CN107048406A - It is a kind of that there are the astaxanthin health products for improving immunity function - Google Patents
It is a kind of that there are the astaxanthin health products for improving immunity function Download PDFInfo
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- CN107048406A CN107048406A CN201710260582.0A CN201710260582A CN107048406A CN 107048406 A CN107048406 A CN 107048406A CN 201710260582 A CN201710260582 A CN 201710260582A CN 107048406 A CN107048406 A CN 107048406A
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- Prior art keywords
- oil
- astaxanthin
- parts
- health products
- fat
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- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 title claims abstract description 58
- 235000013793 astaxanthin Nutrition 0.000 title claims abstract description 58
- 239000001168 astaxanthin Substances 0.000 title claims abstract description 58
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 title claims abstract description 58
- 229940022405 astaxanthin Drugs 0.000 title claims abstract description 58
- 230000036541 health Effects 0.000 title claims abstract description 39
- 230000036039 immunity Effects 0.000 title claims abstract description 35
- 241001300674 Plukenetia volubilis Species 0.000 claims abstract description 33
- 241000218236 Cannabis Species 0.000 claims abstract 6
- 239000000203 mixture Substances 0.000 claims description 40
- 230000006870 function Effects 0.000 claims description 24
- 239000003292 glue Substances 0.000 claims description 21
- 239000007901 soft capsule Substances 0.000 claims description 12
- 239000002775 capsule Substances 0.000 claims description 10
- 238000009413 insulation Methods 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- 239000006187 pill Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 241000238557 Decapoda Species 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 239000000084 colloidal system Substances 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
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- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 4
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 4
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
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- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000011068 loading method Methods 0.000 claims description 4
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- 230000000694 effects Effects 0.000 abstract description 32
- 238000002474 experimental method Methods 0.000 abstract description 3
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- LOTKRQAVGJMPNV-UHFFFAOYSA-N 1-fluoro-2,4-dinitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(F)C([N+]([O-])=O)=C1 LOTKRQAVGJMPNV-UHFFFAOYSA-N 0.000 description 2
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 229940087603 grape seed extract Drugs 0.000 description 2
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- 241000972773 Aulopiformes Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 235000008697 Cannabis sativa Nutrition 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
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- 235000003434 Sesamum indicum Nutrition 0.000 description 1
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- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
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- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
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- 208000021822 hypotensive Diseases 0.000 description 1
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- 210000000987 immune system Anatomy 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
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- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 235000020636 oyster Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
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- 231100000572 poisoning Toxicity 0.000 description 1
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- 230000001737 promoting effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- 239000008158 vegetable oil Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of astaxanthin health products for having and improving immunity function, the health products are made up of following raw material proportioning：70 ~ 180 parts of natural astaxanthin oil, 150 ~ 360 parts of oil and fat of sacha inchi, 70 ~ 180 parts of fructus cannabis oil.Experiment shows that astaxanthin health products provided by the present invention are matched through scientific quantification, and astaxanthin oil, oil and fat of sacha inchi, the effect of fructus cannabis oil in terms of immunity is improved have been played to greatest extent.
Description
Technical field
The invention belongs to Medicines and Health Product field, and in particular to a kind of to have the astaxanthin health products for improving immunity function
And preparation method.
Background technology
Astaxanthin (astaxanthin), also known as ASX, astaxanthin, are shrimp crab shell, oyster, salmon and some algae
In the carotenoid containing oxygen derivative that contains, can effectively quenching activity oxygen, with higher healthy nutritive value.In recent years
There are some researches show astaxanthin has stronger raising immunity, anticancer suppression cancer, strengthen immunity, the memory that improves, the prevention heart
The health-care effects such as vascular diseases, have broad application prospects.
U.S. rattan fruit is the perennial bejuco of Euphorbiaceae, also known as prints strange fruit, astral oil rattan etc., originates in South America Peru
Amazon is a kind of rich in grease, protein, the oilseed plant of vitamin E.Oil and fat of sacha inchi is rich in polyunsaturated fatty acid, dimension
The mineral matters such as element A, vitamin E, and calcium, phosphorus, iron are given birth to, its unsaturated fatty acid content has good up to more than 92% to human body
Good trophism；In reduction cholesterol, prevention and treatment angiocardiopathy, hard anti-atherogenic, maintenance skin, anti-aging tool
There is good action.
