CN107137505A - It is a kind of that there is the Chinese medicine composition for improving sleep function - Google Patents
It is a kind of that there is the Chinese medicine composition for improving sleep function Download PDFInfo
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- CN107137505A CN107137505A CN201710332416.7A CN201710332416A CN107137505A CN 107137505 A CN107137505 A CN 107137505A CN 201710332416 A CN201710332416 A CN 201710332416A CN 107137505 A CN107137505 A CN 107137505A
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- 239000000203 mixture Substances 0.000 title claims abstract description 36
- 230000007958 sleep Effects 0.000 title claims abstract description 35
- 239000003814 drug Substances 0.000 title claims abstract description 27
- 240000008397 Ganoderma lucidum Species 0.000 claims abstract description 49
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims abstract description 49
- 240000006079 Schisandra chinensis Species 0.000 claims abstract description 39
- 238000002360 preparation method Methods 0.000 claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 19
- 238000009472 formulation Methods 0.000 claims abstract description 16
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 9
- 235000013305 food Nutrition 0.000 claims abstract description 4
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 3
- 239000002131 composite material Substances 0.000 claims abstract description 3
- 235000008434 ginseng Nutrition 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 62
- 239000000706 filtrate Substances 0.000 claims description 36
- 235000020710 ginseng extract Nutrition 0.000 claims description 31
- 235000008422 Schisandra chinensis Nutrition 0.000 claims description 30
- 238000001914 filtration Methods 0.000 claims description 25
- 230000006837 decompression Effects 0.000 claims description 24
- 239000011812 mixed powder Substances 0.000 claims description 24
- 239000002245 particle Substances 0.000 claims description 24
- 239000006071 cream Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 238000001035 drying Methods 0.000 claims description 16
- 239000003826 tablet Substances 0.000 claims description 15
- 238000000605 extraction Methods 0.000 claims description 14
- 206010013786 Dry skin Diseases 0.000 claims description 10
- 239000011122 softwood Substances 0.000 claims description 10
- 235000020985 whole grains Nutrition 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 7
- 238000004064 recycling Methods 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 4
- 206010022437 insomnia Diseases 0.000 claims description 4
- 241000208340 Araliaceae Species 0.000 claims description 2
- 230000036541 health Effects 0.000 abstract description 5
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 21
- 238000002474 experimental method Methods 0.000 description 12
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 7
- 238000005469 granulation Methods 0.000 description 7
- 230000003179 granulation Effects 0.000 description 7
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 7
- 239000008108 microcrystalline cellulose Substances 0.000 description 7
- 229940016286 microcrystalline cellulose Drugs 0.000 description 7
- 230000006870 function Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
- 210000004556 brain Anatomy 0.000 description 5
- 239000008101 lactose Substances 0.000 description 5
- 235000019359 magnesium stearate Nutrition 0.000 description 5
- 238000012216 screening Methods 0.000 description 5
- 229920000881 Modified starch Polymers 0.000 description 4
- 238000007689 inspection Methods 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000000594 mannitol Substances 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- 208000019116 sleep disease Diseases 0.000 description 3
- 208000020685 sleep-wake disease Diseases 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 238000013546 non-drug therapy Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 description 1
- 206010052804 Drug tolerance Diseases 0.000 description 1
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 210000000467 autonomic pathway Anatomy 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000001447 compensatory effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000005059 dormancy Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000004424 eye movement Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 230000026781 habituation Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 206010020765 hypersomnia Diseases 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical compound [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000036640 muscle relaxation Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention belongs to technical field of traditional Chinese medicines or technical field of health care food, particularly relate to a kind of Chinese medicine composition for having and improving sleep function, its traditional Chinese medicine composite is ginseng, the fruit of Chinese magnoliavine and ganoderma lucidum, the Chinese medicine composition is prepared into oral formulations, and wherein oral formulations auxiliary material is residue after ganoderma lucidum is extracted.Said composition is prepared into preparation, can not only prepare the more outstanding formulation products of mass, but also can reduce cost.
Description
Technical field
The invention belongs to Chinese medicine or technical field of health care food, and in particular to a kind of to have the Chinese medicine group for improving sleep function
Compound.
