CN107137589A - It is a kind of to treat pharmaceutical composition of sciatica and preparation method thereof - Google Patents
It is a kind of to treat pharmaceutical composition of sciatica and preparation method thereof Download PDFInfo
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- CN107137589A CN107137589A CN201710384331.3A CN201710384331A CN107137589A CN 107137589 A CN107137589 A CN 107137589A CN 201710384331 A CN201710384331 A CN 201710384331A CN 107137589 A CN107137589 A CN 107137589A
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- chinese magnoliavine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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- Biotechnology (AREA)
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Abstract
The invention discloses a kind of pharmaceutical composition for treating sciatica, it is made up of the raw material components of following weight：10 30 parts of 3 10 parts of pseudo-ginseng, 15 30 parts of radix polygonati officinalis, 10 25 parts of rhizoma typhonii, 8 15 parts of the fruit of Chinese magnoliavine and the root of bidentate achyranthes.The present invention is by by the ingenious combination of above raw material components, scientific compatibility, produces and acts synergistically between raw material, the wherein root of bidentate achyranthes is as monarch drug in a prescription, and main function is anti-inflammatory analgetic；Pseudo-ginseng and rhizoma typhonii as ministerial drug, on the one hand for aiding in the promoting flow of qi and blood circulation, it is promoting blood circulation and removing obstruction in channels, on the other hand build up health, warming meridian；Radix polygonati officinalis as adjutant main function be nourish qi and blood, improve in follow it is bad；To strengthen body, nourshing kidney puckery smart as making medical instrument play the role of cardiac stimulant for the fruit of Chinese magnoliavine.Result is proved through clinical usage, and pill produced by the present invention is evident in efficacy to treatment sciatica.
Description
Technical field
The present invention relates to the drug therapy field of orthopaedics disease, more particularly, to a kind of medicine for treating sciatica
Composition and preparation method thereof.
Background technology
Sciatica is the syndrome based on sciatic nerve pathway and distributed areas pain.Sciatica it is exhausted big
Stimulation compressing and infringement that majority of cases is the lesion secondary to sciatic nerve part and surrounding structure to sciatic nerve, be referred to as after
Send out sciatica；Minority is primary, i.e. ischiatitis.
The clinical manifestation of sciatica is：
(1) pain is limited primarily to outside and foot, the disease of sharp ache after sciatic nerve distributed area, back of thighs, shank
People can be in distinctive posture；Waist flexing, go down on one's knees, tiptoe lands.When being located at nerve root such as lesion, the increase of intraspinal tube pressure (is coughed
Cough, firmly) when pain aggravate.
(2) degree of muscular strength decline can be widely different because of the degree difference of the cause of disease, diseased region, infringement, can there is ischium god
Through dominating, all or part of power of muscle is weak or paralysis.
(3) can with or without sciatic nerve-trunk at incisura ischiadica tenderness.
(4) sciatic nerve drawing levies, Lasegue is levied and its equipotential levies the positive, and this presence levied is often serious with pain
Degree is parallel.Local anaesthesia sciatic nerve root or nerve cord this levy and can disappear.
(5) Achilles jerk decline or disappearance, knee jerk can increase because of stimulation.
(6) there can be sciatic nerve to dominate the decline or disappearance of the various sensations in region, include the hypopallesthesia of external malleolus, also
There can be extremely light sensory disturbance.
The treatment of current sciatica is main based on expectant treatment, and expectant treatment is mainly to take vitamin B level medicine
Based on thing and analgesic drug product, but often index is not effected a permanent cure, the patient of many sciatica due to being tormented for a long time by pain,
Food does not know taste, lies awake all night, suffers untold misery.
The content of the invention
To overcome existing technological deficiency, prepared the invention provides a kind of use Chinese herbal medicine and treatment seat evident in efficacy
Pharmaceutical composition of osteoneuralgia and preparation method thereof.