Fructus cannabis is the dry mature seed of moraceae plants hemp (Cannabis sativa L.), also known as cannabis,fructus, fire
Fiber crops, hemp.Its property is sweet, flat, returns spleen, stomach, large intestine channel, with moisturizing, laxation, treating stranguria, promoting blood circulation effect, be used as medicine in China
Food is homologous to use the history for having had 3000.Fructus cannabis oil is remembered as the extract of fructus cannabis with immunity, improvement is improved
The effects such as recalling power, hypotensive, diuresis, analgesia, anti-inflammatory, antithrombus formation, treatment constipation, delay senility, is eaten for a long time to chronic
Neuritis, paralysis, constipation, hypertension, high fat of blood and gynecological disease etc. have preferable auxiliary curative effect.
The immune system of human body includes immune organ, immunocyte and immune factor.Immune organ be immunocyte generation,
The place of ripe or centralized distribution；Immunocyte is divided into lymphocyte, BMDC, Monocytes/Macrophages, granulocyte, fertilizer
Maxicell etc.；Lymphocyte is located in lymph node, blood and lymph, has T cell, B cell, K lymphocytes, NK lymphs thin
Born of the same parents；Immune factor (material of the performance immunization produced by immunocyte or other cells) has antibody, lymphokine, bacteriolyze
Enzyme etc..Immunocyte, immune factor distribution whole body, stream past in an endless flow, form a network mutually restricted, dominate the immune of human body
Function resists bacterium, poisoning intrusion, removes the cell of damage denaturation in vivo and aging, removes internal metabolic waste, maintains machine
The stabilization of vivo environment.People's is whether healthy, keeps relative homeostasis depending on the immunologic function of body, that is, is immunized
The relative equilibrium of function.Hypoimmunity is divided into primary and the class of Secondary cases two.Primary is that congenital development is incomplete caused, mostly
Number is relevant with heredity, multiple to be born in children；Secondary cases is then by the infection such as virus, bacterium, fungi or medicine, tumour, fatigue, mistake
Sleep, malnutritive, pressure is excessive etc., and reason causes, it is seen that in the crowd at various ages.It is most weak after being ill, easily send out infectious disease
Patient belongs to Secondary cases hypoimmunity.
Health products are various in style in the market, and raising immunity composition is numerous and diverse, and quality is uneven, and improve immunity
Effect is not good, and more famous has：Spring sesame hall board panax notoginseng grape seed capsule (main component：Notogineng Extract, grape pip are extracted
Thing, Turmeric P.E), Tongrentang's board grape seed extract soft capsule (main component：Grape seed extract, powder phospholipid) etc..
But these products are not still very satisfactory in immunity enhancing effect, it is necessary to further raising.What the present invention was provided
Composition is matched through scientific quantification using natural plain astaxanthin oil, oil and fat of sacha inchi, fructus cannabis oil as raw material, i.e., sent out to greatest extent
The effect of strengthen immunity is waved and has been complementary to one another the action character of three kinds, this composition is improved the effect of immunity
Comprehensively, effect is notable.
The content of the invention
It is an object of the invention to provide the health food that a kind of Ricipe for health care food containing astaxanthin oil, the present invention are provided
By natural astaxanthin oil, oil and fat of sacha inchi, fructus cannabis oil composition compatibility is made, tests prove that, have the immunity that increases significantly
The healthcare function of active function.
Health food is being prepared it is a further object to provide a kind of Ricipe for health care food containing astaxanthin oil
In application, be prepared into health products using the formula.
It is a kind of that there are the astaxanthin health products for improving immunity function, it is characterised in that the health products are blue or green by natural shrimp
70~180 parts of vegetable oil, 150~360 parts of oil and fat of sacha inchi, 70~180 parts of compositions of fructus cannabis oil.
Described is a kind of with the astaxanthin health products for improving immunity function, it is characterised in that：The health products are by day
Right 90~160 parts of astaxanthin oil, 180~320 parts of oil and fat of sacha inchi, 100~160 parts of compositions of fructus cannabis oil.