Background technology
Sleep (sleep), be a kind of spontaneous and reversible quiescent condition occurred in the higher vertebrate cycle, show as
Reactivity reduction and the temporary transient interruption of consciousness that body is stimulated to external world.The activity of normal brain, and all higher vertebrates
Brain it is the same, awakening and sleep both states for being alternately present are in all the time.This alternating is one of biological rhythm phenomenon.Awakening
When, the sensitiveness that body is internal, external environment is stimulated increases, and can make purposeful and effective reaction.Then on the contrary, machine during sleep
Body is reduced to the sensitiveness of stimulation, and Muscle tensility declines, and reflection threshold increases, although the function of also maintains autonomic nerves system is adjusted
Section, but all complicated higher nervous activities, such as learn, remember, logical thinking activity can not be carried out, and only retain few
Measure the activity acquired a special sense.Someone studies, and periodically occurs dream in sleep procedure, and with unique physiology table
Levy, it is believed that dream be independently of awakening and sleep outside three state.This three state has the close of inherence in fact
System, such as awakening for a long time can cause the increase of " compensatory " sleep and dream.
Sleep is people's research topic interested at all times, is spent because the life of people there are about 1/3 in sleep,
And sleeping can refresh and relieving fatigue.From early 20th century, by the analysis of electroencephalogram, electrical activity of brain during sleep is found
Special slow wave is presented.Nineteen fifty-two again it has been found that in sleep procedure often occur short time, quick eye movement, and with
Quick brain wave by a narrow margin.This important discovery causes flourishing for sleep study.It is verified.Sleep is the active of brain
Active procedure, rather than passive waking state cancellation；The many neuromechanisms of intracerebral and mediator participate in generation and the hair of sleep
Exhibition (so that having carried out the Physiologic Studies of dream and the antidiastole of clinical sleep disordered disease and treatment etc.).But so far to sleep
Origin, the mechanism of occurrence and development, when phase transformation physiological foundation, and sleep how the major issue such as dispelling fatigue still
Have little understanding.
Sleep is a kind of biological instinct, and people is in sleep, whole-body muscle relaxation, and stimulate the reaction lowers to external world, heartbeat, is exhaled
The activities such as suction, excretion are reduced, and are conducive to various organs to regain the function.Biological clock in human body dominates internal system, release
Various hormones.Wherein there is a kind of growth hormone, it is to promote muscle metabolism that it, which is acted on, regains one's strength, promotes bone to grow up.
The material provided according to Chinese Medical Association shows that China there are about 300,000,000 adults with the sleep such as insomnia and hypersomnia
Obstacle, is mainly distributed on China's economic with respect to developed regions.Worldwide, about 1/3 adult is once by fault
The torment of dormancy disease, wherein 1/3 already belongs to severe insomnia.At present, the method for the treatment of sleep-disorder is divided into non-drug therapy and medicine
Thing therapy.Non-drug therapy is often difficult to operate during actual therapeutic, worked slowly.Medicinal treatment effect is definite, take effect
It hurry up, but be also easy to produce situations such as habituation, tolerance.And with people's health care consciousness and to the understanding of health product progressively plus
By force, sleep-disorder patient is more desirable to by daily health care mode, i.e., remove sleep-disorder by a kind of effective dietotherapy mode.
The A of Chinese patent CN 103039996 are disclosed using ginseng extract, Schisandra chinens P.E, Ganodenna Lucidum P.E as original
Material, is prepared into and microcrystalline cellulose excipients etc. is added in the health food of sleep function, its preparation method for improving, but the patent
Do not disclose, add whether microcrystalline cellulose can prepare qualified preparation, carried out deeply accordingly, it would be desirable to carry out preparation composition
The research entered.
The content of the invention
For these reasons, applicant has been surprisingly found that by multiple research and adds the residue after ganoderma lucidum is extracted, be used as auxiliary material
Use, can not only prepare the more outstanding formulation products of mass, but also cost can be reduced.
What the present invention was achieved through the following technical solutions.
