CN107137489A - One kind is used for traditional Chinese medicinal composition with effect of reducing blood sugar and its preparation method and application - Google Patents
One kind is used for traditional Chinese medicinal composition with effect of reducing blood sugar and its preparation method and application Download PDFInfo
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention discloses a kind of traditional Chinese medicinal composition with effect of reducing blood sugar and its preparation method and application.Said composition is main as made by the bulk drug of following parts by weight：20 40 parts recklessly of 60 80 parts of honeysuckle, 30 55 parts of peppermint, silver, 18 34 parts of cow-bezoar, 15 24 parts of dried orange peel, 12 20 parts of radix glycyrrhizae, 10 20 parts of the fruit of Chinese magnoliavine, 10 18 parts of cortex albiziae, 8 15 parts of donkey-hide gelatin.The present invention's is simple and convenient for traditional Chinese medicinal composition with effect of reducing blood sugar preparation method, and cost is low.Compared with current hypoglycemic chemotherapeutic agent, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, and adverse reaction and side effect are significantly reduced.Chinese medicine composition effect is comprehensive, medication effect more preferably, in pharmaceutical composition add the pharmaceutical composition prepared after a certain proportion of cortex albiziae and donkey-hide gelatin are mixed with other Chinese medicine materials can be effectively reduced patient blood glucose and recurrence rate it is low, synergy can significantly be effectively improved the symptom of hyperglycaemia.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to one kind is used for traditional Chinese medicinal composition with effect of reducing blood sugar and preparation method thereof
And application.
Background technology
Sugar in blood is referred to as blood glucose, is all glucose in most cases.Sugared part is that our bodies are essential
One of nutrition, the energy needed for each tissue cellular activity is largely from glucose, people's intake cereal, vegetables and fruits etc., warp in vivo
Cross digestive system and be converted into glucose and enter blood, systemic cell is transported to, as the source of energy, so blood glucose must be kept
The need for certain level could maintain internal each organ and tissue.Normal person is 4.1~6.0mmol/ in fasting plasma glucose concentration
L.Fasting plasma glucose concentration is referred to as hyperglycaemia more than 6.0mmol/L, at this moment can some glucose with urine ejection, here it is sugared
Urine.
With increasingly increasing for people's living standard, the patient with diabetes is also more and more, diabetes be it is a kind of very
Refractory disease more, patient needs Long-term taking medicine and kept on a diet, and diabetes model case often has diuresis, many drinks, eats more, disappears
It is thin to wait performance, i.e. " three-many-one-little " symptom.And diabetes easily cause cardiovascular pathological changes, renal lesions, DPN etc. simultaneously
Send out disease.
At present, global about 1.5 hundred million people suffer from diabetes, and its incidence of disease is just in ascendant trend year by year.At present, in the market does not have also
It is a kind of thoroughly to effect a radical cure the medicine of diabetes, and hypoglycemic chemicals long-term taking has certain toxic side effect.In order to
The persistent ailment of this influence of diabetes people life is treated and prevented, people also need further to be explored and studied.
Traditional Chinese medicine is so long lasting, and still highly visible so far, it is to use pure natural, multi-flavor polypharmacy at all,
Multicomponent, multichannel, Mutiple Targets are developed, while effect is played, it is evident in efficacy, with advantageous advantage.Chinese medicine compound prescription is not
Blood glucose, glucose in urine can only be reduced, can also comprehensively regulating whole body reach the purpose treated both principal and secondary aspect of disease.Therefore the whole society especially needs further
A class toxicity is researched and developed low, eutherapeutic Traditional Chinese medicine for decreasing blood sugar, the present invention has exactly adapted to this demand, to reduction diabetic
Blood sugar level, improves patient symptom, and reduction of patient pain has important social value.
The content of the invention
Goal of the invention：The problem of existing for prior art, the present invention provides a kind of for traditional Chinese medicinal composition with effect of reducing blood sugar.
The pharmaceutical composition can be effectively reduced blood glucose, and recurrence rate is low, have no side effect.
