CN107115430A - Chinese medicine drink containing huperzine and preparation method thereof - Google Patents
Chinese medicine drink containing huperzine and preparation method thereof Download PDFInfo
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- CN107115430A CN107115430A CN201710474215.0A CN201710474215A CN107115430A CN 107115430 A CN107115430 A CN 107115430A CN 201710474215 A CN201710474215 A CN 201710474215A CN 107115430 A CN107115430 A CN 107115430A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 44
- 239000003814 drug Substances 0.000 title claims abstract description 25
- ZQPQGKQTIZYFEF-WCVJEAGWSA-N Huperzine Natural products C1([C@H]2[C@H](O)C(=O)N[C@H]2[C@@H](O)C=2C=CC=CC=2)=CC=CC=C1 ZQPQGKQTIZYFEF-WCVJEAGWSA-N 0.000 title claims abstract description 21
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims abstract description 58
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 26
- 238000002386 leaching Methods 0.000 claims abstract description 15
- 241001504070 Huperzia Species 0.000 claims abstract description 12
- 102000011842 Serrate-Jagged Proteins Human genes 0.000 claims abstract description 12
- 108010036039 Serrate-Jagged Proteins Proteins 0.000 claims abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 12
- 244000001632 Acorus gramineus Species 0.000 claims abstract description 11
- 235000013073 Acorus gramineus Nutrition 0.000 claims abstract description 11
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 11
- 241000132012 Atractylodes Species 0.000 claims abstract description 11
- 241000112528 Ligusticum striatum Species 0.000 claims abstract description 11
- 235000006484 Paeonia officinalis Nutrition 0.000 claims abstract description 11
- 241000208966 Polygala Species 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000011114 ammonium hydroxide Nutrition 0.000 claims abstract description 9
- 238000007654 immersion Methods 0.000 claims abstract description 9
- 239000012141 concentrate Substances 0.000 claims abstract description 8
- 238000005119 centrifugation Methods 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 6
- 241000736199 Paeonia Species 0.000 claims description 10
- 238000010828 elution Methods 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229960001866 silicon dioxide Drugs 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract description 8
- 206010039966 Senile dementia Diseases 0.000 abstract description 8
- 201000010099 disease Diseases 0.000 abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 230000000116 mitigating effect Effects 0.000 abstract description 3
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 230000035939 shock Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001662 opsonic effect Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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Abstract
The invention discloses a kind of Chinese medicine drink containing huperzine and preparation method thereof, wherein, the preparation method includes：1) serrate clubmoss herb powder and hydrochloric acid solution are mixed and extracted 25 times after immersion, merged and collect leaching liquor；2) to step 1) in ammoniacal liquor is added in obtained leaching liquor and is adjusted to pH is after 8 10, to add chloroform and extract 25 times, merge and collect chloroform layer；3) by step 2) the middle chloroform layer centrifugation collected, remove after upper aqueous layer, concentrated, then eluted above-mentioned concentrate, paste is made；4) bighead atractylodes rhizome, polygala, grass-leaved sweetflag, Chinese herbaceous peony, Ligusticum wallichii, Radix Angelicae Sinensis and honeysuckle are added water to cook, preparation is made；5) by step 1) in obtained paste and step 4) in obtained preparation mixing, the Chinese medicine drink containing huperzine is made.Realizing has good treatment and mitigation to diseases such as senile dementias, and combines the effect that plurality of Chinese realization is effectively nursed one's health.
Description
Technical field
The present invention relates to the production preparation field of medicine drink, in particular it relates to containing huperzine Chinese medicine drink and its
Preparation method.
Background technology
With the continuous quickening of social senilization's speed, the quantity and ratio of elderly population are increasing.And with the age
Growth, the ratio of the population with senile dementia also sharply increases.And suffered from once the elderly after senile dementia symptom, then can
Tremendous influence is brought to society and its family.
Therefore it provides a kind of have good treatment and mitigation to diseases such as senile dementias, and combine plurality of Chinese
Realize the problem of drink of the Chinese medicine containing huperzine effectively nursed one's health and preparation method thereof is urgent need to resolve of the present invention.
The content of the invention
For above-mentioned prior art, once it is an object of the invention to overcome in the prior art the elderly suffer from senile dementia
After symptom, then the problem of bringing tremendous influence to society and its family, so as to provide a kind of to the diseases such as senile dementia tool
There is good treatment and mitigation, and combine plurality of Chinese and realize the drink of the Chinese medicine containing huperzine effectively nursed one's health and its make
Preparation Method.
