CN107029612A - A kind of micro-fluidic flash mixer based on copline coil group - Google Patents
A kind of micro-fluidic flash mixer based on copline coil group Download PDFInfo
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- CN107029612A CN107029612A CN201610979759.8A CN201610979759A CN107029612A CN 107029612 A CN107029612 A CN 107029612A CN 201610979759 A CN201610979759 A CN 201610979759A CN 107029612 A CN107029612 A CN 107029612A
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- coil
- entrance
- hybrid channel
- micro
- coil group
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/3032—Micromixers using magneto-hydrodynamic [MHD] phenomena to mix or move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
Abstract
The invention belongs to microfluidic device association area, and disclose a kind of micro-fluidic flash mixer based on copline coil group, it includes hybrid channel, it is arranged in multiple entrance and exits of hybrid channel opposite sides, and be sequentially arranged along hybrid channel axis direction and multiple coil group units in same plane, plurality of entrance is respectively used to importing different fluid to be mixed and magnetic nano-particle, each coil group unit is constituted by four coils, the upper and lower and composition that these coils set up in hybrid channel axis separately are arranged symmetrically, and it is used to be passed through identical frequency and amplitude but the alternating current of phase successively in the presence of 90 degree of difference between this four coils, thus rotating excitation field is constantly produced along hybrid channel direction, drive magnetic nano-particle rotation, accelerate stirring mixed process.By the present invention, test shows that stirring mixed process can be substantially speeded up compared with prior art, and suitable for obtaining high-quality mixing effect of fluid in longer distance and scope.
Description
Technical field
The invention belongs to microfluidic device association area, more particularly, to a kind of miniflow based on copline coil group
Control flash mixer, it can form multiple rotary magnetic field domains along hybrid channel axial direction, and cause fluid obtain efficiently,
High-quality and larger range of mixed effect.
Background technology
The mixing of micro liquid is the important step for realizing clinical biochemical reaction.It is tight due to Trace Elements and quality
Liquid needs microlitre in lattice requirement, the Micro biochemical analysis of many quantitative analyses, the control of nanoliter level, traditional hybrid mode
This needs are extremely difficult to, correspondingly, the micro-hybrid system research based on micro-fluidic chip is obtained as a uncharted field
Obtained tremendous development.The hybrid system for microfluid mainly includes static type and dynamic two kinds of type from being generally divided at present, its
In the former rely on the phase counterdiffusion of liquid itself, the reaction time that this mode needs is long, it is difficult to meet the requirement quickly mixed；
The latter is the flowing for accelerating microfluid by external force, and it is driving that existing research includes electromagnetic drive type, thermal drivers type, ultrasonic wave
Deng, due to its generally mixing velocity relatively faster, therefore in recent years on dynamic type laboratory research achieve it is very big
Progress, but be not committed in practical application area, its major reason is that complex process or application field are narrow.
Specifically, for example Liang-Hsuan Lu et al. have developed the micro motor of array using MEMS technology, should
Micro motor can rotate at a high speed to realize the mixing of microfluid, but its complex manufacturing technology under outside magnetically-actuated, be difficult to realize
Promote on a large scale；The vapor that Evan is produced using high temperature flows back and forth in Multiple Cycle intracavitary so that fluid molecule chaos
Be sufficiently mixed, but which is for the affected liquid of property under heat effect and does not apply to, thus its application by
Very big limitation；In addition, H.Monnier et al. produces turbulent flow, domestic Zhen Yang domestic people using acoustics cavitation
The small vortex of flow field generation can be disturbed based on ultrasonic wave is focused on, vibrates ultrasonic wave and focus on flow field to carry so as to produce using PZT
High mixed effect, but this kind of mode can only equally cause preferable mixing in a small range, thus it is difficult to fully mixed in practice
Close effect.Correspondingly, this area, which is needed badly, makes further research and designs, to conform better to the complexity under practical application
Demand.
The content of the invention
For more than prior art not enough or Improvement requirement, the invention provides a kind of based on the micro- of copline coil group
Stream control flash mixer, wherein by combining the micro-fluidic quick hybrid system application demand of itself, it is pointedly crucial to it
The many aspects such as composition structure, set-up mode and the operation principle of for example multiple copline coil groups of component make design, while right
Hybrid system integral layout construction make improvement, mutually should be able to by compact conformation, be easy to quality control in the way of perform reality
Micro-fluidic quick mixed function under application scenario, and its mixing velocity is fast, energy-efficient performance is good, is easy to the later stage to separate, thus
It is particularly suitable for use in towards performing the micro-fluidic application scenario quickly mixed in a big way.
