CN107050001A - A kind of cannabidiol suppository with heat-clearing sterilization functions and preparation method thereof - Google Patents

Abstract

A kind of cannabidiol suppository with heat-clearing sterilization functions and preparation method thereof, it is prepared from following components in parts by weight by raw material, 57 parts of cannabidiol, 45 parts of reed rhizome, 34 parts of cape jasmine, 23 parts of purslane, 12 parts of pseudo-ginseng, 12 parts of eleusine indica, 12 parts of Caulis et Folium piperis, 12 parts of Ramulus euonymi, 12 parts of mantis egg-case, 12 parts of tabasheer, 12 parts of the bark of ash, 12 parts of mole cricket, 150 160 parts of 1 1.5 part, part mixed fatty glycerides of field pennycress；Its preparation method is concretely comprised the following steps：Step 1, weighing；Step 2, preparation mixing；It is step 3, filling；Step 4, packaging.A kind of cannabidiol suppository with heat-clearing sterilization functions of the present invention and preparation method thereof, takes full advantage of the pharmacological action of cannabidiol, and compatibility multi-flavor natural traditional Chinese medicine, the effect with heat-clearing sterilizing, anti-inflammatory analgetic.

Description

A kind of cannabidiol suppository with heat-clearing sterilization functions and preparation method thereof

Technical field

The present invention relates to field of medicaments, more particularly to a kind of cannabidiol suppository with heat-clearing sterilization functions and Its preparation method.

Background technology

Suppository refers to the solid pharmaceutical preparation being administered in the effigurate confession body cavities of tool that medicine is made with appropriate substrate, Suppository at normal temperatures be solid, fill in after cavity, can rapidly soften under body temperature or be dissolved in juice, gradually discharge medicine and Generation is locally or systemically acted on.In early days it is believed that suppository only plays the local actions such as lubrication, convergence, antibacterial, desinsection, local anaesthesia, after To find that suppository is still acted on, and can avoid the first pass effect of liver by rectal absorption drugs for systemic again.Modern study It was found that, suppository not only plays local therapeutic effects, but also can be haveed an effect on the whole body by rectal absorption, treats multiclass disease.Cause This, multi items full-scale development suppository can turn into another evolutionary path of modern pharmaceutical enterprise.

The content of the invention

It is an object of the invention to provide a kind of cannabidiol suppository with heat-clearing sterilization functions and preparation method thereof, fully It make use of the pharmacological action of cannabidiol, and compatibility multi-flavor natural traditional Chinese medicine, the effect with heat-clearing sterilizing, anti-inflammatory analgetic.

The purpose of the present invention is achieved through the following technical solutions：

A kind of cannabidiol suppository with heat-clearing sterilization functions, is prepared from following components in parts by weight, cannabidiol by raw material 5-7 parts, 4-5 parts of reed rhizome, 3-4 parts of cape jasmine, 2-3 parts of purslane, 1-2 parts of pseudo-ginseng, 1-2 parts of eleusine indica, 1-2 parts of Caulis et Folium piperis, terrible arrow 1-2 parts of plumage, 1-2 parts of mantis egg-case, 1-2 parts of tabasheer, 1-2 parts of the bark of ash, 1-2 parts of mole cricket, 1-1.5 parts of field pennycress, fatty acid mixed are sweet 150-160 parts of grease.

A kind of cannabidiol suppository with heat-clearing sterilization functions, raw material presses preferred weight number, cannabidiol 5-6 Part, 4-4.5 parts of reed rhizome, 3-3.6 parts of cape jasmine, 2.5-3 parts of purslane, 1.5-2 parts of pseudo-ginseng, 1-1.5 parts of eleusine indica, Caulis et Folium piperis 1- 1.5 parts, 1-1.5 parts of Ramulus euonymi, 1-1.5 parts of mantis egg-case, 1-1.5 parts of tabasheer, 1-1.5 parts of the bark of ash, 1-1.5 parts of mole cricket, field pennycress 1-1.2 parts, 155-160 parts of mixed fatty glycerides.

