CN102513014B - Magnetic stirring chaotic mixing method for laminar flow in microfluidic system and device thereof - Google Patents
Magnetic stirring chaotic mixing method for laminar flow in microfluidic system and device thereof Download PDFInfo
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- CN102513014B CN102513014B CN201110413965.XA CN201110413965A CN102513014B CN 102513014 B CN102513014 B CN 102513014B CN 201110413965 A CN201110413965 A CN 201110413965A CN 102513014 B CN102513014 B CN 102513014B
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Abstract
The invention discloses a magnetic stirring chaotic mixing method for the laminar flow in a microfluidic system and a device thereof. The rotary vortex generation, the vortex magnitude and rotation direction in a mixing chamber can be indirectly controlled by utilizing a sequential rotating magnetic field generated by a miniature polyphase magnetic field sequential generator to control the motion of a miniature magnetic stirrer bar in the mixing chamber on the outside of the mixing chamber of a microfluidic chip. The bottom of the miniature polyphase magnetic field sequential generator is provided with a sliding dolly freely sliding in a slide way, the position of the rotation magnetic field is displaced through the resultant force of the attractive force of an electromagnet to a permanent magnet and the elastic force of a miniature spring, the overall rotation position of the stirrer bar in the mixing chamber is displaced through controlling the overall displacement of the bottom electromagnetic field, and multistage chaotic convection is rapidly formed in the stirring (mixing) chamber by utilizing the rapid change of the rotation position of the stirrer bar and the fluid rotation inertia, so the full liquid mixing is guaranteed, and a problem that the microscale liquid is difficult to effectively mix because of the laminar flow is solved.
Description
Technical field
The present invention relates to mixing arrangement and the method for laminar flow in a kind of microfluidic system, the fluid in Microfluidic Mixing chamber is realized and being mixed.
Background technology
Mixing is a physical process, its objective is the homogeneous branch of the different component of realizing participation process.Mixing is that any chemistry and biochemical reaction are the most basic, is also essential operation.In meta system, mix and conventionally by convection current, complete.In micro-fluidic chip, the physical dimension of system is less than hundreds of micron conventionally, fluid Reynolds number under micro-meter scale very little (
re ≈ 0.1～100), turbulent flow can not occur and mix, fluid is laminar condition completely and flows, and mixing can only be undertaken by diffusion.Therefore, when the liquid layer thickness of microfluid is greater than typical diffusion length, mix effectively and quickly and be difficult to realize by diffusion, fast or the fluid that contains low diffusion coefficient solable matter of flow velocity particularly, it is a quite slow process that diffusion mixes, and needs time enough and connect interfacial area just to reach mixing completely.For the In Microfluidic Analytical Systems that chemical reaction occurs, if mix not exclusively reaction, also can not complete, now incorporation time and mixing efficiency become the bottleneck of whole system analysis time and effect.The rapid mixing of therefore, how to carry out fluid under minute yardstick is the important topic of microfluidic system always.
At present, according to microfluid mixer multi-form, different principle, be broadly divided into two kinds of active blender and passive mixing devices.Passive mixing device is simple in structure, but hybrid channel that need to be longer, and mixed process is uncontrollable; Active mixer structure is complicated, the mixed effect that shorter passage just can reach, and mixed process is controlled.2004, Kee, waited and has designed a kind of micro-mixer that drives micro-magnetic stirring bar to mix with outside rotating excitation field, and this blender forms eddy current by the stirring of miniature stirring rod, thereby has greatly improved mixing efficiency.But its structure is comparatively complicated, and micron order stirring rod intermediate demand is made hollow, and through fixed axis, it is extremely difficult and need comparatively complicated rotating magnetic field generator that this makes to make this structure of processing under micron order.In addition, complicated internal structure also makes the easy fouling of chip, and is difficult to effective cleaning.
Summary of the invention
The object of the invention is to propose a kind of processing simple in structure, easy, less scaling microfluidic system laminar flow magnetic agitation chaotic mixing device in order to solve problem that the liquid in microfluidic system in above-mentioned prior art is difficult to effectively to mix due to laminar flow, the present invention also provides a kind of mixed method of the good mixing effect based on this device simultaneously.
