CN103964110A - Low-temperature storage system - Google Patents
Low-temperature storage system Download PDFInfo
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- CN103964110A CN103964110A CN201310351323.0A CN201310351323A CN103964110A CN 103964110 A CN103964110 A CN 103964110A CN 201310351323 A CN201310351323 A CN 201310351323A CN 103964110 A CN103964110 A CN 103964110A
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- low temperature
- container
- low
- accepting groove
- safeguard system
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- 238000003860 storage Methods 0.000 title claims abstract description 86
- 239000003507 refrigerant Substances 0.000 claims description 41
- 238000005192 partition Methods 0.000 claims description 25
- 238000001816 cooling Methods 0.000 claims description 24
- 238000012546 transfer Methods 0.000 claims description 12
- 238000007789 sealing Methods 0.000 claims description 6
- 229910052751 metal Inorganic materials 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 5
- 238000000605 extraction Methods 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 239000002826 coolant Substances 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 238000007710 freezing Methods 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000009509 drug development Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000000112 cooling gas Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000012362 drug development process Methods 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/42—Low-temperature sample treatment, e.g. cryofixation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
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- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Warehouses Or Storage Devices (AREA)
- Sampling And Sample Adjustment (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a low-temperature storage system, which does not cause a temperature rise of a container in extraction action, prevents deterioration of a sample in the container and moisture condensation on the container, does not require a special machine, and can work at high speed, and costs required by manufacture and use are reduced and the system is easy to use. Specifically, a low-temperature storage system (100) has a container housing unit (110) which formed in a manner of being movable in a space at an upper side of a lower-temperature storage chamber (101) where a plurality of containers (C) housing samples are stored, and the container housing unit (110) has a low-temperature housing groove (120), an upper opening, and housing containers (C), and a coolant tube (121) which cools the inside of the low-temperature housing groove (120).
Description
Technical field
The present invention relates to a kind of low temperature safeguard system, it possesses: low-temperature storage chamber, stores the multiple containers that contain sample; And container accepting unit, form and transfer described container in the mode that can move at the superjacent air space of this low-temperature storage chamber, relate in particular to a kind of for keeping drug development (drug discovery) under ultralow temperature be the low temperature safeguard system that drug development that medical science, biological engineering and pharmaceutically finding used in the process of medicament or design uses with sample.
Background technology
In recent years, in the basic investigation or applied research of existing chemistry, biochemistry, biology, pharmacy etc., the sample of a large amount of biological specimen of keeping, clinical sample, synthetics etc. in order to check etc.
For example, in drug development process, in order to investigate biologically active etc., need to use the sample for a lot of trace of diversified inspection, experiment, the technology that a large amount of keepings are contained in the sample in the containers such as miniature (test) pipe and promptly take out any sample under the stable environment of ultralow temperature is indispensable.
Known following low temperature safeguard system, the container that contains this sample that should carry out low temperature keeping is taken care of in low-temperature storage chamber, from low-temperature storage chamber, take out as required the container of specifying, and known following low temperature safeguard system, multiple containers that contain the sample that should carry out low temperature keeping are held in to keeping dish, on above-below direction, multiple these keeping dishes are contained in to storage rack and take care of in low-temperature storage chamber, automatically take out as required target keeping dish, the container (for example, with reference to patent documentation 1) of specifying from this keeping dish selection.
This known low temperature safeguard system 100 has: storage rack 104, accommodate in the vertical the keeping dish 203 of the multiple containers 201 of multiple maintenances; Low-temperature storage chamber 105, stores multiple these storage racks 104; Work room 106, is arranged in abutting connection with this low-temperature storage chamber 105; And dish carrying mechanism 110, being arranged in this work room 106, transfer/storage dish 203 is accessed in storage rack 104 simultaneously.
In work room 106, be provided with can from keeping coil 203 do not take out container 201 pick up mechanism 120, be provided with out warehouse-in chamber 108 in abutting connection with work room 106.
Dish carrying mechanism 110 forms as follows, have by storage rack 104 from low-temperature storage chamber 105 storage rack mobile units 111 that are not accessed in work room 106, and keeping is coiled to the 203 keeping dish mobile units 112 from 104 other accesses of storage rack, simultaneously can be at operation indoor moving.
Thus, can need the keeping dish 203 of the container 201 taking out to be transported to and to pick up mechanism 120 from low-temperature storage chamber 105 by maintaining, thereby take out of from going out to put in storage chamber 108 by picking up 120 indivedual taking-ups of the container that needs are taken out of mechanism.