A kind of to have the Chinese medicine composition for improving sleep function, traditional Chinese medicine composite is ginseng, the fruit of Chinese magnoliavine and ganoderma lucidum, is somebody's turn to do
Chinese medicine composition is prepared into oral formulations, and wherein oral formulations auxiliary material is residue after ganoderma lucidum is extracted.
Wherein oral formulations be tablet, capsule and granule,
Wherein oral formulations are prepared from by following supplementary materials：Ginseng extract, Schisandra chinens P.E, ganoderma lucidum are extracted
Residue after thing, ganoderma lucidum are extracted.
Tablet or capsule are prepared from by following supplementary materials wherein in oral formulations：The parts by weight of ginseng extract 4, the five tastes
The parts by weight of seed extract 9, the parts by weight of Ganodenna Lucidum P.E 9, the parts by weight of residue 4.8 after ganoderma lucidum is extracted；
Granule has following supplementary materials to be prepared from：The parts by weight of ginseng extract 4, the parts by weight of Schisandra chinens P.E 9, ganoderma lucidum
The parts by weight of extract 9, the parts by weight of residue 4.0 after ganoderma lucidum is extracted.
Application of the described Chinese medicine composition in the food for improving sleep.
Application of the described Chinese medicine composition in medicament for treating insomnia.
The preparation method of the oral formulations is：
Take people to participate in 70% ethanol, soak 2 hours, refluxing extraction 2 times, 1.5 hours every time, alcohol adding amount is respectively 10 times, 8
Times, filtration, merging filtrate, decompression filtrate recycling ethanol is concentrated under reduced pressure into 60 DEG C of relative density 1.25-1.30, temperature≤70 DEG C
It is dried under reduced pressure, dry cream is crushed, crosses 80 mesh sieves, obtain ginseng extract；
Take the fruit of Chinese magnoliavine to soak 2 hours, decoct 2 times, 1.5 hours every time, amount of water was respectively 10 times, 8 times, filtration,
Merging filtrate, filtrate decompression is concentrated into 60 DEG C of relative density 1.25-1.30, and temperature≤70 DEG C are dried under reduced pressure, and dry cream is crushed, and crosses 80
Mesh sieve, obtains Schisandra chinens P.E；
Take ganoderma lucidum to soak 2 hours, decoct 2 times, 1.5 hours every time, amount of water was respectively 10 times, 8 times, filtration is obtained
Standby, the merging filtrate to residue A, filtrate decompression surveys relative density 1.25-1.30 when being concentrated into 60 DEG C, temperature≤70 DEG C decompression is dry
Dry, dry cream is crushed, and is crossed 80 mesh sieves, is obtained Ganodenna Lucidum P.E；
Standby residue A is taken, 12 times of amount of water soaks 24-48 hours, filtering, it is small that residue adds 4 times of amount ethanol immersion 8-12
When, filtering, residue drying and crushing obtains residue after ganoderma lucidum is extracted standby；
Ginseng extract, Schisandra chinens P.E, Ganodenna Lucidum P.E are taken, is well mixed, 5/6ths standby weight are added
Residue after ganoderma lucidum is extracted, it is well mixed to obtain mixed powder, it is 30% ethanol softwood with concentration, addition is mixed powder weight
8%, 30 mesh sieves granulation, 50 DEG C of -60 DEG C of dryings, 30 mesh sieve whole grains obtain particle standby；
Standby particle is taken, packs, obtains granule.
Or residue after the ganoderma lucidum extraction of remaining 1/6th standby weight is taken, 80 mesh sieves are crossed, with above-mentioned standby particle
It is well mixed, it is encapsulated, obtain capsule.
Or residue after the ganoderma lucidum extraction of remaining 1/6th standby weight is taken, 80 mesh sieves are crossed, with above-mentioned standby particle
Mixing is equal, and tabletting obtains tablet.
Illustrate technical scheme, but protection scope of the present invention not limited to this with specific embodiment below.