The technical scheme that microfluidic system laminar flow magnetic agitation chaotic mixing device of the present invention adopts is: in the mixing chamber of micro-fluidic chip, be placed with miniature magnetic stirrer, mixing chamber bottom arranges that top is affixed on or near the miniature heterogeneous magnetic field timing sequencer of mixing chamber bottom surface, miniature heterogeneous magnetic field timing sequencer is comprised of with the heterogeneous minitype electromagnet group that is fixedly connected with described cylinder top a cylinder perpendicular to mixing chamber; Affixed permanent magnet one end, cylinder middle part, permanent magnet right opposite is provided with electromagnet, and the fixed terminal of the affixed chute of electromagnet top, arranges microsprings between permanent magnet and electromagnet; Cylinder bottom is fixed in the sliding machine in chute, and the trend of chute is consistent to the direction of mixing chamber outlet with mixing chamber inlet; The monomer electromagnet that described heterogeneous minitype electromagnet group is all embedded in described cylinder top outer one circle by several forms, and each monomer electromagnet is comprised of electromagnet ontology and the copper wire on electromagnet ontology; Described electromagnet connects controller by the first regulated power supply and the first switch, between controller and each copper wire, be all connected in series gauge tap, all gauge taps all and connect the second adjustable power supply, each copper wire is all parallel to the both positive and negative polarity of the second regulated power supply, and the second adjustable power supply connects controller.
The technical scheme that the chaotic mixing method of above-mentioned microfluidic system laminar flow magnetic agitation chaotic mixing device adopts is to comprise the steps: 1) controller control electromagnet to the size of making a concerted effort between permanent magnet attraction and microsprings elastic force to move the operating position of heterogeneous magnetic field timing sequencer, 2) miniature heterogeneous magnetic field timing sequencer is located adjacent to the primary importance place of mixing chamber inlet, controller output timing control signal, first by gauge tap, control one of them monomer electromagnet open-minded, then close this monomer electromagnet and open an adjacent monomer electromagnet simultaneously, close again subsequently this adjacent monomer electromagnet and open another adjacent successively monomer electromagnet simultaneously, so repeat, until a conducting of all monomer electromagnet is with to close quick switching complete, miniature magnetic stirrer is along with the switching direction rotation of heterogeneous minitype electromagnet group, thereby place has formed eddy current in primary importance, 3) after swirl stabilization, miniature heterogeneous magnetic field timing sequencer is moved to second place place from primary importance, miniature magnetic stirrer is also followed miniature heterogeneous magnetic field timing sequencer and is come second place place, by controller output timing control signal, sequentially switch fast the conducting of each monomer electromagnet in heterogeneous minitype electromagnet group and close again, thereby having formed eddy current at second place place, 4) miniature heterogeneous magnetic field timing sequencer continues, toward the 3rd position motion or more position motion afterwards, to repeat the step that each position forms eddy current, thereby form multistage chaotic advection mixed effect at whole mixing chamber inner chamber.
The present invention is based on micro-magnetic agitation eddy current control principle, by the sequential rotating excitation field of a kind of novelty of mixing chamber outer setting at micro-fluidic chip, and by electromagnet, the size of making a concerted effort between the attraction of permanent magnet and microsprings elastic force is carried out to displacement to the position of rotating excitation field, by the global displacement to bottom electrical magnetic field, control the global displacement of realizing stirrer position of rotation in mixing chamber, controlling sequential rotating excitation field moves and controls the miniature magnetic stirrer in mixing chamber, utilize the quick variation of stirrer position of rotation and the rotatory inertia of fluid, can in teeter chamber, form fast Multistage Chaotic convection current, thereby indirectly realize the generation to rotating vortex in mixing chamber, the size of eddy current and the control of direction of rotation, the Multistage Chaotic of realizing flow field mixes, guarantee that liquid mixes fully.Compare with technology with existing method, tool has the following advantages:
1, microfluidic system laminar flow chaotic mixing method of the present invention, has solved the hybrid channel that passive mixer need to be longer and just can complete a difficult problem for mixing, has simplified the body construction of micro-fluidic chip.
