CN107126584A - Remove in drainage-fluid haemocyte and assist the negative pressure filtration device of component quantifying - Google Patents

Abstract

The invention relates to a negative pressure filter device for removing blood cells in drainage fluid and assisting in the quantification of components. The drainage tube is connected to an anti-seepage blood pollution device through a joint, the anti-seepage blood pollution device is connected to a component enrichment device through a joint, and the component enrichment device is connected to a collection device. The collection conduit has a cut-off valve on the joint; the blood seepage prevention device is provided with a first conduit, and the first conduit is provided with a blood seepage removal and filling device; the component enrichment device is provided with a second conduit, and the second conduit is provided with a component enrichment tube. Set filling, component enrichment filling is more than one layer of filling film, or filling; the collection conduit extends into the collection bottle, and the collection bottle is connected to the negative pressure device through the negative pressure conduit; the detection device is equipped with a front-end detection sensor for detection and a rear The end detection sensor, the front end detection sensor and the rear end detection sensor are respectively connected to the controller, and the controller is respectively connected to the input and output device and the alarm device. The invention is convenient for disassembly and replacement, has the function of filtering, and monitors the drainage fluid in real time.

Description

Negative pressure filter device that removes blood cells from drainage fluid and assists in the quantification of components

technical field

The invention relates to the technical field of medical detection equipment, in particular to a negative pressure filter device which is convenient for disassembly and replacement, has a filtering function, monitors drainage fluid in real time, removes blood cells in drainage fluid, and assists in the quantification of components.

Background technique

Existing negative pressure drainage devices can only suck out the liquid in the thoracic cavity, abdominal cavity and other human organ cavities for measurement, but it cannot prevent the bleeding from the drainage incision from being sucked into the drainage device together, resulting in the volume of drainage fluid, cells, proteins and The distortion of the quantitative components of nucleic acid can easily lead to clinical misdiagnosis. At the same time, various components in the drainage fluid are mixed, which will lead to difficulties in downstream analysis such as chromatography and mass spectrometry. At present, the main solution is to drain the liquid for a period of time. The default is early drainage fluid contamination, and then reconnect the drainage tube after dumping. However, this operation has the problems of secondary pollution and complicated clinical operations. In addition, the early contaminated liquid is in the Adhesion on the inner wall of the drainage tube is difficult to completely remove, which will have an adverse effect on the subsequent fluid that continues to be drained.

Most of the existing drainage devices are in the unmanned monitoring state. During the drainage process of the patient, the drainage pipeline is often pulled out due to body position changes, dragging and other reasons. Excessive protein content leads to blockage of the pipeline, which is difficult for medical staff to detect in a short period of time. When it is discovered, it is often necessary to remove and implant a new drainage tube, which is easy to introduce retrograde infection, increase patient wound pain, and related medical expenses. At the same time, most of the drainage volume depends on the scale reading outside the bottle, which is inaccurate and cannot provide real-time retrospective drainage data.

Existing drainage tubes can only collect specimens in a limited area, relying more on the liquid poured directly from the drainage bottle, which is very inconvenient and likely to cause contamination of the specimens. At the same time, there is the problem of easy crushing and poor drainage. Although the cross-sectional diameter of the pipeline is increased to strengthen the support strength of the tube wall, the effect is still not good and the manufacturing cost of the pipeline is greatly increased.

There is a need for a negative pressure filter device that is convenient to disassemble and replace, has a filtering function, monitors the drainage fluid in real time, removes blood cells in the drainage fluid, and assists in the quantification of components.

Contents of the invention

The object of the present invention is to provide a negative pressure filter device which is convenient to disassemble and replace, has a filtering function, monitors the drainage fluid in real time, removes blood cells in the drainage fluid, and assists in the quantification of components.