Content described in this specification embodiment is only enumerating to the way of realization of inventive concept, protection of the invention
Scope is not construed as being only limitted to the concrete form that embodiment is stated, protection scope of the present invention is also and in art technology
Personnel according to present inventive concept it is conceivable that equivalent technologies mean.Although embodiment of the invention below is retouched
State, but the invention is not limited in above-mentioned specific embodiments and applications field, following specific embodiments is only to show
It is meaning property, directiveness rather than restricted.One of ordinary skill in the art is under the enlightenment of this specification and is not taking off
In the case of the scope protected from the claims in the present invention, the form of many kinds can also be made, these belong to the present invention
The row of protection.
The following experiments of the present invention, are on the basis of multiple creative experiment, with claimed technical scheme of the invention
Based on, the conclusive experiment of the research staff of summary.
First, screening test I
Take people to participate in 70% ethanol, soak 2 hours, refluxing extraction 2 times, 1.5 hours every time, alcohol adding amount is respectively 10 times, 8
Times, filtration, merging filtrate, decompression filtrate recycling ethanol is concentrated under reduced pressure into 60 DEG C of relative density 1.25-1.30, temperature≤70 DEG C
It is dried under reduced pressure, dry cream is crushed, crosses 80 mesh sieves, obtain ginseng extract；
Take the fruit of Chinese magnoliavine to soak 2 hours, decoct 2 times, 1.5 hours every time, amount of water was respectively 10 times, 8 times, filtration,
Merging filtrate, filtrate decompression is concentrated into 60 DEG C of relative density 1.25-1.30, and temperature≤70 DEG C are dried under reduced pressure, and dry cream is crushed, and crosses 80
Mesh sieve, obtains Schisandra chinens P.E；
Take ganoderma lucidum to soak 2 hours, decoct 2 times, 1.5 hours every time, amount of water was respectively 10 times, 8 times, filtration is obtained
Standby, the merging filtrate to residue A, filtrate decompression surveys relative density 1.25-1.30 when being concentrated into 60 DEG C, temperature≤70 DEG C decompression is dry
Dry, dry cream is crushed, and is crossed 80 mesh sieves, is obtained Ganodenna Lucidum P.E；
Standby residue A is taken, 12 times of amount of water soaks 36 hours, filtering, residue adds 4 times of amount ethanol and soaked 10 hours, mistake
Filter, residue drying and crushing obtains residue after ganoderma lucidum is extracted standby；
Test 1 group：Ginseng extract 40g, Schisandra chinens P.E 90g, Ganodenna Lucidum P.E 90g, microcrystalline cellulose 178g, firmly
Fatty acid magnesium 2g.
Preparation method：Ginseng extract, Schisandra chinens P.E, Ganodenna Lucidum P.E, microcrystalline cellulose are taken, 80 mesh are crossed respectively
Sieve, is well mixed, obtains mixed powder；50% ethanol softwood is added in mixed powder, consumption is the 10% of mixed powder amount, 30 mesh sieve series
Grain, 50 DEG C of -60 DEG C of dryings, 30 mesh sieve whole grains obtain particle；Magnesium stearate is taken, 80 mesh sieves is crossed, is well mixed with above-mentioned particle, is pressed
Piece, obtains 1000.
Test 2 groups：Ginseng extract 40g, Schisandra chinens P.E 90g, Ganodenna Lucidum P.E 90g, pregelatinized starch 235g, firmly
Fatty acid magnesium 2g.
Preparation method：Ginseng extract, Schisandra chinens P.E, Ganodenna Lucidum P.E, pregelatinized starch are taken, 80 mesh are crossed respectively
Sieve, is well mixed, obtains mixed powder；50% ethanol softwood is added in mixed powder, consumption is the 10% of mixed powder amount, 30 mesh sieve series
Grain, 50 DEG C of -60 DEG C of dryings, 30 mesh sieve whole grains obtain particle；Magnesium stearate is taken, 80 mesh sieves is crossed, is well mixed with above-mentioned particle, is pressed
Piece, obtains 1000.
Test 3 groups：Ginseng extract 40g, Schisandra chinens P.E 90g, Ganodenna Lucidum P.E 90g, lactose 195g, magnesium stearate
2g。
Preparation method：Ginseng extract, Schisandra chinens P.E, Ganodenna Lucidum P.E, lactose are taken, 80 mesh sieves, mixing are crossed respectively
Uniformly, mixed powder is obtained；50% ethanol softwood is added in mixed powder, consumption is the 10% of mixed powder amount, the granulation of 30 mesh sieves, 50
DEG C -60 DEG C of dryings, 30 mesh sieve whole grains obtain particle；Magnesium stearate is taken, 80 mesh sieves is crossed, is well mixed with above-mentioned particle, tabletting is obtained
To 1000.
