the invention is as follows:
the preparation method of the poly (glycolide-co-lactide) and glycolide-trimethylene carbonate copolymer composite fiber provided by the invention comprises the following steps:
respectively obtaining the section of the poly (glycolide-co-trimethylene carbonate) and the section of the glycolide-co-trimethylene carbonate;
and carrying out composite spinning on the poly (lactide-co-glycolide) slices and the glycolide-trimethylene carbonate copolymer slices, so that the poly (lactide-co-glycolide) is positioned in a core layer of the composite fiber, and the poly (lactide-co-trimethylene carbonate) covers the poly (lactide-co-glycolide) to form a skin layer of the composite fiber, thereby obtaining the poly (lactide-co-glycolide) -trimethylene carbonate copolymer composite fiber.
The preparation method of the poly (glycolide-co-lactide) and glycolide-trimethylene carbonate copolymer composite fiber provided by the invention can be further realized by adopting the following technical measures.
Preferably, the composite spinning process for the poly (lactide-co-glycolide) chips and the poly (lactide-co-trimethylene carbonate) chips comprises the following steps:
vacuum drying is carried out at the temperature of 80-100 ℃, the value range of the vacuum degree of the vacuum drying is-0.08 MPa-0.09 MPa, and the value range of the duration time is 16 h-24 h.
Preferably, the method for obtaining the polyglycolide-trimethylene carbonate copolymer chips comprises the following steps:
and drying the glycolide-trimethylene carbonate copolymer in vacuum to obtain the glycolide-trimethylene carbonate copolymer slice, wherein the value range of the vacuum drying temperature is 50-55 ℃, and the value range of the vacuum drying duration time is 16-24 h.
Preferably, the method for obtaining the glycolide-lactide slice comprises the following steps:
adding glycolide and L-lactide with the mass ratio of (90-92) to (8-10), stannous octoate accounting for 0.01-0.015% of the total monomer substances and lauryl alcohol accounting for 0.01-0.015% of the total monomer substances into a polymerization reaction kettle;
closing the polymerization reaction kettle;
vacuumizing the closed polymerization reaction kettle, introducing N2 into the vacuum polymerization reaction kettle, and circulating for 3-5 times in such a way, wherein the duration time of each time is 30-35 min, so as to obtain the polymerization reaction kettle with a clean reaction environment;
heating and stirring the polymerization reaction kettle with a clean reaction environment to raise the temperature in the polymerization reaction kettle to 160-165 ℃ and keeping for 40-50 min to obtain a first intermediate product;
raising the temperature of the first intermediate product to 230-235 ℃ at the speed of 5 ℃/5-8 ℃/5min to obtain a second intermediate product;
stopping the reaction of the polymerization reaction kettle when the intrinsic viscosity of the second intermediate product reaches 1.6 +/-0.2 dg/dL;
charging N into the polymerization reactor in which the reaction has been terminated2Thereafter, extruding the second intermediate product;
and cooling, granulating, drying, slicing and vacuum packaging the extruded second intermediate product in sequence to obtain the poly (glycolide-co-lactide) slices, wherein the operation environment of the drying step is as follows: the temperature is 30-35 ℃, and the drying duration is 24-36 h.
Preferably, the composite spinning process for the poly (lactide-co-glycolide) chips and the poly (lactide-co-trimethylene carbonate) chips is realized by a spinning-stretching one-step method, and the stretching ratio ranges from 5 times to 6 times.
Preferably, the process conditions for composite spinning of the poly (lactide-co-glycolide) chips and the poly (lactide-co-trimethylene carbonate) chips comprise:
for the core layer:
the temperature of the components ranges from 220 ℃ to 240 ℃,
the value range of the screw pressure is 9.8 MPa-10.5 MPa,
the value range of the spinning speed is 200 m/min-400 m/min;
for the skin layer:
the temperature range of the components is 150-180 ℃,
the value range of the screw pressure is 8.0MPa to 9.0MPa,
the value range of the spinning speed is 220 m/min-240 m/min;
the cooling mode is air cooling, the blowing mode adopts side blowing, and the value range of the blowing speed is 3 m/min-5 m/min.
Preferably, the method for determining the intrinsic viscosity of the second intermediate product comprises the steps of:
preparing phenol and tetrachloroethane with the mass ratio of 1: 1 into a solvent;
adding the second intermediate product to the solvent to configure a solution having a second intermediate product content of 0.1 g/dL;
and determining the intrinsic viscosity of the second intermediate product by using a Ubbelohde viscosity agent at the temperature of 25 ℃.
