CN107137586A

CN107137586A - Chinese medicine composition and preparation method for treating tinnitus

Info

Publication number: CN107137586A
Application number: CN201710356442.3A
Authority: CN
Inventors: 魏增强; 董文学
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-05-19
Filing date: 2017-05-19
Publication date: 2017-09-08

Abstract

The present invention provides a kind of Chinese medicine composition and preparation method for being used to treat tinnitus, and the Chinese medicine composition is composed of the following components by mass percentage：Semen sesami nigrum 5%~7%, sealwort 5%~7%, mulberry fruit 5%~7%, lily 5%~7%, gingko 3%~5%, Chinese yam 8%~10%, the fruit of Chinese wolfberry 6%~8%, honeysuckle 8%~10%, chrysanthemum 5%~7%, the sophora bud 5%~7%, Radix Angelicae Sinensis 5%~7%, peach kernel 5%~7%, oyster 11%~13%, spina date seed 5%~7%, radix glycyrrhizae 3%~5%.Will above-mentioned component mix after add water be boiled into after paste with maltodextrin and potassium sorbate mixing granulation, dry, sterilizing,.Chinese medicine of the present invention has clearing liver to purge heat, stagnation resolvation is sensible, nourishing Yin and falling fire work(；Treat tinnitus effect caused by disturbing upward of liver-fire good, and also play the role of to treat well to other symptoms caused by irascibility.

Description

Chinese medicine composition and preparation method for treating tinnitus

Technical field

The invention belongs to the Chinese medicine composition of integration of drinking and medicinal herbs category, and in particular to a kind of Chinese traditional medicine composition for being used to treat tinnitus Thing and preparation method.

Background technology

Tinnitus refers to that the extraneous patient without sound source feels a kind of otopathy of ring in ear.Tinnitus is divided into subjective tinnitus and visitor The property seen tinnitus, subjective tinnitus refers to stimulate in extraneous noiseless source or during without electro photoluminescence in ear or the disease of sound perception occurs in encephalic Shape, also referred to as spontaneous tinnitus.Objective tinnitus refers to that the sound felt is produced by body and by bone conduction or tympanum It is delivered to cochlea, such as vascular pulsation sound, the click sound of palate throat myoclonia, the breathing of undue patency of eustachian tube.It is most of to suffer from Person is subjective tinnitus.