2, the chaotic mixing method of microfluidic system laminar flow of the present invention, by a kind of control method of sequential rotating excitation field, realized the control of stirrer whipping process, compare with existing miniature magnetic stirring means, this stirring means does not need to process meticulous stirrer, the corrosion-resistant ferromagnetic material of common micron order, greatly reduces difficulty of processing.
3, microfluidic system laminar flow chaotic mixing method of the present invention, by a kind of control method of sequential rotating excitation field, realized the control of stirrer whipping process, compare with existing miniature magnetic stirring means, the miniature stirrer relating to can free migration and less scaling in mixing chamber, a difficult problem that has solved the easy fouling of existing fixing rotary miniature magnetic stirring means and be difficult to clean.
4, microfluidic system laminar flow chaotic mixing device of the present invention, relate to a kind of miniature heterogeneous magnetic field timing sequencer, by SECO and Current Control, can be easy to magnetic field size that control generator produces and the direction that rotatablely moves of stirrer, control method is simply effective.
5, microfluidic system laminar flow chaotic mixing device of the present invention, relates to a kind of absorption type displacement and controls dolly, for controlling the position of miniature heterogeneous magnetic field timing sequencer, thereby guarantees the Multistage Chaotic flow field that miniature magnetic stirrer produces.Multistage Chaotic flow field can be that the liquid that Reynolds number is little is realized good mixed effect in the short period of time.
6, microfluidic system laminar flow chaotic mixing device of the present invention, can realize the control of flow field size, flow field direction and mixing time according to the actual conditions of liquid to be mixed by programming, and automaticity is high, can be handling good, and portable strong.
Accompanying drawing explanation
Fig. 1 is the structural representation of the magnetic agitation chaotic mixing device of microfluidic system laminar flow of the present invention;
Fig. 2 is the top view of mixing chamber 2 in Fig. 1;
Fig. 3 is that the structure of miniature heterogeneous magnetic field timing sequencer 11 in Fig. 1 connects enlarged diagram;
Fig. 4 be in Fig. 3 electromagnet group 5 overlook mounting structure schematic diagram;
Fig. 5 is the electromagnet coiling of electromagnet group 5 in Fig. 1, electromagnet 9 and the connection diagram of controller;
Fig. 6 is that the Multistage Chaotic that produces of the chaotic mixing of magnetic agitation shown in Fig. 1 device is to flow diagram;
In figure: 1. mixing chamber inlet; 2. mixing chamber; 3. mixing chamber outlet; 4. miniature magnetic stirrer; 5. heterogeneous minitype electromagnet group; 6. permanent magnet; 7. microsprings; 8. sliding machine; 9. electromagnet; 10. chute; 11. miniature heterogeneous magnetic field timing sequencers; 12. copper wires; 13. pulleys; 14 fixed terminals.
The specific embodiment
The general structure schematic diagram of microfluidic system laminar flow magnetic agitation chaotic mixing device of the present invention shown in Figure 1.Micro-fluidic chip body can be laid by chip carrier, in the mixing chamber 2 of micro-fluidic chip, place miniature magnetic stirrer 4, miniature magnetic stirrer 4 is for any irregular gengon and have enough sizes and can not run out of from mixing chamber inlet 1 or mixing chamber outlet 3.Mixing chamber 2 bottom vertical at micro-fluidic chip arrange miniature heterogeneous magnetic field timing sequencer 11, and the top of miniature heterogeneous magnetic field timing sequencer 11 is attached on mixing chamber 2 bottom surfaces or near mixing chamber 2 bottom surfaces.Miniature heterogeneous magnetic field timing sequencer 11 is comprised of a cylinder and heterogeneous minitype electromagnet group 5, and cylinder is perpendicular to mixing chamber 2, and cylinder top is fixedly connected with heterogeneous minitype electromagnet group 5, and cylinder bottom is fixedly mounted on the sliding machine 8 in chute 10.Again referring to Fig. 3, in the both sides of sliding machine 8, pulley 13 is set, thereby be limited in chute 10 and be free to slide and drive sliding machine 8 to move along chute 10 by pulley 13, the trend of chute 10 is consistent to the direction of mixing chamber outlet 3 with the mixing chamber inlet 1 of mixing chamber 2, and the side to mixing chamber outlet 3 moves up at mixing chamber inlet 1 to make sliding machine 8.