To achieve the above object, it is proposed, according to the invention, there is provided a kind of micro-fluidic quick mixing based on copline coil group
Device, the micro-fluidic flash mixer includes first entrance, second entrance, the 3rd entrance, outlet, hybrid channel and multiple coils
Group unit, it is characterised in that：
The first entrance, outlet are separately positioned on the horizontal both sides of the hybrid channel, and the wherein first entrance is used for
Magnetic nano-particle is injected, and it is moved along the hybrid channel until being exported via the outlet；The second entrance,
3rd entrance is symmetricly set on its both sides up and down relative to the first entrance, and it is to be mixed that the two entrances are respectively used to injection
A kind of fluid, two kinds of fluids cross to the hybrid channel via branch pipe, continue to move then along this hybrid channel until warp
Exported by the outlet；In addition, above-mentioned first entrance, second entrance, the 3rd entrance, outlet and hybrid channel are arranged and are in
In same plane p；
Axis direction of the multiple coil group unit along the hybrid channel and be sequentially arranged and be completely in described
In same plane p, wherein each coil group unit by the first coil that is arranged horizontally in above the hybrid channel axis and
Second coil and the tertiary coil being equally arranged horizontally in below the hybrid channel axis and the 4th coil composition, and
Each relative to the hybrid channel axle between the first coil and the 4th coil, between second coil and tertiary coil
Line is arranged symmetrically above and below；In addition, when performing fluid married operation, the first coil is used to be passed through preset frequency and amplitude
Alternating current, second coil is used to be passed through identical with the first coil frequency and amplitude and phase is advanced or quadrature lagging
Alternating current, the tertiary coil is used to be passed through identical with second coil frequency and amplitude and phase is advanced or quadrature lagging
Alternating current, and the 4th coil is then used to be passed through identical with the tertiary coil frequency and amplitude and phase is advanced or delayed 90
The alternating current of degree.
Conceive more than, based on Faraday's electromagnetic induction law, each coil will produce magnetic in its surrounding space
, and cause also produce mixed magnetic field in plane p residing for hybrid channel, due to using above-mentioned arrangement, when coil alternating current
When being changed with certain frequency, each coil also changes in magnetic field intensity caused by microring array channel plane；On the one hand,
When four coils are passed through variable-current as previously described, the microring array channel plane that four coils are enclosed can produce rotary magnetic place
Domain, and magnetic nano-particle can produce rotation fortune when moving to this rotating excitation field region under magnetic couple moment loading of its application
Dynamic, this rotary motion further can effectively drive the fusion between two kinds of different liquids, so as to accelerate its hybrid directional along circle
The change in week；On the other hand, due to being also sequentially arranged multiple above-mentioned rotary magnetic places along the flow direction of microring array passage
Domain, accordingly can flexibly, easily carry out the quantity adjustment of rotating excitation field according to demand on the premise of operation is not influenceed, so that
High-quality mixing effect of fluid is obtained in longer distance and scope.
As present invention further optimization scheme, the magnetic nano-particle is preferably ferroso-ferric oxide material.
As present invention further optimization scheme, for each coil of the coil group unit, it is passed through
The frequency of alternating current be preferably set to 60Hz, its amplitude is preferably set to 1A.
As present invention further optimization scheme, the first coil, the second coil are relative to the hybrid channel
Spacing is preferably designed to 1mm~3mm.
As present invention further optimization scheme, the two kinds of fluids injected via the second entrance, the 3rd entrance
After crossing in the hybrid channel, preferably continue to move with 40 μm/s~100 μm/s speed.
As present invention further optimization scheme, the mixing ratio between the magnetic nano-particle and described two fluids
Decision design is as follows：The quality of magnetic nano-particle：The μ g of μ g of the cumulative volume of two kinds of fluids=10~25：1μl..
As present invention further optimization scheme, the mixtures of the magnetic nano-particle and described two fluids via
After the outlet export, preferably directly acted on using external magnetic field and make it that magnetic nano-particle is precipitated, thus completed and stream
Separation between body.
As present invention further optimization scheme, described two fluids are preferably the medicine used in chemical or biomedicine
And its particle is micron dimension.
