CN1071047A - The control of poultry aspergillosis and prevention - Google Patents

The control of poultry aspergillosis and prevention Download PDF

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Publication number
CN1071047A
CN1071047A CN 92109299 CN92109299A CN1071047A CN 1071047 A CN1071047 A CN 1071047A CN 92109299 CN92109299 CN 92109299 CN 92109299 A CN92109299 A CN 92109299A CN 1071047 A CN1071047 A CN 1071047A
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natamycin
poultry
aspergillus
mould
fumagitus
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B·D·金
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DUCOA
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DUCOA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/22—Phase substances, e.g. smokes, aerosols or sprayed or atomised substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/14—Disinfection, sterilisation or deodorisation of air using sprayed or atomised substances including air-liquid contact processes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)

Abstract

The disease that in poultry, takes place of controlling and preventing to cause by the natamycin that makes the poultry rearing place be exposed to effective dose by Aspergillus fumagitus.

Description

The control of poultry aspergillosis and prevention
The present invention relates to the method for the aspergillus disease (aspergillo sis) that a kind of prevention and treatment take place in poultry, the measure of being adopted is that the natamycin with effective quantity sprays on the respiratory system of fowl nest and/or poultry.
Aspergillus disease is the mould bacterial diseases of a kind of common poultry, and the respiratory system of usually attacking poultry is although also may involve some other position.Aspergillus disease is caused by Aspergillus fumagitus mould that generally this mould is a kind of of mould family.Aspergillus fumagitus especially is higher than 25 ℃ in high humility and temperature in the environment of oxygen is arranged, propagation.Sent out mould fowl nest, cereal, feed, dust and uncleanly incubation equipment and all relation has been arranged with aspergillus disease unexpected.
Suck the seemingly main route of transmission of spore of Aspergillus fumagitus, chicken and poult are vulnerable to infect most.Because mould just grows in the inside of egg, aspergillus disease takes place also can occur with hatching.The chicken that pips in such egg just has very high onset risk.In addition, the unexpected generation of aspergillus disease generally is in the middle of immature poultry, normally age in 1-3 week.When aspergillus disease took place, lethality was approximately 10-50%.
The symptom of aspergillus disease is impaired development, pant, be short of breath, lethargic sleep and very thirsty.Yet, existing in these symptoms one or more can't be diagnosed as aspergillus disease and infect, the clinical identification of mould is unique diagnosis of determining on the poultry that infects.As F.T.W.Jordan in " Poultry Diseases ", (Bailliere Tindall, 3rd Edition), discussed like that, aspergillus disease is not also had suitable methods of treatment at present.Ill and poultry that infected will be disposed usually, and must advance cleaning completely and strict sterilization to the environment that infects.
In the past, egg will be with many kinds of reagent (comprising natamycin) sterilizations (United States Patent (USP) 3343968).It is useful handling egg with natamycin, but can not control the aspergillus disease that hatching back environmental condition produces.
Natamycin is polyenoid family a kind of of antifungi (antimycotics).The compound natamycin is that molecular weight is approximately 666 tetraene, and the corresponding experience molecular formula generally is C 33H 47NO 13, and include (glycosidically-linked) carbohydrate part of joining the sugar connection, i.e. a mycosamine.It has the isoelectric point of pH6.5.Natamycin exists with two kinds of versions (enol structure and ketone structure) usually.
Natamycin is known a kind of human body antibiotic, at Flory " Analytical Profile of Drug Substances " vol.10, relevant argumentation is arranged in 1981.As Wolfgang P.Raab, at " Pharmacology ", Natamycin(Pimaricin) (1972, Georg Thieme Publishers Stuttgart, 18 and 19 pages) in discussed like that, make saccharomycete that the people infects and mould show susceptibility usually to natamycin.The disclosed content of each of those above-mentioned publications is here taken in for referencial use in the lump.
A task of the present invention is utilized natamycin control and prevention and Aspergillus fumagitus mould diseases associated exactly.People's inhabitation place is different with the environmental characteristic of the raising farm of poultry (perhaps can be subjected to the infection of Aspergillus fumagitus), thereby the anti-Aspergillus fumagitus of natamycin is a surprising discovery to the validity of the infection of poultry.When we when emphasizing the surprising efficient of natamycin treatment and Aspergillus fumagitus diseases associated, consider between people and the poultry in anatomy the difference of aspects such as metabolism.
Another task of the present invention is by natamycin being sprayed the infection that prevents and treat Aspergillus fumagitus in the atmosphere in fowl nest and/or poultry rearing place.
Although given prominence to the special Aspergillus fumagitus bacterial strain diseases associated of control and prevention and invasion and attack poultry especially, other bird (for example duck, turkey, pheasant etc.) also can effectively be treated according to the present invention.In addition, the present invention can also be used to controlling the disease that causes with the mould that prevents by other relevant with Aspergillus fumagitus.
The present invention a kind ofly is used for prevention and control and Aspergillus fumagitus(hereinafter referred to as Aspergillus) method of diseases associated.A kind of poultry disease that is called aspergillus disease can be controlled under the natamycin of effective dose and prevented by making poultry (for example respiratory system) and/or their environmental exposure.
