CN107184676A - It is a kind of for preparation of anti-curing hyperosteogeny, rheumatism osteoarthritis and arthralgia and myalgia and preparation method thereof - Google Patents
It is a kind of for preparation of anti-curing hyperosteogeny, rheumatism osteoarthritis and arthralgia and myalgia and preparation method thereof Download PDFInfo
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- CN107184676A CN107184676A CN201710479515.8A CN201710479515A CN107184676A CN 107184676 A CN107184676 A CN 107184676A CN 201710479515 A CN201710479515 A CN 201710479515A CN 107184676 A CN107184676 A CN 107184676A
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- 201000008482 osteoarthritis Diseases 0.000 title claims abstract description 14
- 241000601164 Clematis orientalis Species 0.000 claims abstract description 97
- 239000000341 volatile oil Substances 0.000 claims abstract description 68
- 239000000203 mixture Substances 0.000 claims abstract description 36
- 238000000605 extraction Methods 0.000 claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 11
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- RNYZJZKPGHQTJR-UHFFFAOYSA-N protoanemonin Chemical compound C=C1OC(=O)C=C1 RNYZJZKPGHQTJR-UHFFFAOYSA-N 0.000 description 2
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- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
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- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 description 1
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- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
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- 229960001259 diclofenac Drugs 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
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- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
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- 239000002994 raw material Substances 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
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- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
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- 235000007586 terpenes Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of preparation for anti-curing hyperosteogeny, rheumatism osteoarthritis and arthralgia and myalgia, the preparation method of said preparation comprises the following steps：The extraction of root of Chinese clematis volatile oil composition and refined, the preparation of root of Chinese clematis volatile oil preparation, wherein the extraction of root of Chinese clematis volatile oil includes the way of distillation and solvent extraction method, at least one of root of Chinese clematis volatile oil that the aromatic waters and volatile oil, solvent extraction method that obtained root of Chinese clematis volatile oil composition is obtained including steam distillation are prepared.The present invention is optimized by the extraction to root of Chinese clematis volatile oil composition and purification step, anti- curing hyperosteogeny, rheumatism osteoarthritis and arthralgia and myalgia so that the preparation containing single root of Chinese clematis volatile oil compositions prepared is particularly suitable for use in, and realize the variation of type of preparation, patient may be selected plastics, transdermal patch, paste to substitute parenteral solution, which reduce the number of times that patient comes and goes hospital, the demand of many patients is met.
Description
Technical field
It is used for anti-curing hyperosteogeny, rheumatic Bones and joints the present invention relates to technical field of traditional Chinese medicine preparation, more particularly to one kind
Preparation of scorching and arthralgia and myalgia and preparation method thereof.
Background technology
The root of Chinese clematis, is Ranunculaceae, the perennial woody climber of Clematis.Clinically, it is used to treat stupid numbness of gout, limb
Body numbness, muscle arteries and veins contraction, weaken arthralgia pain due to rheumatism, relax the muscles and stimulate the blood circulation, swelling and pain relieving the effects such as, it is clinically widely used in controlling
Treat the diseases such as rheumatalgia, tumble injury, osteoproliferation and rheumatic arthritis.
The chemical composition of the root of Chinese clematis includes volatile ingredient and involatile constituent.There is scholar to be carried using steam distillation
Take in the root of Chinese clematis volatile ingredient and analyzed and identified using GC-MS technologies, find its chemical composition predominantly aliphatic acid
Other compounds such as class, esters, terpene and protoanemonin.
But the current root of Chinese clematis is applied to treatment related bone condition, such as Chinese patent in the form of compound preparation
CN1879846 discloses a kind of Chinese medicine preparation for treating rheumatism, osteoproliferation and osteoporosis, mainly by scythian lamb rhizome, the black tip
Snake, the root of kudzu vine, barrenwort, pawpaw, achyranthes aspera, Companumoea root, turmeric, the root of Chinese clematis, psoralea corylifolia, starch, carboxyrnethyl starch sodium and talcum powder
Composition, Chinese medicine species is various contained by the Chinese medicine preparation, and containing rare medicinal herbs, its price makes consumer hang back；Chinese patent
CN105362540A provides a kind of Chinese traditional medicine composition for treating osteoproliferation, and it is by pyrola, the root of Chinese clematis, arisacma consanguineum schott, licorice, the Qin
Macrophylla, borneol, light-coloured vinegar, which are mixed with, to be formed, and the Chinese traditional medicine composition reduces the species of drug matching, effectively reduces cost, but in this
The root of Chinese clematis still needs to be cooperated and acted synergistically with other drugs component in medicine combination.