A kind of cannabidiol suppository with heat-clearing sterilization functions, raw material presses optimum weight number, cannabidiol 5.5 Part, 4 parts of reed rhizome, 3.3 parts of cape jasmine, 2.8 parts of purslane, 1.8 parts of pseudo-ginseng, 1.2 parts of eleusine indica, 1.2 parts of Caulis et Folium piperis, Ramulus euonymi 1.2 Part, 1.2 parts of mantis egg-case, 1.2 parts of tabasheer, 1.2 parts of the bark of ash, 1.2 parts of mole cricket, 1.1 parts of field pennycress, mixed fatty glycerides 156 Part.

A kind of cannabidiol suppository with heat-clearing sterilization functions, its preparation method is concretely comprised the following steps：

Step 1, weighing：

By weight, recipe quantity cannabidiol, mixed fatty glycerides are accurately weighed to be respectively charged into stainless steel cask, then claimed Take reed rhizome, cape jasmine, purslane, pseudo-ginseng, eleusine indica, Caulis et Folium piperis, Ramulus euonymi, mantis egg-case, tabasheer, the bark of ash, mole cricket, the Patrinia scaniosaefolia of high-quality Grass, it is standby；

Step 2, preparation mixing

By weight, reed rhizome, cape jasmine, purslane, pseudo-ginseng, eleusine indica, Caulis et Folium piperis, Ramulus euonymi, mantis egg-case, tabasheer, the bark of ash, mole cricket Mqb, field pennycress, which are respectively placed in inside micronizer, carries out ultramicro grinding, is placed in inside mixer and is mixed after ultramicro grinding, After well mixed, mixed powder is obtained；

By weight, mixed fatty glycerides are taken to be added in homogenizer, 70 DEG C of substrate heating dissolves, and is cooled to after dissolving 40-50 DEG C, add cannabidiol, mixed powder, stirring 60 minutes is to well mixed, then obtained mixture is incubated in 38-42 It is DEG C standby；

It is step 3, filling

Mixture is taken, is placed in bottle placer and carries out filling, pouring process, a loading amount was surveyed every 1 hour or so, it is ensured that loading amount is poor It is different in acceptability limit, it is filling to obtain cannabidiol suppository；

Step 4, packaging

Cannabidiol suppository is taken, loads in capsule, capsule and puts 1 specification, one bag of fingerstall and 1 plate medicine（6/plate）, 10 capsules Contracting envelope one is wrapped, and 30 bags are a big case, is put packing slip, packing, is got product.

In the feed, reed rhizome is used for the diseases such as pyreticosis polydipsia, gastropyretic vomiting, cough with lung heat, puckery pain of heat gonorrhea, with heat-clearing profit The effect urinate, promoted the production of body fluid to quench thirst；Cape jasmine has the effect such as protect liver, cholagogic, decompression, calmness, hemostasis, detumescence；Purslane has heat-clearing profit Wet, removing toxicity for detumescence, anti-inflammatory, quench the thirst, diuresis；Pseudo-ginseng has dissipate stasis of blood hemostasis, the effect of detumescence ding-tong；Eleusine indica has heat-clearing profit Wet effect；Caulis et Folium piperis energy wind-damp dispelling, strong waist and knee, analgesic, cough-relieving, mend aging, play sun, control arthralgia pain due to rheumatism, bruise, waist and knee without Power, dysmenorrhoea, anemofrigid cold, cough and asthma；Field pennycress has effects that clearing heat and detoxicating, stasis-dispelling and pain-killing.Ramulus euonymi energy blood-breaking is stimulated the menstrual flow, Removing toxicity for detumescence, desinsection, control abdominal mass caking, trusted subordinate's pain, amenorrhoea, dysmenorrhoea, metrorrhagia and metrostaxis, postpartum stasis of blood, lochia not under, hernia Gas, severe and migratory arthralgia numbness pain, sore swells, injuries from falls as well, abdominal pain due to enterositosis, burn and scald, venomous snake bite；Mantis egg-case, energy astringent sperm contracting urine, kidney tonifying is helped Under positive, main seminal emission, premature ejaculation, impotence, the enuresis, frequent micturition, aconuresis, gonorrhoea, band, it is supplementing the kidney to control the nocturnal, contracting urine, only turbid.Tabasheer can be changed Phlegm and relieving cough, promoting blood circulation by removing wind, dampness removing, control coughing with a lot of sputum, pertussis, band under, stomachache, arthralgia pain due to rheumatism, child convulsion, traumatic injury, Arthralgia pain due to rheumatism, numb limb, infantile pertussis, leukorrhea, have meaning still control stomach trouble；Bark of ash energy heat-clearing and damp-drying drug, antiasthmatic-antitussive, Improving eyesight, controls bacillary dysentery, enteritis, leukorrhea, chronic bronchitis, red eye, swell pain, tearing against wind, psoriasis；Mole cricket, energy Li Shui leads to Drench, subdhing swelling and detoxicating controls difficult urination, oedema, urolithiasis, scrofula, malignant sore, inducing diuresis for removing edema, oedema, ascites, the disease such as difficult urination.

