CN107137436A - A kind of percolation extraction method of penthorum chinense pursh - Google Patents
A kind of percolation extraction method of penthorum chinense pursh Download PDFInfo
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- CN107137436A CN107137436A CN201710314929.5A CN201710314929A CN107137436A CN 107137436 A CN107137436 A CN 107137436A CN 201710314929 A CN201710314929 A CN 201710314929A CN 107137436 A CN107137436 A CN 107137436A
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- penthorum chinense
- chinense pursh
- extraction method
- ethanol
- percolation extraction
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- 241000244938 Penthorum chinense Species 0.000 title claims abstract description 32
- 238000000605 extraction Methods 0.000 title claims abstract description 12
- 238000005325 percolation Methods 0.000 title claims abstract description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 37
- 239000000463 material Substances 0.000 claims abstract description 13
- 239000000284 extract Substances 0.000 claims abstract description 11
- 238000010298 pulverizing process Methods 0.000 claims abstract description 6
- 238000001291 vacuum drying Methods 0.000 claims abstract description 6
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 230000002075 anti-alcohol Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 206010023126 Jaundice Diseases 0.000 description 2
- 208000034189 Sclerosis Diseases 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 231100000753 hepatic injury Toxicity 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 208000007848 Alcoholism Diseases 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 241000006479 Cyme Species 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 240000008397 Ganoderma lucidum Species 0.000 description 1
- 235000001637 Ganoderma lucidum Nutrition 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 206010019755 Hepatitis chronic active Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 244000241838 Lycium barbarum Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 241000220151 Saxifragaceae Species 0.000 description 1
- 240000006079 Schisandra chinensis Species 0.000 description 1
- 241000320380 Silybum Species 0.000 description 1
- 235000010841 Silybum marianum Nutrition 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000013160 medical therapy Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000008816 organ damage Effects 0.000 description 1
- 230000003119 painkilling effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Botany (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of percolation extraction method of penthorum chinense pursh, it is characterised in that comprises the steps of：Take penthorum chinense pursh pulverizing medicinal materials, cross 10 30 mesh sieves, weighed weight is put in diacolation post, 80% 95% ethanol for adding 1 12 times of medicinal material amounts carry out diacolation, collect percolate, ethanol is recovered under reduced pressure, vacuum drying produces penthorum chinense pursh extract.A kind of beneficial effect of the percolation extraction method of penthorum chinense pursh of the present invention：Yield simple to operate is high, and large-scale production can be achieved.
Description
Technical field
The present invention relates to a kind of percolation extraction method of penthorum chinense pursh.
Background technology
Penthorum chinense pursh, Chinese medicine name.For Saxifragaceae penthorum plant penthorum chinense pursh Penthorum chinense Pursh's
Herb, is distributed mainly on northeast, North China, south China and southwest.With Li Shui dehumidifying, the effect of stasis-dispelling and pain-killing, for jaundice, water
Swollen, traumatic injury swells and ache.
Rhizome is cylindric, bending, has branch, is about 15cm, diameter 3-8cm；Surface bronzing, close raw adventitious root.Stem is justified
Cylindricality, diameter 1-6mm；Surface reddish violet, not branch or base portion branch.Blade is frangible；Complete person is in lanceolar or narrow lanceolar,
Long 3-10cm, wide 0.6-1.2cm；Tip length is tapering or tapering, base portion wedge shape, edge tool serration；The green and brown color in surface；Stockless or
Nearly stockless；Blade film quality.Sometimes the visible cyme in branch end, spends yellow green, no petal.Accidental fruit, aubergine, diameter is about
6mm, gas is micro-, taste sweet tea.
In recent years, the dinner party of people is more and more, and drink turns into a kind of custom, and a kind of mode of communication emotion can be with
Bring enthusiasm, even excitement, inspiration.But drink give people to bring often upset,gastro-intestinal, nausea and vomiting, irritability,
The malaise symptoms such as have a dizzy spell, or even often trigger various accidents because of excessive consumption of alcohol, bring various to society and health
Hidden danger.Long-term excessive consumption of alcohol, can also aggravate burden of liver, sternly plant liver injury, cause fatty liver, alcoholic liver, hepatitis, hepatic sclerosis
Etc. disease, and Modern medical therapy AML only has abstinence from alcohol at present, and symptomatic treatment has no specific drug.
The concentration for reducing ethanol and its metabolite in internal blood is that the effect of antialcoholic drugs is crucial, mitigates it to each organ
Damage.Current disintoxicating product is main to play antialcoholism action at following two aspects.First, antialcoholic drugs suppress the stomach of alcohol
Intestinal absorption, strengthens ethanol in intestines and stomach first pass effect, reduces Ethanol concentration in rat blood；Second, antialcoholic drugs directly act on liver generation
The supersession rate of the enzyme system thanked, accelerating alcohol and its metabolite, mitigates its infringement to cell and tissue.For a long time, lead to
The method development relieving alcoholism and protecting liver medicine for crossing chemical synthesis does not obtain big breakthrough.It is existing commercially available many with Pueraria lobota with the product relieved the effect of alcohol
Root, ganoderma lucidum, vitamin, milk thistle, the fruit of Chinese magnoliavine, matrimony vine, originating from the U.S. and Japan the health product based on hoveniae semoveniae semen, product has more
The formulations such as capsule, tablet, tea and drinks, primary efficacy is Antialcoholic liver-protecting.
