CN107157947A - A kind of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece and preparation method thereof - Google Patents
A kind of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece and preparation method thereof Download PDFInfo
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- CN107157947A CN107157947A CN201710309015.XA CN201710309015A CN107157947A CN 107157947 A CN107157947 A CN 107157947A CN 201710309015 A CN201710309015 A CN 201710309015A CN 107157947 A CN107157947 A CN 107157947A
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- propen
- chloromethyl
- amine polymer
- carbonate
- oxirane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Engineering & Computer Science (AREA)
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Abstract
The invention discloses a kind of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece and preparation method thereof, the component that the 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece includes by mass percentage has：2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate 78.79%；Microcrystalline cellulose 102 13.92%；Sodium carbonate 0.10%；Zinc stearate 0.19%；Water 7.00%.The step of preparation method, includes：2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate and microcrystalline cellulose 102 are mixed；Sodium carbonate liquor is added in mixture；Granulation；Sieving；Zinc stearate is added, and is mixed；Tabletting；It is coated.The present invention is used for the high phosphorus disease for treating end-stage renal disease Syndrome patients.The preparation method of the present invention employs sodium carbonate as stabilizer, therefore the 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate tablet of the present invention has more stable disintegration time, and its active constituents of medicine has more preferable validity to patient.
Description
Technical field
The invention belongs to medical research and development technology field, in particular to a kind of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece and its preparation side
Method.
Background technology
2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate is a kind of cross-linked polymer that will not be absorbed by the body, be 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece activity into
Point.It carries multiple amidos, is connected by a carbon atom with polymer backbone, chemical structural formula is as follows：
Wherein, a and b represent primary amine group number, and a+b=9；
C represents crosslinked group number, and c=1；
M represents to extend the quantity of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate in polymer network.
2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate is water insoluble, the similar sevelamer hydrochloride of the mechanism of action, by oral, in the effect of stomach hydrochloric acid in gastric juice
Under, change into sevelamer hydrochloride.These amidos can in enteron aisle Partial protons, and with ion exchange and hydrogen bond and phosphoric acid point
Son combine, formed it is insoluble, not by absorption phosphoric acid sevelamer compound, eventually through swill, excrement is excreted.Carbonic acid
Sevelamer reduces its absorption, the effect of reduction serium inorganic phosphorus concentration is reached, for treating late period kidney by combining the phosphorus in intestines and stomach
Sick Syndrome patients' high phosphorus disease.
The content of the invention
It is comprehensive for treating end-stage renal disease it is an object of the invention to provide a kind of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece and preparation method thereof
The high phosphorus disease of combination of syndromes patient.
To realize above-mentioned technical purpose and the technique effect, the present invention is achieved through the following technical solutions：
A kind of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece, by mass percentage（%w/w）, including following components：
Active component：2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate 78.79%；
Diluent：Microcrystalline cellulose -102 13.92%；
Stabilizer：Sodium carbonate 0.10%；
Lubricant：Zinc stearate 0.19%；
Adhesive：Water 7.00%.
A kind of preparation method of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece, comprises the following steps：
Step 1）2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate and microcrystalline cellulose -102 are well mixed；
Step 2）Sodium carbonate liquor is added in the mixture of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate and microcrystalline cellulose -102；
Step 3）By the granulating mixture of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate, microcrystalline cellulose -102 and sodium carbonate liquor；
Step 4）Powder is sieved；
Step 5）Zinc stearate is added in powder after sizing, and is well mixed；
Step 6）Tabletting；
Step 7）It is coated.
Further, step 4）In, the size of powder sieving is 24 mesh.
The beneficial effects of the invention are as follows：
The invention provides a kind of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece and preparation method thereof, the height for treating end-stage renal disease Syndrome patients
Phosphorus disease.The preparation method of the present invention employs sodium carbonate to be had as stabilizer, therefore the 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate tablet of the present invention
More stable disintegration time, its active constituents of medicine has more preferable validity to patient.
Described above is only the general introduction of technical solution of the present invention, in order to better understand the technological means of the present invention,
And can be practiced according to the content of specification, below with presently preferred embodiments of the present invention and coordinate accompanying drawing describe in detail as after.
The embodiment of the present invention is shown in detail by following examples and its accompanying drawing.
Brief description of the drawings
Accompanying drawing described herein is used for providing a further understanding of the present invention, constitutes the part of the application, this hair
Bright schematic description and description is used to explain the present invention, does not constitute inappropriate limitation of the present invention.In the accompanying drawings：
Fig. 1 is the process chart of preparation method of the present invention.
