CN107126411A - With cannabidiol gel for alleviating nervous headache effect and preparation method thereof - Google Patents
With cannabidiol gel for alleviating nervous headache effect and preparation method thereof Download PDFInfo
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- CN107126411A CN107126411A CN201710173288.6A CN201710173288A CN107126411A CN 107126411 A CN107126411 A CN 107126411A CN 201710173288 A CN201710173288 A CN 201710173288A CN 107126411 A CN107126411 A CN 107126411A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
With cannabidiol gel for alleviating nervous headache effect and preparation method thereof, it is prepared from following components in parts by weight by raw material, 5 10 parts of cannabidiol, 60 70 parts of sodium carboxymethylcellulose, 150 160 parts of glycerine, 23 parts of ethylparaben, 80 90 parts of 95% ethanol, 667 703 parts of purified water；Its preparation method is concretely comprised the following steps：Step 1, get the raw materials ready；Step 2, dissolving；Step 3, mixing.The a kind of of the present invention has cannabidiol gel of alleviation nervous headache effect and preparation method thereof, can effectively alleviate nervous headache, evident in efficacy, safe and reliable.
Description
Technical field
It is more particularly to a kind of that there is the big of alleviation nervous headache effect the present invention relates to a kind of pharmaceutical gel preparation
Numb diphenol gel and preparation method thereof.
Background technology
Nervous headache is primarily referred to as tension headache, feature headache and angioneurotic headache, more by it is nervous,
Anger causes, and cardinal symptom is the vexed pain in head, constriction, sense of heaviness of continuation；Most of patient is both sides headache, mostly two
Temporo side, rear pillow part and overhead or full head.With the quickening of modern life rhythm, the stress of people is also increasing,
Nervous headache generally occurs, and violent headache often makes one fidgety, agonizing, and the disease of nervous headache
People, because corticocerebral interior suppression declines, is difficult to cause extensive suppression diffusion, it is difficult to which sleep is not deep enough during sleep,
Easily wake up with a start or the length of one's sleep is too short, had difficulty in going to sleep after waking up, for a long time in this way, intractable aypnia can be formed, drastically influence people
Life, work and learn.
At present, medicine on the market only has lenitive effect mostly, can only respite pain symptom, but easily
Recurrence, and drug ingedient is complicated, is also easy to produce dependence, long-term taking has certain side effect, is unfavorable for the health of people.
The content of the invention
There is the cannabidiol gel for alleviating nervous headache effect and its preparation side it is an object of the invention to provide a kind of
Method, can effectively alleviate nervous headache, evident in efficacy, safe and reliable.
The purpose of the present invention is achieved through the following technical solutions：
With the cannabidiol gel for alleviating nervous headache effect, it is prepared from following components in parts by weight by raw material, hemp two
5-10 parts of phenol, 60-70 parts of sodium carboxymethylcellulose, 150-160 parts of glycerine, 2-3 parts of ethylparaben, 80-90 parts of 95% ethanol,
667-703 parts of purified water.
Described has the cannabidiol gel for alleviating nervous headache effect, and following preferred weight number system is pressed by raw material
It is standby to form, it is 5 parts of cannabidiol, 65 parts of sodium carboxymethylcellulose, 155 parts of glycerine, 2 parts of ethylparaben, 80 parts of 95% ethanol, pure
Change 693 parts of water.
Described has the cannabidiol gel for alleviating nervous headache effect, and following preferred weight number system is pressed by raw material
It is standby to form, it is 10 parts of cannabidiol, 70 parts of sodium carboxymethylcellulose, 150 parts of glycerine, 3 parts of ethylparaben, 90 parts of 95% ethanol, pure
Change 677 parts of water.
Described has the cannabidiol gel for alleviating nervous headache effect, and raw material presses optimum weight number, hemp two
5 parts of phenol, 60 parts of sodium carboxymethylcellulose, 150 parts of glycerine, 2 parts of ethylparaben, 80 parts of 95% ethanol, 703 parts of purified water.