Do not occur the report that osteoproliferation, rheumatism osteoarthritis and arthralgia and myalgia are individually treated using the root of Chinese clematis at present
Road.
The content of the invention
It is an object of the invention to overcome defect of the prior art, it is intended to which protection individually uses root of Chinese clematis volatile oil preparation
For anti-curing hyperosteogeny, rheumatism osteoarthritis and arthralgia and myalgia.
The root of Chinese clematis injection that applicant has been widely popularized at present is used clinically for treatment osteoproliferation, rheumatic bone and closed
The history of the disease application in existing more than 20 years such as section inflammation and arthralgia and myalgia, root of Chinese clematis parenteral solution is the aqua aromatica by distilling extraction
Agent, its main component for playing drug action is volatile ingredient, the injection liquid energy dispelling wind and eliminating dampness, is removed obstruction in channels to relieve pain.Clinical practice
Situation shows that the parenteral solution determined curative effect does not find obvious side effect,.But the preparation process of said preparation also needs further excellent
Change to adjust the content of effective volatile ingredient, and in order to meet the demand of many patients, the species of preparation need to be carried out various
Change and prepare.
To achieve the above object, the present invention is adopted the following technical scheme that：
The present invention provides a kind of preparation for anti-curing hyperosteogeny, rheumatism osteoarthritis and arthralgia and myalgia, and it includes
Root of Chinese clematis volatile oil composition.
Preferably, the root of Chinese clematis volatile oil composition includes aromatic waters and the volatilization that steam distillation is prepared
At least one of root of Chinese clematis volatile oil that oil, solvent extraction method are prepared
Preferably, the form of the preparation includes injection, plastics, transdermal patch and paste, and wherein paste is preferably soft
Cream and Babu cream.
The present invention also provides a kind of above-mentioned preparation for anti-curing hyperosteogeny, rheumatism osteoarthritis and arthralgia and myalgia
Preparation method, it comprises the following steps：
Step 1) root of Chinese clematis volatile oil composition extraction；
Step 2) root of Chinese clematis volatile oil preparation preparation.
In order to further optimize above-mentioned technical proposal, the technical measures that the present invention is taken also include：
Preferably, in step 1) in, after the extraction of root of Chinese clematis volatile oil composition, in addition to root of Chinese clematis volatile oil
Composition it is refined.
Preferably, step 1) in root of Chinese clematis volatile oil composition extraction include the way of distillation and solvent extraction method.
Preferably, the refined of the root of Chinese clematis volatile oil composition includes redistillation, extraction, freezing and chromatographic isolation.
Preferably, the extraction of root of Chinese clematis volatile oil composition and refined operating process are as follows：Take the Wheeling of certain mass
Elixir material, adds the distilled water of 5-15 times of quality of medicinal material, and 40-80 degrees Celsius of temperature is soaked 3-24 hours, then distilled 3-6 hours, receive
Collect the distillate of 2 times of quality of medicinal materials；Distillate redistillation 2-4 hours, obtains 1 times of quality of medicinal material re-distilled liquid.
Preferably, the extraction of root of Chinese clematis volatile oil composition and refined operating process are as follows：Take the Wheeling of certain mass
Elixir material, adds the distilled water of 5-10 times of quality of medicinal material, and 40-80 degrees Celsius of temperature is soaked 3-12 hours, then distilled 3-8 hours, receive
Collect the volatile oil composition on upper strata, the volatile oil composition is freezed or chromatographic isolation is refined.Preferably, the root of Chinese clematis volatilizees
The extraction of oil component and refined operating process are as follows：
By the clematis chinensis medicinal materials of certain mass, plus appropriate distilled water and lanolin, hot water bath temperature leaching 10~14 hours, then
Take appropriate lanolin liquid to distill 4~6 hours, collect the mixed liquor of volatile oil and lanolin, the mixed liquor is extracted using liquid-liquid
Technology is taken to separate root of Chinese clematis volatile oil.
Also extraction that can be using other conventional volatile oil compositions of this area and purification step.
