CN111467416B

CN111467416B - Traditional Chinese medicine composition for invigorating spleen and removing food retention, patch and preparation method

Info

Publication number: CN111467416B
Application number: CN202010364542.2A
Authority: CN
Inventors: 王凯铭; 郜菲; 艾方磊
Original assignee: Beijing Huimin Traditional Chinese Medicine Children's Hospital Co ltd
Current assignee: Beijing Huimin Traditional Chinese Medicine Children's Hospital Co ltd
Priority date: 2020-04-30
Filing date: 2020-04-30
Publication date: 2021-12-21
Anticipated expiration: 2040-04-30
Also published as: CN111467416A

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for tonifying spleen and removing food retention, which comprises the following traditional Chinese medicines in parts by weight: 1-3 parts of fried radish seed, 1-3 parts of ginger processed pinellia tuber and 0.1-1 part of fried burdock. The invention also provides a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is suitable for preventing and/or treating children with yellow tongue fur, halitosis, abdominal distension or dry stool. The traditional Chinese medicine composition has the advantages of few traditional Chinese medicine varieties, few medicines, obvious curative effect and no side effect.

Description

Traditional Chinese medicine composition for invigorating spleen and removing food retention, patch and preparation method

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for tonifying spleen and removing food retention, a patch and a preparation method thereof.

Background

Infantile indigestion is the most common disease in pediatric clinic, and the symptoms are mainly manifested by milk indigestion, abdominal distension, belch, acid and decay, loose stool or acid and odor. The traditional Chinese medicine considers that the disease is a gastrointestinal tract disease formed by internal injury of milk and food, stagnation of qi and accumulation of middle-jiao, accumulation but not transformation and qi stagnation, the initial treatment is easy, the infantile malnutrition state is easy to develop if the infantile malnutrition is not treated for a long time, and the healthy development of children is seriously influenced.

The infantile indigestion can be treated by western medicine or traditional Chinese medicine. The western medicine treatment scheme is as follows: diet guidance, namely strictly controlling the intake of food which is not suitable for digestion, and mainly taking good digestion food as the main material; the exercise guidance can accelerate metabolism, accelerate energy consumption and promote food intake by proper exercise; correcting the deficiency of trace elements, such as the zinc deficiency patient appropriately supplementing the zinc element intake; in the medicine treatment, oral gastric enzyme mixture or yeast tablet has a little effect on appetite promotion, and oral gastric motility promoting medicine such as domperidone promotes gastric peristalsis, accelerates gastric emptying, and reduces gastrointestinal function burden. The traditional Chinese medicine treatment scheme comprises internal treatment and external treatment, wherein the internal treatment mainly adopts oral decoction, and the external treatment mainly adopts infant massage, acupuncture therapy and acupoint application. The decoction is prepared by combining traditional Chinese medicines with the effects of activating spleen with fragrance, promoting digestion and removing food stagnation with a marrow prescription of traditional Chinese medicine dialectical treatment, so as to achieve the purposes of strengthening spleen, harmonizing stomach and relieving stasis; infant tuina and Patch therapy are used to stimulate corresponding meridian points to achieve the purpose of removing food retention, such as Nie Ji stimulation of Du channel points, Bu pijing, Rou ban Men, Yun Nei eight Diagram, etc., acupuncture therapy is the simplest and most convenient and cheap method for treating infantile malnutrition at the basal level, and the purpose of removing food retention can be achieved by needling four suture points to squeeze out yellow liquid in the points.

Patent document CN108653622A discloses a traditional Chinese medicine watered pill for conditioning sub-health, which comprises the following components: ginger processed pinellia tuber, dried orange peel, tuckahoe, medicated leaven, fried malt, fried hawthorn, nutgrass galingale rhizome, red paeony root, peach seed, safflower, fried radish seed, raw gardenia, fermented soya bean, szechuan lovage rhizome, medicinal cyathula root, thinleaf milkwort root-bark, acorus calamus, tuber fleeceflower stem, fried chicken's gizzard-membrane, dahurian angelica root, rhizoma corydalis, trogopterus dung, divaricate saposhnikovia root and great burdock achene, and is used for treating sub-health symptoms such as gastrointestinal discomfort, poor sleep quality, repeated internal heat, fever, cold and the like.