Negative pressure filtration devices that remove blood cells from drainage fluid and assist in the quantification of components, including:

Drainage tube, the drainage tube is connected to the anti-seepage blood pollution device through the joint, the anti-seepage blood pollution device is connected to the component enrichment device through the joint, the component enrichment device is connected to the collection conduit of the collection device, and the joint is provided with Shut-off valve;

The anti-seepage blood pollution device is provided with a first conduit, and the first conduit is provided with a blood seepage removal filling; the component enrichment device is provided with a second conduit, and the second conduit is provided with a component enrichment filling , the enrichment of the components is filled with more than one layer of filling film, or filler; the collection conduit extends into the collection bottle, and the collection bottle is connected to a negative pressure device through a negative pressure conduit;

A detection device, the detection device is provided with a front-end detection sensor and a rear-end detection sensor for detection, the front-end detection sensor and the rear-end detection sensor are respectively connected to a controller, and the controller is respectively connected to an input and output device and an alarm device.

There are more than one second conduits. When the second conduits are connected in series, the component-enriched filling is a filling film, or a filling, or a filling film and a filling are connected in series, or the second conduits are in parallel.

The filled membrane filled with enriched components is one or more of protein enriched membranes, enriched nucleic acid membranes, enriched polypeptide membranes, and enriched polysaccharide membranes, and the filled fillers enriched with components are filler particles.

The front-end detection sensor and the rear-end detection sensor are respectively arranged at two ends of the second conduit.

The front-end detection sensor and the rear-end detection sensor are contact flow sensors and air bubble sensors respectively.

The outer side of the collection bottle is provided with a collection bag for sealing, or a sealing plug.

The collection bottle is provided with a scale.

A one-way valve is arranged inside the collecting conduit, and the number of the one-way valve is more than one.

One or more of the drainage tube, the first conduit, the second conduit, and the collection conduit are anti-bending tubes, and the outside of the anti-bending tube is a hollow sleeve, or a solid sleeve, or an annular partition, and the The solid casing annular compartment communicates with the outside world through a switch valve.

One or more of the drainage tube, the first conduit, the second conduit and the collection conduit are provided with an elastic sealing film.

The drainage tube of the present invention is connected to the anti-seepage blood pollution device through a joint, the anti-seepage blood pollution device is connected to the component enrichment device through the joint, the component enrichment device is connected to the collection conduit of the collection device, and the joint is provided with a stop valve; There is a first conduit, the first conduit is provided with bleeding removal filling; the component enrichment device is provided with a second conduit, the second conduit is provided with component enrichment filling, and the component enrichment filling is more than one layer of filling film, or Filler; the collection conduit extends into the collection bottle, and the collection bottle is connected to the negative pressure device through the negative pressure conduit; the detection device is equipped with a front-end detection sensor and a rear-end detection sensor for detection, and the front-end detection sensor and the rear-end detection sensor are respectively connected to the controller , the controller is respectively connected to the input and output devices and the alarm device. Avoid early wound blood leakage (red blood cells and hemolysis) of the drainage fluid from contaminating the drainage fluid to be analyzed; through the detachable design, the components of the filtered and concentrated drainage fluid can be directly exported, seamlessly connected to the subsequent chromatographic mass spectrometry analysis process; drainage is achieved through a detachable device Filtration and concentration of different components of the liquid; through the monitoring probe and remote monitoring connection, the precise retrospective quantification of the drainage volume in the drainage pipeline, and the real-time online alarm of invalid air drainage caused by blockage or drainage tube prolapse. The invention is convenient for disassembly and replacement, has the function of filtering and monitors the drainage fluid in real time.