In one aspect of the invention, because the aspergillus disease that causes of Aspergillus can be by making the fowl nest contact with natamycin to be controlled and preventing.
In another aspect of the present invention, owing to the natamycin that infects the respiratory system contact effective dose that aspergillus disease that Aspergillus causes can be by making poultry is prevented and controls.
In addition, carry out early time treatment with natamycin and can prevent mycotic infection.Therefore, need handle the chicken or the young fowl (for example within hatching three weeks of back) of fowl nest and/or new hatching with natamycin, subsequent being handled termly in life these poultry.
Method of the present invention relate to widely some and a kind of being called as " Aspergillus fumagitus(is hereinafter referred to as " Aspergillus ") the prevention and the control of tedious mould diseases associated.This tedious mould can be invaded the health of poultry, causes some diseases (for example aspergillus disease), and this disease is communicable, and generally causes death.The present invention reaches control and prevention and Aspergillus diseases associated by the growth that suppresses (if indelible words) this tedious mould.
This tedious mould generally be grown within the employed fowl nest of poultry or on.Conversely, because the most close fowl nest of poultry, Aspergillus just may make the respiratory system of poultry be infected.For example, the Aspergillus among the fowl nest can produce spore, and they are propagated in air, are sent near the poultry.Spore may be sucked by poultry, and the respiratory system of poultry is infected, and causes aspergillus disease.
Method of the present invention is to control and prevention and Aspergillus diseases associated by fowl nest and/or poultry are contacted with the natamycin of effective dose.The scope of the effective dose of natamycin generally be from about 1.0ppm to about 70ppm, usually the atmosphere of processing environment is about 5-30ppm.Yet, depend on the concrete environment that this tedious mould is arranged and decide for the effectively actual dosage of anti-Aspergillus.According to the present invention, this refers to the infection site of fowl nest, poultry environment, or the like, these positions all may be subjected to the harmful invasion and attack of Aspergillus.If environment is suitable to this mould metabolic activity, may need quite heavy dose of natamycin could be to suppressing this mould effectively (for example natamycin of 20-30ppm).One warm, has pH neutral, contains oxygen, a kind of matrix is arranged, and this matrix promotes fungus growth, and such environment needs quite heavy dose of natamycin could suppress this tedious mould effectively.Prevent the dosage of the dosage of the growth of this tedious mould and the possible necessary natamycin of infection less than the necessary natamycin of the existing mycotic infection of treatment.Therefore, environment and/or poultry being handled according to the present invention at chicken or the poult initial stage of growing is favourable (for example, handling immediately to prevent the infection of this tedious mould after the chicken hatching).
In addition, implement the present invention although preferably adopt natamycin, yet, the derivative (for example calcium salt of natamycin, sodium salt and ester class) of acceptable natamycin on pharmacology is effective for control and prevention poultry infection Aspergillus, they can be individually, or combine with natamycin and to be used for the present invention.The form of natamycin the best is a crystal, yet any natamycin for the effective form of mould fungus inhibition all is an acceptable implementing when of the present invention.Moreover, be used for natamycin of the present invention and can have (for example, monohydrate, dihydrate and trihydrate) with the form of monohydrate or polyhydrate.Trihydrate is because its stability should use more favourable.In some cases, may need by natamycin being smashed to pieces or porphyrize improves the effectiveness of natamycin in the mode of the surface area that increases it.
In one embodiment of the invention, the used fowl nest of poultry can be handled with natamycin.The fowl nest that is fit to comprises at least with one of next group material: earth, hardwood bar, wood shavings etc.Natamycin (for example crystal habit) can directly spray in the fowl nest in any suitable manner, for example natamycin can form suspension in atoxic carrier liquid, be sprayed on the fowl nest, to use non-toxic carrier liquid be for natamycin is sprayed on the fowl nest, so carrier liquid generally is a dissolving natamycin not.Yet some derivative at acceptable natamycin on the pharmacology may dissolve in this non-toxic carrier liquid.The non-toxic carrier liquid that is suitable for comprises at least with one of next group material: alcohol, for example, and methyl alcohol, water, or the like.When the natamycin that uses effective dose was handled the fowl nest, if Aspergillus is not eliminated, its growth (for example gemma formation) had just reduced, and this helps to prevent the infection of Aspergillus to the respiratory system of poultry.
In addition, according to the concentration of Aspergillus in the fowl nest, perhaps need be before putting poultry in a suitable place to breed, and handle with natamycin in the use.And then, in some cases, perhaps, continuously the fowl nest being handled with natamycin after removing contaminated fowl nest is useful (for example, near any fowl nest that was cleaned of poultry that leaves in all may discharge spore, can make the infection in respiratory system Aspergillus of poultry).
In another embodiment of the present invention, the respiratory system of poultry can contact with natamycin, so that the infection of prevention and/or control Aspergillus.When natamycin is applied to the respiratory system of poultry effectively, can prevents the infection of Aspergillus, and control the infection that has existed, if indelible words.The use of natamycin can be adopted any mode that the natamycin of effective dose can be introduced the respiratory system of poultry.A convenient and efficient way that natamycin is applied to poultry is sent into a limited zone or a cubicle (for example so-called " spraying chamber ") to airborne natamycin suspension (for example a kind of aerosol, a kind of smog, a kind of aerosol etc.) exactly, and to make poultry pass through this zone or cubicle, poultry can be with any adoptable equipment, conveyer belt for example, carry to that limited zone, by, leave then.Poultry floats over airborne natamycin that limited suction when regional, and this natamycin just directly acts on their respiratory system.Poultry should stay for some time in that limited zone that comprises natamycin, and length during this period of time will enough make the natamycin of poultry suction q.s, so that effectively prevent and/or control the infection of Aspergillus.
This natamycin suspension (for example, a kind of aerosol, a kind of smog, a kind of aerosol etc.) can be produced by the suspension that at first forms a kind of natamycin in suitable carriers liquid.This carrier liquid must be nontoxic, and general dissolving natamycin not.A kind of suitable liquid comprises at least with next group one of material: alcohol, methyl alcohol for example, water etc.
Natamycin suspension discussed above can be converted into a kind of aerosol, a kind of smog, a kind of aerosol etc., and this will utilize any technology that can produce the natamycin of the form that poultry can suck.For example the water sample suspension of natamycin can be discharged by a nozzle, this nozzle and that the limited regional connectivity that is placed with poultry, and the speed that is adopted will enough be sent into this fluid that limited zone, to produce the natamycin of the form that can suck.Usually the natamycin suspension grain that has quite thin particle has strengthened natamycin and has penetrated into the poultry respiratory system, renders a service thereby increase.
In addition, in some cases, may need whole poultry rearing environment is handled (for example for reducing any activity that floats over mycotic spore in the air).For example natamycin can feed in the ventilation equipment (for example being placed with in the heating/cooling system in room of poultry), and the mode that is adopted is wanted and can be carried out disinfection to the poultry rearing environment effectively, so that can prevent seriously stretching of Aspergillus.
The ability that Aspergillus in natamycin prevention and the treatment poultry infects partly is because the anatomy characteristic of poultry uniqueness.For example the anatomy characteristic of chicken is such, makes to suck the infection (for example sucking the aspergillus disease that natamycin can be treated respiratory system, crop, some part of digestive system etc.) that natamycin just can effectively prevent and control the Aspergillus of each pith of poultry health.
It is believed that it is activated or effective that natamycin grows for antifungi, and invalid, and do not wish to be subjected to the constraint of any theory and opinion bacterium.A kind of opinion may think that mould (rather than bacterium) contains ergosterol at their film.
Usually, if environment is suitable, mould will grow, up to till natamycin contacts.The theoretical mechanism of natamycin effect is that the ergosterol in natamycin molecule and the fungal cell film is combined.By the neutralization of ergosterol to the antifungi activity of natamycin inhibition Aspergillus fumagitus, confirmation is compound with ergosterol.Compound it is believed that between natamycin and the fungal cell film changed permeability of the membrane, because natamycin is sizable molecule, this molecule has produced a surface pressing that has increased, this pressure helps to reduce the reorientation of the ergosterol that exists in film, thereby changed the permeance property of cell and caused infiltration to be impacted, the metabolic activity (for example can cause abnormal fungus growth, sporulation etc.) that is enough to hinder (if not the words that stop) Aspergillus is impacted in this infiltration.
Aspect some, it may be favourable that natamycin is used with additive method and/or material of the present invention.For example, natamycin suspension can be sent into a kind of vaccine and be sprayed the chamber, so that the treatment a group is just dyed the poultry of disease.
The natamycin that has been sprinkled into the fowl nest and/or has formed suspension generally has an acceptable half life period.According to storage requirement, can expect that natamycin can suppress this tedious mould effectively in a few weeks or months.Yet in order to guarantee the efficient of natamycin maximum, any fowl nest that does not have used natamycin suspension or handled all should be protected and not be subjected to illumination (being that natamycin suspension should be stored in dark place before entering the spraying chamber).
Any (for example sucking) natamycin that is consumed by poultry generally can not kept by poultry, the result, and natamycin can not participate in the meat and egg of poultry.Therefore, can not influence the people to the egg of any processing or the consumption of poultry.On the contrary, can participate in this mould and/or its toxin in egg and the meat with the contacted poultry of the sort of tedious mould (for example Aspergillus mould).Such mould and/or toxin may be harmful to the people who ate this egg and poultry; Need accomplish to prevent and control poultry and any tangible contact arranged with the sort of tedious mould.Therefore, the present invention helps to improve the output of the birds, beasts and eggs that are not subjected to mould and antifungi reagent contamination.
Although aspects more of the present invention and embodiment have been done detailed introduction, the those skilled in the art in this field can be easy to recognize, remove outside those contents that exemplified, and the present invention also includes many combining forms, equivalents and version.

Claims (9)

1, a kind of method of preventing and controlling the disease that causes by Aspergillus fumagitus, comprise: handle a kind of among the respiratory system of poultry nest and poultry at least, the measure of being taked is that it is contacted with the natamycin of many quantity like that is enough to suppress Aspergillus fumagitus growth.
2, method according to claim 1 is characterized in that the way of using of described natamycin is to make described poultry and be dispersed in airborne natamycin suspension grain subtly and contact.
3, method according to claim 2 is characterized in that described natamycin is a kind of aqueous solution aerosol.
4, method according to claim 1 is characterized in that described poultry is a chicken.
5, method according to claim 1 is characterized in that described poultry is a turkey.
6, method according to claim 1 is characterized in that described processing comprises natamycin is sprayed on the poultry nest.
7, method according to claim 6 is characterized in that having polluted the fowl nest with the natamycin spraying.
8, method according to claim 1, the concentration range that it is characterized in that the q.s natamycin are from the about 70ppm of about 1.0-.
9, method according to claim 1 is characterized in that this method comprises the poultry that treatment is infected by Aspergillus fumagitus.
CN 92109299 1991-07-12 1992-07-11 The control of poultry aspergillosis and prevention Pending CN1071047A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72937791A 1991-07-12 1991-07-12
US729,377 1991-07-12

Publications (1)

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CN1071047A true CN1071047A (en) 1993-04-21

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CN 92109299 Pending CN1071047A (en) 1991-07-12 1992-07-11 The control of poultry aspergillosis and prevention

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CN (1) CN1071047A (en)
AU (1) AU2338192A (en)
CA (1) CA2113342A1 (en)
MX (1) MX9204067A (en)
WO (1) WO1993000911A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3343968A (en) * 1965-03-19 1967-09-26 American Cyanamid Co Control of mold growth in eggs
GB1559840A (en) * 1975-12-01 1980-01-30 Gist Brocades Nv Antifungal compositions
US4950477A (en) * 1988-08-23 1990-08-21 Memorial Hospital For Cancer And Allied Dieseas Method of preventing and treating pulmonary infection by fungi using aerosolized polyenes

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CA2113342A1 (en) 1993-01-21
AU2338192A (en) 1993-02-11
WO1993000911A1 (en) 1993-01-21
MX9204067A (en) 1994-03-31

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