CN107115417A - A kind of Chinese medicine preparation for treating the spleen and stomach in children disharmony type baby anorexia - Google Patents
A kind of Chinese medicine preparation for treating the spleen and stomach in children disharmony type baby anorexia Download PDFInfo
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- CN107115417A CN107115417A CN201710356249.XA CN201710356249A CN107115417A CN 107115417 A CN107115417 A CN 107115417A CN 201710356249 A CN201710356249 A CN 201710356249A CN 107115417 A CN107115417 A CN 107115417A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The invention discloses a kind of Chinese medicine preparation for treating the spleen and stomach in children disharmony type baby anorexia, belong to technical field of traditional Chinese medicines.Inventor is in clinical practice for many years, according to the cause of disease of the spleen and stomach in children disharmony type baby anorexia, according to the theory of tcm treatment according to syndrome differentiation, select Chinese medicine turnip, fringed iris rhizome, Himalayan Eriosema, common anneslea bark or leaf, narrowbract Indian kalimeris herb, asiatic striga herb, tomentose pummelo fruit, traditional Chinese herbal decoction is made, clinical tests prove that, total effective rate reaches 100%.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine for treating the spleen and stomach in children disharmony type baby anorexia
Preparation.
Background technology
Baby anorexia refers to infant long period anorexia, and appetite is reduced, and sees that food is not coveted, or even one kind of food refusal disappears
Change dysfunction syndrome.It is clinical common with 1-6 Sui children, do not feel like eating is shown as, is eaten without digesting, defecate uncomfortable etc., it is
Section's common disease, frequently-occurring disease, long-term apocleisis can cause infantile malnutrition, anaemia, rickets and hypoimmunity, and appearance is exhaled repeatedly
Road infection is inhaled, normal growth and development is very then influenceed.Current doctor trained in Western medicine still lacks ideal treatment measure to this disease.Traditional Chinese medicine thinks, this
Much more sick because of children's asthenic susceptibility of spleen, breast food is not known from saving, and partial eclipse, selects food, irregular eating, or addiction to greasy and sweet foods savoury, is with the passing of time damaged
The impairment of the spleen；Or because misdiagnosis after long let out, or native endowment are not enough, emptiness of spleen and stomach causes the strong fortune mistake department of spleen.Drug therapy is mainly adopted
With zinc agent and promote gastroenteritic power medicine, zinc supplementation only for zinc-deficiency person effectively, and if research confirm combined with Zn-ef ficiency merely
The direct zinc supplementation of thing, then easily excessive, Zn content can excessively suppress the absorption of copper, iron, internal Equilibrium of Trace Elements can be caused again
Imbalance, or even cause zinc poisoning, there are the symptoms such as heating, nausea,vomiting,diarrhea, the application for promoting digestive tract power reinforcing medicine is to be based on
WeiDongLi Capsule lacks caused apocleisis, is only used for the infant of gastric hypokinesia in apocleisis, and some drugses side effect is not suitable for greatly youngster
Child uses.The traditional Chinese medical science have accumulated rich experience in long-term clinical practice to treating this disease, and evident in efficacy.It is of the invention selected
Chinese herbal medicine can not only improve appetite, strengthen gastrointestinal peristalsis, even more rich in various trace elements such as zinc, copper, calcium, manganese, iron, make treatment
Effect is more notable.It is more safe and reliable to infant and Chinese herbal medicine toxic side effect is low.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine preparation for treating the spleen and stomach in children disharmony type baby anorexia.
The purpose of the present invention is achieved through the following technical solutions, treatment the spleen and stomach in children disharmony type baby anorexia
Chinese medicine preparation is made up of the Chinese medicine of following parts by weight：11-15 parts of turnip, 5-9 parts of fringed iris rhizome, 8-12 parts of Himalayan Eriosema, common anneslea bark or leaf 3-7
Part, 6-10 parts of narrowbract Indian kalimeris herb, 6-10 parts of asiatic striga herb, 3-7 parts of tomentose pummelo fruit.