And the symbol in the bracket of above-mentioned each inscape is the symbol of recording in patent documentation 1.
Patent documentation 1: the JP 2012-56730 of Japan communique
In the known low temperature safeguard system shown in patent documentation 1, the multiple containers that are supported on keeping dish are transported to work room from low-temperature storage chamber, in work room, from be supported on the multiple containers keeping dish, extract the container of specifying by selection mechanism out, afterwards the container staying is taken care of again in low-temperature storage chamber.
Thereby, in carrying and at work room by choosing in the extraction action that mechanism carries out, the container that should again take care of beyond the specified containers of low-temperature storage chamber also can be exposed under above-mentioned environment, likely causes the temperature rise of the sample in container, thereby rotten suffering damage occurs sample.
In addition, if there is a large amount of dewfall on container and directly again take care of in low-temperature storage chamber in the extraction action of being undertaken by selection mechanism, freeze and cause keeping dish to stick together with container, therefore the selection of the container of next time likely becomes difficulty, in order to prevent this situation, need to carry out brute force dehumidifying to taking out of the environment in region.
In order to reduce these problems, can consider the ambient temperature of the superjacent air space of low-temperature storage chamber, work room to be held in the low temperature taking low-temperature storage chamber as standard.
But, need to use special machine type in order to be formed in carrying unit, the selection mechanism etc. of working under such low temperature, and such special machine class is difficult to obtain and price is high, with slow running, thereby the problem of manufacture, cost, work speed etc. is larger compared with general machine type.
In addition, also need strengthening for making the superjacent air space of low-temperature storage chamber, the conditioning unit of low temperature safeguard system entirety that work room is low temperature environment, its operating cost also can improve, also need upkeep operation after the machine type of ultralow temperature has just been brought into operation etc. simultaneously, therefore can bring larger burden to operating personnel, the problem in use is also larger.
Summary of the invention
The present invention carries out in order to address these problems a little, its object is to provide a kind of low temperature safeguard system, its vessel temp that can not make to extract out in action rises, there is dewfall on rotten and container in the sample that prevents from being contained in container, do not need special machine type simultaneously, can carry out at a high speed work, reduce and manufacture, use required expense and easily use.
The related invention of the technical program 1 is a kind of low temperature safeguard system, and it possesses: low-temperature storage chamber, stores the multiple containers that contain sample; And container accepting unit, can move at the superjacent air space of this low-temperature storage chamber, and can keep described container, described container accepting unit possesses: low temperature accepting groove, upper opening, accepting container; And refrigerant pipe, cooling this low temperature accepting groove inside, solves above-mentioned problem thus.
The related invention of the technical program 2 is as follows, on the basis of the structure of the related low temperature safeguard system of technical scheme 1, described low temperature accepting groove is at least separated into 2 above regions of accommodating by 1 partition wall, madial wall and described partition wall along described low temperature accepting groove are provided with described refrigerant pipe, solve thus above-mentioned problem.
The related invention of the technical program 3 is as follows, and on the basis of the structure of the related low temperature safeguard system of technical scheme 2, the madial wall of described low temperature accepting groove and described partition wall are metal system, solve thus above-mentioned problem.
The related invention of the technical program 4 is as follows, on the basis of the structure of technical scheme 2 or the related low temperature safeguard system of technical scheme 3, be provided with separator of battery plates in described inside of accommodating region, between the madial wall of described separator of battery plates and described low temperature accepting groove or described partition wall, be formed with circulating cold air space, described refrigerant pipe is arranged in described circulating cold air space, solves thus above-mentioned problem.
The related invention of the technical program 5 is as follows, on the basis of the structure of the related low temperature safeguard system of technical scheme 4, above described circulating cold air space, is provided with circulating fan, solves thus above-mentioned problem.
The related invention of the technical program 6 is as follows, in technical scheme 2 to the basis of the structure of any 1 related low temperature safeguard system in technical scheme 5, on described low temperature accepting groove, be provided with the top wall of accommodating a part for the upper opening in region described in sealing, solve thus above-mentioned problem.
The related invention of the technical program 7 is as follows, on the basis of the structure of the related low temperature safeguard system of technical scheme 6, is provided with described refrigerant pipe below described top wall, solves thus above-mentioned problem.
The related invention of the technical program 8 is as follows, in technical scheme 2 to the basis of the structure of any 1 related low temperature safeguard system in technical scheme 7, described refrigerant pipe is set to contact madial wall and the described partition wall of described low temperature accepting groove, solves thus above-mentioned problem.