The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
It is described that there is the preparation method for alleviating the cannabidiol gel that nervous headache is acted on, the specific step of its preparation method
Suddenly it is：
Step 1, get the raw materials ready：
By weight, cannabidiol, sodium carboxymethylcellulose, glycerine, ethylparaben, 95% ethanol, purified water are weighed, it is standby
With；
Step 2, dissolving：
Sodium carboxymethylcellulose is taken, addition purifying is water-swellable, is completely dissolved, obtains taking sodium carboxymethyl cellulose solution, standby；
Cannabidiol is taken, is added into 95% ethanol, is stirred continuously dissolving, obtains cannabidiol ethanol solution, it is standby；
Step 3, mixing：
Cannabidiol ethanol solution is taken, is added in glycerine, after stirring, ethylparaben is added, after being again stirring for uniformly,
Add into sodium carboxymethyl cellulose solution, stir, finished product.
Cannabidiol (CBD) be extracted from hemp floral leaf a kind of it is nontoxic can be used for medicine, cosmetics, health food
A kind of high added value aldehydes matter.CBD is the non-additive composition in hemp, can hinder THC to nerve system of human body shadow
Ring, and with pharmacological activity such as anti-spasm, resisting rheumatoid arthritis, antianxiety, calm nerves.
Beneficial effects of the present invention：The present invention's has the cannabidiol gel for alleviating nervous headache effect, Neng Goubiao
Originally take into account, it is evident in efficacy, have no toxic side effect, no drug dependence has good therapeutic action to nervous headache；The present invention
Drug effect it is gentle, it is safe and reliable, can effective calm nerves, alleviate nervous headache, the sleep of promotion people.
The present invention is through two groups of clinical verifications, and one of which is cannabidiol gel of the treatment group using the present invention, per angel
With the present invention once, 7 days are a course for the treatment of, and another group of control group uses tablet for alleviating pain, are used once daily, are within 7 days a course for the treatment of,
Per group selection outpatient 110, wherein man 55, female 55, max age 75 years old, minimal ages 35 years old, clinical manifestation is
Headache, dizzy, palpitation and short breath, table one are to take the contrasting data after a course for the treatment of：
Table 1 takes front and rear two groups of courses for the treatment of and compares (unit:People)
There were significant differences for treatment group and control group, it will thus be seen that the application of the present invention clinically has significant curative effect.
Embodiment
Embodiment 1
With the cannabidiol gel for alleviating nervous headache effect, it is prepared from following components in parts by weight by raw material, hemp two
5-10 parts of phenol, 60-70 parts of sodium carboxymethylcellulose, 150-160 parts of glycerine, 2-3 parts of ethylparaben, 80-90 parts of 95% ethanol,
667-703 parts of purified water.
The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
Its preparation method is concretely comprised the following steps：
Step 1, get the raw materials ready：
By weight, cannabidiol, sodium carboxymethylcellulose, glycerine, ethylparaben, 95% ethanol, purified water are weighed, it is standby
With；
Step 2, dissolving：
Sodium carboxymethylcellulose is taken, addition purifying is water-swellable, is completely dissolved, obtains taking sodium carboxymethyl cellulose solution, standby；
Cannabidiol is taken, is added into 95% ethanol, is stirred continuously dissolving, obtains cannabidiol ethanol solution, it is standby；
Step 3, mixing：
Cannabidiol ethanol solution is taken, is added in glycerine, after stirring, ethylparaben is added, after being again stirring for uniformly,
Add into sodium carboxymethyl cellulose solution, stir, finished product.
Embodiment 2
Described has the cannabidiol gel for alleviating nervous headache effect, by raw material by the preparation of following preferred weight number
Into 5 parts of cannabidiol, 65 parts of sodium carboxymethylcellulose, 155 parts of glycerine, 2 parts of ethylparaben, 80 parts of 95% ethanol, purified water
693 parts.
The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
Its preparation method is concretely comprised the following steps：
Step 1, get the raw materials ready：
By weight, cannabidiol, sodium carboxymethylcellulose, glycerine, ethylparaben, 95% ethanol, purified water are weighed, it is standby
With；
Step 2, dissolving：
Sodium carboxymethylcellulose is taken, addition purifying is water-swellable, is completely dissolved, obtains taking sodium carboxymethyl cellulose solution, standby；
Cannabidiol is taken, is added into 95% ethanol, is stirred continuously dissolving, obtains cannabidiol ethanol solution, it is standby；
Step 3, mixing：
Cannabidiol ethanol solution is taken, is added in glycerine, after stirring, ethylparaben is added, after being again stirring for uniformly,
Add into sodium carboxymethyl cellulose solution, stir, finished product.