It is preferred that：13 parts of turnip, 7 parts of fringed iris rhizome, 10 parts of Himalayan Eriosema, 5 parts of common anneslea bark or leaf, 8 parts of narrowbract Indian kalimeris herb, 8 parts of asiatic striga herb, tangerine
Red 5 parts of pearl.
Preparation method：Decoction is traditionally made.
Fang Zhong：Turnip appetizer under the gas, eliminating damp, detoxifying；Fringed iris rhizome helps digestion desinsection, clearing away heat and loosing the bowels；Himalayan Eriosema benefiting stomach and stopping pain, solution
Poison；Common anneslea bark or leaf stomach invigorating relax liver, bring down a fever；Narrowbract Indian kalimeris herb food digesting stomach fortifying, dissolving stasis removing toxic substances；Asiatic striga herb clearing liver invigorating the spleen, disperse accumulations desinsection；Tomentose pummelo fruit
Cough-relieving is aid digestion, except the stagnation of the circulation of vital energy in the heart.
Embodiment
Embodiment one：Weigh turnip 11g, fringed iris rhizome 5g, Himalayan Eriosema 8g, common anneslea bark or leaf 3g, narrowbract Indian kalimeris herb 6g, asiatic striga herb 6g,
Tomentose pummelo fruit 3g, is traditionally made decoction.
Embodiment two：Weigh turnip 13g, fringed iris rhizome 7g, Himalayan Eriosema 10g, common anneslea bark or leaf 5g, narrowbract Indian kalimeris herb 8g, asiatic striga herb 8g,
Tomentose pummelo fruit 5g, is traditionally made decoction.
Embodiment three：Weigh turnip 15g, fringed iris rhizome 9g, Himalayan Eriosema 12g, common anneslea bark or leaf 7g, narrowbract Indian kalimeris herb 10g, asiatic striga herb
10g, tomentose pummelo fruit 7g, are traditionally made decoction.
Toxicity test
1st, experimental animal cleaning grade healthy SD female rats 40, weight (199 ± 4) g, as chronic toxicity；
The female small white mouse 20 in cleaning grade health Kunming, weight (22 ± 2) g, as acute toxicological experiment.Feed with normal diet, it is general
Logical drinking-water.Room temperature is controlled in (25 ± 2) DEG C, humidity (54 ± 3) %, natural lighting.
2nd, acute toxicological experiment is according to (Chinese medicine, researches on natural drugs register operation manuals), from the healthy Kunming of cleaning grade
Female small white mouse 20, is randomly divided into 2 groups, Chinese medicine group and each 10 of blank control group.Chinese medicine group is rolled over by normal children oral dose
The dosage of small white mouse is counted as, Chinese medicine is gavaged daily 1 time.Blank control group gives the sodium chloride injection of 1mL/20g weights 0.9% to fill
Clothes.
3rd, long term toxicity test cleaning grade healthy SD female rats 40, are randomly divided into 4 groups, Normal group and Chinese medicine
Group it is small, in, heavy dose of each 10.Control group gives the sodium chloride injection of 1ml/20g weights 0.9%, Chinese medicine group it is small, in,
Heavy dose of group be children's normal usage be converted to rat dosage 20,30,40 times, be gastric infusion, one time a day, experiment week
Phase is 3 months.
4th, acute toxicity testing result small white mouse is being administered in 10d without death, to observation post administration mouse outward appearance, hair color, light
Damp normal, social action, reaction are normal, ingest, drain normal.It is artificial after 10d to put to death dissection, observe its heart, liver, spleen
Dirty, lungs, kidney, brain, ovary, uterus are showed no exception.Pathological examination：Yihong of haematine one (HE) is dyed, and Chinese medicine group is dirty
Device surface is smooth, institutional framework aligned orderly, and cell size, form are normal, and endochylema, karyon dyeing are clear, with blank control group
Comparing difference is not statistically significant (P ＞ 0.05).
5th, chronic toxicity result Chinese medicine group it is small, in, outward appearance, the hair color of heavy dose of group and rats in normal control group,
Social action, excitant etc. and not statistically significant (P ＞ 0.05) to comparing differences such as surrounding environment, food, the interest of water.
