CN107027799B - Sterilization synergistic composition containing pefurazoate - Google Patents
Sterilization synergistic composition containing pefurazoate Download PDFInfo
- Publication number
- CN107027799B CN107027799B CN201710400099.8A CN201710400099A CN107027799B CN 107027799 B CN107027799 B CN 107027799B CN 201710400099 A CN201710400099 A CN 201710400099A CN 107027799 B CN107027799 B CN 107027799B
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- China
- Prior art keywords
- pefurazoate
- chinese yam
- yam polysaccharide
- synergistic composition
- composition containing
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a kind of sterilization synergistic composition containing pefurazoate, is made of Chinese yam polysaccharide and pefurazoate, and the synergy weight ratio of the Chinese yam polysaccharide and pefurazoate is 1:0.3-0.5.The present invention compounds Chinese yam polysaccharide and pefurazoate according to specific weight ratio, it has obvious synergistic function, inhibiting effect very little of the Chinese yam polysaccharide for fungi itself, its synergist mainly as pefurazoate, pefurazoate can be significantly improved to the inhibitory activity of germ, the two mixture can also reduce the use of pefurazoate, to reduce cost, reduce the residual of chemical agent.
Description
Technical field
The present invention relates to disinfectant use in agriculture application field, in particular to a kind of sterilization synergistic composition containing pefurazoate.
Background technique
Fungicide single dose due to being currently used in prevention and treatment rice blast produces different degrees of resist to Pyricularia oryzae
Pharmacological property problem, the improvement of drug resistance become the research hotspot currently paid close attention to.Solving resistance problems most straightforward approach is exactly to create
The different new type bactericide of the mechanism of action processed, but the research and development of new type bactericide take, fund throwing even longer up to 8-10
Enter and generally require billions of dollars, difficulty is big, at high cost.The mixed important means effectively administered as drug resistance of fungicide, plays the part of
More and more important role.Therefore, targetedly carrying out the mixed of fungicide has positive meaning.
By the formula for generating synergistic effect by after combined use of pesticides, have following advantages: (1) expanding prevention spectrum, prevention and treatment is simultaneously
The multiple diseases of generation；(2) difference for controlling disease infects the stage；(3) control efficiency of pesticide can be improved using synergistic effect；
(4) drug cost is reduced, or reduces the usage amount of some high price pesticide in mixed pesticide；(5) overcome the anti-medicine of old farmer's medicine
Property and delay or avoid novel pesticide drug resistance generation；(6) lead time is short；(7) development cost is low, has apparent economical
Benefit.
Chinese yam polysaccharide is the main active in Chinese yam.Chinese yam polysaccharide is mainly by mannose, xylose, arabinose, Portugal
Grape sugar and galactolipin composition.Studies have shown that Chinese yam purifies through hot water extraction, deproteinized, ethanol precipitation, SephadexG-100
Chinese yam polysaccharide, molecular weight are 8.1 × 10-4.People are concentrated mainly on following aspect for the research of Chinese yam polysaccharide at present: drop blood
Sugar, tonifying middle-Jiao and Qi, stimulation adjust the functions such as immune system, and also fewer for the research of its bacteria resistance function.
Currently, Chinese yam polysaccharide for fungi inhibiting effect and Chinese yam polysaccharide for fungicide synergistic effect also not
Seeing has research open.
Summary of the invention
The technical problem to be solved in the present invention is that providing a kind of sterilization synergistic composition containing pefurazoate, rice is significantly improved
The activity of pest ester reduces chemical pesticide dosage, the drug resistance of pathogen is delayed to generate.
It is as follows that the present invention solves the technical solution that above-mentioned technical problem is taken:
A kind of sterilization synergistic composition containing pefurazoate, is made of Chinese yam polysaccharide and pefurazoate, the Chinese yam polysaccharide and
The synergy weight ratio of pefurazoate is 1:0.3-0.5.
The sterilization synergistic composition is prepared into pesticidal preparations.
The pesticidal preparations are for preventing and treating rice blast.
The beneficial effect that the present invention has is: Chinese yam polysaccharide and pefurazoate are compounded according to specific weight ratio, are had
Apparent synergistic function, Chinese yam polysaccharide itself for fungi inhibiting effect very little, mainly as the synergy of pefurazoate
Agent can significantly improve pefurazoate to the inhibitory activity of germ, and the two mixture can also reduce the use of pefurazoate, to reduce
Cost reduces the residual of chemical agent.
Specific embodiment
Technical solution of the present invention and beneficial effect are described further combined with specific embodiments below, it is of the present invention
Percentage be mass percent.
One indoor joint toxicity measuring test
The Chinese yam polysaccharide of synergistic effect in order to illustrate to(for) pefurazoate, the present invention calculate co-toxicity coefficient using Sun Yunpei's Method
(CTC) it evaluates mixed effect.
Toxicity index TI (A)=(EC50 of the EC50 ÷ A agent of standard agent A) × 100
Toxicity index TI (B)=(EC50 of the EC50 ÷ B agent of standard agent A) × 100
Actual toxicity index ATI (AB)=(EC50 of the EC50 ÷ AB of A) × 100
Percentage+TI (B) × B percentage in mixture of theoretical toxicity index TTI (AB)=TI (the A) × A in mixture
Number
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI) ÷ mixtures theoretical toxicity index (TTI)] × 100
Evaluation criterion are as follows: co-toxicity coefficient >=120 show as synergistic effect；Co-toxicity coefficient≤80 show as antagonism；80<
Co-toxicity coefficient < 120 show as summation action.