Therefore, although the traditional Chinese medicine formula of the patent documents comprises the fried radish seeds, the ginger processed pinellia and the fried burdock, the application of the medicine in strengthening the spleen and removing food retention, stimulating the appetite and removing food retention is not involved, the variety of the traditional Chinese medicinal materials in the whole medicine formula is up to 24, the risks of stimulation of the medicine to the gastrointestinal tract and aggravation of liver and kidney burden are increased undoubtedly, meanwhile, the compliance of children to oral administration preparations is poor, especially, the children are difficult to feed, the administration dosage is difficult to guarantee due to vomiting after the medicine is taken, and the curative effect is often influenced.

Therefore, there is a need to develop a traditional Chinese medicine composition for invigorating spleen, removing food retention, stimulating appetite and removing food stagnation, which has the advantages of less medicine consumption, obvious curative effect and no side effect.

The present invention has been made in view of the above circumstances.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for tonifying spleen, removing food retention, stimulating appetite and removing food retention, which has the advantages of less medicine consumption, obvious curative effect and no side effect.

In order to realize the purpose of the invention, the invention provides a traditional Chinese medicine composition for invigorating spleen and removing food retention, which is prepared from the following traditional Chinese medicinal materials in parts by weight: 1-3 parts of fried radish seed, 1-3 parts of ginger processed pinellia tuber and 0.1-1 part of fried burdock.

The fried radish seed is prepared by preparing radish seed raw materials according to a legal processing method in Chinese pharmacopoeia. The pinellia ternate is prepared from pinellia ternate raw materials according to a legal processing method in Chinese pharmacopoeia. The fried burdock is prepared by the burdock raw material according to the legal processing method of Chinese pharmacopoeia.

Further optionally, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 1-3 parts of fried radish seed, 1-3 parts of ginger processed pinellia tuber and 0.1-1 part of fried burdock.

Further optionally, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 2 parts of fried radish seed, 2 parts of ginger processed pinellia and 0.1 part of fried burdock.

Further optionally, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 3 parts of fried radish seed, 1 part of ginger processed pinellia and 1 part of fried burdock.

Further optionally, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 2 parts of fried radish seed, 2 parts of ginger processed pinellia and 0.5 part of fried burdock.

Further optionally, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 1 part of fried radish seed, 3 parts of ginger processed pinellia and 0.2 part of fried burdock.

In a specific embodiment of the invention, the raw materials of the traditional Chinese medicine composition comprise the following traditional Chinese medicinal materials in parts by weight: 1-3 parts of fried radish seed, 1-3 parts of ginger processed pinellia tuber and 0.1-1 part of fried burdock.

Further optionally, the Chinese medicinal composition is powder.

The invention also provides a preparation method of the traditional Chinese medicine composition for invigorating spleen and removing food retention, which comprises the following steps:

(1) weighing the medicinal materials according to weight parts, respectively, cleaning the medicinal materials, and oven drying at 50-60 deg.C for 30-40 min;

(2) pulverizing the dried Chinese medicinal materials to 50-100 mesh, and mixing.

Further optionally, the preparation method comprises:

(1) weighing the medicinal materials according to weight parts, respectively, cleaning the medicinal materials, and drying at 50-60 deg.C for 30 min;

(2) pulverizing the dried Chinese medicinal materials, pulverizing to 80 mesh, and mixing.

The invention also provides a patch which comprises a carrier and the traditional Chinese medicine composition.

Further optionally, the patch also comprises ginger juice, and the ginger juice and the traditional Chinese medicine composition are mixed into paste and then placed on the carrier to prepare the patch.

Further optionally, the ratio of ginger to water in the ginger juice is 1: 1-1.5, and preferably 1:1.