The poly (glycolide-co-lactide) -glycolide-co-trimethylene carbonate composite fiber provided by the invention can be used for surgical suture.
The surgical suture provided by the invention is prepared from the poly (glycolide-co-lactide) and glycolide-co-trimethylene carbonate copolymer composite fiber provided by the invention.
The poly (lactide-co-glycolide) and glycolide-trimethylene carbonate copolymer fiber prepared by the preparation method provided by the invention has the tensile strength of 4.4-4.6CN/dtex, the elongation at break of 22-27%, good hand feeling, and the degradation time prolonged by 2 months compared with that of pure poly (lactide-co-glycolide) fiber, and can better meet the requirements of surgical sutures. Therefore, the poly (lactide-co-glycolide) and glycolide-trimethylene carbonate copolymer composite fiber can be used for surgical sutures, and the surgical sutures can be made of the poly (lactide-co-glycolide-trimethylene carbonate) composite fiber, wherein the core layer PGLA has better biodegradation rate and biocompatibility, and the skin layer glycolide-trimethylene carbonate copolymer has flexibility and moderate degradation rate. Therefore, the PGLA/glycolide-trimethylene carbonate copolymer composite fiber slows down the characteristic of high degradation speed of the PGLA fiber, the degradation time can be prolonged by 2 months compared with the PGLA, the flexibility of the poly (glycolide-lactide) fiber is increased, the surface is smooth, knotting is easy, the operability is good, skin cannot be damaged, and the poly (glycolide-lactide) -glycolide-trimethylene carbonate copolymer composite fiber has higher applicability as a surgical suture.
Drawings
Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Also, like reference numerals are used to refer to like parts throughout the drawings. In the drawings:
FIG. 1 is a schematic structural diagram of a cross-section of a poly (glycolide-co-trimethylene carbonate) composite fiber provided by an embodiment of the present invention;
FIG. 2 is a flow chart of the steps of a method for preparing poly (glycolide-co-trimethylene carbonate) composite fibers according to an embodiment of the present invention.
Detailed Description
The invention provides a poly (lactide-co-glycolide) -co-glycolide-co-trimethylene carbonate copolymer composite fiber, a preparation method and application thereof and an operation suture line, aiming at solving the problems in the prior art, and the prepared operation suture line has the advantages of low cost and wide application range, thereby being more practical.
To further illustrate the technical means and effects of the present invention for achieving the predetermined objects, the following detailed description of the composite fiber of poly (glycolide-co-trimethylene carbonate), its preparation method, its use and surgical suture according to the present invention, its structure, characteristics and effects will be made with reference to the accompanying drawings and preferred embodiments. In the following description, different "one embodiment" or "an embodiment" refers to not necessarily the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
The term "and/or" herein is merely an association describing an associated object, meaning that three relationships may exist, e.g., a and/or B, with the specific understanding that: both a and B may be included, a may be present alone, or B may be present alone, and any of the three cases can be provided.
Referring to fig. 1, the poly (lactide-co-glycolide) and glycolide-trimethylene carbonate) composite fiber provided by the embodiment of the invention comprises poly (lactide-co-glycolide) fiber and glycolide-trimethylene carbonate fiber,
after the composite fiber is formed, the poly (lactide-co-glycolide) fiber is used as a core layer 1 of the composite fiber, and the poly (glycolide-co-trimethylene carbonate) fiber is used as a skin layer 2 of the composite fiber.
Wherein, the value range of the ratio of the cross-sectional area of the core layer to the cross-sectional area of the skin layer is as follows: (15-50) and (85-50).
Wherein, the core layer and the skin layer are in a concentric structure when viewed from the cross section of the composite fiber.
Wherein the tensile strength of the poly (glycolide-co-trimethylene carbonate) composite fiber ranges from 4.4CN/dtex to 4.6CN/dtex, and the elongation at break of the poly (glycolide-co-trimethylene carbonate) composite fiber ranges from 22% to 27%.
Referring to fig. 2, a method for preparing a poly (glycolide-co-trimethylene carbonate) composite fiber according to an embodiment of the present invention comprises the following steps:
step S1: respectively obtaining a poly (glycolide-co-lactide) slice and a glycolide-co-trimethylene carbonate slice;
step S2: and performing composite spinning on the poly (lactide-co-glycolide) slices and the glycolide-trimethylene carbonate copolymer slices to enable the poly (lactide-co-glycolide) to be positioned in a core layer of the composite fiber, and the poly (glycolide-co-trimethylene carbonate) copolymer to wrap the poly (lactide-co-glycolide) to form a skin layer of the composite fiber, so as to obtain the poly (lactide-co-glycolide) and poly (glycolide-co-trimethylene carbonate) copolymer composite fiber.