In general, possess following compared with prior art, mainly according to the above technical scheme constructed by the present invention
Technological merit：
1st, by the key component to this microfluidic mixer such as multiple entrances, fluid passage and copline coil group
Layout designs, while the research to cooperating mode inside each coil group and each other, test shows can be along stream
The mixed path direction of body conveying produces rotating magnetic field, thus via the rotation of magnetic nano-particle itself, from microcosmic
Aspect substantially speeds up stirring mixed process；In addition, can also flexibly, easily be carried out according to demand on the premise of operation is not influenceed
The quantity adjustment of rotating excitation field, so as to obtain high-quality mixing effect of fluid in longer distance and scope；
2nd, the present invention also further receives to some the key index parameter such as coil-spans, magnetic for influenceing above-mentioned working mechanism
Mixing ratio, movement rate of rice corpuscles and fluid etc. have been made research and designed, and actual test shows, above-mentioned Optimal Parameters design
It can ensure that the whole fluid mixed system based on rotary magnetic field domain performs more effective, efficient operation processing, and due to upper
The microstructure that coil may be designed as being integrated on micro-fluidic chip in itself is stated, can be prepared using MEMS technology, it is not only overall
System bulk very little, and the i.e. achievable larger driving force of less driving electric energy is only needed to, thus it is easy to actual industrialization
Manufacture and use；
3rd, according to the above-mentioned blender compact overall structure, ingenious in design of the present invention, it is easy to operation and quality control, second phase
Using magnetic nano-particle as accelerate mixing intermediate be easily obtained, it is with low cost, at the same can give full play to again its with it is many
The efficient mixed effect between fluid is planted, finally obtain liquid directly can cause magnetic nano-particle by external magnetic field
It is deposited in bottom and realizes the separation with mixing liquid, is therefore particularly suitable for the occasion of large-scale industrial application.
Brief description of the drawings
Fig. 1 is the overall structure diagram of the micro-fluidic flash mixer according to exemplary display of the invention；
In all of the figs, identical reference is used for representing identical element or structure, wherein：
The coil 5- second entrance 6- first entrances 7- of 1- first coils 2- the second coil 3- tertiary coils 4- the 4th
3rd entrance 8- hybrid channel 9- are exported
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.As long as in addition, technical characteristic involved in each embodiment of invention described below
Not constituting conflict each other can just be mutually combined.
Fig. 1 is the overall structure diagram of the micro-fluidic flash mixer according to exemplary display of the invention, such as institute in Fig. 1
Show, if the micro-fluidic flash mixer including first entrance 6, second entrance 5, the 3rd entrance 7, outlet 9, hybrid channel 8 with
And multiple coil group units (the exemplary structure for showing 2 coil group units in figure), these components will one by one be entered below
Row specific explanations explanation.
First, the hybrid channel for conveying and mixing different fluid is arranged in along the x-axis horizontal direction shown in Fig. 1
8, and the horizontal both sides of hybrid channel 8 are each disposed with first entrance 6 and outlet 9.It is specific and, wherein the first entrance 6 is used
In the magnetic nano-particle (average grain diameter is preferably 10nm~100nm) of injection for example ferroso-ferric oxide, and make it along described
Hybrid channel motion via outlet 8 until export.In addition, second entrance 5, the 3rd entrance 7 are symmetrical arranged relative to first entrance 6
Both sides above and below it, the two entrances are respectively used to inject a kind of fluid to be mixed, and two kinds of fluids can for example exist via branch pipe
Close on the first entrance 6 nearby to cross to the hybrid channel, continue to move until via going out then along this hybrid channel
Mouth 8 is exported；In addition, set the direction vertical with above-mentioned x-axis as y-axis, the plane definition that x-axis and y-axis are collectively constituted is p, above-mentioned the
One entrance, second entrance, the 3rd entrance, outlet and hybrid channel are arranged in same plane p.