Further optionally, the carrier comprises at least one of a non-woven fabric, gauze, adhesive tape, plaster, or medical rubber.

The invention also provides application of the traditional Chinese medicine composition for tonifying spleen and removing food retention, and promoting appetite and removing food retention or the patch in preparation of a medicine, wherein the medicine is used for preventing and/or treating pediatric or adult diseases, preferably, the diseases are selected from tongue fur yellow, halitosis, abdominal distension or dry stool.

The medicinal materials used in the invention have the following effects:

the parched Raphani semen is dried mature seed of Raphanus sativus L of Brassicaceae, has pungent, sweet, neutral nature, and effects of resolving food stagnation, relieving flatulence, lowering qi and eliminating phlegm. It is mainly used for treating diet stagnation, abdominal pain, constipation, dysentery, phlegm stagnation, and cough and asthma.

The rhizoma Pinelliae is dried tuber of pinellia Ternata Thunb of Araceae, has pungent taste and warm nature, and has effects of eliminating dampness and phlegm, lowering adverse qi and relieving vomit. It is mainly used for treating cough and asthma with excessive phlegm, phlegm and fluid retention, dizziness and palpitation, wind phlegm, vertigo, phlegm syncope, headache, emesis, regurgitation, chest and gastric fullness, and globus hystericus.

The parched fructus Arctii is dry mature fruit of Arctium lappa L.of Ernnial herb of Compositae, has pungent, bitter and cold properties, and has effects of dispelling pathogenic wind and heat, dispersing lung qi, relieving sore throat, removing toxic substance, promoting eruption, detumescence and treating sore. It is mainly used for treating measles without adequate eruption, sore throat, and cough and asthma due to wind-heat.

Based on the clinical experience of the traditional Chinese medicine for many years, the inventor of the invention carries out deep research on the infantile indigestion disease, and thinks that the pathological changes of viscera are in the spleen and the stomach, and the spleen governs transportation and transformation and is easy to be assimilated because the stomach governs accepting and is easy to be assimilated, so that food can be digested. If the spleen and stomach are damaged, the spleen and stomach are disharmony, the food retention and accumulation cannot be relieved, and qi stagnation cannot be removed, the food retention and stagnation will be formed. If the food stays long and cannot be cured, the spleen and stomach can be further injured, which causes qi and blood generation and transformation deficiency, nutrient and growth and development disorder, and the body becomes increasingly thin and turns into malnutrition. The common causes include improper feeding, impairment of spleen and stomach, or deficiency of spleen and stomach, which can result in recurrent impairment of milk and food. Aiming at the etiology and pathogenesis, the treatment principle is as follows: promoting digestion, relieving food stagnation, regulating qi-flowing, and activating stagnancy. The invention combines the fried radish seed, ginger processed pinellia tuber and fried burdock into powder or further uses the powder to prepare a patch for treating the infantile indigestion, and the formula thought is as follows: ginger processed pinellia is the monarch drug, pungent and warm in property and resolving masses and can eliminate the phlegm-food mixed with the sexual caking and also can dispel the qi stagnation without the shaped caking. The radish seeds are ministerial drugs and have the functions of promoting digestion and relaxing the bowels. The burdock is used as an assistant and guide drug, and stagnation is easy to remove heat, so the medicine can be used for preventing heat accumulation, clearing heat and relaxing bowels, and belongs to the category of stagnation.

When the infantile indigestion disease is treated, the traditional Chinese medicine composition is generally prepared into a patch and then is externally applied, and the externally applied traditional Chinese medicine composition is specifically prepared into the following components: the traditional Chinese medicine patch is pasted on the Shenque acupoint for two hours every day, one treatment course is 7 days, and good curative effect can be obtained after four treatment courses are continuously used.