The composite spinning process aiming at the poly (glycolide-co-lactide) chips and the glycolide-co-trimethylene carbonate copolymer chips comprises the following steps:
vacuum drying is carried out at the temperature of 80-100 ℃, and the value range of the vacuum degree of the vacuum drying is-0.08 MPa-0.09 MPa.
In step S1, the method for obtaining polyglycolide-trimethylene carbonate copolymer chips includes the steps of:
and (3) drying the glycolide-trimethylene carbonate copolymer in vacuum to obtain glycolide-trimethylene carbonate copolymer slices, wherein the value range of the vacuum drying temperature is 50-55 ℃, and the value range of the vacuum drying duration time is 16-24 h.
In step S1, the method for obtaining glycolide segments includes the following steps:
adding glycolide and L-lactide with the mass ratio of (90-92) to (8-10), stannous octoate accounting for 0.01-0.015% of the total monomer substances and lauryl alcohol accounting for 0.01-0.015% of the total monomer substances into a polymerization reaction kettle;
closing the polymerization reaction kettle;
vacuumizing a closed polymerization reaction kettle, introducing N2 into the vacuum polymerization reaction kettle, and circulating for 3-5 times in such a way, wherein the duration time of each time is 30-35 min, so as to obtain the polymerization reaction kettle with a clean reaction environment;
heating and stirring a polymerization reaction kettle with a clean reaction environment to raise the temperature in the polymerization reaction kettle to 160-165 ℃ and keeping for 40-50 min to obtain a first intermediate product;
raising the temperature of the first intermediate product to 230-235 ℃ at the speed of 5 ℃/5-8 ℃/5min to obtain a second intermediate product;
stopping the reaction of the polymerization reaction kettle when the intrinsic viscosity of the second intermediate product reaches 1.6 +/-0.2 dg/dL;
charging N into the polymerization reactor in which the reaction has been terminated2Then, extruding the second intermediate product;
and cooling, granulating, drying, slicing and vacuum packaging the extruded second intermediate product in sequence to obtain the poly (lactide-co-glycolide) slice, wherein the operation environment of the drying step is as follows: the temperature is 30-35 ℃, and the drying duration is 24-36 h.
The composite spinning process aiming at the poly (glycolide-co-lactide) slices and the glycolide-co-trimethylene carbonate copolymer slices is realized by a spinning-stretching one-step method, and the value range of the stretching multiple is 5-6 times.
Wherein, the process conditions for carrying out composite spinning on the poly (glycolide-co-lactide) slices and the glycolide-co-trimethylene carbonate copolymer slices comprise:
aiming at the core layer:
the temperature of the components ranges from 220 ℃ to 240 ℃,
the value range of the screw pressure is 9.8 MPa-10.5 MPa,
the value range of the spinning speed is 200 m/min-400 m/min;
for the cortex:
the temperature range of the components is 150-180 ℃,
the value range of the screw pressure is 8.0MPa to 9.0MPa,
the value range of the spinning speed is 220 m/min-240 m/min;
the cooling mode is air cooling, the blowing mode adopts side blowing, and the value range of the blowing speed is 3 m/min-5 m/min.
Wherein the method for determining the intrinsic viscosity of the second intermediate product comprises the following steps:
preparing phenol and tetrachloroethane with the mass ratio of 1: 1 into a solvent;
adding the second intermediate product into a solvent to prepare a solution with the content of the second intermediate product being 0.1 g/dL;
the intrinsic viscosity of the second intermediate product was measured using a Ubbelohde viscosity agent at 25 ℃.
The poly (glycolide-co-lactide) and glycolide-trimethylene carbonate composite fiber provided by the embodiment of the invention can be used for surgical suture.
The surgical suture provided by the embodiment of the invention is made of the poly (glycolide-co-lactide) and glycolide-co-trimethylene carbonate) composite fiber provided by the invention.