Preferably, the step 1) in use clematis chinensis medicinal materials be the Ranunculaceae Actions of Clematis Species root of Chinese clematis
(Clematis chinensis Osbeck), Clematis hexapetala (C.hexapetala), northeast clematis (C.manshurica)
Drying root and rhizome, it is ground into powdered or is cut into sheet.
Preferably, the preparation method of root of Chinese clematis volatile oil preparation includes：Root of Chinese clematis parenteral solution, root of Chinese clematis Babu cream, Wheeling
The preparation method of the preparations such as celestial ointment, root of Chinese clematis transdermal patch, root of Chinese clematis volatile oil.
Compared with prior art, the invention has the advantages that：
Extraction and purification step of the present invention to root of Chinese clematis volatile oil composition are optimized, effectively in adjustment extract solution
The content of effective volatile ingredient so that said preparation is particularly suitable for use in anti-curing hyperosteogeny, rheumatism osteoarthritis and arthralgia and myalgia,
And the variation of type of preparation is realized, patient may be selected plastics, transdermal patch, ointment and Babu cream to substitute parenteral solution,
Which reduce the number of times that patient comes and goes hospital, the demand of many patients is met.
Embodiment
With reference to embodiment, the embodiment to the present invention is further described.Following examples are only used for more
Plus technical scheme is clearly demonstrated, and can not be limited the scope of the invention with this.
The prepared preparation for anti-curing hyperosteogeny, rheumatism osteoarthritis and arthralgia and myalgia is equal in following embodiments
Including root of Chinese clematis volatile oil composition, its raw material used is the Ranunculaceae Actions of Clematis Species root of Chinese clematis (Clematis
Chinensis Osbeck), Clematis hexapetala (C.hexapetala), the dry root of northeast clematis (C.manshurica) and
Rhizome, it is ground into powdered or is cut into sheet, wherein powdered granularity is 5-10mm, sliced length, width and
Thickness is more conducive to the extraction of volatile ingredient using above-mentioned size no more than 50mm.
Embodiment 1
This embodiment is the preparation of root of Chinese clematis parenteral solution, and its step is as follows：
1.0 kilograms of the root of Chinese clematis, adds 5 times of amount distilled water and is soaked 12 hours in 50 degrees Celsius of temperature, then 100 degrees Celsius of distillations 4
Hour, collect 2000 milliliters of distillate；Distillate collected about 900 milliliters of distillate in 100 degrees Celsius of redistillation 2 hours；Add
Polyoxyethylene sorbitan monoleate amounts to 5 milliliters, and heating for dissolving shakes filtration, adjusts pH to 6.0, with double distilled water to 1000 milliliters, filters, and fills
Envelope, steam sterilizing produces root of Chinese clematis parenteral solution.Root of Chinese clematis parenteral solution discrimination method is to take 1 milliliter of distillate after redistillation, plus is steamed
Distilled water is diluted to 50 milliliters, shakes up, and has absorption maximum at ultraviolet-visible spectrophotometry detection 255 ± 3nm wavelength.The root of Chinese clematis is noted
Penetrate 2 milliliters of liquid every, intramuscular injection, one time 2-4 milliliters, 1-2 times on the one.
Embodiment 2
This embodiment is the preparation of root of Chinese clematis parenteral solution, and its step is as follows：
1.0 kilograms of the root of Chinese clematis, adds 10 times of amount distilled water and is soaked 6 hours in 60 degrees Celsius of temperature, then 100 degrees Celsius of distillations 8
Hour, collect 4000 milliliters of distillate；Distillate collected about 900 milliliters of distillate in 100 degrees Celsius of redistillations 3 hours；Add
Polyoxyethylene sorbitan monoleate amounts to 5 milliliters, and heating for dissolving shakes filtration, adjusts pH to 6.0, with double distilled water to 1000 milliliters, filters, and fills
Envelope, steam sterilizing produces root of Chinese clematis parenteral solution.Root of Chinese clematis parenteral solution discrimination method is to take 1 milliliter of distillate after redistillation, plus is steamed
Distilled water is diluted to 50 milliliters, shakes up, and has absorption maximum at ultraviolet-visible spectrophotometry detection 255 ± 3nm wavelength.The root of Chinese clematis is noted
Penetrate 2 milliliters of liquid every, intramuscular injection, one time 2-4 milliliters, 1-2 times on the one.