Cannabidiol (CBD) be extracted from hemp floral leaf a kind of it is nontoxic can be used for medicine, cosmetics, health food A kind of high added value aldehydes matter.CBD is the non-additive composition in hemp, can hinder THC to nerve system of human body shadow Ring, and with pharmacological activity such as anti-spasm, resisting rheumatoid arthritis, antianxiety, clearing away damp-heat, hypoglycemic, reducing blood lipid.

Beneficial effects of the present invention：A kind of cannabidiol suppository with heat-clearing sterilization functions of the present invention, makes full use of The pharmacological action of cannabidiol, and compatibility multi-flavor natural traditional Chinese medicine, have effects that good heat-clearing sterilizing, anti-inflammatory, purging intense heat；Its Secondary, the present invention makes full use of its pharmacological activity using mostly natural traditional Chinese medicine, and composition is natural, has no toxic side effect, safe and reliable, and It is evident in efficacy；In addition, the present invention is carried, using being quite convenient to, can go directly focus, and curative effect is stable, will not produce bad anti- Should.

The present invention is through two groups of clinical verifications, and one of which is cannabidiol suppository of the treatment group using the present invention, per angel With the present invention once, 7 days are a course for the treatment of, and another group of control group uses heat clearing and detoxicating pill, are used once daily, are within 7 days one The course for the treatment of, every group selection outpatient 110, wherein man 55, female 55, max age 75 years old, minimal ages 35 years old, clinical table It is now pyreticosis polydipsia, gastropyretic vomiting, cough with lung heat, table 1 is to take the contrasting data after a course for the treatment of：

Table 1 takes front and rear two groups of courses for the treatment of and compares (unit:People)

There were significant differences for treatment group and control group, it will thus be seen that the application of the present invention clinically has significant curative effect.

Embodiment

Embodiment 1

A kind of cannabidiol suppository with heat-clearing sterilization functions, is prepared from following components in parts by weight, cannabidiol by raw material 5-7 parts, 4-5 parts of reed rhizome, 3-4 parts of cape jasmine, 2-3 parts of purslane, 1-2 parts of pseudo-ginseng, 1-2 parts of eleusine indica, 1-2 parts of Caulis et Folium piperis, terrible arrow 1-2 parts of plumage, 1-2 parts of mantis egg-case, 1-2 parts of tabasheer, 1-2 parts of the bark of ash, 1-2 parts of mole cricket, 1-1.5 parts of field pennycress, fatty acid mixed are sweet 150-160 parts of grease.