Described is a kind of with the astaxanthin health products for improving immunity function, it is characterised in that：The health products are by day
Right 120 parts of astaxanthin oil, 253 parts of oil and fat of sacha inchi, 127 parts of compositions of fructus cannabis oil.
A kind of described astaxanthin health products with auxiliary improving memory function, it is characterised in that：By the health products system
Into soft capsule, finish, preferably soft capsule.
Described is a kind of with the astaxanthin health products for improving immunity function, it is characterised in that the astaxanthin soft capsule
Preparation technology be：
1. dispensing
After astaxanthin is well mixed by recipe quantity with oil and fat of sacha inchi and fructus cannabis oil, colloid mill 2~3 times are crossed, then mistake
80~120 mesh sieves were both obtained.
2. glue is changed
Gelatin 100-250 parts by weight, glycerine 40-100 parts by weight, water 100-250 parts by weight are pressed 1：0.4-0.6：0.8-1
Being put into of ratio glue bucket in, the heating of water-bath chuck dissolves it, the preservatives such as ethylparaben is added, to stirring and dissolving, 60
± 1 DEG C is incubated 1~2 hour, and vacuum deviates from bubble under 0.06MPa~0.08MPa, and insulation filtering is standby as homogeneous glue.
3. pelletization is suppressed
By glue compressed air, insulation is conveyed into pellet press or so glue box, starts automatic rotation Zhanang machine, with 1
~3 revs/min of control system speed, adjust loading amount, suppress capsule and pill.
4. shape drying
Capsule and pill cooling shaping 1 hour in rotating cage, then dries 36 hours, to rubber water content 8%~13%, then uses
95% ethanol or petroleum ether are deoiled, and are drying to obtain.
Described is a kind of with the astaxanthin health products for improving immunity function, it is characterised in that the health products, which have, to be carried
High efficacy of immunity.
Astaxanthin health products described in the invention, which have, improves immunity function, wherein natural astaxanthin oil, oil and fat of sacha inchi
And fructus cannabis oil three is mutually coordinated can eliminate interior free yl, enhancing improves immunity ability and reaches the effect of anti-aging
Really.
Embodiment
Below by embodiment, the present invention will be further described, but the present invention is not limited only to embodiment.
Embodiment 1：
A kind of to have the astaxanthin health products for improving immunity function, the composition of the health products includes：Parts by weight are 70
The natural astaxanthin oil of part, parts by weight are 150 parts of oil and fat of sacha inchi, and parts by weight are 70 parts of fructus cannabis oil, by soft capsule
Preparation method soft capsule is made.
The preparation process of soft capsule is：
(1) dispensing：By natural astaxanthin oil and oil and fat of sacha inchi and fructus cannabis oil, by above-mentioned weight fraction ratio, mixing is equal
After even, colloid mill 2 times are crossed, 80 mesh sieves are crossed；
(2) glue is changed：By the parts by weight of gelatin 100, the parts by weight of glycerine 40, the parts by weight of water 100, by above-mentioned ratio of weight and number,
In being put into glue bucket, the heating of water-bath chuck dissolves it, adds the preservatives such as ethylparaben, to stirring and dissolving, 60 DEG C of insulations
1 hour, vacuum deviate from bubble under 0.06MPa~0.08MPa, and insulation filtering is standby as homogeneous glue；
(3) pelletization is suppressed
By glue compressed air, insulation is conveyed into pellet press or so glue box, starts automatic rotation Zhanang machine, with 1
Rev/min control system speed, adjusts loading amount, suppresses capsule and pill；
(4) shape drying
Capsule and pill cooling shaping 1 hour in rotating cage, is then dried 36 hours, to rubber water content 13%, then with 95%
Ethanol washing is deoiled, and is drying to obtain.
Embodiment 2：
A kind of to have the astaxanthin health products for improving immunity function, the composition of the health products includes：Parts by weight are 120
The natural astaxanthin oil of part, parts by weight are 253 parts of oil and fat of sacha inchi, and finish is made for 127 parts of fructus cannabis oil in parts by weight
Astaxanthin health products.