Embodiment 3
Described has the cannabidiol gel for alleviating nervous headache effect, by raw material by the preparation of following preferred weight number
Into 10 parts of cannabidiol, 70 parts of sodium carboxymethylcellulose, 150 parts of glycerine, 3 parts of ethylparaben, 90 parts of 95% ethanol, purified water
677 parts.
The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
Its preparation method is concretely comprised the following steps：
Step 1, get the raw materials ready：
By weight, cannabidiol, sodium carboxymethylcellulose, glycerine, ethylparaben, 95% ethanol, purified water are weighed, it is standby
With；
Step 2, dissolving：
Sodium carboxymethylcellulose is taken, addition purifying is water-swellable, is completely dissolved, obtains taking sodium carboxymethyl cellulose solution, standby；
Cannabidiol is taken, is added into 95% ethanol, is stirred continuously dissolving, obtains cannabidiol ethanol solution, it is standby；
Step 3, mixing：
Cannabidiol ethanol solution is taken, is added in glycerine, after stirring, ethylparaben is added, after being again stirring for uniformly,
Add into sodium carboxymethyl cellulose solution, stir, finished product.
Embodiment 4
Described has the cannabidiol gel for alleviating nervous headache effect, and raw material presses optimum weight number, cannabidiol 5
Part, 60 parts of sodium carboxymethylcellulose, 150 parts of glycerine, 2 parts of ethylparaben, 80 parts of 95% ethanol, 703 parts of purified water.
The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
Its preparation method is concretely comprised the following steps：
Step 1, get the raw materials ready：
By weight, cannabidiol, sodium carboxymethylcellulose, glycerine, ethylparaben, 95% ethanol, purified water are weighed, it is standby
With；
Step 2, dissolving：
Sodium carboxymethylcellulose is taken, addition purifying is water-swellable, is completely dissolved, obtains taking sodium carboxymethyl cellulose solution, standby；
Cannabidiol is taken, is added into 95% ethanol, is stirred continuously dissolving, obtains cannabidiol ethanol solution, it is standby；
Step 3, mixing：
Cannabidiol ethanol solution is taken, is added in glycerine, after stirring, ethylparaben is added, after being again stirring for uniformly,
Add into sodium carboxymethyl cellulose solution, stir, finished product.
Embodiment 5
With the cannabidiol gel for alleviating nervous headache effect, it is prepared from the following materials：
Sodium carboxymethylcellulose 60g
Glycerine 150g
Ethylparaben 2g
The g of cannabidiol 5
95% ethanol 80ml
Purified Water q. s
It is configured to 1000g.
Preparation method：Sodium carboxymethylcellulose plus purifying is water-swellable, it is completely dissolved, cannabidiol is added in ethanol and stirred
Mix dissolving；Cannabidiol ethanol solution is added to after being stirred in glycerine with ethylparaben, be added to carboxymethyl cellulose
Stirred in plain sodium water solution.
Claims (6)
1. with the cannabidiol gel for alleviating nervous headache effect, it is characterised in that：Following parts by weight numeral system is pressed by raw material
It is standby to form, 5-10 parts of cannabidiol, 60-70 parts of sodium carboxymethylcellulose, 150-160 parts of glycerine, 2-3 parts of ethylparaben, 95%
80-90 parts of ethanol, 667-703 parts of purified water.
2. according to claim 1 have the cannabidiol gel for alleviating nervous headache effect, it is characterised in that：By original
Material is prepared from by following preferred weight number, 5 parts of cannabidiol, 65 parts of sodium carboxymethylcellulose, 155 parts of glycerine, nipalgin
2 parts of ethyl ester, 80 parts of 95% ethanol, 693 parts of purified water.