The reason for traditional Chinese medical science thinks to cause tinnitus has：(1) wind-heat is attacked, due to cold warm imbalance, affection of exogenous wind-heat, or chill Heat, impairment of dispersing and descending function of the lung causes exopathogen to follow the key through Committed obsessed ears, emptied and is blinded and caused.Main symptom：Projection tinnitus, such as blowing sample, daytime Night does not stop, Hearing, or with the swollen vexed sense of ear.Whole body can be with nasal obstruction, runny nose, cough, headache, fever with chilliness etc., tongue nature It is red, the thin Huang of tongue, superficial and rapid pulse.(2) disturbing upward of liver-fire：Exogenous pathogens invading from the exterior into the interior, invades few sun；Or depressed emotion, or the violent rage impariment of the liver, cause liver Imbalance reaches, qi depression transforming into fire, liver and gall can be caused intimately to follow through above disturbing ear key, cause Hiccough and deaf.Main symptom：Weight when light during tinnitus, With bitter taste, dry throat, flushing or hot eyes, yellow urine, constipation, night sleeps not peaceful, sternal rib pain, headache or dizziness, red tongue with yellowish fur, veins string. (3) convulsive seizure due to phlegm-fire pent-up：Eating and drinking without temperance, overfeeding fatness, sweet, thick and oily makes taste injured, or worries beyond measure, and injures taste, causes that water is wet not to be transported, Poly- and give birth to phlegm, then stagnation of phlegm converting into fire long, convulsive seizure due to phlegm-fire is strongly fragrant in ear, and clear key is closed in heap soil or fertilizer over and around the roots, so as to cause Hiccough and deaf.Main symptom：Hiccough and deaf, ear In swollen vexed, nose heave giddy, or see and have a dizzy spell, chest distress, coughing with a lot of sputum, bitter taste or tasteless, two is just smooth, and tongue is red, Yellow and greasy fur, slippery and rapid pulse.(4) qi depression to blood stasis：Depressed emotion is unsuccessful, causes stagnation of liver qi, functional activity of QI being not smooth, the stagnation of the circulation of vital energy then blood stasis；Or because falling Servant's pinking, steep loud noise etc. of hearing injure qi and blood, cause to stop in extravasated blood；Or pathogen usually intruding into collateral in protracted disease, it can cause ear key passages through which vital energy circulates to stop up resistance, clear key is closed Plug, occurs tinnitus or deafness.Main symptom：Hiccough and deaf, the course of disease is changeable, and whole body can be without obvious other symptoms, or have a pinking history, Dimly red tongue has petechiae, thready and hesitant pulse.Therapy：Promoting blood circulation and removing blood stasis, promoting the circulation of qi is sensible.(5) damage of kidney-essence：Congenital kidney essence deficiency, or after It loses after being ill is supported, and gives up completely to natural impulse, injures kidney essense, or old kidney essense is gradually lost etc., can cause kidney essense to lose.The deficiency of the kidney yin, then in the fire of deficiency type It is raw, above disturb ear key；The insufficiency of the kidney yang, then ear key lose in warm, can cause Hiccough and deaf.Main symptom：Tinnitus such as cicada, goinges on day and night without stopping, When quiet more so, hearing is gradually reduced, or is seen and felt dizzy, soreness and weakness of waist and knees, dysphoria insomnia, night pollakiuria, and the red few tongue of tongue, arteries and veins is thin It is weak or count accurately.(6) deficiency of qi and blood：Eating and drinking without temperance, the full imbalance of famine, or it is tired, worry beyond measure, cause weakness of the spleen and the stomach, lucid yang failing to raise, gas The source of blood biochemistry is not enough, and causes deficiency of qi and blood, it is impossible to above give in ear, ear key passages through which vital energy circulates is hollow, causes tinnitus or deafness.Or serious disease it Afterwards, sad blood is consumed, blood deficiency, then ear key mistake is supported and causes tinnitus.Main symptom：Tinnitus or sees that burnout is weary on the postemphasis of fatigue Power, the low fright due to decicincy of qi of sound, lusterless complexion, poor appetite, abdominal fullness and distention, big loose stool is thin, and palpitation and insomnia, tongue nature is light red, and tongue is thin white, and arteries and veins is thin It is weak.

The Chinese medicine that tinnitus is treated on existing market is substantially in terms of kidney tonifying, QI invigorating, promoting blood circulation treatment tinnitus of starting with, Not for tinnitus card type come symptomatic treatment.In addition, the few medicines of in the market are to be directed to tinnitus caused by disturbing upward of liver-fire, this Tinnitus can not fundamentally be treated by having resulted in this kind of patient and taking general tinnitus medicine, cause therapeutic effect not good, delay disease The consequence of feelings.

The content of the invention

It is an object of the invention to provide a kind of Chinese medicine composition for treating tinnitus, using the treatment means of solid decoction of medicinal ingredients, specially Door is directed to tinnitus caused by disturbing upward of liver-fire, and therapeutic effect is good, uneasy to recur.

The technical solution adopted in the present invention is,

Chinese medicine composition for treating tinnitus, it is raw materials used composed of the following components by mass percentage：

Semen sesami nigrum 5%~7%, sealwort 5%~7%, mulberry fruit 5%~7%, lily 5%~7%, gingko 3%~5%, mountain Medicine 8%~10%, the fruit of Chinese wolfberry 6%~8%, honeysuckle 8%~10%, chrysanthemum 5%~7%, the sophora bud 5%~7%, Radix Angelicae Sinensis 5% ~7%, peach kernel 5%~7%, oyster 11%~13%, spina date seed 5%~7%, radix glycyrrhizae 3%~5%, the matter of above each component It is 100% to measure percentage summation.