Where key improvements as the present invention, axis side of the multiple coil group unit along the hybrid channel 8
To and be sequentially arranged and be completely in the same plane p, wherein each coil group unit is described mixed by being arranged horizontally in
Close first coil and the second coil above passage axis and be equally arranged horizontally in below the hybrid channel axis the
Three-winding and the 4th coil composition, and each phase between first coil and the 4th coil, between the second coil and tertiary coil
It is arranged symmetrically for the hybrid channel axis above and below；For more sectional drawing, as shown in exemplary in Fig. 1, first coil group list
Member includes first coil 1, the second coil 2, the coil 4 of tertiary coil 3 and the 4th, and the first coil 1, the level of the second coil 2
Above the axis for being arranged in hybrid channel, the 4th coil 4 and tertiary coil 3 are equally arranged horizontally under the axis of hybrid channel
It is arranged symmetrically between side, the coil 4 of first coil 1 and the 4th relative to hybrid channel axis above and below, the second coil 2 and the 3rd line
It is same between circle 3 to be arranged symmetrically relative to hybrid channel axis above and below；Similarly, the second coil group unit includes first coil
1 ', second coil 2 ', tertiary coil 3 ' and the 4th coil 4 ', and the first coil 1 ', the second coil 2 ' be arranged horizontally in it is mixed
Above the axis for closing passage, the 4th coil 4 ' and tertiary coil 3 ' are equally arranged horizontally in below the axis of hybrid channel, the
It is arranged symmetrically between one coil 1 ' and the 4th coil 4 ' relative to hybrid channel axis above and below, the second coil 2 ' and tertiary coil
It is same between 3 ' to be arranged symmetrically relative to hybrid channel axis above and below.
In addition, for each coil group, when performing fluid married operation, its first coil is used to be passed through predetermined frequency
The alternating current of rate and amplitude, second coil be used to being passed through identical with the first coil frequency and amplitude and phase it is advanced or
The alternating current of quadrature lagging, the tertiary coil be used to being passed through identical with second coil frequency and amplitude and phase it is advanced or
The alternating current of quadrature lagging, and the 4th coil is then used to be passed through identical with the tertiary coil frequency and amplitude and phase is super
Preceding or quadrature lagging alternating current.In this way, based on Faraday's electromagnetic induction law, each coil will be around it
Space produces magnetic field, and causes also produce mixed magnetic field in plane p residing for hybrid channel, due to using above-mentioned arrangement, works as line
When circle alternating current is changed with certain frequency, each coil also becomes in magnetic field intensity caused by microring array channel plane
Change；On the one hand, when four coils are passed through variable-current as previously described, the microring array channel plane that four coils are enclosed can be produced
Rotating excitation field region, and magnetic nano-particle injects via first entrance 6 and when moving to this rotating excitation field region, can be applied at it
Plus magnetic couple moment loading under produce rotary motion, this rotary motion further can be effectively driven via second entrance 5 and the 3rd
Fusion between two kinds of different liquids that entrance 7 injects, so as to accelerate the change of its hybrid directional circumferentially；On the other hand,
Due to being also sequentially arranged multiple above-mentioned rotating excitation field regions along the flow direction of microring array passage, operation can not be accordingly influenceed
On the premise of according to demand flexibly, easily carry out rotating excitation field quantity adjustment so that in longer distance and scope obtain
High-quality mixing effect of fluid.
The present invention is also further to influenceing some key index parameters such as coil-span, magnetic Nano of above-mentioned working mechanism
Mixing ratio, movement rate of particle and fluid etc. have been made research and designed.
According to a preferred embodiment of the present invention, for each coil of the coil group unit, it is passed through
The frequency of alternating current be preferably set to 60Hz, its amplitude is preferably set to 1A.According to another preferred reality of the present invention
Example is applied, the mixing ratio decision design between the magnetic nano-particle and described two fluids is as follows：The matter of magnetic nano-particle
Amount：The μ g of μ g of the cumulative volume of two kinds of fluids=10~25：1μl.
Actual test shows that above-mentioned Optimal Parameters design can ensure that the whole fluid mixed system based on rotary magnetic field domain is held
Row is more effective, efficient operation processing, is particularly each horizontal coil relative to the spacing of hybrid channel and directly affects
To mixing efficiency and quality, and because above-mentioned coil may be designed as the microstructure that is integrated on micro-fluidic chip in itself,
It can be prepared using MEMS technology, not only total system volume very little, and it is i.e. achievable larger to only need to less driving electric energy
Driving force, thus be easy to actual industrialized manufacture and use.
According to the another preferred embodiment of the present invention, the two kinds of fluids injected via the second entrance, the 3rd entrance
After crossing in the hybrid channel, preferably continue to move with 40 μm/s~100 μm/s speed.In addition, the magnetic nano particle
After the sub mixture with described two fluids is exported via the outlet, preferably directly acted on using external magnetic field and magnetic is received
Rice corpuscles is precipitated, and thus completes the separation between fluid.