To achieve these goals, the invention provides a kind of preparation method of the Chinese medicine drink containing huperzine, wherein,
The preparation method includes：
1) serrate clubmoss herb powder and hydrochloric acid solution are mixed and extracted 2-5 times after immersion, merged and collect leaching liquor；
2) to step 1) in add in obtained leaching liquor after ammoniacal liquor adjusts and be 8-10 to pH, add chloroform and extract 2-5 times,
Merge and collect chloroform layer；
3) by step 2) the middle chloroform layer centrifugation collected, remove after upper aqueous layer, concentrated, then by above-mentioned concentrate
Eluted, paste is made；
4) bighead atractylodes rhizome, polygala, grass-leaved sweetflag, Chinese herbaceous peony, Ligusticum wallichii, Radix Angelicae Sinensis and honeysuckle are added water to cook, preparation is made；
5) by step 1) in obtained paste and step 4) in obtained preparation mixing, be made containing in huperzine
Medicine is drunk.
Present invention also offers a kind of Chinese medicine drink according to made from preparation method described above containing huperzine.
By above-mentioned technical proposal, the present invention will be extracted after serrate clubmoss herb powder and hydrochloric acid solution immersion, then by above-mentioned extraction
Liquid adds ammoniacal liquor and adjusted to pH after 8-10, to be extracted with chloroform, and takes chloroform layer, after further chloroform layer is centrifuged, goes
Except water layer, then concentrate, paste is made, then the bighead atractylodes rhizome, polygala, grass-leaved sweetflag, Chinese herbaceous peony, Ligusticum wallichii, Radix Angelicae Sinensis and honeysuckle added water pan-fried
Boil, preparation is made, then mix above-mentioned paste and preparation, the Chinese medicine drink containing huperzine is made, so that passing through
Chinese medicine kitchenware made from the above method and raw material has good prevention and alleviates the effect of senile dementia, and with preferably conditioning
Effect.
Other features and advantages of the present invention will be described in detail in subsequent embodiment part.
Embodiment
The embodiment to the present invention is described in detail below.It should be appreciated that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to limit the invention.
The end points and any value of disclosed scope are not limited to the accurate scope or value herein, these scopes or
Value should be understood to comprising the value close to these scopes or value.For number range, between the endpoint value of each scope, respectively
It can be combined with each other between the endpoint value of individual scope and single point value, and individually between point value and obtain one or more
New number range, these number ranges should be considered as specific open herein.
The invention provides a kind of preparation method of the Chinese medicine drink containing huperzine, wherein, the preparation method includes：
1) serrate clubmoss herb powder and hydrochloric acid solution are mixed and extracted 2-5 times after immersion, merged and collect leaching liquor；
2) to step 1) in add in obtained leaching liquor after ammoniacal liquor adjusts and be 8-10 to pH, add chloroform and extract 2-5 times,
Merge and collect chloroform layer；
3) by step 2) the middle chloroform layer centrifugation collected, remove after upper aqueous layer, concentrated, then by above-mentioned concentrate
Eluted, paste is made；
4) bighead atractylodes rhizome, polygala, grass-leaved sweetflag, Chinese herbaceous peony, Ligusticum wallichii, Radix Angelicae Sinensis and honeysuckle are added water to cook, preparation is made；
5) by step 1) in obtained paste and step 4) in obtained preparation mixing, be made containing in huperzine
Medicine is drunk.
Above-mentioned design after serrate clubmoss herb powder and hydrochloric acid solution immersion by will extract, and above-mentioned leaching liquor then is added into ammoniacal liquor adjusts
After section is 8-10 to pH, extracted with chloroform, and take chloroform layer, after further chloroform layer is centrifuged, remove water layer, it is then dense
Contracting, is made paste, then the bighead atractylodes rhizome, polygala, grass-leaved sweetflag, Chinese herbaceous peony, Ligusticum wallichii, Radix Angelicae Sinensis and honeysuckle are added water to cook, and preparation is made, and
Above-mentioned paste and preparation are mixed afterwards, the Chinese medicine drink containing huperzine is made, so that passing through the above method and raw material
Obtained Chinese medicine kitchenware has good prevention and alleviates the effect of senile dementia, and with preferable opsonic action.
The present invention it is a kind of preferred embodiment in, in order that the use of most people, step 5 must be suitable for) in
Relative to the paste of 1 parts by weight, the consumption of the preparation is 100-1000 parts by weight.