The related invention of the technical program 9 is as follows, and in technical scheme 2, to the basis of the structure of any 1 related low temperature safeguard system in technical scheme 8, described refrigerant pipe has radiating gill, solves thus above-mentioned problem.
The related invention of the technical program 10 is as follows, in technical scheme 1 to the basis of the structure of any 1 related low temperature safeguard system in technical scheme 9, arranged outside at the madial wall of described low temperature accepting groove has adiabatic wall, the cooling unit of supplying with refrigerant at the oriented described refrigerant pipe of arranged outside of described adiabatic wall, solves above-mentioned problem thus.
The related invention of the technical program 11 is as follows, in technical scheme 1 to the basis of the structure of any 1 related low temperature safeguard system in technical scheme 10, on described low temperature accepting groove, be provided with and can seal and open open-close lid upper opening, solve thus above-mentioned problem.
The related invention of the technical program 12 is as follows, in technical scheme 1 to the basis of the structure of any 1 related low temperature safeguard system in technical scheme 11, described low-temperature storage chamber forms in the mode that can store to access multiple storage racks from above, described storage rack is accommodated the keeping dish that much maintains multiple containers on above-below direction, superjacent air space in described low-temperature storage chamber possesses: storage rack carrying unit, storage rack described in access; Transfer unit is coiled in keeping, described storage rack with described in accommodate and between region, transfer described keeping and coil; And selection unit, described accommodating in region, the described container that is held in described keeping dish is processed individually, described container accepting unit is configured to and can coils transfer unit and selection unit with described storage rack carrying unit, keeping and be one and move at the superjacent air space of described low-temperature storage chamber, solves thus above-mentioned problem.
The low temperature safeguard system related according to technical scheme 1, owing to possessing low temperature accepting groove and the refrigerant pipe of upper opening and accepting container, therefore low temperature accepting groove inside can be held in to the ultralow temperature taking low-temperature storage chamber as standard, be configured to and can move at the superjacent air space of low-temperature storage chamber owing to thering is the container accepting unit of this low temperature accepting groove, therefore can the low temperature accepting groove that is promptly contained in ultralow temperature in the container of the superjacent air space of low-temperature storage chamber will be taken out, so the container of extracting out in action can be remained under the environment of ultralow temperature for a long time.
Thus, multiple container support are on keeping dish etc., take out a whole keeping dish extraction as the container of target and take out of outside, in the time again taking care of the keeping such as dish in low-temperature storage chamber, there is dewfall on rotten and container in the sample that can prevent from being contained in the container of again taking care of, can not suffer damage because sample is rotten, in addition, can not occur to stick together with container because freezing to take care of dish, so that the selection of next container becomes difficulty.
And, due to the upper opening of low temperature accepting groove, therefore can in low temperature accepting groove, contain the operation of carrying out waiting from keeping dish selection under the state of container, can container be remained under the environment of ultralow temperature more longways extracting out in action.
In addition, owing to just making low temperature accepting groove inside be ultralow temperature, therefore do not need other space to be held in ultralow temperature, so as carrying, move, the machine type of selection etc., can use general carrying mechanism, industrial robot etc., do not need to use the special machine class that can work under ultralow temperature, can high speed operation, cost also reduces, and the upkeep operation after just having moved etc. also becomes easy.
The structure of recording according to technical scheme 2, because low temperature accepting groove is at least separated into 2 above regions of accommodating by 1 partition wall, therefore at low temperature accepting groove in the time that the superjacent air space of low-temperature storage chamber moves, or carry out picking etc. in low temperature accepting groove time, the situation that cold air in low temperature accepting groove leaks to outside also can tail off, the rising of temperature is suppressed, can more positively container be remained under the environment of ultralow temperature.
In addition, because the madial wall along low temperature accepting groove and partition wall are provided with refrigerant pipe, therefore can be certain and respectively accommodate region in cooling low temperature accepting groove equably.
The structure of recording according to technical scheme 3, because madial wall and the partition wall of low temperature accepting groove are metal system, therefore can be more effective and the cooling region of respectively accommodating equably.
The structure of recording according to technical scheme 4, owing to being provided with separator of battery plates accommodating intra-zone, between the madial wall of separator of battery plates and low temperature accepting groove or partition wall, be formed with circulating cold air space, and refrigerant pipe is arranged in circulating cold air space, therefore can in circulating cold air space, temperature be declined equably by the cooling cold air of refrigerant pipe, and by separator of battery plates the more effective and cooling region of respectively accommodating equably.