The above-mentioned preparation method for being used to treat tinnitus Chinese medicine composition, including following operating procedure：

Step 1,

By mass percentage, weigh Semen sesami nigrum 5%~7%, sealwort 5%~7%, mulberry fruit 5%~7%, lily 5%~ 7%th, gingko 3%~5%, Chinese yam 8%~10%, the fruit of Chinese wolfberry 6%~8%, honeysuckle 8%~10%, chrysanthemum 5%~7%, Chinese scholartree Rice 5%~7%, Radix Angelicae Sinensis 5%~7%, peach kernel 5%~7%, oyster 11%~13%, spina date seed 5%~7%, radix glycyrrhizae 3%~ 5%, the mass percent summation of above each component is 100%；

Step 2,

15 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, it is 1.20~1.40 (60 DEG C) that filtrate, which is concentrated into relative density, Thick paste；

Step 3,

Separately maltodextrin and potassium sorbate are taken, and maltodextrin and potassium sorbate were crushed into 80 mesh, it is standby；

Step 4,

By mass percentage, thick paste 24%~26.97%, the and of maltodextrin 73%~75.97% that step 2 is obtained are weighed Potassium sorbate 0.01%~0.03%, the mass percent summation of above each component is 100%；Thick paste and water are stirred To whitewashing, the weight ratio of thick paste and water is 1:2；

Step 5,

In multifunctional fluidized bed, maltodextrin and potassium sorbate are subjected to material heating and premixed, mixed material is obtained, so Pelletized afterwards toward whitewashing on mixed material, finally dry, cool, discharging, shutdown；

Step 6,

Last whole grain and filling, is produced.

In step 5, by maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 15m³/ h~25m³/ H, EAT is set to 80 DEG C~100 DEG C, heating premix is carried out to material 7~15 minutes, obtains mixed material；Premix is finished Afterwards, it is then multifunctional fluidized bed to start by adjusting air quantity and EAT so that mixed material temperature reaches 35 DEG C~40 DEG C Whitewashing, spouting velocity is set to 15rpm~20rpm, and atomizing pressure is 1.50bar~2.0bar, because material is aggravated after whitewashing, Temperature is reduced, and air quantity is adjusted at any time and keeps material fully to jump, and regulation EAT makes temperature of charge be maintained at 35 DEG C at any time ~40 DEG C, whitewashing 15min~30min after close whitewashing, complete granulation；Multifunctional fluidized bed EAT is set to again 100 DEG C material is dried, and regulation air quantity keeps material fully to jump, when the moisture≤2.0% of material, by EAT 25 DEG C~45 DEG C are down to, the temperature of material is reduced to 25 DEG C~45 DEG C, finally discharging shutdown.

In step 6, the particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole The dry particl of selection, is then fitted into bag and completes filling by grain.

The beneficial effects of the invention are as follows：There is clearing liver to purge heat, stagnation resolvation is sensible, nourishing Yin and falling fire work(；Symptomatic treatment, treats irascibility On disturb caused by tinnitus effect it is good, and also play the role of to treat well to other symptoms caused by irascibility；Whole prescription science Compatibility, the property of medicine is gentle, and human body is had no toxic side effect, can long-term taking.

Embodiment

The present invention provides a kind of Chinese medicine composition for being used to treat tinnitus, raw materials used by mass percentage by following components Composition：

The pharmacological action of Chinese medicine of the present invention is as follows：

Semen sesami nigrum：Filling liver kidney, benefiting essence-blood, ease constipation is dry, for blood and essence asthenia, dizzy, Hiccough and deaf, poliosis, Post disease alopecia, dry constipation of intestines.

Sealwort：Boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing, for deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, dry deficiency of food, Deficiency syndrome of the lung cough caused by dryness, overstrain cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, poliosis, Heat Diabetes.

Mulberry fruit：Nourishing yin and supplementing blood, fluid dryness, for the deficiency of liver-yin and kidney-yin, dizziness and tinnitus, palpitation and insomnia, poliosis, Tianjin wound Yearningly, Heat Diabetes, dry constipation of intestines.