To sum up, according to the above-mentioned blender compact overall structure, ingenious in design of the present invention, it is easy to operation and quality control,
It is with low cost wherein by using magnetic nano-particle as accelerating the intermediate of mixing to be easily obtained, while can fully send out again
Its efficient mixed effect between multiple fluid is waved, finally obtain liquid directly can cause magnetic by external magnetic field
Nano-particle is deposited in bottom and realizes the separation with mixing liquid, is therefore particularly suitable in for example chemistry or biomedicine
The large-scale industrial application occasion of medicine mixing application etc.
As it will be easily appreciated by one skilled in the art that the foregoing is merely illustrative of the preferred embodiments of the present invention, it is not used to
The limitation present invention, any modifications, equivalent substitutions and improvements made within the spirit and principles of the invention etc., it all should include
Within protection scope of the present invention.
Claims (7)
1. a kind of micro-fluidic flash mixer based on copline coil group, the micro-fluidic flash mixer includes first entrance
(6), second entrance (5), the 3rd entrance (7), outlet (9), hybrid channel (8) and multiple coil group units, it is characterised in that：
The first entrance (6), outlet (9) are separately positioned on the horizontal both sides of the hybrid channel (8), the wherein first entrance
(6) it is used to inject magnetic nano-particle, and it is moved along the hybrid channel until via outlet (8) export；Institute
State second entrance (5), the 3rd entrance (7) and be symmetricly set on its both sides up and down, the two entrances point relative to the first entrance
A kind of fluid to be mixed Yong Yu not be injected, two kinds of fluids cross to the hybrid channel via branch pipe, then along this mixing
Passage continues to move until via outlet (8) export；In addition, above-mentioned first entrance, second entrance, the 3rd entrance, outlet
It is arranged in same plane p with hybrid channel；
Axis direction of the multiple coil group unit along the hybrid channel (8) and be sequentially arranged and be completely in described same
In one plane p, wherein each coil group unit by the first coil (1) being arranged horizontally in above the hybrid channel axis and
Second coil (2) and the tertiary coil (3) and the 4th coil (4) being equally arranged horizontally in below the hybrid channel axis
Composition, and between the first coil (1) and the 4th coil (4), between second coil (2) and tertiary coil (3) respectively
It is arranged symmetrically from relative to the hybrid channel axis above and below；In addition, when performing fluid married operation, the first coil
(1) it is used for the alternating current for being passed through preset frequency and amplitude, second coil (2) is used to be passed through and the first coil same frequency
Rate and amplitude and phase be advanced or alternating current of quadrature lagging, and the tertiary coil (3) is used to be passed through and the second coil phase
Same frequency and amplitude and phase be advanced or alternating current of quadrature lagging, and the 4th coil (4) is then used to being passed through and described the
The identical frequency of three-winding and amplitude and phase be advanced or alternating current of quadrature lagging.
2. a kind of micro-fluidic flash mixer based on copline coil group as claimed in claim 1, it is characterised in that described
Magnetic nano-particle is preferably ferroso-ferric oxide material.
3. a kind of micro-fluidic flash mixer based on copline coil group as claimed in claim 1 or 2, it is characterised in that
For each coil of the coil group unit, the frequency of its alternating current being passed through is preferably set to 60Hz, its
Amplitude is preferably set to 1A.
4. a kind of micro-fluidic flash mixer based on copline coil group as described in claim 1-3 any one, it is special
Levy and be, the first coil, the second coil are preferably designed to 1mm~3mm relative to the spacing of the hybrid channel.
5. a kind of micro-fluidic flash mixer based on copline coil group as claimed in claim 4, it is characterised in that via
After two kinds of fluids that the second entrance, the 3rd entrance are injected cross in the hybrid channel, preferably with the μ of 40 μm/s~100
M/s speed continues to move.
6. a kind of micro-fluidic flash mixer based on copline coil group as described in claim 4 or 5, it is characterised in that
Mixing ratio decision design between the magnetic nano-particle and described two fluids is as follows：The quality of magnetic nano-particle：Two
The μ g of μ g of the cumulative volume of kind of fluid=10~25：1μl.