The poly (lactide-co-glycolide) and glycolide-trimethylene carbonate copolymer fiber prepared by the preparation method provided by the embodiment of the invention has the tensile strength of 4.4-4.6CN/dtex, the elongation at break of 22-27%, good hand feeling, and the degradation time prolonged by 2 months compared with that of pure poly (lactide-co-glycolide) fiber, and can better meet the requirements of surgical sutures. Therefore, the poly (lactide-co-glycolide) and glycolide-trimethylene carbonate copolymer composite fiber can be used for surgical sutures, and the surgical sutures can be made of the poly (lactide-co-glycolide-trimethylene carbonate) composite fiber, wherein the core layer PGLA has better biodegradation rate and biocompatibility, and the skin layer glycolide-trimethylene carbonate copolymer has flexibility and moderate degradation rate. Therefore, the PGLA/glycolide-trimethylene carbonate copolymer composite fiber slows down the characteristic of high degradation speed of the PGLA fiber, increases the flexibility of the poly (glycolide-lactide) fiber, has smooth surface, easy knotting and good operability, does not cause damage to the skin, and has higher applicability as a surgical suture.
Example 1
The ratio of the cross-sectional area of the skin layer to the core layer (PGLA as the core of the composite fiber, glycolide-trimethylene carbonate copolymer as the skin of the composite fiber) was 20: 80, respectively carrying out vacuum drying on the PGLA/glycolide-trimethylene carbonate copolymer for later use, wherein the drying temperature is 80 ℃ and the vacuum degree is-0.09 MPa, and the composite fiber adopts a spinning-drawing one-step method, and the drawing multiple is 5 times. The fineness of the filaments was 2.2dtex (50D/24 f). The spinning process conditions are as follows: the temperature range of the core layer component is 220-180 ℃, the screw pressure is 9.8MPa, the spinning speed is 240m/min, the temperature range of the skin layer component is 150-180 ℃, the screw pressure is 8.0MPa, the spinning speed is 240m/min, air cooling is carried out, and the side blowing speed is 3m/min, so that the PGLA/glycolide-trimethylene carbonate copolymer composite fiber can be obtained.
The performance parameters of the prepared PGLA/glycolide-trimethylene carbonate copolymer composite fiber are as follows: the tensile strength reaches 4.5CN/dtex, the elongation at break is 27%, the hand feeling is good, the fiber is slightly softer than PGLA pure fiber, the degradation speed is prolonged by 2 months than the PGLA pure fiber, and the requirement of an operation suture can be better met.
Examples 2 to 20
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (7)
1. The preparation method of the poly (lactide-co-glycolide) and glycolide-trimethylene carbonate copolymer composite fiber is characterized in that,
the poly (lactide-co-glycolide) and glycolide-trimethylene carbonate copolymer composite fiber comprises poly (lactide-co-glycolide) and glycolide-trimethylene carbonate copolymer,
after the composite fiber is formed, the poly (lactide-co-glycolide) is a core layer of the composite fiber, the poly (lactide-co-trimethylene carbonate) is a skin layer of the composite fiber, the core layer and the skin layer are of a concentric structure when viewed from the cross section of the composite fiber, and the ratio of the cross sectional area of the core layer to the cross sectional area of the skin layer has the value range of: (15-50) to (85-50);
separately obtaining the sections of the poly (glycolide-co-trimethylene carbonate) and the sections of the glycolide-co-trimethylene carbonate,
the method for obtaining the poly (lactide-co-glycolide) slice comprises the following steps:
adding glycolide and L-lactide with the mass ratio of (90-92) to (8-10), stannous octoate accounting for 0.01-0.015% of the total monomer substances and lauryl alcohol accounting for 0.01-0.015% of the total monomer substances into a polymerization reaction kettle;
closing the polymerization reaction kettle;
after the closed polymerization reaction kettle is vacuumized, introducing N into the vacuum polymerization reaction kettle2The above steps are circulated for 3-5 times, and the duration time of each time is 30-35 min, so that a polymerization reaction kettle with a clean reaction environment is obtained;
heating and stirring the polymerization reaction kettle with a clean reaction environment to raise the temperature in the polymerization reaction kettle to 160-165 ℃ and keeping for 40-50 min to obtain a first intermediate product;
raising the temperature of the first intermediate product to 230-235 ℃ at the speed of 5 ℃/5-8 ℃/5min to obtain a second intermediate product;
stopping the reaction of the polymerization reaction kettle when the intrinsic viscosity of the second intermediate product reaches 1.6 +/-0.2 dg/dL;
charging N into the polymerization reactor in which the reaction has been terminated2Thereafter, extruding the second intermediate product;
cooling, granulating, drying, slicing and vacuum packaging the extruded second intermediate product in sequence to obtain the poly (lactide-co-glycolide) slices;
the method for obtaining the glycolide-trimethylene carbonate copolymer slice comprises the following steps:
vacuum drying the glycolide-trimethylene carbonate copolymer, wherein the value range of the vacuum drying temperature is 50-55 ℃, and the value range of the vacuum drying duration time of the glycolide-trimethylene carbonate copolymer is 16-24 h, so as to obtain glycolide-trimethylene carbonate copolymer slices;
and carrying out composite spinning on the poly (lactide-co-glycolide) slices and the glycolide-trimethylene carbonate copolymer slices, so that the poly (lactide-co-glycolide) is positioned in a core layer of the composite fiber, and the poly (lactide-co-trimethylene carbonate) covers the poly (lactide-co-glycolide) to form a skin layer of the composite fiber, thereby obtaining the poly (lactide-co-glycolide) -trimethylene carbonate copolymer composite fiber.