Technical scheme：To achieve these goals, it is a kind of as described herein to be used for traditional Chinese medicinal composition with effect of reducing blood sugar, mainly
As made by the bulk drug of following parts by weight：60-80 parts of honeysuckle, 30-55 parts of peppermint, silver-colored 20-40 parts of Hu, 18-34 parts of cow-bezoar,
15-24 parts of dried orange peel, 12-20 parts of radix glycyrrhizae, 10-20 parts of the fruit of Chinese magnoliavine, 10-18 parts of cortex albiziae, 8-15 parts of donkey-hide gelatin.
Preferably, described is used for traditional Chinese medicinal composition with effect of reducing blood sugar, mainly as made by the bulk drug of following parts by weight：
65-75 parts of honeysuckle, 35-50 parts of peppermint, silver-colored 30-35 parts of Hu, 20-30 parts of cow-bezoar, 18-22 parts of dried orange peel, 15-18 parts of radix glycyrrhizae, five
12-16 parts of taste, 12-15 parts of cortex albiziae, 10-12 parts of donkey-hide gelatin.
Preparation method of the present invention for traditional Chinese medicinal composition with effect of reducing blood sugar, comprises the following steps：
(1) do not have powder with water logging after weighing honeysuckle, peppermint, Yin Hu, cow-bezoar, dried orange peel mixing in proportion, with being cooked by slow fire,
Collecting decoction is filtered, and obtains filtrate A；
(2) the filtrate A alcohol refluxs for adding 4-6 times of volume are extracted, merges extract solution, reclaimed ethanol to without alcohol taste, obtain
Extract solution B；
(3) radix glycyrrhizae, the fruit of Chinese magnoliavine, cortex albiziae, donkey-hide gelatin are soaked, boiled, filter 6-8 times of volume of backward filtrate addition
Alcohol reflux is extracted, and is merged extract solution, is obtained extract solution C；
(4) by extract solution B and extract solution C, relative density is 1.15~1.20 lotion when being condensed into 70 DEG C, is produced.
Wherein, step (1) is described with being cooked by slow fire 1-2 times, each 30-40min.
Preferably, step (2) and the ethanol that step (3) described ethanol is volume fraction 70-75%.
Application of the present invention for traditional Chinese medicinal composition with effect of reducing blood sugar in treatment hypoglycemic medicament is prepared.
Preferably, the medicine includes decoction, oral liquid, tablet, capsule or granule.
Beneficial effect：It is compared with prior art, of the invention that to be used for traditional Chinese medicinal composition with effect of reducing blood sugar preparation method simply square
Just, cost is low.Compared with current hypoglycemic chemotherapeutic agent, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, no
Good reaction and side effect are significantly reduced, and particularly it does not produce any destruction for intestinal mucosa.Chinese traditional medicine composition of the present invention
Thing effect is comprehensive, medication effect more preferably, in pharmaceutical composition of the invention due to add a certain proportion of cortex albiziae and
Blood glucose and recurrence rate that the pharmaceutical composition that donkey-hide gelatin is prepared after being mixed with other Chinese medicine materials can be effectively reduced patient is low,
Synergy can significantly significantly improve the symptom of hyperglycaemia.
Embodiment
The present invention is further described with reference to embodiment.
Embodiment 1
Component：
40 parts recklessly of 60 parts of honeysuckle, 55 parts of peppermint, silver, 18 parts of cow-bezoar, 24 parts of dried orange peel, 12 parts of radix glycyrrhizae, 10 parts of the fruit of Chinese magnoliavine, conjunction
Joyous 10 parts of skin, 8 parts of donkey-hide gelatin.
Preparation method：
(1) do not have powder with water logging after weighing honeysuckle, peppermint, Yin Hu, cow-bezoar, dried orange peel mixing in proportion, with being cooked by slow fire 2
Secondary, each 30min, collecting decoction filtering obtains filtrate A；
(2) the filtrate A alcohol refluxs of volume fraction 70% for adding 4 times of volumes are extracted 2 times, each 2h merges extract solution,
Ethanol is reclaimed to without alcohol taste, extract solution B is obtained；
(3) radix glycyrrhizae, the fruit of Chinese magnoliavine, cortex albiziae, donkey-hide gelatin are soaked, boiled, filter the body that backward filtrate adds 6 times of volumes
The alcohol reflux of fraction 70% is extracted 2 times, each 2h, is merged extract solution, is obtained extract solution C；
(4) by extract solution B and extract solution C, relative density is 1.15 lotion when being condensed into 70 DEG C, is produced.