Increase the equal nothing of weight comparing difference after (P ＜ 0.05), but 4 groups of experiments before weight relatively this group experiment after 4 groups of rat experiments
Blood cytology index, blood biochemical analysis index, important organ coefficient ratio after statistical significance (P ＞ 0.05), 4 groups of rat experiments
It is not statistically significant (P ＞ 0.05) compared with difference.Important organ row staining pathologic section is checked after 4 groups of rats are put to death, HE dyeing.
Chinese medicine group Rats Organs and Tissues institutional framework aligned orderly, cell size, form are normal, and endochylema, karyon dyeing are clear, with normal control
Group comparing difference is not statistically significant (P ＞ 0.05).
Toxicity test shows that the Chinese medicine preparation administration for the treatment of the spleen and stomach in children disharmony type baby anorexia of the invention is large and small
Toxic reaction is had no after white mouse.
Clinical data
1st, in general information in November, -2014 in January, 2010,270 patients to our hospital, man 160, female 110
Example, age 3-8 Sui, average age 5.5 years old；On the basis of patient knows and be voluntary, patient is divided into 9 groups by us；Only take
It is B groups that turnip simple group, which is A groups, only take fringed iris rhizome simple group, only take Himalayan Eriosema simple group is C groups, only takes
It is F groups that it is E groups that common anneslea bark or leaf simple group, which is D groups, only take narrowbract Indian kalimeris herb simple group, only take asiatic striga herb simple group, is only taken
Be G groups with tomentose pummelo fruit simple group, take the present invention by the preparation group of embodiment two be treatment group, use conventional therapy for pair
According to group.Each group is more not statistically significant (P ＞ 0.05) in general information such as age, sexes, with comparativity.
2nd, diagnostic criteria Western medicine diagnostic criteria (is edited according to Wu Ruiping etc.《All good fortune Chinese bush cherry practical paidonosologies》7th edition, the people
Hygienic publishing house 1996).(1) long-term poor appetite, is shown in that food is not coveted, and enters amount and reduces more than 1/3-1/2 earlier above, morbidity is most in short-term
Between be more than 2 weeks, exclude other systemic diseases；(2) body weight increase is stagnated or mitigated, and has bad appetite to be accustomed to or improper feeding
History.
Differential diagnosis in tcm disease：Apocleisis or food refusal, lustreless complexion, spirit still, compel Nausea and vomiting after food, and gastral cavity abdomen makees swollen, tongue
Greasy and thin fur, arteries and veins is still strong.
3rd, treatment method treatment group takes the medicament as made from embodiment of the present invention two and treated；Weigh respectively A,
The weight of each simple group of B, C, D, E, F, G, the decoction being traditionally made is treated, above each group one portion per day, point
Sooner or later take twice；Control group is treated according to the oral digestion-promoting stomachic of doctor's advice；Each group one week is a course for the treatment of, and each group patient treats
Comparitive study is carried out after 4 courses for the treatment of.
4th, criterion of therapeutical effect is fully recovered：Appetite is significantly increased, and appetite substantially increases, and has been recovered to normal level；It is effective：Food
It is intended to be clearly better, appetite is recovered to the 3/4 of normal level；Effectively：Appetite makes moderate progress, and appetite increased, but not up to just
Ordinary water it is flat 3/4；It is invalid：Appetite and appetite are showed no improvement, or even aggravate.