Cylinder middle part at miniature heterogeneous magnetic field timing sequencer 11 is fixedly connected with permanent magnet 6 one end, permanent magnet 6 other ends connect microsprings 7 one end, microsprings 7 other ends are fixedly connected with the fixed terminal 14 that is positioned at permanent magnet 6 right opposites, the affixed chute of fixed terminal 14 10 tops.Chute 10, microsprings 7 axis are all parallel with mixing chamber 2 bottom surfaces.On fixed terminal 14, be fixedly connected with electromagnet 9, electromagnet 9 is in the face of permanent magnet 6 settings.Or microsprings 7 two ends are enclosed within respectively on permanent magnet 6 and electromagnet 9, microsprings 7 one end are supported on miniature heterogeneous magnetic field timing sequencer 11, the other end is supported on fixed terminal 14.Like this, the manipulation of the control system that sliding machine 8 can consist of permanent magnet 6, microsprings 7 and electromagnet 9 is free to slide in chute 10, and then controls the operating position of miniature heterogeneous magnetic field timing sequencer 11.
Shown in Fig. 1-4, the monomer electromagnet that heterogeneous minitype electromagnet group 5 is all embedded in cylinder top outer one circle by several forms, and each monomer electromagnet is comprised of electromagnet ontology and the copper wire 12 that is wound on electromagnet ontology.Electromagnet ontology is the silicon steel silk that external diameter is about 200 μ m, parallels with the axis of the cylinder of miniature heterogeneous magnetic field timing sequencer 11.The external diameter of copper wire 12 is 30 μ m.Several monomer electromagnet are arranged along miniature heterogeneous magnetic field timing sequencer 11 Yi Quan intervals, upper end.The present invention is preferably: the cross section of timing sequencer 11 upper ends, heterogeneous magnetic field is circular, and in heterogeneous minitype electromagnet group 5, having quantity is that 5-8 monomer electromagnet arranged evenly and at intervals along the circumferencial direction of timing sequencer 11 upper ends, heterogeneous magnetic field.
The processing method of miniature heterogeneous magnetic field timing sequencer 11 can adopt the organic materials such as dimethyl siloxane (PDMS) with reference to the processing method of micro-fluidic chip, by method of molding, makes.
Referring to Fig. 4-5, electromagnet 9 connects controller by the first regulated power supply and the first switch, controller is controlled the size of electromagnet 9 electric currents by the first regulated power supply, thereby the attraction of 9 pairs of permanent magnets 6 of regulating magnet, by controlling the big or small operating position of finely tuning miniature heterogeneous magnetic field timing sequencer 11 of making a concerted effort between attraction and microsprings 7 elastic force.Between controller and each copper wire 12, be all connected in series gauge tap, all gauge taps all and connect the second adjustable power supply, each copper wire 12 is all parallel to the both positive and negative polarity of the second regulated power supply, the second adjustable power supply connects controller, controller can be controlled the open-minded of each monomer electromagnet chronologically by the second adjustable power supply and corresponding gauge tap, the generation of controlling magnetic field and the size in magnetic field, thereby rotary speed and the direction of rotation of the miniature magnetic stirrer 4 in control mixing chamber 2.