Embodiment 3
This embodiment is the preparation of root of Chinese clematis parenteral solution, and its step is as follows：
1.0 kilograms of the root of Chinese clematis, adds 10 times of amount distilled water and is soaked 24 hours in 40 degrees Celsius of temperature, then 100 degrees Celsius of distillations 4
Hour, collect 2000 milliliters of distillate；Distillate collected about 900 milliliters of distillate in 100 degrees Celsius of redistillations 2 hours；Add
Polyoxyethylene sorbitan monoleate amounts to 5 milliliters, and heating for dissolving shakes filtration, adjusts pH to 6.0, with double distilled water to 1000 milliliters, filters, and fills
Envelope, steam sterilizing produces root of Chinese clematis parenteral solution.Root of Chinese clematis parenteral solution discrimination method is to take 1 milliliter of distillate after redistillation, plus is steamed
Distilled water is diluted to 50 milliliters, shakes up, and has absorption maximum at ultraviolet-visible spectrophotometry detection 255 ± 3nm wavelength.The root of Chinese clematis is noted
Penetrate 2 milliliters of liquid every, intramuscular injection, one time 2-4 milliliters, 1-2 times on the one.
Embodiment 4
This embodiment is the preparation of root of Chinese clematis parenteral solution, and its step is as follows：
1.0 kilograms of the root of Chinese clematis, adds 15 times of amount distilled water and is soaked 6 hours in 80 degrees Celsius of temperature, then 100 degrees Celsius of distillations 5
Hour, collect 2500 milliliters of distillate；Distillate collected about 900 milliliters of distillate in 100 degrees Celsius of redistillations 2 hours；Add
Polyoxyethylene sorbitan monoleate amounts to 5 milliliters, and heating for dissolving shakes filtration, adjusts pH to 6.0, with double distilled water to 1000 milliliters, filters, and fills
Envelope, steam sterilizing produces root of Chinese clematis parenteral solution.Root of Chinese clematis parenteral solution discrimination method is to take 1 milliliter of distillate after redistillation, plus is steamed
Distilled water is diluted to 50 milliliters, shakes up, and has absorption maximum at ultraviolet-visible spectrophotometry detection 255 ± 3nm wavelength.The root of Chinese clematis is noted
Penetrate 2 milliliters of liquid every, intramuscular injection, one time 2-4 milliliters, 1-2 times on the one.
Embodiment 5
This embodiment is the preparation of root of Chinese clematis Babu cream, and its step is as follows：
10.0 kilograms of clematis chinensis medicinal materials, add 6 times of amount distilled water and are soaked 12 hours in 50 degrees Celsius of temperature, then distilled 4 hours,
Water-oil separating (cut suitably can cool to accelerate water-oil separating), takes volatile oil, by subzero 20 degrees Celsius of refrigerating refinings, obtains
100 milliliters of root of Chinese clematis volatile oil.100 grams of root of Chinese clematis volatile oil, plus the matrix that gelatin, glycerine etc. are made, are ground into fine and smooth pasty state, make
Into coating, non-woven fabrics is spread evenly across, segment, lid lining is cut into small pieces, produces root of Chinese clematis Babu cream.
Embodiment 6
This embodiment is the preparation of root of Chinese clematis Babu cream, and its step is as follows：
10.0 kilograms of clematis chinensis medicinal materials, add 10 times of amount distilled water and are soaked 12 hours in 60 degrees Celsius of temperature, then distill 5 small
When, water-oil separating (cut suitably can cool to accelerate water-oil separating) takes volatile oil, by subzero 20 degrees Celsius of refrigerating refinings,
Obtain 100 milliliters of root of Chinese clematis volatile oil.Take 1 part of polyvinyl alcohol in right amount with after water-swellable, 90 C water baths dissolve by heating, filter
Cross, let cool；Separately take 4 parts of gelatin to add above-mentioned poly-vinyl alcohol solution in right amount, be fully swelled, 60 C water baths dissolve by heating, plus
Enter 5 parts of glycerine to mix thoroughly, be eventually adding 7 parts of Sodium Polyacrylate, mix thoroughly, be finally slowly added to root of Chinese clematis volatile oil, grind well, it is uniform to apply
Non-woven fabrics is distributed in, polyethylene film is capped, placed naturally, stripping and slicing produces root of Chinese clematis Babu cream.