Decoction is made according to conventional formulation method in lotion.
Embodiment 2
Component：
40 parts recklessly of 80 parts of honeysuckle, 30 parts of peppermint, silver, 34 parts of cow-bezoar, 15 parts of dried orange peel, 20 parts of radix glycyrrhizae, 20 parts of the fruit of Chinese magnoliavine, conjunction
Joyous 18 parts of skin, 15 parts of donkey-hide gelatin.
Preparation method：
(1) do not have powder with water logging after weighing honeysuckle, peppermint, Yin Hu, cow-bezoar, dried orange peel mixing in proportion, with being cooked by slow fire 1
Secondary, each 30min, collecting decoction filtering obtains filtrate A；
(2) the filtrate A alcohol refluxs of volume fraction 75% for adding 6 times of volumes are extracted 3 times, each 1h merges extract solution,
Ethanol is reclaimed to without alcohol taste, extract solution B is obtained；
(3) radix glycyrrhizae, the fruit of Chinese magnoliavine, cortex albiziae, donkey-hide gelatin are soaked, boiled, filter the body that backward filtrate adds 8 times of volumes
The alcohol reflux of fraction 75% is extracted 3 times, each 1h, is merged extract solution, is obtained extract solution C；
(4) by extract solution B and extract solution C, relative density is 1.20 lotion when being condensed into 70 DEG C, is produced.
Oral agents are made according to conventional formulation method in lotion.
Embodiment 3
Component：
35 parts recklessly of 70 parts of honeysuckle, 40 parts of peppermint, silver, 20 parts of cow-bezoar, 18 parts of dried orange peel, 15 parts of radix glycyrrhizae, 12 parts of the fruit of Chinese magnoliavine, conjunction
Joyous 15 parts of skin, 10 parts of donkey-hide gelatin.
Preparation method：
(1) do not have powder with water logging after weighing honeysuckle, peppermint, Yin Hu, cow-bezoar, dried orange peel mixing in proportion, with being cooked by slow fire 2
Secondary, each 35min, collecting decoction filtering obtains filtrate A；
(2) the filtrate A alcohol refluxs of volume fraction 70% for adding 5 times of volumes are extracted 3 times, each 1.5h merges and extracted
Liquid, reclaims ethanol to without alcohol taste, obtains extract solution B；
(3) radix glycyrrhizae, the fruit of Chinese magnoliavine, cortex albiziae, donkey-hide gelatin are soaked, boiled, filter the body that backward filtrate adds 7 times of volumes
The alcohol reflux of fraction 70% is extracted 3 times, each 1h, is merged extract solution, is obtained extract solution C；
(4) by extract solution B and extract solution C, relative density is 1.18 lotion when being condensed into 70 DEG C, is produced.
Tablet is made according to conventional formulation method in lotion.
Embodiment 4
Component：
30 parts recklessly of 65 parts of honeysuckle, 35 parts of peppermint, silver, 20 parts of cow-bezoar, 18 parts of dried orange peel, 15 parts of radix glycyrrhizae, 12 parts of the fruit of Chinese magnoliavine, conjunction
Joyous 12 parts of skin, 10 parts of donkey-hide gelatin.
Preparation method：
(1) do not have powder with water logging after weighing honeysuckle, peppermint, Yin Hu, cow-bezoar, dried orange peel mixing in proportion, with being cooked by slow fire 2
Secondary, each 35min, collecting decoction filtering obtains filtrate A；
(2) the filtrate A alcohol refluxs of volume fraction 75% for adding 6 times of volumes are extracted 2 times, each 1.5h merges and extracted
Liquid, reclaims ethanol to without alcohol taste, obtains extract solution B；
(3) radix glycyrrhizae, the fruit of Chinese magnoliavine, cortex albiziae, donkey-hide gelatin are soaked, boiled, filter the body that backward filtrate adds 8 times of volumes
The alcohol reflux of fraction 70% is extracted 3 times, each 1h, is merged extract solution, is obtained extract solution C；
(4) by extract solution B and extract solution C, relative density is 1.15 lotion when being condensed into 70 DEG C, is produced.Lotion according to
Granule is made in conventional formulation method.