Referring to Fig. 1, 4, 5 and Fig. 6 shown in, when the magnetic agitation chaotic mixing device of microfluidic system laminar flow of the present invention is worked, liquid flows into mixing chamber 2 by the mixing chamber inlet 1 of micro-fluidic chip, the close mixing chamber inlet 1 primary importance place that attraction and make a concerted effort large young pathbreaker position microsprings 7 elastic force between of miniature heterogeneous magnetic field timing sequencer 11 by 9 pairs of permanent magnets 6 of electromagnet is positioned mixing chamber 2, this Time Controller output timing control signal, first by gauge tap, control one of them monomer electromagnet open-minded, then close this monomer electromagnet and open an adjacent monomer electromagnet simultaneously, close again subsequently this adjacent monomer electromagnet and open another adjacent successively monomer electromagnet simultaneously, so repeat, until a conducting of all monomer electromagnet is with to close quick switching complete, once switch fast the conducting of each monomer electromagnet in heterogeneous minitype electromagnet group 5 and close, make miniature magnetic stirrer 4 along with the switching direction of heterogeneous minitype electromagnet group 5 carries out rotation at a high speed, thereby place has formed eddy current in primary importance.After swirl stabilization, miniature heterogeneous magnetic field timing sequencer 11 is positioned next second place place by the attraction of 9 pairs of permanent magnets 6 of electromagnet and the size of making a concerted effort between microsprings 7 elastic force from primary importance, now because the sequential electromagnetic field of miniature heterogeneous magnetic field timing sequencer 11 is not closed, so miniature magnetic stirrer 4 is also followed miniature heterogeneous magnetic field timing sequencer 11 and is come second place place, by controller output timing control signal, switch fast the conducting of each monomer electromagnet in heterogeneous minitype electromagnet group 5 and close again, after so repeating, miniature heterogeneous magnetic field timing sequencer 11 continues toward the 3rd position motion or more position motion afterwards, repeat the step that each position forms eddy current, thereby formed multistage chaotic advection mixed effect at whole mixing chamber 2 inner chambers.
In order further to set forth mixed method of the present invention, 7 the monomer electromagnet of take are below illustrated as example, referring to Fig. 4-6, these 7 monomer electromagnet are respectively monomer electromagnet A, B, C, D, E, F, G, all evenly be embedded in the top outer of cylinder 11, monomer electromagnet A, B, C, D, E, F, G is all parallel to the both positive and negative polarity of the second regulated power supply, controller is by changing monomer electromagnet A, B, C, D, E, F, the output current size of the switching sequence of the power supply of G and the second regulated power supply can be easy to change magnetic field rotating direction and the magnetic field size above miniature heterogeneous magnetic field timing sequencer 11.First, liquid flows into mixing chamber 2 by the mixing chamber inlet 1 of micro-fluidic chip, and miniature heterogeneous magnetic field timing sequencer 11 is positioned the U place in Fig. 6 by the attraction of 9 pairs of permanent magnets 6 of electromagnet and the large young pathbreaker position of making a concerted effort between microsprings 7 elastic force.By gauge tap, control monomer electromagnet A open-minded, then close monomer electromagnet A and open monomer electromagnet B simultaneously, close subsequently monomer electromagnet B and open monomer electromagnet C, until close monomer electromagnet F and open monomer electromagnet G, so once switch fast the conducting of 7 monomer electromagnet in heterogeneous minitype electromagnet group 5 and close, make miniature magnetic stirrer 4 along with the switching direction of heterogeneous minitype electromagnet group 5, carry out rotation at a high speed, thereby formed eddy current at U place.After swirl stabilization, miniature heterogeneous magnetic field timing sequencer 11 is positioned V place by the attraction of 9 pairs of permanent magnets 6 of electromagnet and the large young pathbreaker position of making a concerted effort between microsprings 7 elastic force, now because the sequential electromagnetic field of miniature heterogeneous magnetic field timing sequencer 11 is not closed, so miniature magnetic stirrer 4 is also followed miniature heterogeneous magnetic field timing sequencer 11 and is come V place, now due to 7 monomer electromagnet in heterogeneous minitype electromagnet group 5 still according to the order of monomer electromagnet A → B → C → D → E → F → G successively conducting make miniature magnetic stirrer 4 continue according to originally rotatably direction be rotated, the whirlpool now forming is as shown in the V of Fig. 6, because there is certain inertia in flow field, originally the whirlpool at U place can't disappear at once, now the whirlpool at the whirlpool at V place and U place has formed chaotic advection at the overlapping place of central authorities in U and V region.When chaotic advection disappears, and be positioned at after the swirl stabilization at V place, miniature heterogeneous magnetic field timing sequencer 11 is positioned W place by the attraction of 9 pairs of permanent magnets 6 of electromagnet and the large young pathbreaker position of making a concerted effort between microsprings 7 elastic force, now because the sequential electromagnetic field of miniature heterogeneous magnetic field timing sequencer 11 is not closed, so miniature magnetic stirrer 4 is also followed miniature heterogeneous magnetic field timing sequencer 11 and is come W place, now because 7 monomer electromagnet still make miniature magnetic stirrer 4 stir at W place according to the order of monomer electromagnet A → B → C → D → E → F → G, and formed chaotic advection at the overlapping place of central authorities in V and W region.Then, miniature heterogeneous magnetic field timing sequencer 11 continues toward the next position motion, thereby has formed multistage chaotic advection mixed effect.According to the feature of liquid to be mixed, can be by the parameters such as progression to magnetic field working time, magnetic field size and the chaotic mixing of the miniature heterogeneous magnetic field of controller programming setting timing sequencer 11.