5th, treatment results
| Group | Number of cases | Dose (g) | Recovery from illness | It is effective | It is invalid | Side effect | Total effective rate (%) |
| A | 30 | 75 | 1 | 2 | 27 | 3 | 10.0 |
| B | 30 | 75 | 1 | 3 | 26 | 2 | 13.3 |
| C | 30 | 75 | 1 | 2 | 27 | 2 | 10.0 |
| D | 30 | 75 | 2 | 3 | 25 | 1 | 16.7 |
| E | 30 | 75 | 2 | 2 | 26 | 2 | 13.3 |
| F | 30 | 75 | 0 | 2 | 28 | 2 | 6.7 |
| G | 30 | 75 | 2 | 1 | 27 | 1 | 10.0 |
| Treatment group | 30 | 56 | 19 | 11 | 0 | 0 | 100.0 |
| Control group | 30 | Convention amount | 14 | 9 | 7 | 2 | 76.7 |
By the dose of each simple in upper table, toxicity test is done by the above-mentioned method for doing toxicity test respectively, is tied by experiment
Fruit understands that each single decoction group is nontoxic level.By above clinical data, although treatment group takes less dose, but
It is to achieve preferable therapeutic effect, total effective rate is higher than each simple total effective rate sum, also significantly better than control group, and
Toxicity is reduced, and have no toxic side effect appearance, it follows that generating synergistic function after each simple compatibility, improves treatment
Effect.
When carrying out follow-up to treatment group patient, wherein there are 2 patient parents to teach their another experience to us,
After the Chinese medicine preparation for taking the present invention, not only baby anorexia has obtained effective treatment, and infant bronchitis is also obtained
Effective treatment.Obtain after this message, we suffer from bronchitis using the Chinese medicine preparation of the present invention to 28 immediately
Children are treated.
Curative effect determinate standard reference《Chinese medical disease Standardization of diagnosis and curative effect》Recovery from illness：Clinical symptoms and sign disappear, and body temperature is just
Often, lung's wheezing sound disappears, and x ray photograph pulmonary lesionses absorb；It is effective：Clinical symptoms, sign take an evident turn for the better；Effectively：It is clinical
Sings and symptoms mitigates, and lung's wheezing sound, gurgling weith sputum sound are reduced, and x ray photograph pulmonary lesionses are not fully absorbed；It is invalid：Clinical symptoms,
Sign is without taking a turn for the better or clinical complication or appearance due to serious adverse reaction occur and must change other drugs treatment, leucocyte
Sum, classification and x-ray chest film inspection are without change.
In 28 patients for the treatment of results, fully recover 14 (50), effective 6 (21.43%), effective 6 (21.43%), nothing
2 (7.14%) is imitated, total effective rate 92.86% is evident in efficacy.In whole therapeutic process, patient does not occur obvious bad
Reaction, blood, urine, stool routine examination, electrocardiogram and Liver and kidney function have no significant change.
Claims (2)
1. a kind of Chinese medicine preparation for treating the spleen and stomach in children disharmony type baby anorexia, it is characterised in that the Chinese medicine preparation is by following heavy
The Chinese medicine of amount part is made：11-15 parts of turnip, 5-9 parts of fringed iris rhizome, 8-12 parts of Himalayan Eriosema, 3-7 parts of common anneslea bark or leaf, 6-10 parts of narrowbract Indian kalimeris herb,
6-10 parts of asiatic striga herb, 3-7 parts of tomentose pummelo fruit.
2. a kind of Chinese medicine preparation for treating the spleen and stomach in children disharmony type baby anorexia as claimed in claim 1, it is characterised in that
The Chinese medicine preparation is made up of the Chinese medicine of following parts by weight：13 parts of turnip, 7 parts of fringed iris rhizome, 10 parts of Himalayan Eriosema, 5 parts of common anneslea bark or leaf, roadside
8 parts of grass, 8 parts of asiatic striga herb, 5 parts of tomentose pummelo fruit.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710356249.XA CN107115417A (en) | 2017-05-10 | 2017-05-10 | A kind of Chinese medicine preparation for treating the spleen and stomach in children disharmony type baby anorexia |
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|---|---|---|---|
| CN201710356249.XA CN107115417A (en) | 2017-05-10 | 2017-05-10 | A kind of Chinese medicine preparation for treating the spleen and stomach in children disharmony type baby anorexia |
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| Publication Number | Publication Date |
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| CN107115417A true CN107115417A (en) | 2017-09-01 |
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| CN201710356249.XA Withdrawn CN107115417A (en) | 2017-05-10 | 2017-05-10 | A kind of Chinese medicine preparation for treating the spleen and stomach in children disharmony type baby anorexia |
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Application publication date: 20170901 |
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