CN107050514A - 可注射骨移植材料 - Google Patents

可注射骨移植材料 Download PDF

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CN107050514A
CN107050514A CN201710013418.XA CN201710013418A CN107050514A CN 107050514 A CN107050514 A CN 107050514A CN 201710013418 A CN201710013418 A CN 201710013418A CN 107050514 A CN107050514 A CN 107050514A
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parts
bone graft
graft materials
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weight
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吴彬
王大鹏
刘晓成
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Zhongguancun Research Institute Of Competition Cell And Tissue Engineering
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Abstract

本发明提供一种可注射骨移植材料，由按重量份计的以下组分制得：磷酸三钙3.1‑7.6份，羟基磷灰石4.4‑9.3份，细胞因子1.0‑2.3份，胶原蛋白2.5‑3.4份，α‑半水硫酸1.3‑1.7份，钙3.6‑5.2份，骨粉颗粒2.2‑4.3份，透明质酸0.5‑0.7份，壳聚糖0.9‑1.3份，海藻0.3‑0.5份，酸盐0.2‑0.4份，羧甲基纤维素0.2‑0.3份，十八烷酸0.1‑0.3份，多糖0.2‑0.4份和固化液1.3‑2.7份。本发明提供的可注射骨移植材料孔径和孔隙率大，有利于骨细胞的生长和血管的通过，对病人的康复非常有帮助。