Compared with the prior art, the invention has the beneficial effects that:

(1) the traditional Chinese medicine composition and the patch have good curative effect on infantile indigestion, and have the advantages of reasonable formula, no toxic or side effect, and safe and reliable curative effect;

(2) the traditional Chinese medicine composition and the patch have simple traditional Chinese medicine components, reduce the stimulation of the medicine to the gastrointestinal tract and reduce the burden of liver and kidney.

(3) The traditional Chinese medicine composition and the patch are suitable for infants and children to take, can enhance the immune function of the infants and children, and avoid the pain of injection and transfusion.

Detailed Description

The present invention is further described in the following description of the specific embodiments, which is not intended to limit the invention, but various modifications and improvements can be made by those skilled in the art according to the basic idea of the invention, within the scope of the invention, as long as they do not depart from the basic idea of the invention.

Example 1

Taking 10g of fried radish seeds, 30g of ginger processed pinellia and 2g of fried burdock; cleaning the Chinese medicinal materials, and drying with a dryer; pulverizing the dried Chinese medicinal materials, pulverizing into 80 mesh powder, and mixing to obtain the Chinese medicinal composition.

Wherein, the stir-fried radish seed is directly purchased or prepared according to the legal processing method of Chinese pharmacopoeia; the ginger processed pinellia is obtained directly or prepared by processing pinellia according to the legal processing method of Chinese pharmacopoeia; the fried burdock is directly purchased or prepared by taking burdock according to the legal processing method of Chinese pharmacopoeia;

examples 2 to 6

Examples 2-6 are the preparation of the composition of example 1, using the pharmaceutical ingredients and process conditions shown in table one.

Table one: the components of the Chinese traditional medicines in examples 2-6 and the process conditions

Example 7

The present embodiment is a method for preparing the traditional Chinese medicine composition of embodiment 1 into a traditional Chinese medicine patch, and the method comprises the following steps:

mixing ginger and water according to a ratio of 1:1 to prepare ginger juice, mixing the ginger juice and the traditional Chinese medicine composition prepared in the embodiment 1 to prepare paste, and placing the paste at the midpoint of the medical gauze to obtain the medical gauze.

Example 8

mixing rhizoma Zingiberis recens with water at a ratio of 1:1.5 to obtain succus Zingiberis recens, mixing succus Zingiberis recens with the Chinese medicinal composition prepared in example 1, concocting into paste, and placing in the middle of non-woven fabric.

Example 9

mixing ginger and water at a ratio of 1:1.2 to obtain ginger juice, mixing the ginger juice and the Chinese medicinal composition prepared in the embodiment 1 to prepare paste, and placing the paste at the midpoint of the medical rubber.

Test examples

The experimental example is a clinical study on the traditional Chinese medicine patch prepared in example 7 in the treatment of infantile stagnation disease.

Case selection: randomly selecting 100 children with stagnation disease in Beijing Huimin Chinese medicine children hospital, wherein the average age of the children is 5 years old and 8 months, the male-female ratio is 1:1, and the diagnosis basis is as follows: a thick yellow coating, abdominal distension and poor appetite. Two or more symptoms appear, lasting for one or more weeks without exceeding four weeks, and no improvement is seen.

According to the severity of symptoms, dividing the children patients into four grades of mild, severe and severe, wherein the symptoms of the children patients are thin and white tongue fur, conscious abdominal distension, flat and soft abdomen, no abnormality in percussion, and mild symptoms of poor appetite and normal meal; the symptoms of the infant are as follows: the disease grade of the reduction of the meal is lighter because the fur is white and thick, the abdomen is conscious and is flat and soft, the percussion has slight drum sound, the diet is not thought, and the appetite is reduced; the disease symptoms of the infant are thick and yellowish fur, conscious abdominal distension, slight bulge of abdominal skin, obvious percussion drum sound, poor appetite, large reduction of meal amount and even heavy grade of disease symptoms of no eating; the symptoms of the infant are serious in the grade of yellow and thick dry tongue coating, subjective abdominal distension, obvious abdominal skin bulge, obvious percussion drum sound, or accompanied with abdominal pain, poor appetite and even vomiting after eating.