In addition, also can make the lower end of separator of battery plates and bottom separate, thus, can, by being effectively sent to and being placed on the container being supported on keeping dish of the bottom of respectively accommodating region etc. by the cold air in the cooling circulating cold air space of refrigerant pipe, can more positively container be remained under the environment of ultralow temperature.
The structure of recording according to technical scheme 5, owing to being provided with circulating fan above circulating cold air space, therefore can, by being sent into being placed on the container being supported on keeping dish of the bottom of respectively accommodating region etc. energetically by the cooling cold air of refrigerant pipe, can further positively container be remained under the environment of ultralow temperature.
The structure of recording according to technical scheme 6, owing to being provided with the top wall of a part of sealing the upper opening of accommodating region on low temperature accepting groove, therefore at low temperature accepting groove in the time that the superjacent air space of low-temperature storage chamber moves, or while carrying out picking by selection mechanism etc., the cold air that can further suppress in low temperature accepting groove causes temperature rise to outside leakage.
The structure of recording according to technical scheme 7, owing to being provided with refrigerant pipe below top wall, therefore cooling low temperature accepting groove inside more effectively.
The structure of recording according to technical scheme 8, because refrigerant pipe is set to contact madial wall and the partition wall of low temperature accepting groove, therefore can be by the heat conduction of madial wall and partition wall cooling low temperature accepting groove inside more effectively.
The structure of recording according to technical scheme 9, because refrigerant pipe has radiating gill, therefore cooling low temperature accepting groove inside more effectively.
The structure of recording according to technical scheme 10, because the arranged outside of the madial wall at low temperature accepting groove has adiabatic wall, therefore can prevent the temperature rise of low temperature accepting groove inside, supply with the cooling unit of refrigerant due to the oriented refrigerant pipe of the arranged outside at adiabatic wall simultaneously, therefore low temperature accepting groove can become one with cooling unit and move at the superjacent air space of low-temperature storage chamber, can simplify the machine type of pipe arrangement etc.
The structure of recording according to technical scheme 11, can seal and open open-close lid upper opening owing to being provided with on low temperature accepting groove, therefore beyond where necessary, cover open-close lid, the cold air that can further suppress in low temperature accepting groove leaks and causes temperature rise to outside.
The structure of recording according to technical scheme 12, owing to carrying out picking low temperature accepting groove is stopped under the state above the position that stores specified containers of low-temperature storage chamber, therefore can shorten after container being contained in low temperature accepting groove and should again take care of the time till the container of low-temperature storage chamber to sending back to, in addition, need in low temperature accepting groove, not contain and should again take care of mobile low temperature accepting groove under the state of the container of low-temperature storage chamber.
Thus, can more positively suppress to be contained in the sample that should again take care of in the container of low-temperature storage chamber dewfall on rotten and container occurs.
Brief description of the drawings
Fig. 1 is the schematic perspective view of the related low temperature safeguard system of an embodiment of the invention.
Fig. 2 is the keeping dish that uses of an embodiment of the invention, the schematic diagram of container.
Fig. 3 is the front view of the related low temperature safeguard system of an embodiment of the invention.
Fig. 4 is the birds-eye view of the related low temperature safeguard system of an embodiment of the invention.
Fig. 5 is near the schematic perspective view of container accepting unit of the related low temperature safeguard system of an embodiment of the invention.
Fig. 6 is the birds-eye view of the container accepting unit of the related low temperature safeguard system of an embodiment of the invention.
Fig. 7 is the lateral plan of the container accepting unit of the related low temperature safeguard system of an embodiment of the invention.
Fig. 8 is (a) upward view and (b) lateral plan of the open-close lid of the related low temperature safeguard system of an embodiment of the invention.
Fig. 9 is the side view cutaway drawing of the low temperature accepting groove of the related low temperature safeguard system of an embodiment of the invention.
Figure 10 is the cutaway view of Fig. 9.
Figure 11 is the side view cutaway drawing of the low temperature accepting groove of the related low temperature safeguard system of other embodiments of the present invention.
Nomenclature
100-low temperature safeguard system; 101-low-temperature storage chamber; 102-work room; 103-takes out of and moves into chamber; 110-container accepting unit; 111-accommodates region; 112-circulating cold air space; 113-cooling unit; 120-low temperature accepting groove; 121-refrigerant pipe; 122-partition wall; 123-madial wall; 124-separator of battery plates; 125-circulating fan; 126-top wall; 127-adiabatic wall; 128-open-close lid; 129-sealing member; 151-storage rack; 152-storage rack carrying unit; Transfer unit is coiled in 153-keeping; 154-chooses unit; Pullout unit is coiled in 155-keeping; 156-keeping dish moves puts unit; The 161-turntable that spirals; 162-takes out of and moves into door; P-keeping dish; C-container.