Description

可注射骨移植材料
技术领域
本发明属于骨科材料领域。更具体地说，本发明涉及一种可注射骨移植材料。
背景技术
骨移植材料广泛应用于骨断裂修复、骨植入物的镀膜、人工关节返修、骨质疏松治疗(可注射骨移植材料)、脊椎治疗、拔牙创和颔面外科等方面。现在广泛应用的有自体骨、同种异体骨、异种骨以及人工骨移植材料，它们都有各自的局限性。
发明内容
本发明的一个目的是解决至少上述问题，并提供至少后面将说明的优点。
为了解决上述的问题，本发明提出一种可拆卸防滑鞋，一双鞋子可方便拆卸鞋底的鞋钉，从而随时可以在上述两种环境中切换使用。
本发明提供一种可注射骨移植材料，由按重量份计的以下组分制得：
磷酸三钙3.1-7.6份，羟基磷灰石4.4-9.3份，细胞因子1.0-2.3份，胶原蛋白2.5-3.4份，α-半水硫酸1.3-1.7份，钙3.6-5.2份，骨粉颗粒2.2-4.3份，透明质酸0.5-0.7份，壳聚糖0.9-1.3份，海藻0.3-0.5份，酸盐0.2-0.4份，羧甲基纤维素0.2-0.3份，十八烷酸0.1-0.3份，多糖0.2-0.4份和固化液1.3-2.7份。
优选的是，所述的可注射骨移植材料中，
将按重量份计的磷酸三钙3.1-7.6份，钙3.6-5.2份与生理盐水4.7-6.3份混合制得混合溶液一；
将该混合溶液一制得直径为0.1-0.2mm的第一颗粒。
优选的是，所述的可注射骨移植材料中，将一半的所述第一颗粒表面喷洒生理盐水后，与按重量份计的骨粉颗粒2.2-4.3份、壳聚糖0.9-1.3份混合搅拌制得第二颗粒。
优选的是，所述的可注射骨移植材料中，将按重量份计的细胞因子1.0-2.3份制得载细胞因子微球。
优选的是，所述的可注射骨移植材料中，将按重量份计的羟基磷灰石3.3-9.3份，胶原蛋白2.5-3.4份，α-半水硫酸1.3-1.7份，透明质酸0.5-0.7份，海藻0.3-0.5份，酸盐0.2-0.4份，羧甲基纤维素0.2-0.3份，十八烷酸0.1-0.3份，多糖0.2-0.4份混合后搅拌均匀得到混合物一；
将剩余的一半所述第一颗粒、所述第二颗粒、所述混合物一和按重量份计的固化液1.3-2.7份低温搅拌0.7-1.2min即制得所述可注射骨移植材料。
优选的是，所述的可注射骨移植材料中，所述固化液为生理盐水、注射用水、葡萄糖注射液。
本发明提供一种可注射骨移植材料，由按重量份计的以下组分制得：磷酸三钙3.1-7.6份，羟基磷灰石4.4-9.3份，细胞因子1.0-2.3份，胶原蛋白2.5-3.4份，α-半水硫酸1.3-1.7份，钙3.6-5.2份，骨粉颗粒2.2-4.3份，透明质酸0.5-0.7份，壳聚糖0.9-1.3份，海藻0.3-0.5份，酸盐0.2-0.4份，羧甲基纤维素0.2-0.3份，十八烷酸0.1-0.3份，多糖0.2-0.4份和固化液1.3-2.7份。本发明提供的可注射骨移植材料孔径和孔隙率大，有利于骨细胞的生长和血管的通过，对病人的康复非常有帮助。
可吸收生物活性骨诱导材料植入后3个月左右诱导骨缺损完全再生、自身被彻底降解吸收的优异性能，安全性可靠，适用于骨缺损、骨折、骨裂、骨肿瘤、骨坏死、脊柱关节融合等临床病症。
本发明的其它优点、目标和特征将部分通过下面的说明体现，部分还将通过对本发明的研究和实践而为本领域的技术人员所理解。
具体实施方式
下面对本发明做进一步的详细说明，以令本领域技术人员参照说明书文字能够据以实施。
应当理解，本文所使用的诸如“具有”、“包含”以及“包括”术语并不配出一个或多个其它元件或其组合的存在或添加。
实施例一
本发明提供一种可注射骨移植材料，由按重量份计的以下组分制得：
磷酸三钙3.1份，羟基磷灰石4.4份，细胞因子1.0份，胶原蛋白2.5份，α-半水硫酸1.3份，钙3.6份，骨粉颗粒2.2份，透明质酸0.5份，壳聚糖0.9份，海藻0.3份，酸盐0.2份，羧甲基纤维素0.2份，十八烷酸0.1份，多糖0.2份和固化液1.3份。
所述的可注射骨移植材料中，
将按重量份计的磷酸三钙3.1份，钙3.6份与生理盐水4.7份混合制得混合溶液一；
将该混合溶液一制得直径为0.1mm的第一颗粒。
所述的可注射骨移植材料中，将一半的所述第一颗粒表面喷洒生理盐水后，与按重量份计的骨粉颗粒2.2份、壳聚糖0.9份混合搅拌制得第二颗粒。
所述的可注射骨移植材料中，将按重量份计的细胞因子1.0份制得载细胞因子微球。
所述的可注射骨移植材料中，将按重量份计的羟基磷灰石3.3份，胶原蛋白2.5份，α-半水硫酸1.3份，透明质酸0.5份，海藻0.3份，酸盐0.2份，羧甲基纤维素0.2份，十八烷酸0.1份，多糖0.2份混合后搅拌均匀得到混合物一；
将剩余的一半所述第一颗粒、所述第二颗粒、所述混合物一和按重量份计的固化液1.3份低温搅拌0.7min即制得所述可注射骨移植材料。
所述的可注射骨移植材料中，所述固化液为生理盐水。
实施例二
本发明提供一种可注射骨移植材料，由按重量份计的以下组分制得：
磷酸三钙7.6份，羟基磷灰石9.3份，细胞因子2.3份，胶原蛋白3.4份，α-半水硫酸1.7份，钙5.2份，骨粉颗粒4.3份，透明质酸0.7份，壳聚糖1.3份，海藻0.5份，酸盐0.4份，羧甲基纤维素0.3份，十八烷酸0.3份，多糖0.4份和固化液2.7份。
所述的可注射骨移植材料中，
将按重量份计的磷酸三钙7.6份，钙5.2份与生理盐水6.3份混合制得混合溶液一；
将该混合溶液一制得直径为0.2mm的第一颗粒。
所述的可注射骨移植材料中，将一半的所述第一颗粒表面喷洒生理盐水后，与按重量份计的骨粉颗粒4.3份、壳聚糖1.3份混合搅拌制得第二颗粒。
所述的可注射骨移植材料中，将按重量份计的细胞因子2.3份制得载细胞因子微球。
所述的可注射骨移植材料中，将按重量份计的羟基磷灰石9.3份，胶原蛋白3.4份，α-半水硫酸1.7份，透明质酸0.7份，海藻0.5份，酸盐0.4份，羧甲基纤维素0.3份，十八烷酸0.3份，多糖0.4份混合后搅拌均匀得到混合物一；
将剩余的一半所述第一颗粒、所述第二颗粒、所述混合物一和按重量份计的固化液2.7份低温搅拌1.2min即制得所述可注射骨移植材料。
所述的可注射骨移植材料中，所述固化液为葡萄糖注射液。
实施例三
本发明提供一种可注射骨移植材料，由按重量份计的以下组分制得：
磷酸三钙5.8份，羟基磷灰石7.4份，细胞因子1.7份，胶原蛋白2.9份，α-半水硫酸1.4份，钙4.4份，骨粉颗粒3.8份，透明质酸0.6份，壳聚糖1.1份，海藻0.4份，酸盐0.3份，羧甲基纤维素0.2份，十八烷酸0.2份，多糖0.3份和固化液2.2份。
所述的可注射骨移植材料中，
将按重量份计的磷酸三钙5.8份，钙4.4份与生理盐水5.2份混合制得混合溶液一；
将该混合溶液一制得直径为0.2mm的第一颗粒。
所述的可注射骨移植材料中，将一半的所述第一颗粒表面喷洒生理盐水后，与按重量份计的骨粉颗粒3.8份、壳聚糖1.1份混合搅拌制得第二颗粒。
所述的可注射骨移植材料中，将按重量份计的细胞因子1.7份制得载细胞因子微球。
所述的可注射骨移植材料中，将按重量份计的羟基磷灰石7.4份，胶原蛋白2.9份，α-半水硫酸1.4份，透明质酸0.6份，海藻0.4份，酸盐0.3份，羧甲基纤维素0.2份，十八烷酸0.2份，多糖0.3份混合后搅拌均匀得到混合物一；
将剩余的一半所述第一颗粒、所述第二颗粒、所述混合物一和按重量份计的固化液2.2份低温搅拌0.9min即制得所述可注射骨移植材料。
所述的可注射骨移植材料中，所述固化液为注射用水。
本发明提供的可注射骨移植材料，其孔隙率可达到40％，其孔径可达到21微米，且可注射时间长，可以达到103-114min。
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节。