Embodiment 2

A kind of cannabidiol suppository with heat-clearing sterilization functions, raw material press preferred weight number, 5-6 parts of cannabidiol, 4-4.5 parts of reed rhizome, 3-3.6 parts of cape jasmine, 2.5-3 parts of purslane, 1.5-2 parts of pseudo-ginseng, 1-1.5 parts of eleusine indica, Caulis et Folium piperis 1-1.5 Part, 1-1.5 parts of Ramulus euonymi, 1-1.5 parts of mantis egg-case, 1-1.5 parts of tabasheer, 1-1.5 parts of the bark of ash, 1-1.5 parts of mole cricket, field pennycress 1- 1.2 parts, 155-160 parts of mixed fatty glycerides.

Embodiment 3

A kind of cannabidiol suppository with heat-clearing sterilization functions, raw material press optimum weight number, 5.5 parts of cannabidiol, 4 parts of reed rhizome, 3.3 parts of cape jasmine, 2.8 parts of purslane, 1.8 parts of pseudo-ginseng, 1.2 parts of eleusine indica, 1.2 parts of Caulis et Folium piperis, 1.2 parts of Ramulus euonymi, 1.2 parts of mantis egg-case, 1.2 parts of tabasheer, 1.2 parts of the bark of ash, 1.2 parts of mole cricket, 1.1 parts of field pennycress, 156 parts of mixed fatty glycerides.

Embodiment 4

A kind of cannabidiol suppository with heat-clearing sterilization functions, its preparation method is concretely comprised the following steps：

Step 1, weighing：

By weight, recipe quantity cannabidiol, mixed fatty glycerides are accurately weighed to be respectively charged into stainless steel cask, then claimed Take reed rhizome, cape jasmine, purslane, pseudo-ginseng, eleusine indica, Caulis et Folium piperis, Ramulus euonymi, mantis egg-case, tabasheer, the bark of ash, mole cricket, the Patrinia scaniosaefolia of high-quality Grass, it is standby；

Step 2, preparation mixing

By weight, reed rhizome, cape jasmine, purslane, pseudo-ginseng, eleusine indica, Caulis et Folium piperis, Ramulus euonymi, mantis egg-case, tabasheer, the bark of ash, mole cricket Mqb, field pennycress, which are respectively placed in inside micronizer, carries out ultramicro grinding, is placed in inside mixer and is mixed after ultramicro grinding, After well mixed, mixed powder is obtained；

By weight, mixed fatty glycerides are taken to be added in homogenizer, 70 DEG C of substrate heating dissolves, and is cooled to after dissolving 40-50 DEG C, add cannabidiol, mixed powder, stirring 60 minutes is to well mixed, then obtained mixture is incubated in 38-42 It is DEG C standby；

It is step 3, filling

Mixture is taken, is placed in bottle placer and carries out filling, pouring process, a loading amount was surveyed every 1 hour or so, it is ensured that loading amount is poor It is different in acceptability limit, it is filling to obtain cannabidiol suppository；

Step 4, packaging

Cannabidiol suppository is taken, loads in capsule, capsule and puts 1 specification, one bag of fingerstall and 1 plate medicine（6/plate）, 10 capsules Contracting envelope one is wrapped, and 30 bags are a big case, is put packing slip, packing, is got product.

Embodiment 5

In the step 3, it is filling before, receiving and beam worker with interior packaging material should be produced according to the requirement of batch production ordering Make, and by production ordering, change the product batch number and the term of validity of bottle placer, squad leader checks, be connected to the middle production of Quality Mgmt Dept's granting After product Rleasing Notice, start filling；After filling end, canned suppository loads in transferring box, hands over terminal and records, and hangs up properly Mark " to be tested ", fills in circulation card, calculates material balance.

Embodiment 6

In the step 4, before packaging, according to the requirement of batch production ordering, receiving and beam worker with packaging material is produced Make, by production ordering, to the capsule of product, carry out the test print of date of manufacture, batch number and the term of validity, squad leader to be packaged answers After core is correct, start to be capped date of manufacture, batch number, the term of validity as requested on printing, big case.