Detailed description of the invention
As long as low temperature safeguard system of the present invention is following low temperature safeguard system, its concrete structure can be structure arbitrarily, and it possesses: low-temperature storage chamber, stores the multiple containers that contain sample; And container accepting unit, can in the superjacent air space of this low-temperature storage chamber, move, and can keep described container, described container accepting unit possesses: low temperature accepting groove, upper opening, accepting container; And refrigerant pipe, cooling this low temperature accepting groove inside, extracts the temperature rise that can not make container in action out, there is dewfall on rotten and container in the sample that prevents from being contained in container, do not need special machine type, can carry out at a high speed work, reduce and manufacture, use needed expense and easily use simultaneously.
Embodiment
According to Fig. 1 to Fig. 5 to the summary of the related low temperature safeguard system 100 of an embodiment of the invention describe (in order to illustrate, omit, reduced representation a part of structure of each figure, be not correctly to represent actual size, structure.）。
As shown in Figure 2, in the related low temperature safeguard system 100 of an embodiment of the invention use the multiple container C that contain sample keeping coil on P, be supported for rectangular.
As shown in Fig. 1, Fig. 3, Fig. 4, low temperature safeguard system 100 is configured to, and P overlapping storage rack 151 that is contained on above-below direction is coiled in multiple keepings, and this storage rack 151 is stored in low-temperature storage chamber 101 from top.
The superjacent air space fabrication process chamber 102 of low-temperature storage chamber 101, in work room 102, disposing can be at the container accepting unit 110 of work room 102 interior movements, and container accepting unit 110 possesses the low temperature accepting groove 120 of upper opening and accepting container.
In addition, as shown in Fig. 1, Fig. 3 to Fig. 5, can be one with container accepting unit 110 and dispose movably: storage rack carrying unit 152, is accessed in low-temperature storage chamber 101 by storage rack 151; Keeping coil transfer unit 153(by certainly coil Pullout unit 155 and keeping dish move put unit 156 and form), between storage rack 151 and low temperature accepting groove 120, transfer to take care of and coil P; And selection unit 154, process individually in the interior container C of coiling P to being held in keeping of low temperature accepting groove 120.
And, in the present embodiment, be provided with in the end of work room 102 for coiling taking out of of P from external access keeping and move into chamber 103.
Take out of to move in chamber 103 and dispose and place the turntable 161 that spirals that certainly coils P, can rotate to move into door 162 sides and container accepting unit 110 towards taking out of, move into door 162 and take care of the access of coiling P with outside by taking out of by being situated between, simultaneously container accepting unit 110 moves to adjoining position, thus by keeping coil move put unit 156 and low temperature accepting groove 120 between take care of and coil moving of P and put.
Next, according to Fig. 6 to Figure 10, the container accepting unit 110 of the related low temperature safeguard system 100 of an embodiment of the invention is described (in order to illustrate, omitting, simplify a part of structure of each figure and represent, is not correctly to represent actual size, structure.）。
As shown in Figure 6, Figure 7, container accepting unit 110 possesses low temperature accepting groove 120, it is adiabatic wall 127 around and surrounds, upper opening and accepting container, while is in the outside of adiabatic wall 127, be wholely set oriented refrigerant pipe described later 121 and supply with the cooling unit 113 of refrigerant, above low temperature accepting groove 120, be provided with open-close lid 128.
As shown in Figure 8, below open-close lid 128, side is provided with sealing member 129, as shown in Figure 7, when sealing seal low temperature accepting groove 120 above.
And, although the on-off action of open-close lid 128 is to be undertaken by the slip on the up and down left and right directions with at Fig. 7 slightly of detent position, also can be according to combining other actions such as spinning movement with the configuration relation of other structures or multiple action is carried out.
As shown in Figure 9, Figure 10, low temperature accepting groove 120 inside of container accepting unit 110 are divided into 4 by 3 partition walls 122 and accommodate region 111, along the two sides of each partition wall 122 and the madial wall of accommodating region 111 123 at two ends be provided with the refrigerant pipe 121 for cooled interior.
As shown in Figure 9, keeping is coiled P and is placed on the bottom of respectively accommodating region 111.
In the present embodiment, because each partition wall 122 and madial wall 123 are metal systems, in the mode that contacts partition wall 122, madial wall 123, refrigerant pipe 121 is set, therefore can be more effectively, the cooling region of respectively accommodating equably.