Description of drawings

Fig. 1 is a structural representation of the present invention;

Fig. 2 is the schematic diagram of the second catheter parallel structure of the present invention;

Fig. 3 is the cross-sectional view of the anti-bending pipe with hollow casing of the present invention;

Fig. 4 is the cross-sectional view of the anti-bending pipe with solid casing of the present invention;

Fig. 5 is the cross-sectional view of the anti-bending pipe with switching valve of the present invention;

Fig. 6 is a schematic structural view of the elastic sealing film of the present invention;

In the figure: 1. Drainage tube, 2. Anti-seepage blood pollution device, 3. Component enrichment device, 4. Collection device, 5. Detection device, 6. Connector, 7. Stop valve, 8. Anti-bending tube, 9. Elastic sealing membrane, 21, first conduit, 22, bleeding removal filling, 31, second conduit, 32, component enrichment filling, 41, collection bottle, 42, collection conduit, 43, negative pressure conduit, 44, negative pressure Device, 45, collection bag, 46, scale, 47, one-way valve, 51, front-end detection sensor, 52, rear-end detection sensor, 53, controller, 54, input and output device, 55, alarm device, 81, hollow sleeve Pipe, 82, solid casing, 83, switch valve.

detailed description

The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

Example 1:

A negative pressure filtration device that removes blood cells in the drainage fluid and assists the quantification of components, including: a drainage tube 1, the drainage tube 1 is connected to the anti-seepage blood pollution device 2 through the joint 6, and the anti-seepage blood pollution device 2 is connected to the component enrichment device 3 through the joint 6 , the component enrichment device 3 is connected to the collection conduit 42 of the collection device 4, and the joint 6 is provided with a stop valve 7; the blood seepage prevention device 2 is provided with a first conduit 21, and the first conduit 21 is provided with a blood oozing removal filling 22; The component enrichment device 3 is provided with a second conduit 31, and the second conduit 31 is provided with a component enrichment filling 32, the component enrichment filling 32 is more than one layer of filling film or filler; the collection conduit 42 extends into the collection bottle 41 Among them, the collection bottle 41 is connected to the negative pressure device 44 through the negative pressure conduit 43; the detection device 5, the detection device 5 is provided with a front end detection sensor 51 and a rear end detection sensor 52 for detection, and the front end detection sensor 51 and the rear end detection sensor 52 are respectively A controller 53 is connected, and the controller 53 is respectively connected with an input and output device 54 and an alarm device 55 .

There are more than one second conduits 31. When the second conduits 31 are in series, the component-enriched filling 32 is a filling film, or a filling, or a filling film and a filling in series, or the second conduits 31 are in parallel. The component-enrichment filling 32 is filled with one or more of protein-enriched membranes, nucleic acid-enriched membranes, polypeptide-enriched membranes, and polysaccharide-enriched membranes, and the component-enriched filling 32 is filled with filler particles. The front end detection sensor 51 and the rear end detection sensor 52 are respectively provided at both ends of the second conduit 31 . The front end detection sensor 51 and the rear end detection sensor 52 are contact flow sensors and air bubble sensors respectively. A collection bag 45 for sealing, or a sealing plug, is provided on the outside of the collection bottle 41 . The collection bottle 41 is provided with a scale 46 . A one-way valve 47 is arranged inside the collection conduit 42, and the number of the one-way valve 47 is more than one.

Drainage tube 1, first conduit 21, second conduit 31, one or more in collecting conduit 42 is anti-bending pipe 8, and the outside of anti-bending pipe 8 is hollow casing 81, or solid casing 82, or annular partition Layer, the hollow sleeve 81 annular partition communicates with the outside world through the switch valve 83, and is inflated with positive pressure to resist buckling. One or more of the drainage tube 1 , the first conduit 21 , the second conduit 31 and the collection conduit 42 is provided with an elastic sealing film 9 .

Avoid early wound blood leakage (red blood cells and their hemolysis) of the drainage fluid from contaminating the drainage fluid to be analyzed. Through the detachable design of the connector 6 and the shut-off valve 7, the components of the filtered and concentrated drainage fluid can be directly exported, and the subsequent chromatographic mass spectrometry analysis process is seamlessly connected. Filtration and concentration of different components of the drainage fluid is achieved through a detachable device. Realize fine traceability quantification of the drainage volume in the drainage pipeline, and real-time online alarm for invalid air drainage caused by blockage or drainage tube prolapse. The anti-bending characteristics of the pipeline are realized through the inner sleeve and the inflatable design. Aseptic sampling at different parts of the drainage pipeline can be realized through the building-block connection of the specially designed elastic sealing film 9 and the drainage pipeline.