Claims (4)

1. a kind of cannabidiol suppository with heat-clearing sterilization functions, it is characterised in that：Prepared by raw material by following parts by weight Form, 5-7 parts of cannabidiol, 4-5 parts of reed rhizome, 3-4 parts of cape jasmine, 2-3 parts of purslane, 1-2 parts of pseudo-ginseng, 1-2 parts of eleusine indica, heath 1-2 parts of rattan, 1-2 parts of Ramulus euonymi, 1-2 parts of mantis egg-case, 1-2 parts of tabasheer, 1-2 parts of the bark of ash, 1-2 parts of mole cricket, 1-1.5 parts of field pennycress, 150-160 parts of mixed fatty glycerides.

2. a kind of cannabidiol suppository with heat-clearing sterilization functions according to claim 1, it is characterised in that：Raw material is by excellent Select parts by weight, 5-6 parts of cannabidiol, 4-4.5 parts of reed rhizome, 3-3.6 parts of cape jasmine, 2.5-3 parts of purslane, 1.5-2 parts of pseudo-ginseng, ox 1-1.5 parts of muscle grass, 1-1.5 parts of Caulis et Folium piperis, 1-1.5 parts of Ramulus euonymi, 1-1.5 parts of mantis egg-case, 1-1.5 parts of tabasheer, bark of ash 1-1.5 Part, 1-1.5 parts of mole cricket, 1-1.2 parts of field pennycress, 155-160 parts of mixed fatty glycerides.

3. a kind of cannabidiol suppository with heat-clearing sterilization functions according to claim 1, it is characterised in that：Raw material is by most Good parts by weight, 5.5 parts of cannabidiol, 4 parts of reed rhizome, 3.3 parts of cape jasmine, 2.8 parts of purslane, 1.8 parts of pseudo-ginseng, 1.2 parts of eleusine indica, 1.2 parts of Caulis et Folium piperis, 1.2 parts of Ramulus euonymi, 1.2 parts of mantis egg-case, 1.2 parts of tabasheer, 1.2 parts of the bark of ash, 1.2 parts of mole cricket, field pennycress 1.1 Part, 156 parts of mixed fatty glycerides.

4. a kind of cannabidiol suppository with heat-clearing sterilization functions according to claim 1-3 any one, its feature exists In：Its preparation method is concretely comprised the following steps：

Step 1, weighing：

By weight, recipe quantity cannabidiol, mixed fatty glycerides are accurately weighed to be respectively charged into stainless steel cask, then claimed Take reed rhizome, cape jasmine, purslane, pseudo-ginseng, eleusine indica, Caulis et Folium piperis, Ramulus euonymi, mantis egg-case, tabasheer, the bark of ash, mole cricket, the Patrinia scaniosaefolia of high-quality Grass, it is standby；

Step 2, preparation mixing

By weight, take reed rhizome, cape jasmine, purslane, pseudo-ginseng, eleusine indica, Caulis et Folium piperis, Ramulus euonymi, mantis egg-case, tabasheer, the bark of ash, Mole cricket, field pennycress, are respectively placed in inside micronizer and carry out ultramicro grinding, are placed in inside mixer and are mixed after ultramicro grinding Close, after being well mixed, obtain mixed powder；

By weight, mixed fatty glycerides are taken to be added in homogenizer, 70 DEG C of substrate heating dissolves, and is cooled to after dissolving 40-50 DEG C, add cannabidiol, mixed powder, stirring 60 minutes is to well mixed, then obtained mixture is incubated in 38-42 It is DEG C standby；

It is step 3, filling

Mixture is taken, is placed in bottle placer and carries out filling, pouring process, a loading amount was surveyed every 1 hour or so, it is ensured that loading amount is poor It is different in acceptability limit, it is filling to obtain cannabidiol suppository；

Step 4, packaging

Cannabidiol suppository is taken, loads in capsule, capsule and puts 1 specification, one bag of fingerstall and 1 plate medicine（6/plate）, 10 capsules Contracting envelope one is wrapped, and 30 bags are a big case, is put packing slip, packing, is got product.