To realize the purpose of the present invention, it is achieved using following technical scheme：
A kind of pharmaceutical composition for treating sciatica, is made up of the raw material components of following weight：Pseudo-ginseng 3-
10-30 parts of 10 parts, 15-30 parts of radix polygonati officinalis, 10-25 parts of rhizoma typhonii, 8-15 parts of the fruit of Chinese magnoliavine and the root of bidentate achyranthes.
Preferably, being made up of the raw material components of following weight：5 parts of pseudo-ginseng, 25 parts of radix polygonati officinalis, 18 parts of rhizoma typhonii,
18 parts of 12 parts of the fruit of Chinese magnoliavine and the root of bidentate achyranthes.
It is a kind of to be applied to a kind of above-mentioned preparation method for the pharmaceutical composition for treating sciatica, its preparation process bag
Include：
S1：Pseudo-ginseng and the root of bidentate achyranthes are pulverized, 80 mesh sieves is crossed, is mixed into medicinal powder；
S2：Radix polygonati officinalis and rhizoma typhonii are cut into slices, dried, cleans, is mixed into section thing, is put into the crock for decocting medicine, adds
The weight of section thing and pure water is 1:1.8-2 pure water, after soaking 20-50 minutes, is first boiled, then use with vigorous fire
Moderate heat is decocted 30-60 minutes, until the weight for decocting into section thing and decoction is 1:0.8-1, takes obtained decoction；
S3：The fruit of Chinese magnoliavine is cleaned, is put into container, the honey that weight is 15-30 parts is added, sealing is refined into
Fruit of Chinese magnoliavine sauce；
S4：Obtained fruit of Chinese magnoliavine sauce in obtained decoction in step S2 and step S3 is added to medicinal powder made from step S1
In, mixing preparation is into pill, 3-10 grams of the weight per ball.
The pharmacology and efficacy effect of above-mentioned each raw material components are as follows：
Pseudo-ginseng：Sweet, slight bitter, temperature.Channel tropism：Enter liver, stomach.Function：Hemostasia and dissipation blood stasis, detumescence hemostasis.Cure mainly：Wound swells and ache
Bleeding, hematemesis blood, bloody flux, uterine bleeding, postpartum blood stasis stomachache, carbuncle sore tumefacting virus.
Radix polygonati officinalis：Nature and flavor：It is sweet, be slightly cold.Channel tropism：Enter lung, stomach.Function：Nourishing yin to moisten dryness, promotes the production of body fluid to quench thirst.Cure mainly：Pyreticosis is hindered
The moon, dysphoria and thirsty, dry throat, the disease such as lung heat dry cough.
Rhizoma typhonii：Nature and flavor：Pungent, sweet, big temperature.It is included into stomach.Function：Wind-dispelling phlegm, antispastic.Cure mainly：Heap soil or fertilizer over and around the roots of apoplexy phlegm, mouth eye is askew
Tiltedly, migraine and general headache, the disease such as lockjaw.
The fruit of Chinese magnoliavine：Nature and flavor are sour, salty, temperature.It is included into lung, kidney channel.Function：Astringe the lung to stop cough, the puckery essence of nourshing kidney, above rush down, hidroschesis.It is main
Control：Cough due to deficiency of the lung, thirsty, seminal emission, spontaneous perspiration, night sweat, the disease such as protracted dysentery and diarrhea.
The root of bidentate achyranthes：It is bitter in taste, sour, flat.It is included into liver, kidney, bladder warp.Function：Filling liver kidney, strong waist and knee, the blood-breaking row stasis of blood.Cure mainly：
The soreness of bones and muscles of kidney deficiency and liver, lumbocrural pain, Amenorrhea hemostasis, rheumatalgia pain.
By the ingenious combination of above raw material components, scientific compatibility produces synergy between raw material, wherein the root of bidentate achyranthes is used as monarch
Medicine, main function is anti-inflammatory analgetic；Pseudo-ginseng and rhizoma typhonii as ministerial drug, on the one hand for aiding in the promoting flow of qi and blood circulation, it is promoting blood circulation and removing obstruction in channels, separately
One side is built up health, warming meridian；Radix polygonati officinalis as adjutant main function be nourish qi and blood, improve in follow it is bad；Fruit of Chinese magnoliavine conduct
Medical instrument is played the role of cardiac stimulant, to strengthen body, nourshing kidney puckery smart.Result is proved through clinical usage, and pill produced by the present invention is to treatment ischium
Neuralgia is evident in efficacy.