2. The method for preparing the poly (lactide-co-glycolide) -co-glycolide-co-trimethylene carbonate) composite fiber according to claim 1, wherein the tensile strength of the poly (lactide-co-glycolide-co-trimethylene carbonate) composite fiber is in the range of 4.4CN/dtex to 4.6CN/dtex, and the elongation at break of the poly (lactide-co-glycolide-co-trimethylene carbonate) composite fiber is in the range of 22% to 27%.
3. The method for preparing the poly (lactide-co-glycolide) -co-glycolide-co-trimethylene carbonate) composite fiber according to claim 1, wherein the composite spinning process for the poly (lactide-co-glycolide) chips and the poly (lactide-co-trimethylene carbonate) chips is realized by a spinning-stretching one-step method, and the stretching ratio ranges from 5 times to 6 times.
4. The method for preparing the poly (lactide-co-glycolide) and glycolide-trimethylene carbonate copolymer composite fiber according to claim 1, wherein the process conditions for the composite spinning of the poly (lactide-co-glycolide) chips and the poly (lactide-co-trimethylene carbonate) chips comprise:
for the core layer:
the temperature of the components ranges from 220 ℃ to 240 ℃,
the value range of the screw pressure is 9.8 MPa-10.5 MPa,
the value range of the spinning speed is 200 m/min-400 m/min;
for the skin layer:
the temperature range of the components is 150-180 ℃,
the value range of the screw pressure is 8.0MPa to 9.0MPa,
the value range of the spinning speed is 220 m/min-240 m/min;
the cooling mode is air cooling, the blowing mode adopts side blowing, and the value range of the blowing speed is 3 m/min-5 m/min.
5. The method for preparing poly (lactide-co-glycolide) -co-glycolide-co-trimethylene carbonate) composite fibers according to claim 1, wherein the method for determining the intrinsic viscosity of the second intermediate product comprises the steps of:
preparing phenol and tetrachloroethane with the mass ratio of 1: 1 into a solvent;
adding the second intermediate product to the solvent to configure a solution having a second intermediate product content of 0.1 g/dL;
the intrinsic viscosity of the second intermediate product was measured using a Ubbelohde viscometer at 25 ℃.
6. Use of the poly (glycolide-co-lactide-co-glycolide-co-trimethylene carbonate) composite fiber obtained by the preparation method according to any one of claims 1 to 5, as a surgical suture.