Embodiment 5
Component：
35 parts recklessly of 75 parts of honeysuckle, 50 parts of peppermint, silver, 30 parts of cow-bezoar, 22 parts of dried orange peel, 18 parts of radix glycyrrhizae, 16 parts of the fruit of Chinese magnoliavine, conjunction
Joyous 15 parts of skin, 12 parts of donkey-hide gelatin.
Preparation method：
(1) do not have powder with water logging after weighing honeysuckle, peppermint, Yin Hu, cow-bezoar, dried orange peel mixing in proportion, with being cooked by slow fire 1
Secondary, each 40min, collecting decoction filtering obtains filtrate A；
(2) the filtrate A alcohol refluxs of volume fraction 70% for adding 5 times of volumes are extracted 3 times, each 1h merges extract solution,
Ethanol is reclaimed to without alcohol taste, extract solution B is obtained；
(3) radix glycyrrhizae, the fruit of Chinese magnoliavine, cortex albiziae, donkey-hide gelatin are soaked, boiled, filter the body that backward filtrate adds 7 times of volumes
The alcohol reflux of fraction 70% is extracted 2 times, each 1h, is merged extract solution, is obtained extract solution C；
(4) by extract solution B and extract solution C, relative density is 1.18 lotion when being condensed into 70 DEG C, is produced.
Capsule is made according to conventional formulation method in lotion.
Test example 1
Toxicological experiment
40 SD rats, are grouped at random by body weight, every group 10, institute prepared by the oral embodiment 1-5 of above-mentioned rat
Chinese medicine composition is obtained, consumption is that one day consumption carries out acute toxicity test, and dosage is 1.0g/, is not as a result occurred any
Toxic reaction, to observation post administration 7 days, as a result all rats perfected, and its activity, diet, hair, excreta are no abnormal, not
See toxic reaction.To place's post mortem, its main organs observation Non Apparent Abnormality.
Test example 2
1st, general information
200 hyperglycemic patients, man 100, female 100.Stochastic averagina is divided into five groups, respectively control group 1, control group
2nd, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, each group sex, age, course of disease etc. are statistically analyzed, no significant difference
Meaning (P>O.05), with comparativity.
2nd, treatment method
Control group 1 gives Glipizide sustained release tablets (Qin Su) (commercially available), is used by package insert, orally, one time 1
Piece, one month is a course for the treatment of 1 times a day.
Control group 2 is given identical with the prescription and preparation method of embodiment 3, and difference is not with having cortex albiziae in prescription
With the Chinese medicine composition obtained by donkey-hide gelatin, consumption is one day consumption, once a day, is within one month a course for the treatment of.
3 groups of 1 group of embodiment, 2 groups of embodiment and embodiment give the embodiment of the present invention 1, embodiment 2 and embodiment 3 respectively
Gained Chinese medicine composition, consumption is one day consumption, once a day, is within one month a course for the treatment of.
3rd, diagnostic criteria
Recovery from illness：Blood glucose is down to normally, and drug withdrawal does not rebound for 1 year, and cardinal symptom disappears；It is effective：Blood glucose is decreased obviously, disease
Shape is obviously improved；It is invalid：Blood glucose and symptom are without improvement.
4th, treatment results
As stated above treat ten courses for the treatment of after, investigate each group eventually treatment total effective rate (%), and be discontinued 1 year after
Recurrence rate (%), the results are shown in Table 1.
The each group patient clinical of table 1 treats total effective rate and recurrence rate investigates result (%)
From the result of upper table 1, compared with the existing medicine of control group 1, the embodiment of the present invention 1,2 and 3 gained Chinese medicines
Composition, the therapeutic effect for hyperglycaemia is more preferable, it was demonstrated that it can effectively reduce blood glucose；Simultaneously control group compared with 2 originally
The effective cure rate and recovery from illness ratio of invention are also higher, illustrate that cortex albiziae and donkey-hide gelatin inside serve key effect；And
In terms of recurrence rate, the recurrence rate after traditional Chinese medicine composition for treating of the present invention is only up to 5%, well below control group 1 and 2, card
Bright Chinese medicine composition of the present invention can significantly reduce the recurrence rate of hyperglycaemia, patient can be made to fully recover.And over the course for the treatment of, and
Over the course for the treatment of, side reaction 6 occurs for control group 1, and other each treatment groups occur without side reaction.