A detachable part is added to the negative pressure system, including: an anti-seepage blood pollution device 2 for filtering cells, a component enrichment device 3, and a detection device 5 for monitoring the specific components of the concentrated drainage fluid; the former can avoid the influence of blood oozing in the early drainage fluid , at the same time, the module is a detachable and replaceable module, which can be replaced according to the degree of early bleeding, fundamentally avoiding the influence of bleeding on the drainage fluid; the latter can be connected to different component enrichment membranes or enrichment columns according to needs , to realize the continuous online enrichment of one or more specific components (different molecular weight proteins, special proteins, nucleic acids) in the drainage fluid, and it is also designed to be detachable. Seamless connection with subsequent analysis.

In addition, a flow monitoring module is connected to the upstream of the drainage pipeline, which can more accurately prompt and record the drainage volume per time. At the same time, through the online detection of the air in the pipeline, combined with photoelectric and remote warning devices, the drainage system will come out and the drainage device will be released. Inhalation of a large amount of air or blockage of the pipeline leads to the reminder of no drainage fluid outflow, which is convenient for medical staff to realize effective and controllable management of the drainage pipeline, deal with problems in a timely manner, and reduce a series of problems caused by pipeline prolapse or blockage, and the flow monitoring module can provide Retrospective and accurate extraction of liquid quantification.

Further, reproducible sampling windows closed by membranes are provided on the upstream and downstream of the pipeline module to help achieve accurate evaluation of the drainage fluid composition and the efficiency of the filtration and concentration module. Elastic sealing films 9 are reserved in multiple parts of the drainage tube, and the building block series connection of the above-mentioned modules and the drainage tube can realize sampling at different parts according to actual needs; More than two inflatable deformable or non-deformable small pipelines can significantly improve the support strength of the tube wall and avoid severe deformation or collapse of the pipeline under the pressure of the patient's body, resulting in poor or interrupted drainage.

Compared with prior art, the advantages of the present invention:

1. Avoid early wound blood leakage (red blood cells and hemolysis) of the drainage fluid from contaminating the drainage fluid to be analyzed;

2. Through the detachable design, the direct export of the components of the filtered and concentrated drainage fluid is realized, and the subsequent chromatographic mass spectrometry analysis process is seamlessly connected;

3. Realize the filtration and concentration of different components of the drainage fluid through a detachable device;

4. Through the monitoring probe and remote monitoring connection, the fine traceable quantification of the drainage volume in the drainage pipeline is realized, and the real-time online alarm of invalid air drainage caused by blockage or drainage tube prolapse;

5. Realize the anti-bending characteristics of the pipeline through the inner sleeve and inflatable design;

6. Aseptic sampling can be realized at different parts of the drainage pipeline through the building block connection between the specially designed membrane-enclosed puncture-resistant module and the drainage pipeline.

It is suitable for all kinds of negative pressure drainage pipelines, especially the pipeline system that requires subsequent analysis of drainage fluid. The detachable module is used to avoid the pollution of wound bleeding to the subsequent drainage fluid; the enrichment module connected to the pipeline can realize the enrichment and closure of one or some specific components in the drainage fluid to facilitate subsequent analysis; through the monitoring probe and remote monitoring Fine traceability analysis of the drainage volume and alarm prompts for drainage pipeline prolapse or blockage; through the inner sleeve pipeline and inflatable design, the pressure resistance of all or specific sections of pipelines can be realized; through the specially designed elastic sealing membrane9 The modular connection with the drainage line can realize aseptic sampling at different parts of the drainage line.

The basic principles, main features and advantages of the present invention have been shown and described above. Those skilled in the industry should understand that the present invention is not limited by the above-mentioned embodiments, and that described in the above-mentioned embodiments and the description only illustrates the principles of the present invention, and the present invention also has various aspects without departing from the spirit and scope of the present invention. Variations and improvements all fall within the scope of the claimed invention. The protection scope of the present invention is defined by the appended claims and their equivalents.