Embodiment 7
This embodiment is the preparation of root of Chinese clematis ointment, and its step is as follows：
10.0 kilograms of clematis chinensis medicinal materials, add 6 times of amount distilled water and are soaked 12 hours in 50 degrees Celsius of temperature, then distilled 4 hours,
Water-oil separating (cut suitably can cool to accelerate water-oil separating), takes volatile oil, by subzero 20 degrees Celsius of refrigerating refinings, obtains
100 milliliters of root of Chinese clematis volatile oil.100 grams of root of Chinese clematis volatile oil, adds 10 milliliters of atoleine, is ground into fine and smooth pasty state；Separately take sheep
20 grams of fat of hair and vaseline put heating water bath thawing altogether in right amount, when temperature is down to 50 degrees Celsius, equivalent progressively increase add by several times with
Upper mixture, side edged lapping-in develops condensation, produces root of Chinese clematis ointment.
Embodiment 8
This embodiment is the preparation of root of Chinese clematis ointment, and its step is as follows：
10.0 kilograms of clematis chinensis medicinal materials, add 10 times of amount distilled water and are soaked 12 hours in 60 degrees Celsius of temperature, then distill 5 small
When, water-oil separating (cut suitably can cool to accelerate water-oil separating) takes volatile oil, by subzero 20 degrees Celsius of refrigerating refinings,
Obtain 100 milliliters of root of Chinese clematis volatile oil.Take 3:The Macrogol 4000 and polyethylene glycol 400 of 2 ratios, put heating water bath in container
Melt, stir, wait be cooled to will be solidifying when add 100 grams of root of Chinese clematis volatile oil, side edged lapping-in develops condensation, produces Wheeling
Celestial ointment.
Embodiment 9
This embodiment is the preparation of root of Chinese clematis transdermal patch, and its step is as follows：
10.0 kilograms of clematis chinensis medicinal materials, add 10 times of amount distilled water and are soaked 12 hours in 60 degrees Celsius of temperature, then distill 5 small
When, water-oil separating (cut suitably can cool to accelerate water-oil separating) takes volatile oil, by subzero 20 degrees Celsius of refrigerating refinings,
Obtain 100 milliliters of root of Chinese clematis volatile oil；Proper amount of acetone, DMSO, azone are added, and adds polyvinyl formal acetal, side
Edged is stirred, and to whole dissolvings, is ground into fine and smooth pasty state, coating is made, and is spread evenly across non-woven fabrics, and segment, lid lining is cut into small
Block, produces root of Chinese clematis transdermal patch.
Embodiment 10
This embodiment is the preparation of root of Chinese clematis volatile oil, and its step is as follows：
10.0 kilograms of clematis chinensis medicinal materials, are placed in extraction element after crushing, and add water 60L, and lanolin is put in hot bath and added
Hot temperature leaching 12 hours, lanolin liquid 30ml is added in volatile oil oil water separator, carried with steam distillation after melting
Take volatile oil 5 hours, collect and obtain volatile oil and the mixed liquor of lanolin.Waved using the liquid-liquid technique separation root of Chinese clematis
Hair oil.Absolute ethyl alcohol 100ml is added in obtained volatile oil and the mixed liquor of lanolin, shakes uniform, through 3000 turns per minute
Centrifuge, oil reservoir is added water twice, each 60ml shakes uniform, centrifuged 5 minutes through 3000 turns per minute again, will
The water layer discarded separated, obtains root of Chinese clematis volatile oil 100ml.
Embodiment 11
Influence of this embodiment for the preparation of the invention prepared to analgesic effect.
The present embodiment is using healthy mice as research object, and every mouse is with electric pet grainer by mouse web portion
Hair is purified.It is randomly divided into six groups, the i.e. low high dose of root of Chinese clematis volatile oil, middle high dose and high dose group (volatile oil containing the root of Chinese clematis
Respectively 16,24,32mg/cm2), positive controls diclofenac emulsion (0.3mg/cm2), bare substrate group (give equivalent matrix/
cm2) and blank control group.Every group 10, the daily coating in two times of every group of animal, coating area is 1cm2/ only once in the morning and once at night,
Midfeather 10 hours, successive administration seven days.Last dose half an hour pneumoretroperitoneum injects 0.6% acetic acid (now with the current, 0.2ml/
Secondary/only) mouse peritoneum is caused inflammation, writhing number of times in 30min is counted, and calculate inhibiting rate (%).High dose group, middle dose group and
Low dose group root of Chinese clematis volatile oil ointment machin positive control drug Voltarol can substantially reduce acetic acid intraperitoneal injection induced mice writhing
Number of times, the inhibiting rate of high dose group, middle dose group and low dose group root of Chinese clematis volatile oil ointment is respectively 68.4%, 56.6% and
42.8%.Middle dose group root of Chinese clematis volatile oil ointment analgesic effect is suitable with the analgesic effect of positive control drug.
