CN107108712A - 提高重组蛋白产量的方法 - Google Patents

提高重组蛋白产量的方法 Download PDF

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Publication number
CN107108712A
CN107108712A CN201580073185.1A CN201580073185A CN107108712A CN 107108712 A CN107108712 A CN 107108712A CN 201580073185 A CN201580073185 A CN 201580073185A CN 107108712 A CN107108712 A CN 107108712A
Authority
CN
China
Prior art keywords
refolding buffer
refolding
protein
polypeptide
arginine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580073185.1A
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English (en)
Chinese (zh)
Inventor
J·S·K·陈
B·H·根森
J·B·穆姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Armo BioSciences Inc
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Armo BioSciences Inc
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Filing date
Publication date
Application filed by Armo BioSciences Inc filed Critical Armo BioSciences Inc
Publication of CN107108712A publication Critical patent/CN107108712A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201580073185.1A 2014-12-23 2015-12-21 提高重组蛋白产量的方法 Pending CN107108712A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462096359P 2014-12-23 2014-12-23
US62/096,359 2014-12-23
PCT/US2015/067135 WO2016106229A1 (en) 2014-12-23 2015-12-21 Methods of improving yield in recombinant protein production

Publications (1)

Publication Number Publication Date
CN107108712A true CN107108712A (zh) 2017-08-29

Family

ID=56151492

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580073185.1A Pending CN107108712A (zh) 2014-12-23 2015-12-21 提高重组蛋白产量的方法

Country Status (8)

Country Link
US (1) US20170362291A1 (enExample)
EP (1) EP3237441A4 (enExample)
JP (1) JP2018500341A (enExample)
CN (1) CN107108712A (enExample)
AU (1) AU2015369808A1 (enExample)
CA (1) CA2969574A1 (enExample)
HK (1) HK1245297A1 (enExample)
WO (1) WO2016106229A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107106655A (zh) 2014-10-22 2017-08-29 阿尔莫生物科技股份有限公司 使用白细胞介素‑10治疗疾病和病症的方法
WO2016126615A1 (en) 2015-02-03 2016-08-11 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
KR20180020141A (ko) 2015-05-28 2018-02-27 아르모 바이오사이언시스 인코포레이티드 암 치료에 사용되는 peg화된 인터류킨-10
KR20180038553A (ko) 2015-08-25 2018-04-16 아르모 바이오사이언시스 인코포레이티드 질환 및 장애를 치료하기 위한 인터류킨-10을 사용하는 방법
EP4083058A3 (en) * 2018-11-07 2023-01-11 Applied Molecular Transport Inc. Delivery constructs for transcytosis and related methods
US12239793B2 (en) 2019-07-09 2025-03-04 O2Matic Aps Device for regulating oxygen for automated oxygen therapy
KR20220066056A (ko) * 2019-08-16 2022-05-23 어플라이드 몰레큘라 트랜스포트 인크. 조성물, 제형, 및 인터루킨 제조 및 정제

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020033A2 (en) * 1996-11-06 1998-05-14 Schering Corporation RENATURATION AND PURIFICATION OF VIRAL INTERLEUKIN-10 (vIL-10)
CN1408863A (zh) * 2001-09-28 2003-04-09 中山大学 一种人白细胞介素－10基因序列及含该基因序列的大肠杆菌
CN101506222A (zh) * 2006-07-14 2009-08-12 健泰科生物技术公司 重组蛋白的重折叠
US20120142033A1 (en) * 2010-09-21 2012-06-07 PrevenTec, Inc. Method for extraction and purification of recombinant proteins from transgenic plants

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005033307A1 (ja) * 2003-09-30 2005-04-14 Kyowa Hakko Kogyo Co., Ltd. 新規のリフォールディング方法およびその方法によって得られたタンパク質
CA2625208A1 (en) * 2005-10-04 2007-04-12 Zymogenetics, Inc. Production and purification of il-29

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020033A2 (en) * 1996-11-06 1998-05-14 Schering Corporation RENATURATION AND PURIFICATION OF VIRAL INTERLEUKIN-10 (vIL-10)
CN1408863A (zh) * 2001-09-28 2003-04-09 中山大学 一种人白细胞介素－10基因序列及含该基因序列的大肠杆菌
CN101506222A (zh) * 2006-07-14 2009-08-12 健泰科生物技术公司 重组蛋白的重折叠
US20120142033A1 (en) * 2010-09-21 2012-06-07 PrevenTec, Inc. Method for extraction and purification of recombinant proteins from transgenic plants

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LISA D. CABRITA AND STEPHEN P. BOTTOMLEY: "Protein expression and refolding - A practical guide to getting the most out of inclusion bodies", 《BIOTECHNOLOGY ANNUAL REVIEW》 *
YOSHIHIRO FUJIWARA ET AL: "Extraction and purification of human interleukin-10 from transgenic rice seeds", 《PROTEIN EXPRESSION AND PURIFICATION》 *
井申荣等: "重组人白细胞介素-10 在大肠杆菌中的表达及生物学活性分析", 《中国生物制品学杂志》 *

Also Published As

Publication number Publication date
EP3237441A4 (en) 2018-06-06
EP3237441A1 (en) 2017-11-01
HK1245297A1 (zh) 2018-08-24
US20170362291A1 (en) 2017-12-21
WO2016106229A1 (en) 2016-06-30
AU2015369808A2 (en) 2017-11-23
CA2969574A1 (en) 2016-06-30
AU2015369808A1 (en) 2017-06-29
JP2018500341A (ja) 2018-01-11

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