In a kind of embodiment being more highly preferred to, step 4) in, relative to the water of 1000 parts by weight, the bighead atractylodes rhizome
Consumption is 3-15 parts by weight, and the consumption of the polygala is 10-15 parts by weight, and the consumption of the grass-leaved sweetflag is 3-10 parts by weight, institute
The consumption for stating Chinese herbaceous peony is 5-15 parts by weight, and the consumption of the Ligusticum wallichii is 3-10 parts by weight, and the consumption of the Radix Angelicae Sinensis is 3-10 weight
Part, the consumption of the honeysuckle is 10-30 parts by weight.
The present invention it is another preferred embodiment in, relative to the serrate clubmoss herb powder of 10 parts by weight, the hydrochloric acid
The consumption of solution is 80-150 parts by weight.
Here the concentration of hydrochloric acid solution can be selected as needed, for example, it is a kind of preferred embodiment in, it is described
The concentration of hydrochloric acid solution is 0.3-0.6mol/L.
In further preferred embodiment, step 3) in elution to use ethanol elution after flowing through silicagel column absorption.
In further preferred embodiment, in order that raw material is greatly utilized, step 1) in soak time
For 3-8h.
Similarly, it is another preferred embodiment in, step 4) in decocting time be 0.5-1h.
Present invention also offers a kind of Chinese medicine drink according to made from preparation method described above containing huperzine.
The present invention will be described in detail by way of examples below.
Embodiment 1
1) the serrate clubmoss herb powder of 10 parts by weight and the hydrochloric acid solution of 80 parts by weight (concentration is 0.5mol/L) are mixed into immersion 3h
Extract 2 times afterwards, merge and collect leaching liquor；
2) to step 1) in ammoniacal liquor is added in obtained leaching liquor and is adjusted to pH is after 8, to add chloroform and extract 2 times, merge
Collect chloroform layer；
3) by step 2) the middle chloroform layer centrifugation collected, remove after upper aqueous layer, concentrated, then by above-mentioned concentrate
Eluted, paste is made；
4) by the bighead atractylodes rhizome of 3 parts by weight, the polygala of 10 parts by weight, the grass-leaved sweetflag of 3 parts by weight, the Chinese herbaceous peony of 5 parts by weight, 3 weight
Part Ligusticum wallichii, the honeysuckle of the Radix Angelicae Sinensis of 3 parts by weight and 10 parts by weight add the decocting of 1000 parts by weight to boil after 0.5h, preparation is made；
5) by the step 1 of 1 parts by weight) in obtained paste and 100 parts by weight step 4) in obtained preparation mixing,
The Chinese medicine drink A1 containing huperzine is made.
Embodiment 2
1) the serrate clubmoss herb powder of 10 parts by weight and the hydrochloric acid solution of 150 parts by weight (concentration is 0.5mol/L) are mixed into immersion 8h
Extract 5 times afterwards, merge and collect leaching liquor；
2) to step 1) in ammoniacal liquor is added in obtained leaching liquor and is adjusted to pH is after 10, to add chloroform and extract 5 times, merge
Collect chloroform layer；
3) by step 2) the middle chloroform layer centrifugation collected, remove after upper aqueous layer, concentrated, then by above-mentioned concentrate
Eluted, paste is made；
4) by the bighead atractylodes rhizome of 15 parts by weight, the polygala of 15 parts by weight, the grass-leaved sweetflag of 10 parts by weight, the Chinese herbaceous peony of 15 parts by weight, 10
The honeysuckle of the Ligusticum wallichii of parts by weight, the Radix Angelicae Sinensis of 10 parts by weight and 30 parts by weight adds the decocting of 1000 parts by weight to boil after 1h, and system is made
Agent；
5) by the step 1 of 1 parts by weight) in obtained paste and 1000 parts by weight step 4) in obtained preparation mix
Close, the Chinese medicine drink A2 containing huperzine is made.
Embodiment 3
1) the serrate clubmoss herb powder of 10 parts by weight and the hydrochloric acid solution of 120 parts by weight (concentration is 0.5mol/L) are mixed into immersion 5h
Extract 3 times afterwards, merge and collect leaching liquor；
2) to step 1) in ammoniacal liquor is added in obtained leaching liquor and is adjusted to pH is after 9, to add chloroform and extract 3 times, merge
Collect chloroform layer；
3) by step 2) the middle chloroform layer centrifugation collected, remove after upper aqueous layer, concentrated, then by above-mentioned concentrate
Eluted, paste is made；
4) by the bighead atractylodes rhizome of 10 parts by weight, the polygala of 12 parts by weight, the grass-leaved sweetflag of 7 parts by weight, the Chinese herbaceous peony of 10 parts by weight, 7 weights
The honeysuckle for measuring the Ligusticum wallichii, the Radix Angelicae Sinensis of 7 parts by weight and 20 parts by weight of part adds the decocting of 1000 parts by weight to boil after 0.5h, and system is made
Agent；
5) by the step 1 of 1 parts by weight) in obtained paste and 500 parts by weight step 4) in obtained preparation mixing,
The Chinese medicine drink A3 containing huperzine is made.