Claims (5)
1. a microfluidic system laminar flow magnetic agitation chaotic mixing method, liquid flows into mixing chamber (2) by the mixing chamber inlet (1) of micro-fluidic chip, it is characterized in that comprising the steps:
1) controller is controlled electromagnet (9) to the operating position of size with the heterogeneous magnetic field of mobile micro timing sequencer (11) of making a concerted effort between permanent magnet (6) attraction and microsprings (7) elastic force;
2) miniature heterogeneous magnetic field timing sequencer (11) is located adjacent to the primary importance place of mixing chamber inlet (1), controller output timing control signal, first by gauge tap, control one of them monomer electromagnet open-minded, then close this monomer electromagnet and open an adjacent monomer electromagnet simultaneously, close again subsequently this adjacent monomer electromagnet and open another adjacent successively monomer electromagnet simultaneously, so repeat, until a conducting of all monomer electromagnet is with to close quick switching complete, miniature magnetic stirrer (4) is along with the switching direction rotation of heterogeneous minitype electromagnet group (5), thereby place has formed eddy current in primary importance,
3) after swirl stabilization, miniature heterogeneous magnetic field timing sequencer (11) is moved to second place place from primary importance, miniature magnetic stirrer (4) is also followed miniature heterogeneous magnetic field timing sequencer (11) and is come second place place, by controller output timing control signal, sequentially switch fast the conducting of each monomer electromagnet in heterogeneous minitype electromagnet group (5) and close again, thereby forming eddy current at second place place;
4) miniature heterogeneous magnetic field timing sequencer (11) continues, toward the 3rd position motion or more position motion afterwards, to repeat the step that each position forms eddy current, thereby form multistage chaotic advection mixed effect at whole mixing chamber (2) inner chamber.
2. magnetic agitation chaotic mixing method according to claim 1, is characterized in that: controller is set magnetic field working time, magnetic field size and the multistage progression of chaos of miniature heterogeneous magnetic field timing sequencer (11) by programming; The size that controller is controlled electromagnet (9) electric current by the first regulated power supply is the attraction to permanent magnet (6) with regulating magnet (9), controller is by the second adjustable power supply and the corresponding generation of gauge tap controlling magnetic field and the size in magnetic field, thus rotary speed and the direction of rotation of the miniature magnetic stirrer (4) in control mixing chamber (2).
3. a device of realizing chaotic mixing method described in claim 1, in the mixing chamber of micro-fluidic chip (2), be placed with miniature magnetic stirrer (4), it is characterized in that: mixing chamber (2) bottom arranges that top is affixed on or near the miniature heterogeneous magnetic field timing sequencer (11) of mixing chamber (2) bottom surface, miniature heterogeneous magnetic field timing sequencer (11) is comprised of with the heterogeneous minitype electromagnet group (5) that is fixedly connected with described cylinder top a cylinder perpendicular to mixing chamber (2); Affixed permanent magnet (6) one end, cylinder middle part, permanent magnet (6) right opposite is provided with electromagnet (9), and the fixed terminal (14) of the affixed chute of electromagnet (9) (10) top, arranges microsprings (7) between permanent magnet (6) and electromagnet (9); Cylinder bottom is fixed in the sliding machine (8) in chute (10), and the trend of chute (10) is consistent to the direction of mixing chamber outlet (3) with mixing chamber inlet (1); The monomer electromagnet that described heterogeneous minitype electromagnet group (5) is all embedded in described cylinder top outer one circle by several forms, and each monomer electromagnet is comprised of electromagnet ontology and the copper wire (12) on electromagnet ontology; Described electromagnet (9) connects controller by the first regulated power supply and the first switch, between controller and each copper wire (12), be all connected in series gauge tap, all gauge taps all and connect the second adjustable power supply, each copper wire (12) is all parallel to the both positive and negative polarity of the second regulated power supply, and the second adjustable power supply connects controller.