Embodiment 3：
A kind of to have the astaxanthin health products for improving immunity function, the composition of the health products includes：Parts by weight are 180
The natural astaxanthin oil of part, parts by weight are 360 parts of oil and fat of sacha inchi, and parts by weight are 180 parts of fructus cannabis oil, according to flexible glue
The preparation method of capsule, is made soft capsule.
The preparation process of soft capsule is：
(1) dispensing：By natural astaxanthin oil, oil and fat of sacha inchi, fructus cannabis oil and corresponding auxiliary material, by above-mentioned weight fraction
Than after being well mixed, crossing colloid mill 2 times, crossing 80 mesh sieves；
(2) glue is changed：By 250 parts of gelatin, 150 parts of glycerine, 250 parts of water, by above-mentioned weight fraction ratio, being put into glue bucket
In, the heating of water-bath chuck dissolves it, adds the preservatives such as ethylparaben, to stirring and dissolving, and 60 DEG C are incubated 1 hour,
Vacuum deviates from bubble under 0.06MPa~0.08MPa, and insulation filtering is standby as homogeneous glue；
(3) pelletization is suppressed
By glue compressed air, insulation is conveyed into pellet press or so glue box, starts automatic rotation Zhanang machine, with 1
Rev/min control system speed, adjusts loading amount, suppresses capsule and pill；
(4) shape drying
Capsule and pill cooling shaping 1 hour in rotating cage, then dries 36 hours, to rubber water content 8%, then uses petroleum ether
Washing is deoiled, and is drying to obtain.
The strengthen immunity capacity experimental of embodiment 4：
1. material：1. cleaning grade C57BL/6J mouse, all-male, 18~22g of body weight, by Liaoning, long-living biotechnology is limited
Company provides, experimental animal production licence number：SCXK (the Liao Dynasty) 2015-0001；YAC-1 mouse lymphoma cells strain, in being purchased from
The academy of sciences of state Kunming Institute of Botany cell bank.
2. experiment group is set：By 18~22g C57BL/6J mouse 84,7 groups, i.e. vehicle control group, shrimp are randomly divided into
Green grass or young crops element 150mg/kg dosage groups, oil and fat of sacha inchi group, fiery sesame oil group, three kinds of compositions 150mg/kg, 300mg/kg and 450mg/kg
Dosage group, every group 12.Each tested group with 20mL/kg body weight administered volume, gavage gives astaxanthin, oil and fat of sacha inchi, fire fiber crops respectively
Three kinds of compositions of oil and various dose, vehicle control group gives isometric solvent, 1 time/d, continuous 30d.Strengthen immunity work(
Can index detection method reference《Health food is examined and assessment technique specification》Carry out, detect that three kinds of compositions are thin to mouse respectively
Born of the same parents are immune, the influence of humoral immunity, monocytes/macrophages function and NK cytoactives.
3. cellular immunity：It is small that ConA inducing mouses Splenic vein hemodynamics experiment (mtt assay) and dinitrofluorobenzene are induced
Mouse Tardive allergy tests (ear swelling method), and result of the test is shown in Tables 1 and 2.
1 three kinds of compositions of table to ConA inducing mouse Splenic vein hemodynamics influence (N=12)
Note：Compared with vehicle control group：*P<0.05,**P<0.01；Compared with astaxanthin group：▲P<0.05,▲▲P<0.01
2 three kinds of compositions of table to dinitrofluorobenzene induced mice Delayed onset ear swell influence (N=12)
Note：Compared with vehicle control group：*P<0.05,**P<0.01；Compared with astaxanthin group：▲P<0.05,▲▲P<0.01
From table 1, compared with vehicle control group, astaxanthin group mouse lymphocyte conversion capability substantially increases (P<
0.05), three kinds of composition 300mg/kg and 450mg/kg dosage group mouse lymphocyte conversion capabilities substantially increase (P<0.01),
And the effect of three kinds of composition 300mg/kg and 450mg/kg dosage is administered alone (P better than astaxanthin<0.01)；And oil and fat of sacha inchi
It is administered alone with fiery sesame oil and model mice is had no significant effect.Compared with vehicle control group, astaxanthin group, oil and fat of sacha inchi group, fire
Sesame oil group and each dosage successive administration 30d of three kinds of compositions, (P is had no significant effect to the weight of animals>0.05).