And, also can further improve cooling effectiveness by suitably radiating gill being arranged to refrigerant pipe 121.
In addition, are metal systems and refrigerant pipe 121 is set to contact partition wall 122 in the situation that at each partition wall 122, also refrigerant pipe 121 can be arranged on the side of any one party of each partition wall 122.
As shown in Figure 9, in the inside of respectively accommodating region 111, be provided with the separator of battery plates 124 being formed by brace panel, aluminium sheet etc.
Between separator of battery plates 124 and madial wall 123 or partition wall 122, be formed with the circulating cold air space 112 that has refrigerant pipe 121.
Move and put that unit etc. can not hindered and the mode of carrying out operation is set the sectional area of the inside of separator of battery plates 124 with selection unit, keeping dish.
Thus, in circulating cold air space 112, can reduce equably temperature, can by separator of battery plates 124 more effectively, the cooling region 111 of respectively accommodating equably.
And, leave bottom during in the lower end that makes as shown in the figure separator of battery plates 124, circulating cold air space 112 can be used as passage performance function, the air cooling by refrigerant pipe 121 is effectively sent to and is placed on the keeping dish P that respectively accommodates 111 bottoms, region in the interior decline in circulating cold air space 112, can really under the environment of ultralow temperature, take care of the container supporting by certainly coiling P.
And, as shown in figure 11, in order to make more energetically this Air Flow, circulating fan 125 also can be set above circulating cold air space 112.
As shown in figure 10, at the upper opening place of respectively accommodating region 111, be provided with top wall 126 to seal a part of mode from side, below top wall 126, be provided with refrigerant pipe 121.
Thus, in the time that the superjacent air space of low-temperature storage chamber 101 moves, or move when putting unit etc. and carrying out operation at selection unit, keeping dish, can suppress respectively to accommodate cold air in region 111 and leak and temperature rise to outside, simultaneously can be by the refrigerant pipe 121 arranging below top wall 126 cooling 111 inside, region of respectively accommodating effectively.
The extraction action of the container C to the appointment in the related low temperature safeguard system 100 of an embodiment of the invention as constructed as above describes.
First, operating personnel moves into empty keeping dish P taking out of of 103 sides, chamber and moves into door 162 and be placed on and spiral turntable 161 from taking out of, and after closing and taking out of and move into door 162, sends and starts instruction to the imperial device (not shown) of system.
By the rotation of the turntable 161 that spirals, empty keeping dish P is towards the side relative with container accepting unit 110, and container accepting unit 110 coils transfer unit 153 with keeping and becomes one and move in abutting connection with taking out of the position of moving into chamber 103.
Under this state, keeping is coiled Pullout unit 155 and is taken out keeping from the turntable 161 of spiraling and coil P, and keeping dish moves to be put unit 156 and empty keeping dish P is moved to the arbitrary bottom of accommodating region 111 that is put into container accepting unit 110.
Next, container accepting unit 110 moves to the position of the storage rack 151 that contains the keeping dish P that supports the container C of specifying.At this, mention storage rack 151 upward from low-temperature storage chamber 101 storage rack carrying unit 152, and keeping is coiled Pullout unit 155 the keeping dish P that supports the container C of specifying is taken out from storage rack 151.
Afterwards, keeping dish moves to be put unit 156 and moves, and the keeping dish P that supports the container C of specifying is moved to the arbitrary bottom of accommodating region 111 that is put into container accepting unit 110.
Under this state, selection unit 154 carries out work, and the container C of appointment is moved and is placed on empty keeping dish P.
Afterwards, the keeping dish P that supports the container C of specifying is sent back to original storage rack 151 and is stored in low-temperature storage chamber 101 with the order contrary with above-mentioned action, the keeping dish P that moves the container C that is placed with appointment is sent back to take out of and moves into chamber 103, and is moved into door and 162 take out of from taking out of by operating personnel.
In the time that appointment has the multiple container C that should take out, repeatedly repeat to take out the keeping dish P that supports the container C of specifying till the operation of sending back to from low-temperature storage chamber 101.
In above action, due to the region 111 of accommodating in low temperature accepting groove 120 is maintained in to the ultralow temperature taking low-temperature storage chamber 101 as standard, therefore to be exposed to the time of the ambient temperature of work room 102 be the extremely of short duration time to container C, there is dewfall in rotten and container C in the sample that can prevent from being contained in the container C of again taking care of, can not suffer damage because sample is rotten, in addition, can not occur to coil P and container C sticks together because freezing to take care of, so that the selection of next container C becomes difficulty.