Claims (10)

1. A negative pressure filter device that removes blood cells in the drainage fluid and assists the quantification of components, characterized in that it includes: Drainage tube (1), the drainage tube (1) is connected to the anti-seepage blood pollution device (2) through the joint (6), and the anti-seepage blood pollution device (2) is connected to the component enrichment device (3) through the joint (6) ), the component enrichment device (3) is connected to the collection conduit (42) of the collection device (4), and the joint (6) is provided with a shut-off valve (7); The anti-seepage blood pollution device (2) is provided with a first conduit (21), and the first conduit (21) is provided with a blood ooze removal filling (22); the component enrichment device (3) is provided with a second Two conduits (31), the second conduit (31) is provided with component enrichment filling (32), and the component enrichment filling (32) is more than one layer of filling film, or filler; the collection conduit (42) stretch in the collecting bottle (41), and described collecting bottle (41) connects negative pressure device (44) by negative pressure conduit (43); Detection device (5), described detection device (5) is provided with the front end detection sensor (51) and the rear end detection sensor (52) that are used for detection, and described front end detection sensor (51) and rear end detection sensor (52) respectively A controller (53) is connected, and the controller (53) is respectively connected with an input and output device (54) and an alarm device (55). 2. The negative pressure filter device for removing blood cells in the drainage fluid according to claim 1 and assisting the quantification of components, characterized in that, the second conduit (31) is more than one, and the second conduit (31) is in series When , the component enrichment filling (32) is a filling film, or a filling, or a filling film and a filling are connected in series, or the second conduit (31) is connected in parallel. 3. The negative pressure filter device for removing blood cells in the drainage fluid according to claim 1 and assisting the quantification of components, characterized in that, the filling membrane of the component enrichment filling (32) is a protein enrichment membrane, a nucleic acid enrichment membrane One or more of polypeptide-enriched membranes and polysaccharide-enriched membranes, the filling of the component-enriched filling (32) is filler particles. 4. The negative pressure filter device for removing blood cells in the drainage fluid according to claim 1 and assisting the quantification of components, characterized in that, the front-end detection sensor (51) and the rear-end detection sensor (52) are respectively arranged in the second catheter Both ends of (31). 5. The negative pressure filter device for removing blood cells in the drainage fluid according to claim 1 and assisting the quantification of components, characterized in that, the front-end detection sensor (51) and the rear-end detection sensor (52) are contact flow sensors respectively and bubble sensor. 6. The negative pressure filter device for removing blood cells in the drainage fluid according to claim 1 and assisting the quantification of components, characterized in that, the outside of the collection bottle (41) is provided with a collection bag (45) for sealing, or a sealing plug . 7. The negative pressure filter device for removing blood cells in the drainage fluid and assisting the quantification of components according to claim 1, characterized in that, the collection bottle (41) is provided with a scale (46). 8. The negative pressure filter device for removing blood cells in the drainage fluid according to claim 1 and assisting the quantification of components, characterized in that a one-way valve (47) is provided inside the collection conduit (42), and the one-way valve (47) is one or more. 9. The negative pressure filter device for removing blood cells in the drainage fluid according to claim 1 and assisting the quantification of components, characterized in that, the drainage tube (1), the first conduit (21), the second conduit (31), One or more of the collection pipes (42) are anti-bending pipes (8), and the outside of the anti-bending pipes (8) is a hollow sleeve (81), or a solid sleeve (82), or an annular partition, The annular partition of the solid sleeve (82) communicates with the outside world through a switch valve (83). 10. The negative pressure filter device for removing blood cells in the drainage fluid according to claim 1 and assisting the quantification of components, characterized in that, the drainage tube (1), the first conduit (21), the second conduit (31), One or more of the collecting pipes (42) are provided with elastic sealing membranes (9).