From table 2, compared with vehicle control group, astaxanthin group mouse Delayed onset ear swelling degree substantially increases (P<
0.05), each dosage group mouse Delayed onset ear swelling degree of three kinds of compositions substantially increases (P<, and three kinds of each dosage of composition 0.01)
Effect be administered alone (P better than astaxanthin<0.05)；And oil and fat of sacha inchi and fiery sesame oil are administered alone to model mice without obvious shadow
Ring.Compared with vehicle control group, astaxanthin group, oil and fat of sacha inchi group, fiery sesame oil group and each dosage successive administration of three kinds of compositions
30d, (P is had no significant effect to the weight of animals>0.05).Result above points out three kinds of compositions are immune to mouse cell to have increasing
Use is pretended, and its effect is better than astaxanthin.
4. humoral immunity：Serum hemolysin determines (Hemagglutination Method), and result of the test is shown in Table 3.
3 three kinds of compositions of table to mice serum Hemolysin formation influence (N=12)
Note：Compared with vehicle control group：*P<0.05,**P<0.01；Compared with astaxanthin group：▲P<0.05,▲▲P<0.01
From table 3, compared with vehicle control group, astaxanthin group and each dosage group mice serum hemolysin of three kinds of compositions
Generation substantially increases (P<0.01), oil and fat of sacha inchi group mice serum Hemolysin formation substantially increases (P<0.05)；Three kinds of compositions
The effect of 150mg/kg dosage is administered alone (P better than astaxanthin<0.05), three kinds of composition 300mg/kg and 450mg/kg dosage
Effect be administered alone (P better than astaxanthin<0.01)；And fiery sesame oil is administered alone to the generation of model mice serum hemolysin without bright
Development rings.Compared with vehicle control group, astaxanthin group, oil and fat of sacha inchi group, fiery sesame oil group and three kinds of each dosage of composition are continuously given
Medicine 30d, (P is had no significant effect to the weight of animals>0.05).Result above points out three kinds of compositions to have mouse humoral immune
Humidification, and its effect is better than astaxanthin.
5. monocytes/macrophages function：Mouse carbon particle clearance result of the test is shown in Table 4.
4 three kinds of compositions of table to mouse phagocytic index α influence (N=12)
Note：Compared with vehicle control group：*P<0.05,**P<0.01；Compared with astaxanthin group：▲P<0.05,▲▲P<0.01
From table 4, compared with vehicle control group, astaxanthin group, oil and fat of sacha inchi, fiery sesame oil and three kinds of each dosage of composition
Group mouse phagocytic index α has no significant change, through statistical analysis, there was no significant difference (P>0.05).With vehicle control group ratio
Compared with astaxanthin group, oil and fat of sacha inchi group, fiery sesame oil group and each dosage successive administration 30d of three kinds of compositions, to the weight of animals without bright
Development rings (P>0.05).Result above points out three kinds of compositions to have no significant effect mouse monokaryon-macrophage function.
6.NK cytoactives：NK cytoactive detections (LDH determination methods), result of the test is shown in Table 5.
5 three kinds of compositions of table to NK cells in mice activity influence (N=12)
Note：Compared with vehicle control group：*P<0.05,**P<0.01；Compared with astaxanthin group：▲P<0.05,▲▲P<0.01
From table 5, compared with vehicle control group, astaxanthin group NK cells in mice activity substantially increases (P<0.05), three
Plant each dosage group NK cells in mice activity of composition substantially increase (P>0.01), the effect of three kinds of composition 450mg/kg dosage is excellent
(P is administered alone in astaxanthin<0.05).Compared with vehicle control group, astaxanthin group, oil and fat of sacha inchi group, fiery sesame oil group and three kinds
Each dosage successive administration of composition 30 days, (P is had no significant effect to the weight of animals>0.05).Result above points out three kinds of combinations
Thing can significantly improve NK cells in mice activity, and its effect is better than astaxanthin.