4. device according to claim 3, it is characterized in that: the cross section of described miniature heterogeneous magnetic field timing sequencer (11) upper end is for circular, and having quantity is that 5-8 monomer electromagnet arranged evenly and at intervals along the circumferencial direction of miniature heterogeneous magnetic field timing sequencer (11) upper end.
5. device according to claim 3, is characterized in that: described electromagnet ontology be parallel with the axis of described cylinder, external diameter is the silicon steel silk of 200 μ m, the external diameter of described copper wire (12) is 30 μ m.
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| CN102861526B (en) * | 2012-09-17 | 2015-02-04 | 江苏大学 | Flexible magnetomotive micro-mixing method and device of micro-fluidic chip |
| CN104162379B (en) * | 2014-07-30 | 2016-03-02 | 江苏大学 | A kind of micro-fluidic chip magnetic bead chaotic mixing method and device |
| CN104492329B (en) * | 2014-11-17 | 2017-01-25 | 中国科学院力学研究所 | Micro-space volume solution magnetic granule stirring device |
| CN106179544B (en) * | 2016-07-14 | 2018-07-06 | 大连海事大学 | Portable immunomagnetic beads three-dimensional hybrid device and application method based on micro-fluidic chip |
| CN106248948B (en) * | 2016-07-14 | 2018-06-29 | 大连海事大学 | A kind of portable micro fluidic device and its application method for active immunity fluorescent marker |
| CN108057377A (en) * | 2017-11-29 | 2018-05-22 | 陈振荣 | A kind of industrial machinery for the stirring of mushroom sauce raw material |
| CN108905838A (en) * | 2018-07-18 | 2018-11-30 | 佛山市高明曦逻科技有限公司 | A kind of laminar flow agitating device and stirring means |
| CN112213174A (en) * | 2019-07-12 | 2021-01-12 | 南京岚煜生物科技有限公司 | Method for uniformly mixing magnetic materials |
| CN110228895B (en) * | 2019-07-23 | 2021-09-14 | 杭州近源环保科技有限公司 | Metal surface treatment wastewater treatment device |
| WO2021130874A1 (en) * | 2019-12-24 | 2021-07-01 | Ykk株式会社 | Electroplating device and method for manufacturing plated product |
| CN117145171A (en) * | 2022-05-24 | 2023-12-01 | 刘启业 | Intelligent paint brushing device for suspended building wall paint industry |
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| EP2105202A1 (en) * | 2008-03-28 | 2009-09-30 | Stichting Dutch Polymer Institute | Apparatus and method for a microfluidic mixer and pump |
| CN101920175A (en) * | 2010-05-26 | 2010-12-22 | 上海大学 | Method and device for modulating electromagnetic stirring and rotating magnetic field based on permanent magnet |
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| JPS60153930A (en) * | 1984-01-23 | 1985-08-13 | Imamura Seisakusho:Kk | Continuous mixing and stirring apparatus for fluid |
| WO2008098117A2 (en) * | 2007-02-08 | 2008-08-14 | Linsheng Walter Tien | Magnetic stirring devices and methods |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2105202A1 (en) * | 2008-03-28 | 2009-09-30 | Stichting Dutch Polymer Institute | Apparatus and method for a microfluidic mixer and pump |
| CN101920175A (en) * | 2010-05-26 | 2010-12-22 | 上海大学 | Method and device for modulating electromagnetic stirring and rotating magnetic field based on permanent magnet |
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