Lily：It is sweet, tremble with fear, thoughts of returning home lung channel Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing, for deficiency of Yin cough caused by dryness, consumptive disease is coughed hemoptysis, dysphoria palpitates with fear, Insomnia and dreamful sleep, it is absent-minded.

Gingko：It is sweet, it is bitter, it is puckery, put down, poisonous, return lung kidney channel astringing lung for relieving asthma, stop-band contracting urine is breathed with cough for abundant expectoration, with lower white It is turbid, enuresis frequent micturition.

Chinese yam：It is sweet, put down, return skin lung kidney channel tonifying spleen nourishing the stomach, engender liquid and benefic lung, for spleen eating less, endless diarrhea, the deficiency syndrome of the lung is breathed heavily Cough, emission due to the kidney deficiency, under band, frequent micturition, abnormal heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney；For spleen eating less, diarrhea loose stool, leukorrhea mistake It is many.

The fruit of Chinese wolfberry：Nourishing liver and kidney, benefiting shrewd head is used for consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus, impotence and seminal emission, interior heat Quench one's thirst, blood deficiency chlorosis, blurred vision.

Honeysuckle：It is sweet, tremble with fear, return lung heart stomach is clearing heat and detoxicating, dispelling wind and heat from the body, for carbuncle swells furunculosis, larynx numbness, erysipelas, heat toxin Bloody flux, anemopyretic cold, warm disease heating.

Chrysanthemum：Wind heat-clearing is dissipated, flat liver improving eyesight is clearing heat and detoxicating, for anemopyretic cold, dizziness of having a headache, red eye, swell pain, eyes dusk Flower, sore and toxic.

The sophora bud：Cooling blood and hemostasis, clearing liver-fire, for having blood in stool, hemorrhoid blood, bloody flux, uterine bleeding is spitted blood, and the hot hot eyes of liver is had a headache dizzy It is dizzy.

Radix Angelicae Sinensis：Replenishing and activating blood, menstruction regulating and pain relieving, moistening dryness for relaxing bowels, for blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, dysmenorrhoea is closed Through asthenia cold abdominalgia, arthralgia pain due to rheumatism, injury from falling down, ulcer sore wound, dry constipation of intestines.

Peach kernel：Promoting blood circulation, relaxes bowel, relieving cough and asthma, for amenorrhoea dysmenorrhoea, lung carbuncle acute appendicitis, injury from falling down, and intestinal dryness is just It is secret, cough and asthma.

Oyster：It is transquilization with heavy material, checking exuberance of yang tonifying yin, softening and resolving hard mass, for insomnia of palpitating with fear, dizziness and tinnitus, calcined oyster shell convergence is astringent or styptic treatment for spontaneous sweating, Relieving haperacidity is relieved pain；For spontaneous sweating, emission and spermatorrhea, under uterine bleeding band, acid regurgitation of having a stomachache.

Spina date seed：Nourishing heart tonifying liver, antitoxic heart-soothing and sedative, arrest sweating promotes the production of body fluid, for restlessness of asrhenia type and insomnia, horrified to much dream, body void hidrosis, Tianjin Wound is thirsty.

Radix glycyrrhizae：It is sweet, put down, thoughts of returning home lung taste are clearing heat and detoxicating through invigorating the spleen and benefiting qi, and remove phlegm and relieving cough, relieving spasm to stop pain, coordinating the drug actions of a prescription； For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate medicine poison Property is strong.

In inventive formulation, oyster is slightly cold, and has effects that tonifying yin checking exuberance of yang, calms the nerves, for water files to nourish wood, hyperactivity of yang due to yin deficiency, Tinnitus etc., is monarch.The fruit of Chinese wolfberry, mulberry fruit, Semen sesami nigrum, sealwort, gingko, lily, spina date seed, filling liver kidney sperm adding and marrow healthing, cool blood are enriched blood, Acted on the tonifying yin for strengthening oyster；Chrysanthemum, honeysuckle, the sophora bud, clearing heat and cooling blood are acted on the fall fire for strengthening oyster；The fruit of Chinese wolfberry, mulberry Mulberry, Semen sesami nigrum, sealwort, gingko, lily, spina date seed, chrysanthemum, honeysuckle, more than the sophora bud it is minister.Radix Angelicae Sinensis, peach kernel, Chinese yam, mend Gas is promoting blood circulation and removing blood stasis, for assistant.Radix glycyrrhizae tonifying Qi and coordinating the drug actions of a prescription, to make.All medicines share, play altogether clearing liver purge heat, nourishing Yin and falling fire, stagnation resolvation lead to The effect of key.