Test 4 groups：Ginseng extract 40g, Schisandra chinens P.E 90g, Ganodenna Lucidum P.E 90g, mannitol 215g, stearic acid
Magnesium 2g.
Preparation method：Ginseng extract, Schisandra chinens P.E, Ganodenna Lucidum P.E, mannitol are taken, 80 mesh sieves are crossed respectively, is mixed
Close uniform, obtain mixed powder；50% ethanol softwood is added in mixed powder, consumption is the 10% of mixed powder amount, the granulation of 30 mesh sieves, 50
DEG C -60 DEG C of dryings, 30 mesh sieve whole grains obtain particle；Magnesium stearate is taken, 80 mesh sieves is crossed, is well mixed with above-mentioned particle, tabletting is obtained
To 1000.
Test 5 groups：Ginseng extract 40g, Schisandra chinens P.E 90g, Ganodenna Lucidum P.E 90g, residue after ganoderma lucidum is extracted
48g。
Preparation method：Ginseng extract, Schisandra chinens P.E, Ganodenna Lucidum P.E are taken, is well mixed, standby 40g is added
Residue after ganoderma lucidum is extracted, it is well mixed to obtain mixed powder, it is 30% ethanol softwood with concentration, addition is mixed powder weight
8%, 30 mesh sieves granulation, 50 DEG C of -60 DEG C of dryings, 30 mesh sieve whole grains obtain particle standby；
Residue after the extraction of 8g ganoderma lucidums is taken, 80 mesh sieves is crossed, is mixed with above-mentioned standby particle, tabletting, obtain 1000, tablet.
Test method：Above-mentioned tablet is taken, according to《Chinese Pharmacopoeia》The requirement of (four) 0923 tablet friability inspection technique, enters
Row checks that inspection result is shown in Table 1.
The friability inspection result of the different tablets of table 1
Result of the test：Tablet is prepared into by auxiliary material of mannitol, has fracture, cracking, shows that tablet quality is unqualified, and with
Residue meets the requirements as the preparation of auxiliary material after microcrystalline cellulose, lactose, pregelatinized starch, ganoderma lucidum are extracted.
2nd, screening test II
Test method：Take " one, 1 group of experiment, 2 groups of experiment, 3 groups of experiment, 5 pack agent of experiment in screening test I ", according to
《Chinese Pharmacopoeia》(four) 0921 disintegration time limited inspection technique, is checked, result of the test is shown in Table 2.
The different preparation slaking test results of table 2
Result of the test：Disintegration time limited shows, tablet is prepared into by auxiliary material of pregelatinized starch, and disintegration time limited advises more than pharmacopeia
It is fixed, and residue meets regulation as the preparation of auxiliary material after being extracted using microcrystalline cellulose, lactose, ganoderma lucidum.
3rd, screening test III
Test method：Take " one, 1 group of experiment, 2 groups of experiment, 3 groups of experiment, 5 pack agent of experiment in screening test I ", according to
《Chinese Pharmacopoeia》(four) 9001 material medicines are tried with influence factor test method in preparation stability test direction principle
Test, after experiment, detect its disintegration time limited, result of the test is shown in Table 3, table 4, table 5.
Preparation slaking test result after the high temperature of table 3
Preparation slaking test result after the high humidity of table 4
Preparation slaking test result after table the last 5 light
Result of the test：After high temperature, high humidity, highlight test, using microcrystalline cellulose, lactose as the tablet of auxiliary material, disintegration
Time limit does not meet pharmacopoeial requirements, and residue is the preparation of auxiliary material after being extracted using ganoderma lucidum, and disintegration time limited is still not above 15 minutes,
Absolutely prove, residue is auxiliary material after being extracted using ganoderma lucidum, with important scientific meaning.