The specific embodiment of the present invention is described in detail above, but it is only used as example, and the present invention is not intended to limit
In particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and to replace
In generation, is also all among scope of the invention.Therefore, the equalization made without departing from the spirit and scope of the invention is converted and repaiied
Change, all should be contained within the scope of the invention.
Claims (10)
1. a kind of preparation for anti-curing hyperosteogeny, rheumatism osteoarthritis and arthralgia and myalgia, it is characterised in that including Wheeling
Celestial volatile oil composition.
2. the preparation according to claim 1 for anti-curing hyperosteogeny, rheumatism osteoarthritis and arthralgia and myalgia, it is special
Levy and be, the root of Chinese clematis volatile oil composition includes the aromatic waters and volatile oil, solvent that steam distillation is prepared
At least one of root of Chinese clematis volatile oil that extraction method is prepared.
3. the preparation according to claim 1 for anti-curing hyperosteogeny, rheumatism osteoarthritis and arthralgia and myalgia, it is special
Levy and be, the form of the preparation includes injection, plastics, transdermal patch and paste.
4. it is a kind of according to any one of claims 1 to 3 for anti-curing hyperosteogeny, rheumatism osteoarthritis and arthralgia and myalgia
Preparation preparation method, it is characterised in that comprise the following steps：
Step 1) root of Chinese clematis volatile oil composition extraction；
Step 2) root of Chinese clematis volatile oil preparation preparation.
5. preparation method according to claim 4, it is characterised in that in step 1) in, in root of Chinese clematis volatile oil composition
Extraction after, include the purification step of root of Chinese clematis volatile oil composition.
6. preparation method according to claim 4, it is characterised in that step 1) in root of Chinese clematis volatile oil composition extraction
Including the way of distillation and solvent extraction method.
7. preparation method according to claim 5, it is characterised in that the root of Chinese clematis volatile oil composition it is refined including
Redistillation, extraction, freezing and chromatographic isolation.
8. preparation method according to claim 5, it is characterised in that the extraction of root of Chinese clematis volatile oil composition and refined
Operating process is as follows：The clematis chinensis medicinal materials of certain mass are taken, the distilled water of 5-15 times of quality of medicinal material, 40-80 degrees Celsius of temperature is added
Leaching 3-24 hours, then distills 3-6 hours, collects the distillate of 2 times of quality of medicinal materials；Distillate redistillation 2-4 hours, obtains 1
Times quality of medicinal material re-distilled liquid.
9. preparation method according to claim 5, it is characterised in that the extraction of root of Chinese clematis volatile oil composition and refined
Operating process is as follows：The clematis chinensis medicinal materials of certain mass are taken, the distilled water of 5-10 times of quality of medicinal material, 40-80 degrees Celsius of temperature is added
Leaching 3-12 hour, then distill 3-8 hours, collection upper strata volatile oil composition, the volatile oil composition freezed or
Chromatographic isolation is refined.
10. the preparation method according to claim 4 or 5, it is characterised in that the step 1) the middle clematis chinensis medicinal materials used
It is the Ranunculaceae Actions of Clematis Species root of Chinese clematis (Clematis chinensis Osbeck), Clematis hexapetala
(C.hexapetala), the drying root and rhizome of northeast clematis (C.manshurica), it is ground into powdered or is cut into
Sheet.
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| CN101116683A (en) * | 2006-08-04 | 2008-02-06 | 黄振华 | Medicine for treating arthritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101116683A (en) * | 2006-08-04 | 2008-02-06 | 黄振华 | Medicine for treating arthritis |
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| Title |
|---|
| XIN WU: "An herbal formula attenuates collagen-induced arthritis via inhibition of JAK2-STAT3 signaling and regulation of Th17 cells in mice", 《ONCOTARGET》 * |
| 傅瑶: "威灵仙挥发油及其制剂研究", 《上海中医药大学硕士学位论文》 * |
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Inventor after: Guo Cheng Inventor after: Yang Quanjun Inventor after: Gong Ruilin Inventor after: Hu Rongmei Inventor after: Cao Yanyan Inventor before: Yang Quanjun |
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Application publication date: 20170922 |