In summary, astaxanthin, three kinds of compositions of oil and fat of sacha inchi and fructus cannabis oil can be remarkably reinforced mouse cell it is immune,
Humoral immunity and NK cytoactives, according to《Health food is examined and assessment technique specification》Evaluation criteria, can determine that three kinds of groups
Compound strengthen immunity function results of animal is positive.From experimental result as can be seen that the strengthen immunity of three kinds of compositions
Effect is alone better than astaxanthin, oil and fat of sacha inchi or fiery sesame oil, shows that astaxanthin, oil and fat of sacha inchi and fructus cannabis oil pass through the proportioning group
The formula closed has played the synergy of three, the effect with more high-quality.Meanwhile, this composition is administered 30 days to animal
Body weight has no significant effect, and toxic side effect is smaller.
Claims (6)
1. a kind of have the astaxanthin health products for improving immunity function, it is characterised in that the health products are by natural astaxanthin
70 ~ 180 parts of oil, 150 ~ 360 parts of oil and fat of sacha inchi, 70 ~ 180 parts of compositions of fructus cannabis oil.
2. it is as claimed in claim 1 a kind of with the astaxanthin health products for improving immunity function, it is characterised in that：The health care
Product are made up of 90 ~ 160 parts of natural astaxanthin oil, 180 ~ 320 parts of oil and fat of sacha inchi, 100 ~ 160 parts of fructus cannabis oil.
3. it is a kind of with the astaxanthin health products for improving immunity function as described in claim 1-2, it is characterised in that：The guarantor
Strong product are made up of 120 parts of natural astaxanthin oil, 253 parts of oil and fat of sacha inchi, 127 parts of fructus cannabis oil.
4. a kind of astaxanthin health products with auxiliary improving memory function according to profit requires 1-3, it is characterised in that：Will
Soft capsule, finish, preferably soft capsule is made in the health products.
5. it is a kind of with the astaxanthin health products for improving immunity function as described in claim 1-4, it is characterised in that the shrimp
The preparation technology of blue or green cellulose soft capsules is：
1. dispensing
After astaxanthin is well mixed by recipe quantity with oil and fat of sacha inchi and fructus cannabis oil, colloid mill 2~3 times is crossed, then cross 80~
120 mesh sieves were both obtained；
2. glue is changed
Gelatin 100-250 parts by weight, glycerine 40-100 parts by weight, water 100-250 parts by weight are pressed 1：0.4-0.6：0.8-1 ratio
In being put into of example glue bucket, the heating of water-bath chuck dissolves it, the preservatives such as ethylparaben is added, to stirring and dissolving, 60 ± 1
DEG C insulation 1~2 hour, under 0.06MPa~0.08MPa vacuum deviate from bubble, insulation filtering, it is standby as homogeneous glue；
3. pelletization is suppressed
By glue compressed air, insulation is conveyed into pellet press or so glue box, starts automatic rotation Zhanang machine, with 1~3
Rev/min control system speed, adjusts loading amount, suppresses capsule and pill；
4. shape drying
Capsule and pill cooling shaping 1 hour in rotating cage, then dries 36 hours, to rubber water content 8%~13%, then uses 95% second
Alcohol or petroleum ether are deoiled, and are drying to obtain.
6. it is a kind of with the astaxanthin health products for improving immunity function as described in claim 1-5, it is characterised in that the guarantor
Strong product, which have, improves efficacy of immunity.
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| CN201710260582.0A CN107048406A (en) | 2017-04-20 | 2017-04-20 | It is a kind of that there are the astaxanthin health products for improving immunity function |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101053409A (en) * | 2007-05-11 | 2007-10-17 | 汪昔奇 | Health care food containing natural astaxanthin |
| CN104026260A (en) * | 2013-04-01 | 2014-09-10 | 洛阳春魁农业开发有限公司 | Peony seed blend oil containing hemp seed oil and preparation method thereof |
-
2017
- 2017-04-20 CN CN201710260582.0A patent/CN107048406A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101053409A (en) * | 2007-05-11 | 2007-10-17 | 汪昔奇 | Health care food containing natural astaxanthin |
| CN104026260A (en) * | 2013-04-01 | 2014-09-10 | 洛阳春魁农业开发有限公司 | Peony seed blend oil containing hemp seed oil and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 于学芹等: "美藤果油和磷虾油合剂对小鼠免疫功能的影响", 《食品安全导刊》 * |
| 杜秀园: "《胶囊剂生产与检测技术》", 31 December 2015, 中央广播电视大学出版社 * |
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