Compared with the prior art, the invention has the advantages that：
(1) present invention carries out compatibility using pseudo-ginseng, radix polygonati officinalis, rhizoma typhonii, the fruit of Chinese magnoliavine and the root of bidentate achyranthes, and the patch being made has promoting blood circulation
Dredging collateral, anti-inflammatory analgetic, the effect of the promoting flow of qi and blood circulation, reach the purpose for fundamentally treating sciatica.
(2) medicine material of the present invention is common drug, has sale in major pharmacies, raw material is easy to get and cost
It is relatively low.
Embodiment
To make the object, technical solutions and advantages of the present invention clearer, with reference in conjunction with specific embodiments to this hair
It is bright to be described in more detail.
Embodiment 1
A kind of pharmaceutical composition for treating sciatica, is made up of the raw material components of following weight：Pseudo-ginseng 5
18 parts of part, 25 parts of radix polygonati officinalis, 18 parts of rhizoma typhonii, 12 parts of the fruit of Chinese magnoliavine and the root of bidentate achyranthes.
Its preparation process is as follows：
S1：Pseudo-ginseng and the root of bidentate achyranthes are pulverized, 80 mesh sieves is crossed, is mixed into medicinal powder；
S2：Radix polygonati officinalis and rhizoma typhonii are cut into slices, dried, cleans, is mixed into section thing, is put into the crock for decocting medicine, adds
The weight of section thing and pure water is 1:2 pure water, after soaking 30 minutes, is first boiled with vigorous fire, then is decocted with moderate heat
Boil 45 minutes, until the weight for decocting into section thing and decoction is 1:0.8, take obtained decoction；
S3：The fruit of Chinese magnoliavine is cleaned, is put into container, the honey that weight is 25 parts is added, sealing refines into five
Taste sauce；
S4：Obtained fruit of Chinese magnoliavine sauce in obtained decoction in step S2 and step S3 is added to medicinal powder made from step S1
In, mixing preparation weighs 8 grams into pill per ball.
Embodiment 2
A kind of pharmaceutical composition for treating sciatica, is made up of the raw material components of following weight：Pseudo-ginseng 3
10 parts of part, 15 parts of radix polygonati officinalis, 10 parts of rhizoma typhonii, 8 parts of the fruit of Chinese magnoliavine and the root of bidentate achyranthes.
Above raw material is prepared into pill as described in Example 1.
Embodiment 3
A kind of pharmaceutical composition for treating sciatica, is made up of the raw material components of following weight：Pseudo-ginseng 10
30 parts of part, 30 parts of radix polygonati officinalis, 25 parts of rhizoma typhonii, 15 parts of the fruit of Chinese magnoliavine and the root of bidentate achyranthes.
Above raw material is prepared into pill as described in Example 1.
The clinical experiment report of embodiment 4：
Toxicity is tested：With the pertinent regulations according to study of tcm new drug, prepared by embodiment 1, embodiment 2 and implementation 3
Pill carries out a series of toxotest, after tested, does not find obvious toxic action.Patch prepared by the present invention is nontoxic
Side effect.
Selection crowd：Selection clinically suffers from 400 cases of sciatic nerve pain symptom, is divided into 4 groups, is respectively real
Test group 1, experimental group 2, experimental group 3 and contrast groups 4.The patient to experimental group 1 takes pill made from embodiment 1 daily, daily
Twice, every time one, two weeks is a course for the treatment of.The patient to experimental group 2 takes pill made from embodiment 2 daily, daily
Twice, every time one, two weeks is a course for the treatment of.The patient to experimental group 3 takes pill made from embodiment 3 daily, daily
Twice, every time one, two weeks is a course for the treatment of.The patient to contrast groups 4 takes conventional treatment sciatica daily
Analgesic drug product, twice daily, two weeks are a course for the treatment of.
