CN107177494A - Embryo Culture laboratory environment implementing monitoring alarm method and system - Google Patents
Embryo Culture laboratory environment implementing monitoring alarm method and system Download PDFInfo
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- CN107177494A CN107177494A CN201710524835.0A CN201710524835A CN107177494A CN 107177494 A CN107177494 A CN 107177494A CN 201710524835 A CN201710524835 A CN 201710524835A CN 107177494 A CN107177494 A CN 107177494A
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- 210000001161 mammalian embryo Anatomy 0.000 title claims abstract description 54
- 238000012544 monitoring process Methods 0.000 title claims abstract description 21
- 238000000034 method Methods 0.000 title claims abstract description 13
- 238000011161 development Methods 0.000 claims abstract description 15
- 239000000284 extract Substances 0.000 claims description 6
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000013461 design Methods 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- MGWGWNFMUOTEHG-UHFFFAOYSA-N 4-(3,5-dimethylphenyl)-1,3-thiazol-2-amine Chemical compound CC1=CC(C)=CC(C=2N=C(N)SC=2)=C1 MGWGWNFMUOTEHG-UHFFFAOYSA-N 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000003694 hair properties Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/06—Bioreactors or fermenters specially adapted for specific uses for in vitro fertilization
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
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Abstract
The invention discloses Embryo Culture laboratory environment implementing monitoring alarm method and system, including：According to current humidity, the first temperature information is extracted from optimal history parameters are cultivated；According to current air mass value, second temperature information is extracted from optimal history parameters are cultivated；According to the current stage of development information of embryo, humidity and air quality weight proportion are obtained from optimal history parameters are cultivated；Temperature value is currently controlled according to the humidity and air quality weight proportion and the first temperature information, second temperature acquisition of information；If current collecting temperature is mismatched with the control temperature value, warning message is sent out.The beneficial effects of the present invention are：According to the influence of the factors such as embryo growth stage, humidity, air quality, Mobile state management is entered to optimal design temperature, more accurate optimum growth temp is provided in time according to different influence factors.
Description
Technical field
The present invention relates to embryo transfer technology field, more particularly to Embryo Culture laboratory environment implementing monitoring alarm method
And system.
Background technology
In vitro culture is a key link in IVF technology, the direct shadow of external environment of embryo growth
Growing for body early embryo is rung, and then has influence on the plantation success rate of embryo.The in vitro culture of embryo is a complicated mistake
Journey, it has to many factors in growing environment, such as temperature, humidity, air quality, nutrient solution composition and pH value and light
Strict requirements.Wherein temperature is a particularly important parameter, and embryo is very sensitive for the fluctuation of temperature, too low or too high
Temperature can all cause embryo to occur irreversible damage.Therefore, during body culture and manipulation in vitro is carried out to embryo,
How the temperature accuracy in Embryo Culture laboratory is maintained, and be that each current Embryo Culture laboratory must take into consideration important asks
Topic.
In the prior art, more single for the monitoring temperature of Embryo Culture environment, the setting value only to temperature compares
It is right, because the factors such as embryo growth stage, humidity, air quality can cause the dynamic change of optimum temperature, therefore prior art
In for optimum temperature determination it is not accurate enough.
The content of the invention
For above-mentioned the problems of the prior art, the present invention solves the single control in Embryo Culture laboratory for temperature
System, by considering to factors such as embryo growth stage, humidity, air qualities, determines accurately optimal embryo
Growth temperature.
The invention provides Embryo Culture laboratory environment implementing monitoring alarm method, including：
Step S101, according to current humidity, the first temperature information is extracted from optimal history parameters are cultivated；
Step S102, according to current air mass value, extracts second temperature information from optimal history parameters are cultivated；
Step S103, according to the current stage of development information of embryo, obtains humidity and sky from optimal history parameters are cultivated
Makings amount weight proportion；
Step S104, is obtained according to the humidity and air quality weight proportion and the first temperature information, second temperature information
Take current control temperature value；
Step S105, if current collecting temperature is mismatched with the control temperature value, is sent out warning message.
In a preferred embodiment, it is further comprising the steps of in the step S101：
Step S1011, if current humidity is mismatched with setting safe humidity value, is sent out humidity alarm information.
In a preferred embodiment, it is further comprising the steps of in the step S102：
Step S1021, if air quality value is mismatched with setting safety air mass value, is sent out air quality report
Alert information.
In a preferred embodiment, the step S103 includes：
Step S1031, according to the current development time point of embryo, obtains current humidity and sky from Embryonic Stages figure
Spacing value, humidity value and the air quality value of makings amount broken line；
Step S1032, percent humidity value is obtained according to the spacing value and humidity value；According to the spacing value and air matter
Value obtains air quality value ratio value；
Step S1033, humidity and air quality weight proportion are obtained according to percent humidity value and air quality value ratio value.