Chinese medicine composition of the present invention is by the way of oral, oral 10 grams every time, 2 times a day, is within one month a course for the treatment of.

With reference to specific embodiment, the present invention is described in detail.

Embodiment 1

Preparation method for treating tinnitus Chinese medicine composition, including following operating procedure：

Step 1,

Weigh Semen sesami nigrum 5kg, sealwort 7kg, mulberry fruit 7kg, lily 6kg, gingko 5kg, Chinese yam 8kg, fruit of Chinese wolfberry 6kg, gold and silver Flower 8kg, chrysanthemum 7kg, sophora bud 6kg, Radix Angelicae Sinensis 6kg, peach kernel 7kg, oyster 11kg, spina date seed 6kg, radix glycyrrhizae 5kg；

Step 2,

15 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.35 (60 DEG C)；

Step 3,

Step 4,

Weigh thick paste 20.5kg, maltodextrin 61.5kg and potassium sorbate 20g；Thick paste and water are uniformly mixing to obtain spray The weight ratio of slurry, thick paste and water is 1:2；

Step 5,

By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 20m³/ h, EAT is set For 90 DEG C, heating premix is carried out to material 10 minutes, obtain mixed material；After premix is finished, by adjusting air quantity and entering wind-warm syndrome Degree so that mixed material temperature reaches 36 DEG C, then multifunctional fluidized bed to start whitewashing, spouting velocity is set to 17rpm, is atomized Pressure is 1.70bar, because material is aggravated after whitewashing, temperature reduction, and air quantity is adjusted at any time and keeps material fully to jump, and at any time Regulation EAT makes temperature of charge close whitewashing after being maintained at 36 DEG C, whitewashing 20min, completes granulation；Again by multi-functional fluidisation The EAT of bed is set to 100 DEG C material is dried, and regulation air quantity keeps material fully to jump, when material moisture≤ When 2.0%, EAT is down to 25 DEG C, the temperature of material is reduced to 25 DEG C, finally discharging shutdown；

Step 6,

The particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will The dry particl of selection, which is fitted into bag, completes filling.

Embodiment 2

Step 1,

Weigh Semen sesami nigrum 6kg, sealwort 5kg, mulberry fruit 7kg, lily 6kg, gingko 3kg, Chinese yam 10kg, fruit of Chinese wolfberry 7kg, gold and silver Flower 8kg, chrysanthemum 7kg, sophora bud 6kg, Radix Angelicae Sinensis 5kg, peach kernel 7kg, oyster 13kg, spina date seed 6kg, radix glycyrrhizae 4kg；

Step 2,

15 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.20 (60 DEG C)；

Step 3,

Step 4,

Weigh thick paste 24kg, maltodextrin 75.97kg and potassium sorbate 30g；Thick paste and water are uniformly mixing to obtain whitewashing, The weight ratio of thick paste and water is 1:2；

Step 5,

By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 25m³/ h, EAT is set For 80 DEG C, heating premix is carried out to material 7 minutes, obtain mixed material；After premix is finished, by adjusting air quantity and entering wind-warm syndrome Degree so that mixed material temperature reaches 40 DEG C, then multifunctional fluidized bed to start whitewashing, spouting velocity is set to 15rpm, is atomized Pressure is 1.50bar, because material is aggravated after whitewashing, temperature reduction, and air quantity is adjusted at any time and keeps material fully to jump, and at any time Regulation EAT makes temperature of charge close whitewashing after being maintained at 40 DEG C, whitewashing 15min, completes granulation；Again by multi-functional fluidisation The EAT of bed is set to 100 DEG C material is dried, and regulation air quantity keeps material fully to jump, when material moisture≤ When 2.0%, EAT is down to 35 DEG C, the temperature of material is reduced to 35 DEG C, finally discharging shutdown；