Penthorum chinense pursh is genunie medicinal materials, is distributed in the Wumeng Shan Mountain foot of a hill or mountain virgin forest of 1000 meters or so of height above sea level.Its grow, survive with
It is no to have strict demand to soil, sunshine, temperature, rainfall conditions.Penthorum chinense pursh is first recorded in the Ming Dynasty《Herbal for Relief of Famines》, with heat-clearing
The effect of removing toxic substances, removing jaundice dampness elimination, promoting blood circulation to remove blood stasis, inducing diuresis for removing edema, be the Empirical formula of Miao ethnic group's folk therapy hepatopathy, and Miao ethnic group this world generation practises
With she is called " Radix Rhodiolae ".Modern study shows that penthorum chinense pursh includes a variety of effective ingredients and has protective effect to hepatic injury, can be extensive
Multiple liver function, lowers and drinks and infringement of the medicine to liver, suppresses liver fibrosis, hepatic sclerosis, and to hepatitis A, hepatitis B, chronic
Active hepatitis has significant therapeutic effect.
The content of the invention
It is an object of the invention to provide a kind of percolation extraction method of penthorum chinense pursh.
A kind of percolation extraction method of penthorum chinense pursh of the present invention, it is characterised in that comprise the steps of：
Penthorum chinense pursh pulverizing medicinal materials are taken, 10-30 mesh sieves are crossed, weighed weight is put in diacolation post, 1-12 times of medicinal material amount of addition
80%-95% ethanol carries out diacolation, collects percolate, and ethanol is recovered under reduced pressure, and vacuum drying produces penthorum chinense pursh extract.
The present invention is that the extract that will be extracted in penthorum chinense pursh is applied in pre- preventing drunkenness, relieves the effect of alcohol and have to chemical damage
In booster action.Because penthorum chinense pursh extract extracts the features such as difficulty is big, low-solubility, stability are poor, greatly limit its
Application in functional health care product, and by penthorum chinense pursh extract be applied to disintoxicating product in yet there are no relevant report.Therefore to catch up with Huang
Based on careless extract, serial antialcoholism function food and health products of the exploitation with independent intellectual property right have before wide application
Scape.
A kind of beneficial effect of the percolation extraction method of penthorum chinense pursh of the present invention：Yield simple to operate is high, and scale can be achieved
Production.
Embodiment
With reference to embodiment, the present invention is described in further detail, but the embodiment not limited to this of invention.
Embodiment 1：A kind of percolation extraction method of penthorum chinense pursh, it is characterised in that comprise the steps of：
Penthorum chinense pursh pulverizing medicinal materials are taken, 10 mesh sieves are crossed, weighed weight is put in diacolation post, 80% ethanol of 1 times of medicinal material amount is added
Diacolation is carried out, percolate is collected, ethanol is recovered under reduced pressure, vacuum drying produces penthorum chinense pursh extract.
Embodiment 2：A kind of percolation extraction method of penthorum chinense pursh, it is characterised in that comprise the steps of：
Penthorum chinense pursh pulverizing medicinal materials are taken, 30 mesh sieves are crossed, weighed weight is put in diacolation post, 95% ethanol of 12 times of medicinal material amounts is added
Diacolation is carried out, percolate is collected, ethanol is recovered under reduced pressure, vacuum drying produces penthorum chinense pursh extract.
Embodiment 3：A kind of percolation extraction method of penthorum chinense pursh, it is characterised in that comprise the steps of：
Penthorum chinense pursh pulverizing medicinal materials are taken, 20 mesh sieves are crossed, weighed weight is put in diacolation post, 90% ethanol of 6 times of medicinal material amounts is added
Diacolation is carried out, percolate is collected, ethanol is recovered under reduced pressure, vacuum drying produces penthorum chinense pursh extract.
Claims (1)
1. a kind of percolation extraction method of penthorum chinense pursh, it is characterised in that comprise the steps of：
Penthorum chinense pursh pulverizing medicinal materials are taken, 10-30 mesh sieves are crossed, weighed weight is put in diacolation post, the 80%- of 1-12 times of medicinal material amount is added
95% ethanol carries out diacolation, collects percolate, and ethanol is recovered under reduced pressure, and vacuum drying produces penthorum chinense pursh extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710314929.5A CN107137436A (en) | 2017-05-07 | 2017-05-07 | A kind of percolation extraction method of penthorum chinense pursh |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710314929.5A CN107137436A (en) | 2017-05-07 | 2017-05-07 | A kind of percolation extraction method of penthorum chinense pursh |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107137436A true CN107137436A (en) | 2017-09-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710314929.5A Pending CN107137436A (en) | 2017-05-07 | 2017-05-07 | A kind of percolation extraction method of penthorum chinense pursh |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107137436A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105125601A (en) * | 2015-10-13 | 2015-12-09 | 四川古蔺肝苏药业有限公司 | Penthorum chinense pursh extract and preparing method and application thereof |
-
2017
- 2017-05-07 CN CN201710314929.5A patent/CN107137436A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105125601A (en) * | 2015-10-13 | 2015-12-09 | 四川古蔺肝苏药业有限公司 | Penthorum chinense pursh extract and preparing method and application thereof |
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Application publication date: 20170908 |