In a preferred embodiment, also include in the step S105,
Wirelessly it is sent out warning message.
Meanwhile, present invention also offers Embryo Culture laboratory environment implementing monitoring warning system, including：First temperature is believed
Cease acquiring unit, second temperature information acquisition unit, weight proportion acquiring unit, Current Temperatures acquiring unit and warning message life
Into unit；Wherein,
The first temperature information acquiring unit, is configured to according to current humidity, is extracted from optimal history parameters are cultivated
First temperature information；
The second temperature information acquisition unit, is configured to according to current air mass value, from the optimal history parameters of culture
Middle extraction second temperature information；
Weight proportion acquiring unit, is configured to the current stage of development information according to embryo, from the optimal history parameters of culture
Middle acquisition humidity and air quality weight proportion；
Current Temperatures acquiring unit, be configured to according to the humidity and air quality weight proportion and the first temperature information,
Second temperature acquisition of information currently controls temperature value；
Warning message generation unit, is mismatched if being configured to current collecting temperature with the control temperature value, to outgoing
Send warning message.
In a preferred embodiment, the first temperature information acquiring unit is additionally configured to：If current humidity with
Set safe humidity value to mismatch, be then sent out humidity alarm information.
In a preferred embodiment, the second temperature information acquisition unit is additionally configured to：If air quality value
Mismatched with setting safety air mass value, be then sent out air quality alarm information.
In a preferred embodiment, the weight proportion acquiring unit is additionally configured to：
According to the current development time point of embryo, current humidity and air quality broken line are obtained from Embryonic Stages figure
Spacing value, humidity value and air quality value；Percent humidity value is obtained according to the spacing value and humidity value；According to the interval
Value and air quality value obtain air quality value ratio value；
Humidity and air quality weight proportion are obtained according to percent humidity value and air quality value ratio value.
In a preferred embodiment, the warning message generation unit is additionally configured to, wirelessly outwards
Send warning message.
So that the beneficial effects of the present invention are：First, the present invention is according to embryo growth stage, humidity, air quality etc.
The influence of factor, optimal design temperature is entered Mobile state management, according to different influence factors in time provide more it is accurate most
Good growth temperature；Secondly, the present invention is monitored in real time according to dynamic optimum temperature, lab assistant is grasped growth in time
The change of environment, fully ensures that the survival rate of embryo.
Brief description of the drawings
Fig. 1 is the schematic flow sheet of Embryo Culture laboratory environment implementing monitoring alarm method of the present invention；
Fig. 2 is the schematic flow sheet that the present invention obtains humidity and air quality weight proportion；
Fig. 3 is the structural representation of Embryo Culture laboratory environment implementing monitoring warning system of the present invention；
Fig. 4 is the instance graph that the present invention obtains humidity and air quality weight proportion.
Embodiment
Below in conjunction with the accompanying drawing of the present invention, technical scheme is clearly and completely described.Based on this hair
Embodiment in bright, the every other implementation that those of ordinary skill in the art are obtained under the premise of creative work is not made
Example, belongs to the scope of protection of the invention.
The invention provides Embryo Culture laboratory environment implementing monitoring alarm method, the alarm method implementation steps are as schemed
Shown in 1：
Step S101, according to current humidity, the first temperature information is extracted from optimal history parameters are cultivated.
In this step, current humidity is obtained by temperature sensor measurement, culture effect history set when optimal is joined
Number database is screened, and extracts corresponding temperature value or temperature range is used as the first temperature information.For accurately to embryo
Culture experiment room environmental is monitored, in a preferred embodiment, further comprising the steps of in step S101：
Step S1011, if current humidity is mismatched with setting safe humidity value, is sent out humidity alarm information.
Step S102, according to current air mass value, extracts second temperature information from optimal history parameters are cultivated.
In this step, nitrogen dioxide in air, sulfur dioxide are measured by air mass sensor, carbon monoxide, ozone, waved
The concentration of the hair property material such as organic compound, obtains current air mass value, according to current air mass value, to culture effect most
Set historical parameter data storehouse is screened when excellent, extracts corresponding temperature value or temperature range is believed as second temperature
Breath.To be accurately monitored to Embryo Culture laboratory environment, in a preferred embodiment, also wrapped in step S102
Include following steps：
Step S1021, if air quality value is mismatched with setting safety air mass value, is sent out air quality report
Alert information.