Prepare embodiment
Embodiment 1
Take people to participate in 70% ethanol, soak 2 hours, refluxing extraction 2 times, 1.5 hours every time, alcohol adding amount is respectively 10 times, 8
Times, filtration, merging filtrate, decompression filtrate recycling ethanol is concentrated under reduced pressure into 60 DEG C of relative density 1.25-1.30, temperature≤70 DEG C
It is dried under reduced pressure, dry cream is crushed, crosses 80 mesh sieves, obtain ginseng extract；
Take the fruit of Chinese magnoliavine to soak 2 hours, decoct 2 times, 1.5 hours every time, amount of water was respectively 10 times, 8 times, filtration,
Merging filtrate, filtrate decompression is concentrated into 60 DEG C of relative density 1.25-1.30, and temperature≤70 DEG C are dried under reduced pressure, and dry cream is crushed, and crosses 80
Mesh sieve, obtains Schisandra chinens P.E；
Take ganoderma lucidum to soak 2 hours, decoct 2 times, 1.5 hours every time, amount of water was respectively 10 times, 8 times, filtration is obtained
Standby, the merging filtrate to residue A, filtrate decompression surveys relative density 1.25-1.30 when being concentrated into 60 DEG C, temperature≤70 DEG C decompression is dry
Dry, dry cream is crushed, and is crossed 80 mesh sieves, is obtained Ganodenna Lucidum P.E；
Standby residue A is taken, 12 times of amount of water soaks 24 hours, filtering, residue adds 4 times of amount ethanol and soaked 8 hours, mistake
Filter, residue drying and crushing obtains residue after ganoderma lucidum is extracted standby；
Ginseng extract 400g, Schisandra chinens P.E 900g, Ganodenna Lucidum P.E 900g, residue 480g after ganoderma lucidum is extracted.
Preparation method：Ginseng extract, Schisandra chinens P.E, Ganodenna Lucidum P.E are taken, is well mixed, standby 400g is added
Residue after ganoderma lucidum is extracted, it is well mixed to obtain mixed powder, it is 30% ethanol softwood with concentration, addition is mixed powder weight
8%, 30 mesh sieves granulation, 50 DEG C of -60 DEG C of dryings, 30 mesh sieve whole grains obtain particle standby；
Residue after the extraction of 80g ganoderma lucidums is taken, 80 mesh sieves is crossed, is mixed with above-mentioned standby particle, tabletting obtains tablet 10000
Piece.
Embodiment 2
Take people to participate in 70% ethanol, soak 2 hours, refluxing extraction 2 times, 1.5 hours every time, alcohol adding amount is respectively 10 times, 8
Times, filtration, merging filtrate, decompression filtrate recycling ethanol is concentrated under reduced pressure into 60 DEG C of relative density 1.25-1.30, temperature≤70 DEG C
It is dried under reduced pressure, dry cream is crushed, crosses 80 mesh sieves, obtain ginseng extract；
Take the fruit of Chinese magnoliavine to soak 2 hours, decoct 2 times, 1.5 hours every time, amount of water was respectively 10 times, 8 times, filtration,
Merging filtrate, filtrate decompression is concentrated into 60 DEG C of relative density 1.25-1.30, and temperature≤70 DEG C are dried under reduced pressure, and dry cream is crushed, and crosses 80
Mesh sieve, obtains Schisandra chinens P.E；
Take ganoderma lucidum to soak 2 hours, decoct 2 times, 1.5 hours every time, amount of water was respectively 10 times, 8 times, filtration is obtained
Standby, the merging filtrate to residue A, filtrate decompression surveys relative density 1.25-1.30 when being concentrated into 60 DEG C, temperature≤70 DEG C decompression is dry
Dry, dry cream is crushed, and is crossed 80 mesh sieves, is obtained Ganodenna Lucidum P.E；
Standby residue A is taken, 12 times of amount of water soaks 48 hours, filtering, residue adds 4 times of amount ethanol and soaked 12 hours, mistake
Filter, residue drying and crushing obtains residue after ganoderma lucidum is extracted standby；
Ginseng extract 400g, Schisandra chinens P.E 900g, Ganodenna Lucidum P.E 900g, residue 400g after ganoderma lucidum is extracted.