3. according to claim 1 have the cannabidiol gel for alleviating nervous headache effect, it is characterised in that：By original
Material is prepared from by following preferred weight number, 10 parts of cannabidiol, 70 parts of sodium carboxymethylcellulose, 150 parts of glycerine, nipalgin
3 parts of ethyl ester, 90 parts of 95% ethanol, 677 parts of purified water.
4. according to claim 1 have the cannabidiol gel for alleviating nervous headache effect, it is characterised in that：Raw material
By optimum weight number, 5 parts of cannabidiol, 60 parts of sodium carboxymethylcellulose, 150 parts of glycerine, 2 parts of ethylparaben, 95% ethanol
80 parts, 703 parts of purified water.
5. having the cannabidiol gel for alleviating nervous headache effect according to claim 1-4 any one, it is special
Levy and be：The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
6. there is the preparation side for the cannabidiol gel for alleviating nervous headache effect according to claim 1-4 any one
Method, it is characterised in that：Its preparation method is concretely comprised the following steps：
Step 1, get the raw materials ready：
By weight, cannabidiol, sodium carboxymethylcellulose, glycerine, ethylparaben, 95% ethanol, purified water are weighed, it is standby
With；
Step 2, dissolving：
Sodium carboxymethylcellulose is taken, addition purifying is water-swellable, is completely dissolved, obtains taking sodium carboxymethyl cellulose solution, standby；
Cannabidiol is taken, is added into 95% ethanol, is stirred continuously dissolving, obtains cannabidiol ethanol solution, it is standby；
Step 3, mixing：
Cannabidiol ethanol solution is taken, is added in glycerine, after stirring, ethylparaben is added, after being again stirring for uniformly,
Add into sodium carboxymethyl cellulose solution, stir, finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710173288.6A CN107126411A (en) | 2017-03-22 | 2017-03-22 | With cannabidiol gel for alleviating nervous headache effect and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710173288.6A CN107126411A (en) | 2017-03-22 | 2017-03-22 | With cannabidiol gel for alleviating nervous headache effect and preparation method thereof |
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| CN107126411A true CN107126411A (en) | 2017-09-05 |
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| CN201710173288.6A Pending CN107126411A (en) | 2017-03-22 | 2017-03-22 | With cannabidiol gel for alleviating nervous headache effect and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019193210A1 (en) * | 2018-04-06 | 2019-10-10 | Philip Morris Products S.A. | Nicotine gel |
| RU2800618C2 (en) * | 2018-04-06 | 2023-07-25 | Филип Моррис Продактс С.А. | Nicotine gel |
-
2017
- 2017-03-22 CN CN201710173288.6A patent/CN107126411A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 殷莎等: "大麻二酚神经保护作用机制研究进展", 《中草药》 * |
| 马维娜等: "药用凝胶剂的研究进展", 《实用药物与临床》 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019193210A1 (en) * | 2018-04-06 | 2019-10-10 | Philip Morris Products S.A. | Nicotine gel |
| WO2019193209A1 (en) * | 2018-04-06 | 2019-10-10 | Philip Morris Products S.A. | Nicotine gel |
| CN111836557A (en) * | 2018-04-06 | 2020-10-27 | 菲利普莫里斯生产公司 | Nicotine gel |
| CN111867405A (en) * | 2018-04-06 | 2020-10-30 | 菲利普莫里斯生产公司 | Nicotine gel |
| US11589607B2 (en) | 2018-04-06 | 2023-02-28 | Philip Morris Products S.A. | Nicotine gel |
| RU2800618C2 (en) * | 2018-04-06 | 2023-07-25 | Филип Моррис Продактс С.А. | Nicotine gel |
| RU2809761C2 (en) * | 2018-04-06 | 2023-12-18 | Филип Моррис Продактс С.А. | Nicotine gel |
| RU2812254C2 (en) * | 2018-04-06 | 2024-01-26 | Филип Моррис Продактс С.А. | Nicotine gel |
| US11980219B2 (en) | 2018-04-06 | 2024-05-14 | Philip Morris Products S.A. | Nicotine gel |
| RU2820440C1 (en) * | 2019-11-04 | 2024-06-03 | Филип Моррис Продактс С.А. | Modified aerosol-generating element for use in aerosol-generating article or system |
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Application publication date: 20170905 |