Embodiment
Below with reference to the accompanying drawings and in conjunction with the embodiments, the present invention is described in detail.
A kind of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece, by taking every sheet weight 1050mg as an example, the weight of its concrete component is as follows：
Active component：2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate 827.3g；
Diluent：The 146.2g of microcrystalline cellulose -102；
Stabilizer：Sodium carbonate 1g；
Lubricant：Zinc stearate 2g；
Adhesive：Water 73.5g.
Shown in reference picture 1, the preparation method of the 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece comprises the following steps：
Step 1）2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate and microcrystalline cellulose -102 are well mixed；
Step 2）Sodium carbonate liquor is added in the mixture of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate and microcrystalline cellulose -102；
Step 3）By the granulating mixture of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate, microcrystalline cellulose -102 and sodium carbonate liquor；
Step 4）Powder is sieved, 24 mesh；
Step 5）Zinc stearate is added in powder after sizing, and is well mixed；
Step 6）Tabletting；
Step 7）It is coated.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution, improvement etc., should be included in the scope of the protection.
Claims (3)
1. a kind of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece, it is characterised in that by mass percentage（%w/w）, including following components：
Active component：2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate 78.79%；
Diluent：Microcrystalline cellulose -102 13.92%；
Stabilizer：Sodium carbonate 0.10%；
Lubricant：Zinc stearate 0.19%；
Adhesive：Water 7.00%.
2. a kind of method of the 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece prepared described in claim 1, it is characterised in that comprise the following steps：
Step 1）2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate and microcrystalline cellulose -102 are well mixed；
Step 2）Sodium carbonate liquor is added in the mixture of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate and microcrystalline cellulose -102；
Step 3）By the granulating mixture of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate, microcrystalline cellulose -102 and sodium carbonate liquor；
Step 4）Powder is sieved；
Step 5）Zinc stearate is added in powder after sizing, and is well mixed；
Step 6）Tabletting；
Step 7）It is coated.
3. the method according to claim 2 for preparing 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece, it is characterised in that：Step 4）In, powder mistake
The size of sieve is 24 mesh.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710309015.XA CN107157947A (en) | 2017-05-04 | 2017-05-04 | A kind of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710309015.XA CN107157947A (en) | 2017-05-04 | 2017-05-04 | A kind of 2-Propen-1-amine polymer with(chloromethyl)oxirane carbonate piece and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111450068A (en) * | 2019-01-21 | 2020-07-28 | 江苏先声药业有限公司 | Sevelamer carbonate pharmaceutical composition and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006050315A2 (en) * | 2004-11-01 | 2006-05-11 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| CN102908325A (en) * | 2012-11-12 | 2013-02-06 | 南京生命能科技开发有限公司 | Sevelamer carbonate medical tablet composition and preparation method thereof |
| CN104434866A (en) * | 2014-12-30 | 2015-03-25 | 济南康和医药科技有限公司 | Sevelamer carbonate effervescent tablets and preparation method thereof |
| CN104546781A (en) * | 2014-12-22 | 2015-04-29 | 青岛正大海尔制药有限公司 | Sevelamer carbonate tablet and preparation method thereof |
| CN104739786A (en) * | 2013-12-25 | 2015-07-01 | 杭州民生滨江制药有限公司 | Sevelamer carbonate tablet and preparation method thereof |
-
2017
- 2017-05-04 CN CN201710309015.XA patent/CN107157947A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006050315A2 (en) * | 2004-11-01 | 2006-05-11 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| CN102908325A (en) * | 2012-11-12 | 2013-02-06 | 南京生命能科技开发有限公司 | Sevelamer carbonate medical tablet composition and preparation method thereof |
| CN104739786A (en) * | 2013-12-25 | 2015-07-01 | 杭州民生滨江制药有限公司 | Sevelamer carbonate tablet and preparation method thereof |
| CN104546781A (en) * | 2014-12-22 | 2015-04-29 | 青岛正大海尔制药有限公司 | Sevelamer carbonate tablet and preparation method thereof |
| CN104434866A (en) * | 2014-12-30 | 2015-03-25 | 济南康和医药科技有限公司 | Sevelamer carbonate effervescent tablets and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111450068A (en) * | 2019-01-21 | 2020-07-28 | 江苏先声药业有限公司 | Sevelamer carbonate pharmaceutical composition and preparation method thereof |
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Application publication date: 20170915 |