Step 6,

Embodiment 3

Step 1,

Weigh Semen sesami nigrum 7kg, sealwort 6kg, mulberry fruit 5kg, lily 7kg, gingko 4kg, Chinese yam 9kg, fruit of Chinese wolfberry 7kg, gold and silver Flower 9kg, chrysanthemum 6kg, sophora bud 5kg, Radix Angelicae Sinensis 7kg, peach kernel 6kg, oyster 12kg, spina date seed 7kg, radix glycyrrhizae 3kg；

Step 2,

15 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.30 (60 DEG C)；

Step 3,

Step 4,

Weigh thick paste 26.97kg, maltodextrin 73kg and potassium sorbate 30g；Thick paste and water are uniformly mixing to obtain whitewashing, The weight ratio of thick paste and water is 1:2；

Step 5,

By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 15m³/ h, EAT is set For 100 DEG C, heating premix is carried out to material 12 minutes, obtain mixed material；After premix is finished, by adjusting air quantity and entering wind-warm syndrome Degree so that when mixed material temperature reaches 38 DEG C, then multifunctional fluidized bed to start whitewashing, spouting velocity is set to 18rpm, mist Change pressure is 2.0bar, because material is aggravated after whitewashing, temperature reduction, and air quantity is adjusted at any time and keeps material fully to jump, and with When regulation EAT temperature of charge is maintained at 38 DEG C, close whitewashing after whitewashing 30min, complete granulation；Again by multi-functional stream The EAT of change bed is set to 100 DEG C and material is dried, and regulation air quantity keeps material fully to jump, when the moisture of material When≤2.0%, EAT is down to 30 DEG C, the temperature of material is reduced to 30 DEG C, finally discharging shutdown；

Step 6,

Embodiment 4

Step 1,

Weigh Semen sesami nigrum 7kg, sealwort 6kg, mulberry fruit 6kg, lily 5kg, gingko 4kg, Chinese yam 10kg, fruit of Chinese wolfberry 8kg, gold and silver Flower 10kg, chrysanthemum 5kg, sophora bud 7kg, Radix Angelicae Sinensis 6kg, peach kernel 5kg, oyster 12kg, spina date seed 5kg, radix glycyrrhizae 4kg；

Step 2,

15 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.40 (60 DEG C)；

Step 3,

Step 4,

Weigh thick paste 24.02kg, maltodextrin 75.97kg and potassium sorbate 10g；Thick paste and water are uniformly mixing to obtain spray The weight ratio of slurry, thick paste and water is 1:2；

Step 5,

By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 20m³/ h, EAT is set For 95 DEG C, heating premix is carried out to material 15 minutes, obtain mixed material；After premix is finished, by adjusting air quantity and entering wind-warm syndrome Degree so that mixed material temperature reaches 35 DEG C, then multifunctional fluidized bed to start whitewashing, spouting velocity is set to 20rpm, is atomized Pressure is 1.70bar, because material is aggravated after whitewashing, temperature reduction, and air quantity is adjusted at any time and keeps material fully to jump, and at any time Regulation EAT makes temperature of charge close whitewashing after being maintained at 35 DEG C, whitewashing 25min, completes granulation；Again by multi-functional fluidisation The EAT of bed is set to 100 DEG C material is dried, and regulation air quantity keeps material fully to jump, when material moisture≤ When 2.0%, EAT is down to 45 DEG C, the temperature of material is reduced to 45 DEG C, finally discharging shutdown；

Step 6,

Clinical data：

1st, case selection：

In order to verify in the effect of pharmaceutical composition of the present invention, in December, -2016 in June, 2015, the irascibility that selection is made a definite diagnosis Disturb 120 clinical observations of type tinnitus patient, male 58, women 62, age 25-65 Sui, average age 42 years old, tinnitus is repeatedly Breaking-out more than 1 month.