In addition, because being separated wall 122, low temperature accepting groove 120 inside are divided into multiple regions 111 of accommodating, therefore while movement in the superjacent air space of low-temperature storage chamber 101, or in the time carrying out picking etc., the cooling gas leakage of accommodating region 111 can tail off to outside situation, even if carry out above-mentioned operation for several times, the rising of temperature also can be suppressed, can really under the environment of ultralow temperature, keep container C.
Low temperature safeguard system 100 involved in the present invention is not limited to above-mentioned embodiment, if container accepting unit possesses the low temperature accepting groove of upper opening and accepting container and the refrigerant pipe of cooling this low temperature accepting groove inside, each concrete structure can with the structure replacing of known low temperature safeguard system.
In addition, the object of freezing keeping is not limited to sample using in the basic investigation of chemistry, biochemistry, biology, pharmacy etc. or applied research etc., is that any object all can.
Claims (12)
1. a low temperature safeguard system, it possesses: low-temperature storage chamber, stores the multiple containers that contain sample; And container accepting unit, can move at the superjacent air space of this low-temperature storage chamber, and can keep described container, it is characterized by,
Described container accepting unit possesses: low temperature accepting groove, upper opening, accepting container; And refrigerant pipe, cooling this low temperature accepting groove inside.
2. low temperature safeguard system according to claim 1, is characterized by,
Described low temperature accepting groove is at least separated into 2 above regions of accommodating by 1 partition wall,
Madial wall and described partition wall along described low temperature accepting groove are provided with described refrigerant pipe.
3. low temperature safeguard system according to claim 2, is characterized by, and the madial wall of described low temperature accepting groove and described partition wall are metal system.
4. according to the low temperature safeguard system described in claim 2 or 3, it is characterized by,
Be provided with separator of battery plates in described inside of accommodating region,
Between the madial wall of described separator of battery plates and described low temperature accepting groove or described partition wall, be formed with circulating cold air space,
Described refrigerant pipe is arranged in described circulating cold air space.
5. low temperature safeguard system according to claim 4, is characterized by, and above described circulating cold air space, is provided with circulating fan.
6. according to the low temperature safeguard system described in claim 2 to 5 any 1, it is characterized by, on described low temperature accepting groove, be provided with the top wall of accommodating a part for the upper opening in region described in sealing.
7. low temperature safeguard system according to claim 6, is characterized by, and is provided with described refrigerant pipe below described top wall.
8. according to the low temperature safeguard system described in claim 2 to 7 any 1, it is characterized by, described refrigerant pipe is set to contact madial wall and the described partition wall of described low temperature accepting groove.
9. according to the low temperature safeguard system described in claim 2 to 8 any 1, it is characterized by, described refrigerant pipe has radiating gill.
10. according to the low temperature safeguard system described in claim 1 to 9 any 1, it is characterized by,
Arranged outside at the madial wall of described low temperature accepting groove has adiabatic wall,
Supply with the cooling unit of refrigerant at the oriented described refrigerant pipe of arranged outside of described adiabatic wall.
11. according to the low temperature safeguard system described in claim 1 to 10 any 1, it is characterized by, and is provided with and can seals and open open-close lid upper opening on described low temperature accepting groove.