7. a kind of micro-fluidic flash mixer based on copline coil group as claimed in any one of claims 1 to 6, it is special
Levy and be, after the mixture of the magnetic nano-particle and described two fluids is exported via the outlet, preferably directly use
External magnetic field, which is acted on, make it that magnetic nano-particle is precipitated, and thus completes the separation between fluid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610979759.8A CN107029612A (en) | 2016-11-08 | 2016-11-08 | A kind of micro-fluidic flash mixer based on copline coil group |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610979759.8A CN107029612A (en) | 2016-11-08 | 2016-11-08 | A kind of micro-fluidic flash mixer based on copline coil group |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108211960A (en) * | 2018-01-22 | 2018-06-29 | 昆明理工大学 | It is a kind of to be adjusted by the controllable of medium of magnetic liquid than microfluidic mixer device |
| CN109499460A (en) * | 2018-10-31 | 2019-03-22 | 华中科技大学 | A kind of micro mixing device based on PCB |
| CN111318218A (en) * | 2018-12-14 | 2020-06-23 | 深圳先进技术研究院 | Microfluidic device and methods of making and using the same |
| CN111693408A (en) * | 2020-05-14 | 2020-09-22 | 东南大学 | Magnetic nanoparticle control device based on coil micro-control structure |
| CN114112826A (en) * | 2021-11-25 | 2022-03-01 | 天津大学 | Acousto-optic interconnection microfluidic detection system and detection method for fluorescent particles |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4080663A (en) * | 1976-03-09 | 1978-03-21 | Wik G | Magnetic stirrer |
| CN1779430A (en) * | 2004-11-23 | 2006-05-31 | 三星电子株式会社 | Microfluidic device, and methods of mixing sample and lysing cells using it |
| EP2105202A1 (en) * | 2008-03-28 | 2009-09-30 | Stichting Dutch Polymer Institute | Apparatus and method for a microfluidic mixer and pump |
| TW201043962A (en) * | 2009-06-11 | 2010-12-16 | Nat Pingtung University Of Science & Techno Logy | Miniature magnetic fluid mixer |
-
2016
- 2016-11-08 CN CN201610979759.8A patent/CN107029612A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4080663A (en) * | 1976-03-09 | 1978-03-21 | Wik G | Magnetic stirrer |
| CN1779430A (en) * | 2004-11-23 | 2006-05-31 | 三星电子株式会社 | Microfluidic device, and methods of mixing sample and lysing cells using it |
| EP2105202A1 (en) * | 2008-03-28 | 2009-09-30 | Stichting Dutch Polymer Institute | Apparatus and method for a microfluidic mixer and pump |
| TW201043962A (en) * | 2009-06-11 | 2010-12-16 | Nat Pingtung University Of Science & Techno Logy | Miniature magnetic fluid mixer |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108211960A (en) * | 2018-01-22 | 2018-06-29 | 昆明理工大学 | It is a kind of to be adjusted by the controllable of medium of magnetic liquid than microfluidic mixer device |
| CN108211960B (en) * | 2018-01-22 | 2023-11-21 | 昆明理工大学 | Controllable ratio-regulating micro-flow mixer using magnetic liquid as medium |
| CN109499460A (en) * | 2018-10-31 | 2019-03-22 | 华中科技大学 | A kind of micro mixing device based on PCB |
| CN109499460B (en) * | 2018-10-31 | 2020-07-28 | 华中科技大学 | Micro-mixing device based on PCB |
| CN111318218A (en) * | 2018-12-14 | 2020-06-23 | 深圳先进技术研究院 | Microfluidic device and methods of making and using the same |
| CN111318218B (en) * | 2018-12-14 | 2022-01-28 | 深圳先进技术研究院 | Microfluidic device and methods of making and using the same |
| CN111693408A (en) * | 2020-05-14 | 2020-09-22 | 东南大学 | Magnetic nanoparticle control device based on coil micro-control structure |
| CN111693408B (en) * | 2020-05-14 | 2022-04-05 | 东南大学 | Magnetic nanoparticle control device based on coil micro-control structure |
| CN114112826A (en) * | 2021-11-25 | 2022-03-01 | 天津大学 | Acousto-optic interconnection microfluidic detection system and detection method for fluorescent particles |
| CN114112826B (en) * | 2021-11-25 | 2024-04-19 | 天津大学 | Acousto-optic interconnection microfluidic detection system and detection method for fluorescent particles |
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Application publication date: 20170811 |