Make a definite diagnosis standard：Ring in ear is felt, and does not have the objective reality of the sound in surrounding environment；Ear has inaccessible sense, Aggravated after disgruntled；Hearing is normal or with different degrees of Hearing；And with bitter taste, dry throat, flushing hot eyes, yellow urine, Constipation, the symptom of red tongue with yellowish fur.

2nd, medicament selection：

Patient takes medicine of the present invention, and 2 times a day, each 10g, warm water delivery service in half an hour after meal, is within 30 days a treatment Journey, continuously takes 1 to 3 courses for the treatment of, and serious patient increases the amount of discretion.

3rd, efficacy determination：

(1) cure：Conscious tinnitus is wholly absent, and other symptoms are also wholly absent, and hearing is normal；

(2) it is effective：Conscious tinnitus disappears substantially, but still has under quiet environment slight tinnitus, and other symptoms also disappear substantially Lose, hearing is normal；

(3) effectively：Feel that tinnitus mitigates as accidental, breaking-out appearance, other diseases only under quiet environment or under noisy environment Shape has also mitigated, without obvious dysaudia；

(4) it is invalid：Tinnitus hearing is without improvement, and other symptoms also even deteriorate without change.

4th, result：

Take in 120 patients of medicine of the present invention, cure 74, effective 28, effective 12, invalid 6, cure rate For 61.7%, total effective rate 95%.

Case 1

The Zeng of Xianyang, Shanxi province city Liquan County, man, 38 years old；Patient's ears tinnitus 1 month, feels to have that the cicada cried in ear sound, For persisting tinnitus, normally, poor, feverishness in palms and soles of sleeping, vexed uneasiness, mood is easily fluctuated hearing, oliguria, dry and hard excrement, tongue It is partially red, the thin Huang of tongue, veins string.Tcm diagnosis is：Card category tinnitus of hepatobiliary hyperactivity, controls and preferably lets out irascibility, nourishing liver the moon；Take in the present invention After medicine, daily two doses (one 10g), 2 courses for the treatment of, tinnitus substantially mitigates, and switchs to by persisting tinnitus accidental, other symptoms Fade away, continue to take 1 course for the treatment of, tinnitus and other symptoms all disappear, fully recover.

Case 2

The Mr. Wang of Shaanxi Province Ankang City Shiquan County, female, 40 years old；Patient's ears tinnitus 4 months, often feels there is wind and thunder in ear Sound, can break out when angry, with headache and dizzy, and eyes are rubescent, constipation, and urine is in yellow, mood irritability, vexed insomnia. Ear-nose-throat department is checked：External auditory meatus is without hyperemia, without secretion, and eardrum is without perforation, depression；Hearing test is normal, and middle ear CT is normal.In Doctor is diagnosed as：Liver-fire tinnitus, controls suitable soothing liver-qi stagnation, relieves inflammation or internal heat and only ring；Take Chinese medicine of the present invention, daily two doses (one 10g), 2 After the individual course for the treatment of, tinnitus substantially mitigates, and other symptoms also fade away, and continues to take 2 courses for the treatment of, tinnitus and other symptoms all disappear Lose, recovery from illness.

Case 3

The Chen of Shaanxi Province Weinan City Fuping County, 54 years old, man；Continuous 3 months two ears often have tinnitus, and tinnitus has a tidal wave of or in wind Thunder, disgruntled insults tinnitus burst, and the swollen otalgia of ear, and with dysacousis, flushing hot eyes, irritated dizziness, bitter taste in the mouth and dry throat, just It is secret, red tongue with yellowish fur；Once take Western medicine and reconcile nerve, and expand vascular treatment, but it is invalid.Tcm diagnosis is：Disturbing upward of liver-fire type tinnitus, Control suitable purging liver-heat, open strongly fragrant sensible；Medicine of the present invention is taken, 2 courses for the treatment of are treated, tinnitus number of times is reduced, and tinnitus sound mitigates, and ear is swollen The symptom of otalgia substantially mitigates, flushing hot eyes, bitter taste in the mouth and dry throat, the improving situation of constipation；Continue to take 2 courses for the treatment of, tinnitus and its Its symptom is wholly absent, and auditory rehabilitation is normal, recovery from illness, and follow-up is without recurrence after half a year.