Preparation method：Ginseng extract, Schisandra chinens P.E, Ganodenna Lucidum P.E are taken, is well mixed, standby 400g is added
Residue after ganoderma lucidum is extracted, it is well mixed to obtain mixed powder, it is 30% ethanol softwood with concentration, addition is mixed powder weight
8%, 30 mesh sieves granulation, 50 DEG C of -60 DEG C of dryings, 30 mesh sieve whole grains obtain particle standby；
Standby particle is taken, packs, obtains 5000 bags of granule.
Embodiment 3
Take people to participate in 70% ethanol, soak 2 hours, refluxing extraction 2 times, 1.5 hours every time, alcohol adding amount is respectively 10 times, 8
Times, filtration, merging filtrate, decompression filtrate recycling ethanol is concentrated under reduced pressure into 60 DEG C of relative density 1.25-1.30, temperature≤70 DEG C
It is dried under reduced pressure, dry cream is crushed, crosses 80 mesh sieves, obtain ginseng extract；
Take the fruit of Chinese magnoliavine to soak 2 hours, decoct 2 times, 1.5 hours every time, amount of water was respectively 10 times, 8 times, filtration,
Merging filtrate, filtrate decompression is concentrated into 60 DEG C of relative density 1.25-1.30, and temperature≤70 DEG C are dried under reduced pressure, and dry cream is crushed, and crosses 80
Mesh sieve, obtains Schisandra chinens P.E；
Take ganoderma lucidum to soak 2 hours, decoct 2 times, 1.5 hours every time, amount of water was respectively 10 times, 8 times, filtration is obtained
Standby, the merging filtrate to residue A, filtrate decompression surveys relative density 1.25-1.30 when being concentrated into 60 DEG C, temperature≤70 DEG C decompression is dry
Dry, dry cream is crushed, and is crossed 80 mesh sieves, is obtained Ganodenna Lucidum P.E；
Standby residue A is taken, 12 times of amount of water soaks 36 hours, filtering, residue adds 4 times of amount ethanol and soaked 10 hours, mistake
Filter, residue drying and crushing obtains residue after ganoderma lucidum is extracted standby；
Ginseng extract 400g, Schisandra chinens P.E 900g, Ganodenna Lucidum P.E 900g, residue 480g after ganoderma lucidum is extracted.
Preparation method：Ginseng extract, Schisandra chinens P.E, Ganodenna Lucidum P.E are taken, is well mixed, standby 400g is added
Residue after ganoderma lucidum is extracted, it is well mixed to obtain mixed powder, it is 30% ethanol softwood with concentration, addition is mixed powder weight
8%, 30 mesh sieves granulation, 50 DEG C of -60 DEG C of dryings, 30 mesh sieve whole grains obtain particle standby；
Residue after remaining standby 80g ganoderma lucidum extraction is taken, 80 mesh sieves is crossed, is well mixed with above-mentioned standby particle, fill glue
Capsule, obtains capsule 10000.
Claims (7)
1. a kind of have the Chinese medicine composition for improving sleep function, traditional Chinese medicine composite is ginseng, the fruit of Chinese magnoliavine and ganoderma lucidum, and it is special
Levy and be that the Chinese medicine composition is prepared into oral formulations, wherein oral formulations auxiliary material is residue after ganoderma lucidum is extracted.
2. it is according to claim 1 it is a kind of have improve sleep function Chinese medicine composition, wherein oral formulations be tablet,
Capsule and granule.
3. according to claim 1 a kind of with the Chinese medicine composition of sleep function is improved, wherein oral formulations are under
Supplementary material is stated to be prepared from：Residue after ginseng extract, Schisandra chinens P.E, Ganodenna Lucidum P.E, ganoderma lucidum are extracted.
4. it is according to claim 1 a kind of with the Chinese medicine composition for changing sleep function, wherein tablet in oral formulations
Or capsule is prepared from by following supplementary materials：The parts by weight of ginseng extract 4, the parts by weight of Schisandra chinens P.E 9, Ganodenna Lucidum P.E
9 parts by weight, the parts by weight of residue 4.8 after ganoderma lucidum is extracted；
Granule has following supplementary materials to be prepared from：The parts by weight of ginseng extract 4, the parts by weight of Schisandra chinens P.E 9, ganoderma lucidum is extracted
The parts by weight of thing 9, the parts by weight of residue 4.0 after ganoderma lucidum is extracted.