Criterion of therapeutical effect：Reference《Disease of tcm judges criterion of therapeutical effect》In relevant criterion of therapeutical effect.Recovery from illness：Clinical symptoms all disappear
Lose, laboratory checks normal.Take a turn for the better：Clinical symptom relief, laboratory examination improves or normal.It is invalid：Clinical symptoms are without obvious
Take a turn for the better or aggravate.
Treatment results：Curative effect is summarized after one month, the treatment of each experimental group is as shown in the table：
| Project | Total number of persons | Recovery from illness | Take a turn for the better | It is invalid | Cure rate | Improvement rate |
| Experimental group 1 | 100 | 43 | 53 | 4 | 43% | 96% |
| Experimental group 2 | 100 | 35 | 60 | 5 | 35% | 95% |
| Experimental group 3 | 100 | 40 | 56 | 4 | 40% | 96% |
| Contrast groups 4 | 100 | 32 | 62 | 6 | 32% | 94% |
From result above, the present invention has significant curative effect, and quick result to treatment sciatica.
Claims (3)
1. a kind of pharmaceutical composition for treating sciatica, it is characterised in that by the raw material components group of following weight
Into：10-30 parts of 3-10 parts of pseudo-ginseng, 15-30 parts of radix polygonati officinalis, 10-25 parts of rhizoma typhonii, 8-15 parts of the fruit of Chinese magnoliavine and the root of bidentate achyranthes.
2. a kind of pharmaceutical composition for treating sciatica according to claim 1, it is characterised in that by following weight
The raw material components composition of part proportioning：18 parts of 5 parts of pseudo-ginseng, 25 parts of radix polygonati officinalis, 18 parts of rhizoma typhonii, 12 parts of the fruit of Chinese magnoliavine and the root of bidentate achyranthes.
3. a kind of a kind of preparation of pharmaceutical composition for treating sciatica suitable for described in any one of claim 1 or 2
Method, it is characterised in that its preparation process includes：
S1：Pseudo-ginseng and the root of bidentate achyranthes are pulverized, 80 mesh sieves is crossed, is mixed into medicinal powder；
S2：Radix polygonati officinalis and rhizoma typhonii are cut into slices, dried, cleans, is mixed into section thing, is put into the crock for decocting medicine, adds section
The weight of thing and pure water is 1:1.8-2 pure water, after soaking 20-50 minutes, is first boiled, then use moderate heat with vigorous fire
Decoct 30-60 minutes, until the weight for decocting into section thing and decoction is 1:0.8-1, takes obtained decoction；
S3：The fruit of Chinese magnoliavine is cleaned, is put into container, the honey that weight is 15-30 parts is added, the five tastes are refined into sealing
Sub- sauce；
S4：Obtained fruit of Chinese magnoliavine sauce in obtained decoction in step S2 and step S3 is added in medicinal powder made from step S1,
Mixing preparation is into pill, 3-10 grams of the weight per ball.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710384331.3A CN107137589A (en) | 2017-05-26 | 2017-05-26 | It is a kind of to treat pharmaceutical composition of sciatica and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710384331.3A CN107137589A (en) | 2017-05-26 | 2017-05-26 | It is a kind of to treat pharmaceutical composition of sciatica and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107137589A true CN107137589A (en) | 2017-09-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710384331.3A Withdrawn CN107137589A (en) | 2017-05-26 | 2017-05-26 | It is a kind of to treat pharmaceutical composition of sciatica and preparation method thereof |
Country Status (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11668708B2 (en) | 2017-09-29 | 2023-06-06 | Sekisui Medical Co., Ltd. | Method for reducing measurement error in latex agglutination immunoassay |
-
2017
- 2017-05-26 CN CN201710384331.3A patent/CN107137589A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11668708B2 (en) | 2017-09-29 | 2023-06-06 | Sekisui Medical Co., Ltd. | Method for reducing measurement error in latex agglutination immunoassay |
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170908 |
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