Claims (7)
1. one kind is used for traditional Chinese medicinal composition with effect of reducing blood sugar, it is characterised in that mainly as made by the bulk drug of following parts by weight：Gold
60-80 parts of honeysuckle flower, 30-55 parts of peppermint, silver-colored 20-40 parts of Hu, 18-34 parts of cow-bezoar, 15-24 parts of dried orange peel, 12-20 parts of radix glycyrrhizae, the five tastes
Sub- 10-20 parts, 10-18 parts of cortex albiziae, 8-15 parts of donkey-hide gelatin.
2. according to claim 1 be used for traditional Chinese medicinal composition with effect of reducing blood sugar, it is characterised in that mainly by following parts by weight
Made by bulk drug：It is 65-75 parts of honeysuckle, 35-50 parts of peppermint, silver-colored 30-35 parts of Hu, 20-30 parts of cow-bezoar, 18-22 parts of dried orange peel, sweet
Careless 15-18 parts, 12-16 parts of the fruit of Chinese magnoliavine, 12-15 parts of cortex albiziae, 10-12 parts of donkey-hide gelatin.
3. the preparation method for traditional Chinese medicinal composition with effect of reducing blood sugar described in claim any one of 1-2, it is characterised in that including
Following steps：
(1) do not have powder with water logging after weighing honeysuckle, peppermint, Yin Hu, cow-bezoar, dried orange peel mixing in proportion, with being cooked by slow fire, merge
Decocting liquid is filtered, and obtains filtrate A；
(2) the filtrate A alcohol refluxs for adding 4-6 times of volume are extracted, merges extract solution, reclaimed ethanol to without alcohol taste, must extract
Liquid B；
(3) radix glycyrrhizae, the fruit of Chinese magnoliavine, cortex albiziae, donkey-hide gelatin are soaked, boiled, filter the ethanol that backward filtrate adds 6-8 times of volume
Refluxing extraction, merges extract solution, obtains extract solution C；
(4) by extract solution B and extract solution C, the lotion that relative density is 1.15~1.20 is condensed into, is produced.
4. preparation method according to claim 3, it is characterised in that step (1) is described with being cooked by slow fire 1-2 times, every time
30-40min。
5. preparation method according to claim 3, it is characterised in that step (2) and step (3) described ethanol are volume integral
Number 70-75% ethanol.
6. it is used for traditional Chinese medicinal composition with effect of reducing blood sugar answering in treatment hypoglycemic medicament is prepared described in claim any one of 1-2
With.
7. application according to claim 6, it is characterised in that the medicine includes decoction, oral liquid, tablet, capsule
Or granule.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710388489.8A CN107137489A (en) | 2017-05-27 | 2017-05-27 | One kind is used for traditional Chinese medicinal composition with effect of reducing blood sugar and its preparation method and application |
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| CN201710388489.8A CN107137489A (en) | 2017-05-27 | 2017-05-27 | One kind is used for traditional Chinese medicinal composition with effect of reducing blood sugar and its preparation method and application |
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| CN107137489A true CN107137489A (en) | 2017-09-08 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113509509A (en) * | 2021-04-30 | 2021-10-19 | 杭州仁德医药有限公司 | Traditional Chinese medicine emplastrum for reducing hyperglycemia and preparation method thereof |
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| CN102726589A (en) * | 2011-04-15 | 2012-10-17 | 贵州神奇集团控股有限公司 | Chewing gum specially for diabetic patients and preparation method thereof |
| CN103623252A (en) * | 2012-08-20 | 2014-03-12 | 鲁志强 | Hypotensive and hypoglycemic medicine |
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| CN102726589A (en) * | 2011-04-15 | 2012-10-17 | 贵州神奇集团控股有限公司 | Chewing gum specially for diabetic patients and preparation method thereof |
| CN103623252A (en) * | 2012-08-20 | 2014-03-12 | 鲁志强 | Hypotensive and hypoglycemic medicine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113509509A (en) * | 2021-04-30 | 2021-10-19 | 杭州仁德医药有限公司 | Traditional Chinese medicine emplastrum for reducing hyperglycemia and preparation method thereof |
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Application publication date: 20170908 |