Comparative example 1
It is prepared by the preparation method according to embodiment 1, unlike, without step 1), serrate clubmoss herb powder is directly used
Chloroform is extracted, and tablet D1 is made.
Comparative example 2
It is prepared by the preparation method according to embodiment 2, unlike, without step 3) in removal upper aqueous layer and
Concentration step, drying is used after chloroform layer is directly eluted, and tablet D2 is made.
Test case
Many mouse are each fed with the medicament 1 month with A1-A3, D1 and D2, wherein each perfusion 1g, twice daily.It
Step down test is carried out to it afterwards, detects and this experiment is reformed after the number of shocks (i.e. the frequency of failure) in its 5min, 48h, examine again
The number of shocks surveyed in its 5min, obtained result is as shown in table 1.
Table 1
| Numbering | Number of shocks in 5min | Number of shocks in 5min (after 48h) |
| A1 | 3 | 2 |
| A2 | 3 | 2 |
| A3 | 2 | 3 |
| D1 | 15 | 16 |
| D2 | 12 | 11 |
The preferred embodiment of the present invention described in detail above, still, the present invention are not limited in above-mentioned embodiment
Detail, in the range of the technology design of the present invention, a variety of simple variants can be carried out to technical scheme, this
A little simple variants belong to protection scope of the present invention.
It is further to note that each particular technique feature described in above-mentioned embodiment, in not lance
In the case of shield, can be combined by any suitable means, in order to avoid unnecessary repetition, the present invention to it is various can
The combination of energy no longer separately illustrates.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should equally be considered as content disclosed in this invention.
Claims (9)
1. a kind of preparation method of the Chinese medicine drink containing huperzine, it is characterised in that the preparation method includes：
1) serrate clubmoss herb powder and hydrochloric acid solution are mixed and extracted 2-5 times after immersion, merged and collect leaching liquor；
2) to step 1) in add in obtained leaching liquor after ammoniacal liquor adjusts and be 8-10 to pH, add chloroform and extract 2-5 time, merging
Collect chloroform layer；
3) by step 2) the middle chloroform layer centrifugation collected, remove after upper aqueous layer, concentrated, then carry out above-mentioned concentrate
Elution, is made paste；
4) bighead atractylodes rhizome, polygala, grass-leaved sweetflag, Chinese herbaceous peony, Ligusticum wallichii, Radix Angelicae Sinensis and honeysuckle are added water to cook, preparation is made；
5) by step 1) in obtained paste and step 4) in obtained preparation mixing, the Chinese medicine containing huperzine is made
Drink.
2. preparation method according to claim 1, wherein, step 5) in relative to 1 parts by weight the paste, it is described
The consumption of preparation is 100-1000 parts by weight.
3. preparation method according to claim 1 or 2, wherein, step 4) in, relative to the water of 1000 parts by weight,
The consumption of the bighead atractylodes rhizome is 3-15 parts by weight, and the consumption of the polygala is 10-15 parts by weight, and the consumption of the grass-leaved sweetflag is 3-10
Parts by weight, the consumption of the Chinese herbaceous peony is 5-15 parts by weight, and the consumption of the Ligusticum wallichii is 3-10 parts by weight, and the consumption of the Radix Angelicae Sinensis is
3-10 parts by weight, the consumption of the honeysuckle is 10-30 parts by weight.
4. preparation method according to claim 1 or 2, wherein, relative to the serrate clubmoss herb powder of 10 parts by weight, the salt
The consumption of acid solution is 80-150 parts by weight.
5. preparation method according to claim 1 or 2, wherein, the concentration of the hydrochloric acid solution is 0.3-0.6mol/L.
6. preparation method according to claim 1 or 2, wherein, step 3) in elution to use second after flowing through silicagel column absorption
Alcohol is eluted.
7. preparation method according to claim 1 or 2, wherein, step 1) in soak time be 3-8h.
8. preparation method according to claim 1 or 2, wherein, step 4) in decocting time be 0.5-1h.
9. the Chinese medicine drink containing huperzine made from the preparation method in a kind of 1-8 according to claim described in any one.
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