Step S103, according to the current stage of development information of embryo, obtains humidity and sky from optimal history parameters are cultivated
Makings amount weight proportion.
In this step, detected by the specialty of lab assistant, analysis determines the current stage of development, according to the current of embryo
Stage of development information, to culture effect, historical parameter data storehouse set when optimal is screened, and extracts humidity and air matter
Measure weight proportion.
For accurate determination humidity and air quality weight proportion, in a preferred embodiment, in step S103
It is further comprising the steps of：
As shown in Figure 2：Step S1031, according to the current development time point of embryo, obtains from Embryonic Stages figure and works as
Spacing value, humidity value and the air quality value of preceding humidity and air quality broken line.Step S1032, according to spacing value and humidity value
Obtain percent humidity value；Air quality value ratio value is obtained according to spacing value and air quality value.Step S1033, according to humidity
Ratio value and air quality value ratio value obtain humidity and air quality weight proportion.
For example：As shown in Figure 4：The coordinate system of Embryonic Stages, humidity value and air quality value is set up, works as acquisition time
During for t1, resulting humidity value is 50%, and humidity spacing value is 10%, and resulting air quality value is 195, air quality
Spacing value is 70；Obtaining percent humidity value according to calculating is：50%/10%=5, air quality value ratio value is：195/70=
2.79；Humidity weight proportion is worth to for 5/ (5+2.79)=64.22% according to percent humidity value and air quality value ratio, it is empty
Makings amount weight proportion is 2.79/ (5+2.79)=35.78%.
Step S104, works as according to humidity and air quality weight proportion and the first temperature information, second temperature acquisition of information
Preceding control temperature value.
In this step, according to the first temperature information, second temperature information, and the first temperature information and second temperature information
Weight proportion, calculating obtain current desired control temperature value.
For example：It is 64.22% by the obtained humidity weight proportions of above-mentioned steps S103, air quality weight proportion is
35.78%, the first temperature information is 36.9 DEG C, and second temperature information is 38.1 DEG C, is calculated according to weight proportion, obtains current
The temperature value is controlled to be：36.9 × 64.22%+38.1 × 35.78%=37.33.
Step S105, if current collecting temperature is mismatched with control temperature value, is sent out warning message.
To make warning message propagate timely, accurate and coverage greatly, in a preferred embodiment, step
It is further comprising the steps of in S105：
Wirelessly it is sent out warning message.
Meanwhile, the invention also discloses Embryo Culture laboratory environment implementing monitoring warning system, as shown in Figure 3：It is above-mentioned
Warning system includes：First temperature information acquiring unit 1, second temperature information acquisition unit 2, weight proportion acquiring unit 3, when
Preceding temperature acquiring unit 4 and warning message generation unit 5.
First temperature information acquiring unit 1 is configured to：Current humidity is obtained according to temperature sensor 6, most preferably gone through from culture
The first temperature information is extracted in history parameter.First temperature information acquiring unit 1 is additionally configured to：If current humidity and setting safety are wet
Angle value is mismatched, then is sent out humidity alarm information 8.
Second temperature information acquisition unit 2 is configured to：Current air mass value is obtained according to air mass sensor 6, from
Cultivate extraction second temperature information in optimal history parameters.Second temperature information acquisition unit 2 is additionally configured to：If air quality value
Mismatched with setting safety air mass value, be then sent out air quality alarm information 9.
Weight proportion acquiring unit 3, is configured to the current stage of development information according to embryo, from the optimal history parameters of culture
Middle acquisition humidity and air quality weight proportion.Weight proportion acquiring unit 3 is additionally configured to：According to the current development time of embryo
Point, obtains spacing value, humidity value and the air quality value of current humidity and air quality broken line from Embryonic Stages figure；Root
Percent humidity value is obtained according to spacing value and humidity value；Air quality value ratio value is obtained according to spacing value and air quality value；Root
Humidity and air quality weight proportion are obtained according to percent humidity value and air quality value ratio value.
Current Temperatures acquiring unit 4, is configured to according to humidity and air quality weight proportion and the first temperature information, second
Temperature information obtains current control temperature value.
Warning message generation unit 5, mismatches with control temperature value if being configured to current collecting temperature, is sent out report
Alert information.Warning message generation unit 5 is additionally configured to：Wirelessly it is sent out warning message 10.