Test method: referring to " the 8th part of NY/T1156.8-2007 farm-chemical indoor determination test rule fungicide: anti-
Control rice blast test pot-culture method " and " the 6th, NY/T1156.6-2006 farm-chemical indoor determination test rule fungicide
Point: mixed synergy measurement ".
The measurement result of fraction is as shown in the table:
As can be known from the above table, when the weight ratio of pefurazoate and Chinese yam polysaccharide is 0.3-0.5:1, co-toxicity coefficient is all larger than 120,
Show apparent synergistic function；Other ratios show simple summation action or apparent antagonism.
Two crop field test examples
In order to further illustrate beneficial effects of the present invention, applicant has also carried out multiple field medicine effect test.Below
The field experiment for enumerating part rice blast is used as explanation.
Test medicine:
1 6% Chinese yam polysaccharide pefurazoate wettable powder (4:2) of test group
Chinese yam polysaccharide 4%, pefurazoate 2%, sodium carboxymethylcellulose 10%, alkylnaphthalene sulfonate 3%, precipitated calcium carbonate
3%, kaolin supplies 100%.Raw material weighing is carried out by above-mentioned formula, is crushed after being uniformly mixed through airslide disintegrating mill, detection is closed
Lattice obtain 5% Chinese yam polysaccharide pefurazoate wettable powder.
1 6% Chinese yam polysaccharide wettable powder of control group: Chinese yam polysaccharide 6%, sodium carboxymethylcellulose 10%, alkyl naphthalene sulfonic acid
Salt 3%, precipitated calcium carbonate 3%, kaolin supplies 100%.Preparation method is the same as test group 1.
2 6% pefurazoate wettable powder of control group: pefurazoate 6%, sodium carboxymethylcellulose 10%, alkylnaphthalene sulfonate
3%, precipitated calcium carbonate 3%, kaolin supplies 100%.Preparation method is the same as test group 1.
Separately set blank control group.
Test method and drug effect calculation method: referring to " GB/T 17980.19-2000 pesticide field efficacy medicine test criterion
(1) bactericidal agent for preventing and treating rice leaf diseases ".Each plot area is 60 ㎡, and 3 repetitions are arranged, and is administered 2 times altogether, every time between application
Every 7 days.
Investigation method: 7d, 15d carry out 5 sampling surveys, the every company of taking in each cell respectively after the second application
Continuous 3 clumps, look into whole blades, and classification record incidence, calculates disease index and preventive effect as unit of blade；Test site:
Nanning.
Formula (1): disease index calculation formula:
In formula (1): X- disease index；NiThe disease numbers of sheets at different levels；I- is with respect to value of series；N- investigates total number of sheets.
Formula (2): control efficiency calculation formula:
In formula (2): P- control efficiency, unit are percentage (%)；CK0Disease index before blank district is administered；CK1-
Disease index after blank district application；PT0Disease index before chemicals treatment district is administered；PT1The state of an illness after being administered after chemicals treatment
Index.
As a result as shown in the table.
The field control effectiveness test result for preventing and treating rice blast
As seen from the above table, the composition of the invention containing Chinese yam polysaccharide and pefurazoate is in the close control of effective component dosage
It is more significantly excellent than comparison medicament to the control efficiency of rice blast in the case where medicament.7d investigation result after being administered at second
It has been shown that, control efficiency of the invention are higher than pefurazoate single dose by 13.23%；15d investigation result is shown after second of application, the present invention
Control efficiency it is higher than pefurazoate single dose by 12.71%.
Claims (3)
1. a kind of sterilization synergistic composition containing pefurazoate, which is characterized in that be made of Chinese yam polysaccharide and pefurazoate, the mountain
The synergy weight ratio of medicine polysaccharide and pefurazoate is 1:0.3-0.5.
2. sterilization synergistic composition according to claim 1, which is characterized in that the sterilization synergistic composition is prepared into
Wettable powder.
3. the application that wettable powder as claimed in claim 2 is used to prevent and treat rice blast.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710400099.8A CN107027799B (en) | 2017-05-31 | 2017-05-31 | Sterilization synergistic composition containing pefurazoate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710400099.8A CN107027799B (en) | 2017-05-31 | 2017-05-31 | Sterilization synergistic composition containing pefurazoate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107027799A CN107027799A (en) | 2017-08-11 |
| CN107027799B true CN107027799B (en) | 2019-07-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710400099.8A Expired - Fee Related CN107027799B (en) | 2017-05-31 | 2017-05-31 | Sterilization synergistic composition containing pefurazoate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107027799B (en) |
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2017
- 2017-05-31 CN CN201710400099.8A patent/CN107027799B/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 山药块茎多糖生物活性及其机理的研究;魏娜;《内蒙古农业大学硕士学位论文》;20160601;31-32 |
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| CN107027799A (en) | 2017-08-11 |
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