Claims (6)

1.可注射骨移植材料，其特征在于，由按重量份计的以下组分制得：
磷酸三钙3.1-7.6份，羟基磷灰石4.4-9.3份，细胞因子1.0-2.3份，胶原蛋白2.5-3.4份，α-半水硫酸1.3-1.7份，钙3.6-5.2份，骨粉颗粒2.2-4.3份，透明质酸0.5-0.7份，壳聚糖0.9-1.3份，海藻0.3-0.5份，酸盐0.2-0.4份，羧甲基纤维素0.2-0.3份，十八烷酸0.1-0.3份，多糖0.2-0.4份和固化液1.3-2.7份。
2.如权利要求1所述的可注射骨移植材料，其特征在于，
将按重量份计的磷酸三钙3.1-7.6份，钙3.6-5.2份与生理盐水4.7-6.3份混合制得混合溶液一；
将该混合溶液一制得直径为0.1-0.2mm的第一颗粒。
3.如权利要求2所述的可注射骨移植材料，其特征在于，将一半的所述第一颗粒表面喷洒生理盐水后，与按重量份计的骨粉颗粒2.2-4.3份、壳聚糖0.9-1.3份混合搅拌制得第二颗粒。
4.如权利要求3所述的可注射骨移植材料，其特征在于，将按重量份计的细胞因子1.0-2.3份制得载细胞因子微球。
5.如权利要求4所述的可注射骨移植材料，其特征在于，将按重量份计的羟基磷灰石3.3-9.3份，胶原蛋白2.5-3.4份，α-半水硫酸1.3-1.7份，透明质酸0.5-0.7份，海藻0.3-0.5份，酸盐0.2-0.4份，羧甲基纤维素0.2-0.3份，十八烷酸0.1-0.3份，多糖0.2-0.4份混合后搅拌均匀得到混合物一；
将剩余的一半所述第一颗粒、所述第二颗粒、所述混合物一和按重量份计的固化液1.3-2.7份低温搅拌0.7-1.2min即制得所述可注射骨移植材料。
6.如权利要求1所述的可注射骨移植材料，其特征在于，所述固化液为生理盐水、注射用水、葡萄糖注射液。
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Publication number Priority date Publication date Assignee Title
CN1403166A (zh) * 2002-09-26 2003-03-19 东南大学 用于硬组织修复的可吸收活性组合物及其制备方法
CN1416913A (zh) * 2002-11-28 2003-05-14 上海瑞邦生物材料有限公司 自固化磷酸钙原位成骨活性骨水泥及其制备方法和应用
CN102085389A (zh) * 2011-01-14 2011-06-08 北京大清生物技术有限公司 可注射骨修复材料的制备方法
CN102091351B (zh) * 2011-01-14 2014-05-07 北京大清生物技术有限公司 可注射骨修复材料

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1403166A (zh) * 2002-09-26 2003-03-19 东南大学 用于硬组织修复的可吸收活性组合物及其制备方法
CN1416913A (zh) * 2002-11-28 2003-05-14 上海瑞邦生物材料有限公司 自固化磷酸钙原位成骨活性骨水泥及其制备方法和应用
CN102085389A (zh) * 2011-01-14 2011-06-08 北京大清生物技术有限公司 可注射骨修复材料的制备方法
CN102091351B (zh) * 2011-01-14 2014-05-07 北京大清生物技术有限公司 可注射骨修复材料

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