The foregoing is only a specific embodiment of the invention, but protection scope of the present invention is not limited thereto, any
Those familiar with the art the invention discloses technical scope in, change or replacement can be readily occurred in, should all be contained
Cover within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. Embryo Culture laboratory environment implementing monitoring alarm method, including：
Step S101, according to current humidity, the first temperature information is extracted from optimal history parameters are cultivated；
Step S102, according to current air mass value, extracts second temperature information from optimal history parameters are cultivated；
Step S103, according to the current stage of development information of embryo, obtains humidity and air matter from optimal history parameters are cultivated
Measure weight proportion；
Step S104, works as according to the humidity and air quality weight proportion and the first temperature information, second temperature acquisition of information
Preceding control temperature value；
Step S105, if current collecting temperature is mismatched with the control temperature value, is sent out warning message.
2. in Embryo Culture laboratory environment implementing monitoring alarm method according to claim 1, the step S101 also
Comprise the following steps：
Step S1011, if current humidity is mismatched with setting safe humidity value, is sent out humidity alarm information.
3. in Embryo Culture laboratory environment implementing monitoring alarm method according to claim 1 or 2, the step S102
It is further comprising the steps of：
Step S1021, if air quality value is mismatched with setting safety air mass value, is sent out air quality alarm letter
Breath.
4. wrapped in Embryo Culture laboratory environment implementing monitoring alarm method according to claim 1, the step S103
Include：
Step S1031, according to the current development time point of embryo, obtains current humidity and air matter from Embryonic Stages figure
Measure spacing value, humidity value and the air quality value of broken line；
Step S1032, percent humidity value is obtained according to the spacing value and humidity value；According to the spacing value and air quality value
Obtain air quality value ratio value；
Step S1033, humidity and air quality weight proportion are obtained according to percent humidity value and air quality value ratio value.
5. Embryo Culture laboratory environment implementing monitoring alarm method according to claim 1, in the step S105
Also include,
Wirelessly it is sent out warning message.
6. Embryo Culture laboratory environment implementing monitoring warning system, including：First temperature information acquiring unit, second temperature letter
Cease acquiring unit, weight proportion acquiring unit, Current Temperatures acquiring unit and warning message generation unit；Wherein,
The first temperature information acquiring unit, is configured to according to current humidity, and first is extracted from optimal history parameters are cultivated
Temperature information；
The second temperature information acquisition unit, is configured to according to current air mass value, is carried from optimal history parameters are cultivated
Take second temperature information；
Weight proportion acquiring unit, is configured to the current stage of development information according to embryo, is obtained from optimal history parameters are cultivated
Take humidity and air quality weight proportion；
Current Temperatures acquiring unit, is configured to according to the humidity and air quality weight proportion and the first temperature information, second
Temperature information obtains current control temperature value；
Warning message generation unit, mismatches with the control temperature value if being configured to current collecting temperature, is sent out report
Alert information.
7. Embryo Culture laboratory environment implementing monitoring warning system according to claim 6, first temperature information
Acquiring unit is additionally configured to：If current humidity is mismatched with setting safe humidity value, humidity alarm information is sent out.
8. the Embryo Culture laboratory environment implementing monitoring warning system according to claim 6 or 7, the second temperature letter
Breath acquiring unit is additionally configured to：If air quality value is mismatched with setting safety air mass value, air quality is sent out
Warning message.
9. Embryo Culture laboratory environment implementing monitoring warning system according to claim 6, the weight proportion is obtained
Unit is additionally configured to：
According to the current development time point of embryo, obtained from Embryonic Stages figure between current humidity and air quality broken line
Every value, humidity value and air quality value；Percent humidity value is obtained according to the spacing value and humidity value；According to the spacing value and
Air quality value obtains air quality value ratio value；
Humidity and air quality weight proportion are obtained according to percent humidity value and air quality value ratio value.
10. Embryo Culture laboratory environment implementing monitoring warning system according to claim 6, the warning message generation
Unit is additionally configured to, and is wirelessly sent out warning message.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109740994A (en) * | 2019-01-04 | 2019-05-10 | 九州通医疗信息科技（武汉）有限公司 | Cold chain transportation evaluation method and device |
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| CN104755608A (en) * | 2012-08-30 | 2015-07-01 | 尤尼森斯繁殖技术公司 | Automatic surveillance of in vitro incubating embryos |
-
2017
- 2017-06-30 CN CN201710524835.0A patent/CN107177494A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101911927A (en) * | 2010-09-08 | 2010-12-15 | 江苏民星茧丝绸股份有限公司 | Incubation method for enhancing day hatchability rate of silkworm eggs |
| CN104755608A (en) * | 2012-08-30 | 2015-07-01 | 尤尼森斯繁殖技术公司 | Automatic surveillance of in vitro incubating embryos |
| CN104236620A (en) * | 2013-06-14 | 2014-12-24 | 富泰华工业（深圳）有限公司 | Electronic device with temperature and humidity sensor and humidity display method |
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