7. A surgical suture comprising the poly (glycolide-co-trimethylene carbonate) composite fiber obtained by the production method according to any one of claims 1 to 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710915226.8A CN107653516B (en) | 2017-09-30 | 2017-09-30 | Poly (glycolide-lactide-co-glycolide-co-trimethylene carbonate) composite fiber, preparation method thereof, application thereof and surgical suture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710915226.8A CN107653516B (en) | 2017-09-30 | 2017-09-30 | Poly (glycolide-lactide-co-glycolide-co-trimethylene carbonate) composite fiber, preparation method thereof, application thereof and surgical suture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107653516A CN107653516A (en) | 2018-02-02 |
| CN107653516B true CN107653516B (en) | 2021-05-11 |
Family
ID=61117200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710915226.8A Active CN107653516B (en) | 2017-09-30 | 2017-09-30 | Poly (glycolide-lactide-co-glycolide-co-trimethylene carbonate) composite fiber, preparation method thereof, application thereof and surgical suture |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107653516B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110592721A (en) * | 2019-09-11 | 2019-12-20 | 中国纺织科学研究院有限公司 | Colored polylactic acid and glycolide-trimethylene carbonate copolymer composite fiber and preparation method thereof |
| CN111926409A (en) * | 2020-07-06 | 2020-11-13 | 中国纺织科学研究院有限公司 | Preparation method, application and suture line of purple poly (glycolide-lactide) master batch and fiber |
| CN114177343A (en) * | 2021-11-12 | 2022-03-15 | 长春圣博玛生物材料有限公司 | Suture, preparation method and medical braided fabric |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7070610B2 (en) * | 2002-03-30 | 2006-07-04 | Samyang Corporation | Monofilament suture and manufacturing method thereof |
| US9393343B2 (en) * | 2004-12-29 | 2016-07-19 | Samyang Biopharmaceuticals Corporation | Monofilament suture and preparation method thereof |
| US20100291384A1 (en) * | 2009-05-15 | 2010-11-18 | Armark Authentication Technologies, Llc | Fiber having non-uniform composition and method for making same |
| JP5620082B2 (en) * | 2009-10-09 | 2014-11-05 | オーミケンシ株式会社 | Bioabsorbable suture |
| KR101752788B1 (en) * | 2015-11-10 | 2017-07-03 | 한국과학기술연구원 | High strength polymer filament for fdm 3d printer including graphene coated metal nano particle and nano carbon for 3d printer and preparing method of the same |
| CN107059158B (en) * | 2017-05-19 | 2019-10-18 | 中国纺织科学研究院有限公司 | Poly (glycolide-lactide) and polycaprolactone composite fibre, preparation method, purposes and operation suture thread |
-
2017
- 2017-09-30 CN CN201710915226.8A patent/CN107653516B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN107653516A (en) | 2018-02-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9737629B2 (en) | Mechanically strong absorbable polymeric blend compositions of precisely controllable absorption rates, processing methods, and products therefrom | |
| CN107653516B (en) | Poly (glycolide-lactide-co-glycolide-co-trimethylene carbonate) composite fiber, preparation method thereof, application thereof and surgical suture | |
| CN107059158B (en) | Poly (glycolide-lactide) and polycaprolactone composite fibre, preparation method, purposes and operation suture thread | |
| JP6618906B2 (en) | Absorbent polymer blend composition with high accuracy and controllable absorption rate, processing method, and dimensionally stable medical device provided by the composition | |
| EP3216815A1 (en) | Segmented, semicrystalline poly(lactide-co-epsilon-caprolactone) absorbable copolymers | |
| US6048947A (en) | Triblock terpolymer, its use for surgical suture material and process for its production | |
| CN110552082A (en) | colored polylactide and polycaprolactone composite fiber and preparation method thereof | |
| CN109137135B (en) | Poly (glycolide-lactide-poly (p-dioxanone) composite fiber, preparation method and application thereof and surgical suture | |
| CN109234843B (en) | Polylactide and poly (p-dioxanone) composite fiber, preparation method and application thereof and surgical suture | |
| EP1833380B1 (en) | Monofilament suture and preparation method thereof | |
| CN110592721A (en) | Colored polylactic acid and glycolide-trimethylene carbonate copolymer composite fiber and preparation method thereof | |
| EP3062831B1 (en) | Absorbable poly (p-dioxanone-co-glycolide) monofilament fibers possessing mid-term strength retention post-implantation | |
| US6191236B1 (en) | Bioabsorbable suture and method of its manufacture | |
| KR20170072424A (en) | Barbed suture and method for preparing the same | |
| CN112469550B (en) | Absorbable copolymer compositions for high strength sutures with enhanced post-implantation strength retention | |
| CN111945247A (en) | Purple bright and clean polylactide and poly (glycolide-lactide) composite fiber, preparation method and application thereof and surgical suture | |
| KR20190032675A (en) | Suture having a long degrading rate, and method for preparing the same | |
| CN111926408A (en) | Purple poly (glycolide-lactide) fiber, preparation method and application thereof and surgical suture | |
| CN111926409A (en) | Preparation method, application and suture line of purple poly (glycolide-lactide) master batch and fiber | |
| AU2006203366A1 (en) | Absorbable copolymers and surgical articles fabricated therefrom |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: No. 3, Yan Jing Li Zhongjie, Chaoyang District, Beijing, Beijing Applicant after: China Textile Science Research Institute Co., Ltd. Address before: No. 3, Yan Jing Li Zhongjie, Chaoyang District, Beijing, Beijing Applicant before: Chinese Textile Scientific Research Inst. |
|
| CB02 | Change of applicant information | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |