CN107062731A - Automated storing device and its operation method - Google Patents
Automated storing device and its operation method Download PDFInfo
- Publication number
- CN107062731A CN107062731A CN201710090201.9A CN201710090201A CN107062731A CN 107062731 A CN107062731 A CN 107062731A CN 201710090201 A CN201710090201 A CN 201710090201A CN 107062731 A CN107062731 A CN 107062731A
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- China
- Prior art keywords
- protection chamber
- housing
- storing device
- automated storing
- transport mechanism
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
- F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
- F25D3/102—Stationary cabinets
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D23/00—General constructional features
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D23/00—General constructional features
- F25D23/02—Doors; Covers
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D23/00—General constructional features
- F25D23/02—Doors; Covers
- F25D23/028—Details
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D23/00—General constructional features
- F25D23/06—Walls
- F25D23/062—Walls defining a cabinet
- F25D23/063—Walls defining a cabinet formed by an assembly of panels
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D25/00—Charging, supporting, and discharging the articles to be cooled
- F25D25/04—Charging, supporting, and discharging the articles to be cooled by conveyors
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2201/00—Insulation
- F25D2201/10—Insulation with respect to heat
- F25D2201/12—Insulation with respect to heat using an insulating packing material
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2323/00—General constructional features not provided for in other groups of this subclass
- F25D2323/02—Details of doors or covers not otherwise covered
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- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Combustion & Propulsion (AREA)
- Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Thermal Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Warehouses Or Storage Devices (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of automated storing device and its operation method.Automated storing device includes housing, guide rail, protection chamber and transport mechanism, wherein, storage container is provided with housing；Guide rail bracket is in housing, and housing is separated into the operating space and memory block being connected by guide rail, and operating space is located at the top of memory block, and storage container is located at the memory block；Chamber is protected to be located in housing and positioned at the top of memory block, the head end of guide rail is extended in protection chamber, and protection chamber can be opened, for being connected with operating space, and the temperature in protection chamber is more than 0 DEG C；Transport mechanism is slidedly arranged on guide rail, and transport mechanism can enter operating space from protection chamber and stretch into storage container by guide rail takes out cryopreservation tube.Operation method includes：Open protection chamber；Transport mechanism is moved to operating space from protection chamber；Transport mechanism is set to stretch into storage container and take out cryopreservation tube.The automated storing device reliability is preferable, cost is relatively low.
Description
Technical field
The present invention relates to a kind of automated storing device and its operation method, it is more particularly to a kind of for biological specimen from
Dynamicization storage device and its operation method.
Background technology
Biological sample bank is standardization collection, processing, healthy and disease organism the large biological molecule of storage, cell, group
The equipment with organ equal samples is knitted, most of biological specimens need to be stored in profound hypothermia environment, it is particularly some to be used to store
The biological sample bank of the cell of human body is fed back, its storage environment is needed in liquid nitrogen temperature.To store the life for feeding back human body cell
Exemplified by thing Sample Storehouse, cell sample needs to first pass through program cooling and is stored in biological sample bank again, and midway needs to carry out at whole process
In profound hypothermia protection, its activity is damaged to prevent biological specimen from repeating freeze thawing, cell sample is placed after program cools
In the transfer tank equipped with liquid nitrogen, then via manual or automaticization transmission line send into Sample Storehouse in, by manipulator most at last in
Turn the biological specimen in tank to be stored in the liquid nitrogen container in Sample Storehouse.Liquid nitrogen container needs to be placed in low-temperature cold store, not only can be with
Liquid nitrogen consumption is reduced, humidity in space can also be reduced, prevents mechanical moving element frosting from freezing, can also be in transfer cell
It is easier to keep its Profound hypothermia temperature during sample.Profound hypothermia automatic biological Sample Storehouse can be deposited more quickly and easily
Biological specimen is stored up, the reliability and security of storing process can be greatly improved, additionally it is possible to the whole process state of biological specimen
Reviewed, increasingly become the developing direction in modern biotechnology field.
But, existing ultralow temperature automatic biological Sample Storehouse is often uniform in a large cold storage, storehouse using building
Multiple hand baskets are arranged, hand basket memory storage biological specimen freezes disk.By taking European patent EP 2208951A2 as an example, at one large-scale -80
In DEG C freezer, uniformly arrangement freezes the hand basket of disk equipped with biological specimen for bottom, and top is provided with a straight line module three-axis moving
Mechanism, one end of freezer also has freezes disk clamp device at a gateway, gateway, and these mechanical parts are all completely in
In the environment consistent with biological specimen storage temperature.When system, which assigns biological specimen, takes out task, straight line module is moved to mesh
Hand basket is lifted and is sent at gateway by cursor position, and freezing disk clamp device will freeze under disk folder and be placed on the interim of gateway
In storage area, then straight line module again replaces hand basket.Wherein, in the technical scheme, mechanical part is needed in sample
Long-term work under storage temperature, the difficulty of realization is big, cost is high, poor reliability, and due to material, mechanical performance is big under profound hypothermia
Width reduces and can not use lubricant grease, powder can only be used to lubricate, so its mechanical movement needs to control in very low speed.
Motor and electric components of the prior art are placed for a long time at low temperature to cause the life-span to be greatly reduced, its maintenance cost and difficulty
Degree also can be very high.Therefore, although the technical scheme realizes the automation of profound hypothermia biological specimen, but efficiency and reliability are complete
The requirement of large-scale production storage can not be met entirely, and its operation cost also can be very high.
So as to which biological sample bank of the prior art has the defect that reliability is poor, cost is higher.
The content of the invention
The technical problem to be solved in the present invention be in order to overcome biological sample bank of the prior art have reliability it is poor,
There is provided a kind of automated storing device and its operation method for the higher defect of cost.
The present invention is to solve above-mentioned technical problem by following technical proposals：
A kind of automated storing device, for storing biological specimen, the automated storing device includes a housing, described
A storage container is provided with housing, the storage container is used to store the cryopreservation tube equipped with biological specimen, and its feature is, described
Automated storing device also includes：
One guide rail, the guide rail bracket is in the housing, and the housing is separated into the behaviour being connected by the guide rail
Make area and a memory block, and the operating space is located at the top of the memory block, the storage container is located at the memory block；
One protection chamber, the protection chamber is located in the housing and positioned at the top of the memory block, the guide rail
Head end extend in the protection chamber, the protection chamber can be opened, for being connected with the operating space, and described
The temperature protected in chamber is more than 0 DEG C；
One transport mechanism, the transport mechanism is slidedly arranged on the guide rail, and the transport mechanism can be from by the guide rail
The protection chamber, which enters the operating space and stretches into the storage container, takes out the cryopreservation tube.
In the technical program, when that the cryopreservation tube need not be stored in or be taken out, the transport mechanism is all the time
Positioned at the protection chamber, because the temperature in the protection chamber is more than 0 DEG C, on the one hand, the protection chamber does not need one
Directly it is placed in low temperature environment, the transport mechanism can be protected, improve the reliability of the automated storing device, extends
Life-span of the transport mechanism, it correspondingly, just can extend maintenance period, reduce maintenance cost；On the other hand, described anti-
The transport mechanism can be safeguarded with more convenient in shield chamber, reduce the maintenance difficulties of the transport mechanism.When
When needing to take out the cryopreservation tube out of described storage container, the transport mechanism can be rapidly introduced into institute by the guide rail
Operating space is stated, and then the cryopreservation tube can be relatively rapid taken out out of described storage container.
It is preferred that the protection chamber is located at the left side wall of the housing, the protection chamber has an isolating door, described
Isolating door can be opened, for making the protection chamber be connected with the operating space；
The left side wall of the housing has one first vertical portion being sequentially connected from beginning to end, a horizontal part and one second vertical
Portion, first vertical portion and second vertical portion are located at the short transverse of the housing, and the horizontal position is in the shell
The length direction of body；
It is described protection chamber have a front side wall, a rear wall and a top cover, the front side wall, first vertical portion,
The protection chamber is surrounded between the rear wall, the isolating door, the top cover and the horizontal part；
Wherein, the head end of the guide rail is located between the front side wall and the rear wall.
In the technical program, the protection chamber is located at the left side wall of the housing, and the housing is will not interfere with substantially
Internal other structures, do not interfere with the normal operation of the protection chamber and other structures, can further improve it is described from
The reliability of dynamicization storage device.In addition, when needing that the cryopreservation tube is stored in or taken out, the isolating door is in and beaten
Open state；When that the cryopreservation tube need not be stored in or be taken out, the isolating door is closed.That is,
By controlling opening or closing for the isolating door, just can control more conveniently it is described protection chamber whether with the operation
Area is connected.
It is preferred that it is described protection chamber in be provided with a door-opening mechanism, the door-opening mechanism include one first motor and
One connecting rod, first motor is connected to the connecting rod, and first motor is located at the top cover, and the connecting rod connects
It is connected between the isolating door and the top cover.
In the technical program, first motor can drive the connecting rod by V belt translation, and then cause institute
Stating connecting rod drives the isolating door to open or close, and structure is relatively simple, and cost is relatively low.
It is preferred that offering an access hole on first vertical portion, the access hole is connected with the protection chamber,
A maintenance door is articulated with the access hole.
In the technical program, attendant can by the access hole it is more convenient to machines such as the transport mechanisms
Tool part is overhauled, and maintenance difficulties are relatively low.
It is preferred that the isolating door has the first separation layer and the second separation layer, first separation layer is adhered to described
Second separation layer, and the material of first separation layer is that XPS, the material of second separation layer are epoxy glass laminate.
XPS warming plates are exactly extrusion moulding type polystyrene heat insulating board, and it is to add it by raw material of polystyrene resin
His supplementary material and polymer, by heating mixing injecting catalyst simultaneously, then extrusion molding extrusion molding and the hard that produces
Plastic foamboard.In the technical program, the isolating door can either keep good thermal insulation, can have again higher strong
Degree, further increases the reliability of the automated storing device.
It is preferred that the isolating door at the front side wall, the rear wall, the contact position of the horizontal part with being sticked
There is silica gel sealing bar.
In the technical program, the presence of the silica gel sealing bar enables to the isolating door more closely to fit institute
Front side wall, the rear wall and the horizontal part are stated, sealing property is preferable.
It is preferred that being provided with a heating component in the protection chamber, the heating component is used to make in the protection chamber
Temperature be more than 0 DEG C.The heating component can use perfusion blower fan, and electric heater unit is installed in air outlet.
In the technical program, the presence of the heating component ensure that the temperature in the protection chamber is more than 0 DEG C,
Further increase the reliability of the automated storing device.
It is preferred that the end of the transport mechanism, which is connected with one, takes tube head, it is described to take tube head to can extend into the storage appearance
Device is taken out the cryopreservation tube by a vacuum suction system, wherein, the vacuum generator of the vacuum suction system is located at institute
State in protection chamber.
Described to take tube head to take out the cryopreservation tube by vacuum suction system in the technical program, reliability is higher, effect
Rate is also higher.Vacuum generator can be protected in addition, vacuum generator is located in the protection chamber, it is to avoid due to putting
The relatively low influence to vacuum generator performance of environment is put, the reliability of the automated storing device is further increased.
It is preferred that be installed with an end cap on the storage container, the section of the end cap is circle, the end cap it is cylindrical
It is toothed around on side face, the end cap is provided with an opening, and the opening takes tube head to be adapted with described, the length of the opening
Degree is less than the radius of the end cap, and the opening is connected with the inside of the storage container；
The automated storing device also includes an auxiliary body, and the auxiliary body has one second motor and one
Drive gear, second motor is connected to the drive gear, and the drive gear is engaged in the gear teeth.
In the technical program, second motor can drive the end cap to rotate by the drive gear,
And then the cryopreservation tube in the storage container at diverse location can be taken out by the opening more conveniently.
It is preferred that the storage container is liquid nitrogen container, liquid nitrogen is filled with the liquid nitrogen container, the top that the liquid nitrogen is filled is extremely
Region between the top of the housing formed once low-temperature space, below the top of the liquid nitrogen container to the bottom of the housing
Between region in addition to the liquid nitrogen container inside be formed with a low-temperature space, the temperature of described low-temperature space is higher than the low-temperature space
Temperature；
The right side wall of the housing is provided with an interline counter, and the interline counter is connected with the housing, at the interline counter
It is articulated with the corresponding position on a hatch door, the internal face of the right side wall of the housing with the interline counter and is connected with a support
It is placed with platform, the supporting table in a transfer tank, the transfer tank and is filled with liquid nitrogen.
In the technical program, profound hypothermia area can be formed inside the liquid nitrogen container, more reliably can be frozen to described
Pipe is deposited to be stored.In addition, when the cryopreservation tube is stored in or taken out, the transport mechanism is moved to the operating space
Just it is located at time low-temperature space afterwards, can preferably protects the transport mechanism.The transfer tank can be passed in and out from the hatch door, described
Liquid nitrogen is filled with transfer tank, ensure that the cryopreservation tube is in profound hypothermia environment in transport process, can be more reliable
Protect biological specimen in ground.
It is preferred that the transport mechanism is a manipulator.
It is preferred that the top of the housing is provided with an exhaust outlet, the exhaust outlet and the operating space and the memory block
It is connected；The housing is made of insulation material, and the insulation material is polyurethane cold-storage board or EPS or XPS.
EPS is Expanded Polystyrene abbreviation, i.e. polystyrene foam, and it is a kind of light type high-molecule polymerization
Thing, it adds foaming agent using polystyrene resin, while heating is softened, produces gas, forms a kind of rigid closed cell knot
The foamed plastics of structure.In the technical program, the presence of the exhaust outlet ensure that the pressure in the housing is constant.
The present invention also provides a kind of operation method of automated storing device as described above, and its feature is, works as needs
When the cryopreservation tube is taken out out of described storage container, the operation method comprises the following steps：
S1, open the protection chamber；
S2, by the transport mechanism from it is described protection chamber be moved to the operating space；
S3, the transport mechanism is stretched into the storage container and is taken out the cryopreservation tube.
On the basis of common sense in the field is met, above-mentioned each optimum condition can be combined, and produce each preferable reality of the present invention
Example.
The positive effect of the present invention is：
Automated storing device in the present invention has the protection chamber that internal temperature is more than 0 DEG C, and transport mechanism being capable of root
According to needing to slide between protection chamber and operating space, can preferably protect the transport mechanism, can either improve it is described from
The reliability of dynamicization storage device, can extend the maintenance period of the transport mechanism, reduce cost again.
Brief description of the drawings
Fig. 1 is the dimensional structure diagram of the automated storing device of a preferred embodiment of the present invention.
Fig. 2 is the internal structure schematic diagram of the automated storing device of a preferred embodiment of the present invention.
Fig. 3 is the partial structural diagram of the automated storing device of a preferred embodiment of the present invention.
Fig. 4 shows for the attachment structure of door-opening mechanism and isolating door in the automated storing device of a preferred embodiment of the present invention
It is intended to.
Fig. 5 is the flow chart of the operation method of the automated storing device of a preferred embodiment of the present invention.
Description of reference numerals：
10：Housing
101：Storage container
102：Operating space
103：Memory block
104：First vertical portion
105：Horizontal part
106：Second vertical portion
107：Maintenance door
108：End cap
109：Opening
110：Interline counter
111：Hatch door
112：Supporting table
113：Transfer tank
114：Exhaust outlet
20：Guide rail
30：Protect chamber
301：Isolating door
302：Front side wall
303：Rear wall
304：Top cover
40：Transport mechanism
401：Take tube head
50：Door-opening mechanism
501：First motor
502：Connecting rod
503：Belt wheel
60：Auxiliary body
601：Second motor
602：Drive gear
Embodiment
Name preferred embodiment, and become apparent from intactly illustrating the present invention with reference to accompanying drawing.
As depicted in figs. 1 and 2, housing 10, guide rail 20, protection are included for storing the automated storing device of biological specimen
Chamber 30 and transport mechanism 40.Wherein, storage container 101 is provided with housing 10, storage container 101 is used to store equipped with biological sample
This cryopreservation tube；Guide rail 20 is set up in housing 10, and housing 10 is separated into the operating space 102 and memory block being connected by guide rail 20
103, and operating space 102 is located at the top of memory block 103, storage container 101 is located at memory block 103；Chamber 30 is protected to be located at shell
In body 10 and positioned at the top of memory block 103, the head end of guide rail 20 is extended in protection chamber 30, and protection chamber 30 can be beaten
Open, for being connected with operating space 102, and the temperature protected in chamber 30 is more than 0 DEG C；Transport mechanism 40 is slidedly arranged on guide rail 20,
Transport mechanism 40 can enter operating space 102 from protection chamber 30 and stretch into storage container 101 by guide rail 20 to be frozen described
Pipe takes out.
In the present embodiment, when that the cryopreservation tube need not be stored in or be taken out, the position all the time of transport mechanism 40
In protection chamber 30, because the temperature in protection chamber 30 is more than 0 DEG C, on the one hand, protection chamber 30 need not be placed on always
In low temperature environment, transport mechanism 40 can be protected, the reliability of the automated storing device is improved, extends transport mechanism
In 40 life-span, it correspondingly, just can extend maintenance period, reduce maintenance cost；On the other hand, can be compared with protection chamber 30
Easily to be safeguarded to transport mechanism 40, the maintenance difficulties of transport mechanism 40 are reduced.When needs are out of storage container 101
When taking out the cryopreservation tube, transport mechanism 40 can be rapidly introduced into operating space 102 by guide rail 20, and then can be more quick
The cryopreservation tube is taken out out of storage container 101 in ground.
As depicted in figs. 1 and 2, protection chamber 30 is located at the left side wall of housing 10, and protection chamber 30 has isolating door 301,
Isolating door 301 can be opened, for making protection chamber 30 be connected with operating space 102.Wherein, the left side wall of housing 10 has head
The first vertical portion 104 that tail is sequentially connected, the vertical portion 106 of horizontal part 105 and second, the first vertical portion 104 and the second vertical portion
106 are located at the short transverse of housing 10, and horizontal part 105 is located at the length direction of housing 10；Protect chamber 30 that there is front side wall
302nd, rear wall 303 and top cover 304, front side wall 302, the first vertical portion 104, rear wall 303, isolating door 301, the and of top cover 304
Protection chamber 30 is surrounded between horizontal part 105；The head end of guide rail 20 is located between front side wall 302 and rear wall 303.
In the present embodiment, protection chamber 30 is located at the left side wall of housing 10, and enclosure interior 10 is will not interfere with substantially
Other structures, do not interfere with the normal operation of protection chamber 30 and other structures, can further improve the automated storing
The reliability of device.In addition, when needing that the cryopreservation tube is stored in or taken out, isolating door 301 is in open mode；When
When the cryopreservation tube need not be stored in or be taken out, isolating door 301 is closed.That is, by control every
From opening or closing for door 301, it just can control whether protection chamber 30 connects with operating space 102 more conveniently.
In the present embodiment, it is shown as shown in Figure 1, Figure 3 and Figure 4, it is provided with door-opening mechanism 50, door-opening mechanism in protection chamber 30
50 include the first motor 501 and connecting rod 502, and the first motor 501 is connected to 502, and the first motor 501 is located at
Top cover 304, connecting rod 502 is connected between isolating door 301 and top cover 304.First motor 501 can pass through the band of belt wheel 503
The connecting rod is moved, and then the driving isolating door 301 of connecting rod 502 is opened or closed, structure is relatively simple, and cost is relatively low.
In the present embodiment, the isolating door 301 in Fig. 1 have the first separation layer and the second separation layer, described first every
Absciss layer is adhered to second separation layer, and the material of first separation layer is that XPS, the material of second separation layer are ring
Oxygen resin glass fibre reinforced plastics.In this way, isolating door 301 can either keep good thermal insulation, there can be higher intensity again, further
Improve the reliability of the automated storing device.In addition, isolating door 301 and front side wall 302, rear wall 303, horizontal part
Being sticked at 105 contact position has silica gel sealing bar.The presence of the silica gel sealing bar enables to isolating door 301 more tight
Thickly laminating front side wall 302, rear wall 303 and horizontal part 105, sealing property is preferable.
As shown in figure 1, access hole (not shown) is offered on the first vertical portion 104, the access hole and protection chamber 30
It is connected, maintenance door 107 is articulated with the access hole.Attendant can by access hole 107 it is more convenient to transmission
The grade mechanical part of mechanism 40 is overhauled, and maintenance difficulties are relatively low.
As shown in figure 1, being additionally provided with heating component 60 in protection chamber 30, heating component 60 is used to make in protection chamber 30
Temperature is more than 0 DEG C, further increases the reliability of the automated storing device.
As depicted in figs. 1 and 2, the end of transport mechanism 40, which is connected with, takes tube head 401, takes tube head 401 to can extend into storage
Container 101 is taken out the cryopreservation tube by a vacuum suction system, wherein, the vacuum generator position of the vacuum suction system
In in protection chamber 30.Tube head 401 is taken to take out the cryopreservation tube by vacuum suction system, reliability is higher, and efficiency is also higher.
Vacuum generator can be protected in addition, vacuum generator is located in protection chamber 30, it is to avoid relatively low due to placing environment
Influence to vacuum generator performance, further increases the reliability of the automated storing device.
As depicted in figs. 1 and 2, end cap 108 is installed with storage container 101, the section of end cap 108 is circle, end cap 108
Outer circumference surface on be toothed around, end cap 108 be provided with opening 109, opening 109 with take tube head 401 to be adapted, be open 109
Length be less than the radius of end cap 108, opening 109 is connected with the inside of storage container 101.In addition, as Figure 1-3, institute
Stating automated storing device also includes an auxiliary body 60, and auxiliary body 60 has the second motor 601 and drive gear
602, the second motor 601 is connected to drive gear 602, and drive gear 602 is engaged in the gear teeth.Second motor
601 can drive end cap 108 to rotate by drive gear 602, and then can take out storage appearance by opening 109 more conveniently
The cryopreservation tube in device 101 at diverse location.
In the present embodiment, the storage container 101 in Fig. 1 and Fig. 2 is that liquid is filled with liquid nitrogen container, the liquid nitrogen container
The top of once low-temperature space, the liquid nitrogen container is formed to the region between the top of housing 10 on nitrogen, the top that the liquid nitrogen is filled
Hereinafter a low-temperature space is formed with to the region between the bottom of housing 10 in addition to the liquid nitrogen container inside, described low-temperature space
Temperature is higher than the temperature of the low-temperature space.In addition, the right side wall of housing 10 is provided with interline counter 110, interline counter 110 and the phase of housing 10
The corresponding position on hatch door 111, the internal face of the right side wall of housing 10 with interline counter 110 is articulated with connection, interline counter 110
It is connected with supporting table 112, supporting table 112 and is placed with transfer tank 113, liquid nitrogen is filled with transfer tank 113.Wherein, liquid nitrogen container
Inside can form profound hypothermia area, and more reliably the cryopreservation tube can be stored.In addition, working as to enter the cryopreservation tube
When row deposit or taking-up, transport mechanism 40, which is moved to behind operating space 102, is just located at time low-temperature space, simply tube head 401 will be taken to stretch into
Low-temperature space and profound hypothermia area, can preferably protect transport mechanism 40.Transfer tank 113 can be passed in and out from hatch door 111, transfer tank
Liquid nitrogen is filled with 113, ensure that the cryopreservation tube is in profound hypothermia environment in transport process, more can reliably protect
Protect biological specimen.
In the present embodiment, the transport mechanism 40 in Fig. 1 is a manipulator.In other embodiments, transport mechanism
40 can also use other structures, as long as by guide rail 20 operating space 102 can be slid onto out of protection chamber 30, and enable to
Thereon take tube head 401 to extend in liquid nitrogen container.
As depicted in figs. 1 and 2, the top of housing 10 is provided with exhaust outlet 114, exhaust outlet 114 and operating space 102 and memory block
103 are connected, and the presence of exhaust outlet 114 ensure that the pressure in the housing is constant.In addition, in the present embodiment, shell
Body 10 is made of insulation material, and the insulation material is XPS.In other embodiments, XPS can also use polyurethane
Cold storage plate or EPS are made.
In the present embodiment, when the cryopreservation tube is removed and placed in transfer by needs out of storage container 101 in Fig. 1
When in tank, as shown in figure 5, the operation method of automated storing device comprises the following steps：
Step 100, start door-opening mechanism, open isolating door so that protection chamber is connected with operating space；
Step 101, manipulator control system is started so that manipulator is moved to operating space from protection chamber；
Step 102, tube head is taken to be moved downward to memory block and stretched into by opening in storage container arm end,
Vacuum generator is activated so as to take tube head to take out cryopreservation tube；
Step 103, tube head will be taken to move upward out storage container, tube head will be taken to be moved to transfer by manipulator control system
The top of tank；
Step 104, tube head will be taken to be moved downward in transfer tank and discharges cryopreservation tube；
Step 105, tube head will be taken to move upward out transfer tank, manipulator is moved to by protection chamber by manipulator control system
Room；
Step 106, start door-opening mechanism, close isolating door.
Although the embodiment of the present invention is the foregoing described, it will be appreciated by those of skill in the art that this is only
For example, protection scope of the present invention is to be defined by the appended claims.Those skilled in the art without departing substantially from
On the premise of the principle and essence of the present invention, various changes or modifications can be made to these embodiments, but these changes and
Modification each falls within protection scope of the present invention.
Claims (13)
1. a kind of automated storing device, for storing biological specimen, the automated storing device includes a housing, the shell
In vivo be provided with a storage container, the storage container be used for store equipped with biological specimen cryopreservation tube, it is characterised in that it is described from
Dynamicization storage device also includes：
One guide rail, the guide rail bracket is in the housing, and the housing is separated into the operating space being connected by the guide rail
With a memory block, and the operating space be located at the memory block top, the storage container be located at the memory block；
One protection chamber, the protection chamber is located in the housing and positioned at the top of the memory block, the head of the guide rail
End is extended in the protection chamber, and the protection chamber can be opened, for being connected with the operating space, and the protection
Temperature in chamber is more than 0 DEG C；
One transport mechanism, the transport mechanism is slidedly arranged on the guide rail, and the transport mechanism can be from described by the guide rail
Protection chamber, which enters the operating space and stretches into the storage container, takes out the cryopreservation tube.
2. automated storing device as claimed in claim 1, it is characterised in that the protection chamber is located at a left side for the housing
Side wall, the protection chamber has an isolating door, and the isolating door can be opened, for making the protection chamber and the operation
Area is connected；
The left side wall of the housing has one first vertical portion, a horizontal part and one second vertical portion that head and the tail are sequentially connected, institute
State the first vertical portion and second vertical portion and be located at the short transverse of the housing, the horizontal position is in the length of the housing
Spend direction；
The protection chamber has a front side wall, a rear wall and a top cover, the front side wall, first vertical portion, described
The protection chamber is surrounded between rear wall, the isolating door, the top cover and the horizontal part；
Wherein, the head end of the guide rail is located between the front side wall and the rear wall.
3. automated storing device as claimed in claim 2 a, it is characterised in that door lifter is provided with the protection chamber
Structure, the door-opening mechanism includes one first motor and a connecting rod, and first motor is connected to the connecting rod, described
First motor is located at the top cover, and the connecting rod is connected between the isolating door and the top cover.
4. automated storing device as claimed in claim 2, it is characterised in that offer a maintenance on first vertical portion
Mouthful, the access hole is connected with the protection chamber, and a maintenance door is articulated with the access hole.
5. automated storing device as claimed in claim 2, it is characterised in that the isolating door has the first separation layer and the
Two separation layers, first separation layer is adhered to second separation layer, and the material of first separation layer be XPS, it is described
The material of second separation layer is epoxy glass laminate.
6. automated storing device as claimed in claim 2, it is characterised in that the isolating door and the front side wall, described
Being sticked at rear wall, the contact position of the horizontal part has silica gel sealing bar.
7. automated storing device as claimed in claim 1, it is characterised in that a heating group is provided with the protection chamber
Part, the heating component is used to make the temperature in the protection chamber be more than 0 DEG C.
8. automated storing device as claimed in claim 1, it is characterised in that the end of the transport mechanism is connected with one and taken
Tube head, it is described to take tube head to can extend into the storage container to take out the cryopreservation tube by a vacuum suction system, wherein, institute
The vacuum generator for stating vacuum suction system is located in the protection chamber.
9. automated storing device as claimed in claim 8 a, it is characterised in that end cap is installed with the storage container,
The section of the end cap is circle, is toothed around on the outer circumference surface of the end cap, and the end cap is provided with an opening, described
Opening takes tube head to be adapted with described, and the length of the opening is less than the radius of the end cap, and the opening is held with the storage
The inside of device is connected；
The automated storing device also includes an auxiliary body, and the auxiliary body has one second motor and a driving
Gear, second motor is connected to the drive gear, and the drive gear is engaged in the gear teeth.
10. automated storing device as claimed in claim 1, it is characterised in that the storage container is liquid nitrogen container, the liquid
Be filled with liquid nitrogen in nitrogen tank, the top that the liquid nitrogen is filled to the region between the top of the housing formed once low-temperature space,
It is low that to region in addition to the liquid nitrogen container inside between the bottom of the housing one is formed with below the top of the liquid nitrogen container
Warm area, the temperature of described low-temperature space is higher than the temperature of the low-temperature space；
The right side wall of the housing is provided with an interline counter, and the interline counter is connected with the housing, is pivotally connected at the interline counter
Have on a hatch door, the internal face of the right side wall of the housing and to be connected with a supporting table, institute with the corresponding position of the interline counter
State and a transfer tank is placed with supporting table, liquid nitrogen is filled with the transfer tank.
11. automated storing device as claimed in claim 1, it is characterised in that the transport mechanism is a manipulator.
12. automated storing device as claimed in claim 1, it is characterised in that the top of the housing is provided with an exhaust outlet,
The exhaust outlet is connected with the operating space and the memory block；The housing is made of insulation material, and the insulation
Material is polyurethane cold-storage board or EPS or XPS.
13. a kind of operation method of the automated storing device in 1-12 such as claim as described in any one, it is characterised in that
When needing to take out the cryopreservation tube out of described storage container, the operation method comprises the following steps：
S1, open the protection chamber；
S2, by the transport mechanism from it is described protection chamber be moved to the operating space；
S3, the transport mechanism is stretched into the storage container and is taken out the cryopreservation tube.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710090201.9A CN107062731A (en) | 2017-02-20 | 2017-02-20 | Automated storing device and its operation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710090201.9A CN107062731A (en) | 2017-02-20 | 2017-02-20 | Automated storing device and its operation method |
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| CN107062731A true CN107062731A (en) | 2017-08-18 |
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| CN201710090201.9A Pending CN107062731A (en) | 2017-02-20 | 2017-02-20 | Automated storing device and its operation method |
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| CN107624751A (en) * | 2017-09-15 | 2018-01-26 | 上海原能细胞生物低温设备有限公司 | Cryogenic storage system |
| CN107934226A (en) * | 2017-12-05 | 2018-04-20 | 基点维科(成都)医疗机器人技术有限公司 | Biological specimen conveyer method and the transfer device for realizing this method |
| CN108770835A (en) * | 2018-07-23 | 2018-11-09 | 上海东富龙医疗装备有限公司 | Work chamber is automatically stored in biological sample |
| CN111907941A (en) * | 2019-05-08 | 2020-11-10 | 青岛海特生物医疗有限公司 | Liquid nitrogen storage system |
| CN115200295A (en) * | 2022-07-15 | 2022-10-18 | 温州市顶诺食品有限公司 | Freezer pan feeding device |
| CN107934226B (en) * | 2017-12-05 | 2024-06-07 | 基点生物科技(成都)有限公司 | Biological sample transferring method and transferring device for realizing same |
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