The treatment method comprises the following steps: the patch prepared in example 7 was applied to the Shenque point of a child patient once a day for two hours each time for 7 days as a treatment course, and four treatment courses were continuously observed.

Observation indexes are as follows: and (5) adopting a classification statistical method, and setting 10 classifications of improvement conditions of each symptom from weak to strong. The score assignment for each symptom is shown in table two.

Table two: symptom score assignment

The results of clinical experiments are as follows: the diagnosis and treatment conditions of the children patients at different levels after the medicine is taken are divided into invalid, effective and recovery, wherein the total score is 0, 1-15, 16-18 and 19-30, respectively. The clinical test results after administration are shown in Table three.

Table three: clinical trial results after drug administration

	Number of cases before administration	Number of cure cases	Number of effective cases	Effective number of cases	Number of invalid cases
						Light and slight	31	7	15	9	0
Is lighter	54	11	23	19	1
						Heavy weight	8	2	4	1	1
Severe severity of disease	7	1	2	2	2

After four courses of treatment, the stagnation symptoms of most children are effectively improved to a certain extent, and no obvious adverse reaction is found in the treatment process.

The case analysis was as follows:

case one: children patients are 4 years old and sexually female, and have symptoms of inappetence, abdominal distension, yellow tongue coating, halitosis and dry stool (once in three or four days). After one week of the application treatment, the symptoms are well changed, the abdominal distension is relieved, the tongue coating is yellowish, slight breath exists, and the stool is still dry (once every two or three days). After being continuously applied for two weeks, the appetite is improved, the abdominal distension is relieved, the tongue coating is normal, the mouth is occasionally aerated, and the stool is not dry (once every two days). After four weeks the symptoms had disappeared completely.

Case two: children of 5 years old and sexually male, and symptoms of inappetence, yellow tongue coating, bad breath, slightly dry stool and abnormal defecation. After two weeks of application, the appetite is improved, the tongue coating is yellowish, the mouth is occasionally breathed, and the stool is normal. Symptoms disappeared after two weeks of continued treatment.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The traditional Chinese medicine composition for invigorating spleen and removing food retention is characterized by comprising the following traditional Chinese medicinal materials in parts by weight: 1-3 parts of fried radish seed, 1-3 parts of ginger processed pinellia tuber and 0.1-1 part of fried burdock.

2. The traditional Chinese medicine composition for invigorating spleen and removing food retention according to claim 1, which is characterized by comprising the following traditional Chinese medicinal materials in parts by weight: 1 part of fried radish seed, 3 parts of ginger processed pinellia and 0.2 part of fried burdock.

3. The traditional Chinese medicine composition for invigorating spleen and removing food retention according to claim 1, which is characterized by comprising the following traditional Chinese medicinal materials in parts by weight: 2 parts of fried radish seed, 2 parts of ginger processed pinellia and 1 part of fried burdock.

4. The traditional Chinese medicine composition for invigorating spleen and removing food stagnation according to claim 1, which is a powder.

5. A method for preparing the Chinese medicinal composition for invigorating spleen and removing food stagnation according to any one of claims 1 to 4, which comprises the following steps:

6. A patch characterized by comprising a carrier and the Chinese medicinal composition of any one of claims 1 to 5.

7. The patch according to claim 6, further comprising ginger juice, wherein said ginger juice and said Chinese medicinal composition are mixed into paste and then placed on said carrier to obtain said patch.

8. The patch according to claim 7, wherein the ratio of ginger to water in the ginger juice is 1:1 to 1.5.

9. The patch of any one of claims 6 to 8 wherein said carrier comprises at least one of a non-woven fabric, gauze, adhesive, plaster or medical rubber.

10. Use of a traditional Chinese medicine composition according to any one of claims 1 to 4 or a patch according to any one of claims 6 to 9 for the manufacture of a medicament for the prevention and/or treatment of a pediatric condition selected from the group consisting of a yellow tongue coating, halitosis, abdominal distension or dry stool.