Claims

1. the Chinese medicine composition for treating tinnitus, it is characterised in that raw materials used composed of the following components by mass percentage：

Semen sesami nigrum 5%~7%, sealwort 5%~7%, mulberry fruit 5%~7%, lily 5%~7%, gingko 3%~5%, Chinese yam 8%~10%, the fruit of Chinese wolfberry 6%~8%, honeysuckle 8%~10%, chrysanthemum 5%~7%, the sophora bud 5%~7%, Radix Angelicae Sinensis 5%~ 7%th, peach kernel 5%~7%, oyster 11%~13%, spina date seed 5%~7%, radix glycyrrhizae 3%~5%, the quality of above each component Percentage summation is 100%.

2. it is used for the preparation method for treating tinnitus Chinese medicine composition described in a kind of claim 1, it is characterised in that including following behaviour Make step：

Step 1,

By mass percentage, weigh Semen sesami nigrum 5%~7%, it is sealwort 5%~7%, mulberry fruit 5%~7%, lily 5%~7%, white Really 3%~5%, Chinese yam 8%~10%, the fruit of Chinese wolfberry 6%~8%, honeysuckle 8%~10%, chrysanthemum 5%~7%, the sophora bud 5% ~7%, Radix Angelicae Sinensis 5%~7%, peach kernel 5%~7%, oyster 11%~13%, spina date seed 5%~7%, radix glycyrrhizae 3%~5%, with The mass percent summation of upper each component is 100%；

Step 2,

15 taste raw materials in step 1 are added water to cook twice, the water of 10 times of amounts are added for the first time, are decocted 2 hours, second plus 6 times The water of amount, is decocted 2 hours, merges decocting liquid twice, filtering, it is the thick of 1.20~1.40 (60 DEG C) that filtrate, which is concentrated into relative density, Cream；

Step 3,

Step 4,

By mass percentage, thick paste 24%~26.97%, maltodextrin 73%~75.97% and sorb that step 2 is obtained are weighed Sour potassium 0.01%~0.03%, the mass percent summation of above each component is 100%；Thick paste and water are uniformly mixing to obtain spray The weight ratio of slurry, thick paste and water is 1:2；

Step 5,

In multifunctional fluidized bed, maltodextrin and potassium sorbate are subjected to material heating and premixed, mixed material is obtained, it is then past Whitewashing is pelletized on mixed material, is finally dried, cools, discharges, is shut down；

Step 6,

Last whole grain and filling, is produced.

3. it is used for the preparation method for treating tinnitus Chinese medicine composition according to claim 2, it is characterised in that：The step 5 In, by maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 15m³/ h~25m³/ h, EAT is set 80 DEG C~100 DEG C are set to, heating premix is carried out to material 7~15 minutes, mixed material is obtained；After premix is finished, pass through regulation Air quantity and EAT so that mixed material temperature reaches 35 DEG C~40 DEG C, it is then multifunctional fluidized bed to start whitewashing, whitewashing speed Degree is set to 15rpm~20rpm, and atomizing pressure is 1.50bar~2.0bar, because material is aggravated after whitewashing, temperature reduction, with When regulation air quantity keep material fully to jump, and regulation EAT makes temperature of charge be maintained at 35 DEG C~40 DEG C at any time, whitewashing Whitewashing is closed after 15min~30min, granulation is completed；Multifunctional fluidized bed EAT is set into 100 DEG C again to enter material Row drying, regulation air quantity keeps material fully to jump, and when the moisture≤2.0% of material, EAT is down into 25 DEG C~45 DEG C, the temperature of material is reduced to 25 DEG C~45 DEG C, finally discharging shutdown.

4. it is used for the preparation method for treating tinnitus Chinese medicine composition according to claim 2, it is characterised in that：The step 6 In, the particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then by selection Dry particl, which is fitted into bag, completes filling.