5. a kind of Chinese medicine composition with improvement sleep function according to claim any one of 1-4, it is characterised in that
Application of the described Chinese medicine composition in the food for improving sleep.
6. a kind of Chinese medicine composition with improvement sleep function according to claim any one of 1-4, it is characterised in that
Application of the described Chinese medicine composition in medicament for treating insomnia.
7. a kind of Chinese medicine composition with improvement sleep function according to claim 2, it is characterised in that oral formulations
Preparation method be：
Take people to participate in 70% ethanol, soak 2 hours, refluxing extraction 2 times, 1.5 hours every time, alcohol adding amount was respectively 10 times, 8 times,
Filtration, merging filtrate, decompression filtrate recycling ethanol is concentrated under reduced pressure into 60 DEG C of relative density 1.25-1.30, temperature≤70 DEG C decompression
Dry, dry cream is crushed, cross 80 mesh sieves, obtain ginseng extract；
Take the fruit of Chinese magnoliavine to soak 2 hours, decoct 2 times, 1.5 hours every time, amount of water was respectively 10 times, 8 times, filter, merge
Filtrate, filtrate decompression is concentrated into 60 DEG C of relative density 1.25-1.30, and temperature≤70 DEG C are dried under reduced pressure, and dry cream is crushed, and crosses 80 mesh
Sieve, obtains Schisandra chinens P.E；
Take ganoderma lucidum to soak 2 hours, decoct 2 times, 1.5 hours every time, amount of water was respectively 10 times, 8 times, filtration obtains residual
Slag A is standby, merging filtrate, and filtrate decompression surveys relative density 1.25-1.30 when being concentrated into 60 DEG C, and temperature≤70 DEG C are dried under reduced pressure,
Dry cream is crushed, and is crossed 80 mesh sieves, is obtained Ganodenna Lucidum P.E；
Standby residue A is taken, 12 times of amount of water soaks 24-48 hours, filtering, residue adds 4 times of amount ethanol and soaked 8-12 hours,
Filtering, residue drying and crushing obtains residue after ganoderma lucidum is extracted standby；
Ginseng extract, Schisandra chinens P.E, Ganodenna Lucidum P.E are taken, is well mixed, 5/6ths standby weight ganoderma lucidums are added
Residue after extraction, it is well mixed to obtain mixed powder, it is 30% ethanol softwood with concentration, addition is the 8% of mixed powder weight,
30 mesh sieves are pelletized, and 50 DEG C of -60 DEG C of dryings, 30 mesh sieve whole grains obtain particle standby；
Standby particle is taken, packs, obtains granule.
Or residue after the ganoderma lucidum extraction of remaining 1/6th standby weight is taken, 80 mesh sieves are crossed, are mixed with above-mentioned standby particle
Uniformly, it is encapsulated, obtain capsule.
Or residue after the ganoderma lucidum extraction of remaining 1/6th standby weight is taken, 80 mesh sieves are crossed, are mixed with above-mentioned standby particle
, tabletting, obtains tablet.
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| CN111840369A (en) * | 2019-04-30 | 2020-10-30 | 东莞东阳光保健品研发有限公司 | Preparation method and application of sleep-aiding lucid ganoderma compound composition and capsule |
| CN115317544A (en) * | 2022-09-22 | 2022-11-11 | 吉林农业大学 | Traditional Chinese medicine composition for improving sleep, traditional Chinese medicine preparation and preparation method thereof |
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| CN110812415B (en) * | 2019-12-27 | 2021-10-12 | 辽宁上药好护士药业（集团）有限公司 | Preparation method of heart-benefiting and mind-tranquilizing composition for improving sleep |
| CN115317544A (en) * | 2022-09-22 | 2022-11-11 | 吉林农业大学 | Traditional Chinese medicine composition for improving sleep, traditional Chinese medicine preparation and preparation method thereof |
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