12. according to the low temperature safeguard system described in claim 1 to 11 any 1, it is characterized by,
Described low-temperature storage chamber forms in the mode that can store to access multiple storage racks from above,
Described storage rack is accommodated the keeping dish that much maintains multiple containers on above-below direction,
Superjacent air space in described low-temperature storage chamber possesses: storage rack carrying unit, storage rack described in access; Transfer unit is coiled in keeping, described storage rack with described in accommodate and between region, transfer described keeping and coil; And selection unit, described accommodating in region, the described container that is held in described keeping dish is processed individually,
Described container accepting unit is configured to and can coils transfer unit and selection unit with described storage rack carrying unit, keeping and be one and move at the superjacent air space of described low-temperature storage chamber.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013-19472 | 2013-02-04 | ||
| JP2013019472A JP6133070B2 (en) | 2013-02-04 | 2013-02-04 | Cryogenic storage system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103964110A true CN103964110A (en) | 2014-08-06 |
Family
ID=51234204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310351323.0A Pending CN103964110A (en) | 2013-02-04 | 2013-08-13 | Low-temperature storage system |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6133070B2 (en) |
| KR (1) | KR20140099810A (en) |
| CN (1) | CN103964110A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107062731A (en) * | 2017-02-20 | 2017-08-18 | 上海原能细胞医学技术有限公司 | Automated storing device and its operation method |
| CN107438744A (en) * | 2015-03-30 | 2017-12-05 | 布鲁克斯自动化公司 | Automatic low-temp stocking system |
| CN107850614A (en) * | 2015-07-20 | 2018-03-27 | 布鲁克斯自动化公司 | Automate bank module |
| CN109640648A (en) * | 2016-05-17 | 2019-04-16 | 易锐莱科有限公司 | Manipulate and store in very low temperatures the device of biological sample |
| CN111536732A (en) * | 2020-07-10 | 2020-08-14 | 基点生物科技(成都)有限公司 | Biological sample deep low temperature tube picking workstation |
| CN111609641A (en) * | 2020-06-08 | 2020-09-01 | 上海电气慧程智能系统有限公司 | Heat preservation and insulation device and biological sample storehouse |
| CN113272234A (en) * | 2019-01-15 | 2021-08-17 | 株式会社椿本链条 | Low-temperature storage system |
| CN113548358A (en) * | 2016-10-19 | 2021-10-26 | 奥卡多创新有限公司 | Storage system and method |
| CN114051483A (en) * | 2019-05-13 | 2022-02-15 | Abt控股公司 | Apparatus and method for cryogenic storage and handling of multiple container units |
| CN115023400A (en) * | 2020-03-11 | 2022-09-06 | 株式会社椿本链条 | Low-temperature storage container |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116040094B (en) * | 2023-03-28 | 2023-07-14 | 基点生物科技(成都)有限公司 | Sample storage device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0658657A (en) * | 1992-08-06 | 1994-03-04 | Orion Mach Co Ltd | Thermoelectrical conversion type thermostatic storing device |
| JP2004131249A (en) * | 2002-10-10 | 2004-04-30 | Tsubakimoto Chain Co | Automatic storage warehouse |
| JP2005187201A (en) * | 2003-12-26 | 2005-07-14 | Minami Shokuhin:Kk | Warehouse type refrigerator |
| JP5450326B2 (en) * | 2010-09-09 | 2014-03-26 | 株式会社椿本チエイン | Cryogenic storage system |
-
2013
- 2013-02-04 JP JP2013019472A patent/JP6133070B2/en active Active
- 2013-08-05 KR KR1020130092532A patent/KR20140099810A/en not_active Application Discontinuation
- 2013-08-13 CN CN201310351323.0A patent/CN103964110A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107438744A (en) * | 2015-03-30 | 2017-12-05 | 布鲁克斯自动化公司 | Automatic low-temp stocking system |
| CN107850614A (en) * | 2015-07-20 | 2018-03-27 | 布鲁克斯自动化公司 | Automate bank module |
| CN109640648A (en) * | 2016-05-17 | 2019-04-16 | 易锐莱科有限公司 | Manipulate and store in very low temperatures the device of biological sample |
| CN109640648B (en) * | 2016-05-17 | 2022-07-08 | 易锐莱科有限公司 | Device for handling and storing biological samples at very low temperatures |
| CN113548358A (en) * | 2016-10-19 | 2021-10-26 | 奥卡多创新有限公司 | Storage system and method |
| US12049358B2 (en) | 2016-10-19 | 2024-07-30 | Ocado Innovation Limited | Storage systems and methods |
| CN107062731A (en) * | 2017-02-20 | 2017-08-18 | 上海原能细胞医学技术有限公司 | Automated storing device and its operation method |
| CN113272234A (en) * | 2019-01-15 | 2021-08-17 | 株式会社椿本链条 | Low-temperature storage system |
| CN114051483A (en) * | 2019-05-13 | 2022-02-15 | Abt控股公司 | Apparatus and method for cryogenic storage and handling of multiple container units |
| CN115023400A (en) * | 2020-03-11 | 2022-09-06 | 株式会社椿本链条 | Low-temperature storage container |
| CN111609641A (en) * | 2020-06-08 | 2020-09-01 | 上海电气慧程智能系统有限公司 | Heat preservation and insulation device and biological sample storehouse |
| CN111536732A (en) * | 2020-07-10 | 2020-08-14 | 基点生物科技(成都)有限公司 | Biological sample deep low temperature tube picking workstation |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6133070B2 (en) | 2017-05-24 |
| JP2014148415A (en) | 2014-08-21 |
| KR20140099810A (en) | 2014-08-13 |
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Application publication date: 20140806 |