CN107008033B - Chromatographic column exhaust device - Google Patents
Chromatographic column exhaust device Download PDFInfo
- Publication number
- CN107008033B CN107008033B CN201710420689.7A CN201710420689A CN107008033B CN 107008033 B CN107008033 B CN 107008033B CN 201710420689 A CN201710420689 A CN 201710420689A CN 107008033 B CN107008033 B CN 107008033B
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- China
- Prior art keywords
- exhaust
- valve body
- piston plate
- piston
- air
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
Abstract
The invention relates to a chromatographic column exhaust device. A chromatography column exhaust comprising a piston plate; a plurality of piston columns are connected to the piston plate; the bottom of the piston plate is provided with an air collecting plate; a valve body is arranged in the middle of the piston plate; an exhaust chamber is arranged in the valve body; the bottom of the exhaust chamber is contracted to form an air inlet; the air inlet is arranged at the central position of the air collecting plate; a valve rod is also arranged in the exhaust chamber; the top of the valve body is fixed with an air cylinder through an air cylinder fixing seat; the cylinder is connected with the valve rod; one side of the valve body is provided with a mobile phase pipe, and the other side of the valve body is provided with an exhaust pipe; the end of the exhaust pipe is provided with an exhaust port and a cleaning port. The chromatographic column exhaust device is convenient to operate, can easily and quickly exhaust bubbles in a chromatographic column by automatic control of the air cylinder, is high in exhaust efficiency, can thoroughly exhaust the bubbles, is convenient to clean, and is convenient to disinfect and store.
Description
Technical Field
The invention relates to the field of chromatographic columns, in particular to a chromatographic column exhaust device.
Background
The existing chromatographic column with the diameter more than 300 is easy to generate bubbles during filling, is difficult to exhaust, influences the use of the chromatographic column, has a complex integral structure and heavy quality, consumes time and labor during repeated exhaust, and solves the problem of how to realize rapid exhaust.
Disclosure of Invention
In order to solve the technical problems, the invention provides the chromatographic column exhaust device which can easily and quickly exhaust bubbles in a chromatographic column, has high exhaust efficiency and is convenient to disinfect and store.
The technical scheme adopted by the invention for solving the technical problems is as follows: a chromatographic column exhaust device comprises a piston plate; a plurality of piston columns are connected to the piston plate; the bottom of the piston plate is provided with an air collecting plate; a valve body is arranged in the middle of the piston plate; an exhaust chamber is arranged in the valve body; the bottom of the exhaust chamber is contracted to form an air inlet; the air inlet is arranged at the central position of the air collecting plate; a valve rod is also arranged in the exhaust chamber; the top of the valve body is fixed with an air cylinder through an air cylinder fixing seat; the cylinder is connected with the valve rod; one side of the valve body is provided with a mobile phase pipe, and the other side of the valve body is provided with an exhaust pipe; the end of the exhaust pipe is provided with an exhaust port and a cleaning port.
The piston plate is arranged in the chromatographic column, and a sealing ring is arranged between the piston plate and the layer plate column.
The air collecting plate is provided with a taper, and the center position of the air collecting plate is slightly higher than the peripheral positions of the air collecting plate.
When the exhaust chamber is cleaned, the bottom of the valve rod is driven by the cylinder to block the air inlet, and a cleaning pipe is inserted into the cleaning port; the tail end of the cleaning pipe extends to the bottom of the exhaust chamber, and the cleaning liquid is exhausted through the exhaust port after being cleaned.
The valve body is fixed with the piston plate, and a plurality of seals are arranged between the valve body and the piston plate.
The invention has the beneficial effects that: the chromatographic column exhaust device is convenient to operate, can easily and quickly exhaust bubbles in a chromatographic column by automatic control of the air cylinder, is high in exhaust efficiency, can thoroughly exhaust the bubbles, is convenient to clean, and is convenient to disinfect and store.
Drawings
FIG. 1 is a schematic view of a chromatography column vent apparatus according to an embodiment;
FIG. 2 is a schematic view of another angle of a chromatography column vent apparatus according to an embodiment;
FIG. 3 is a partially enlarged schematic view showing a cleaning state of a gas exhaust apparatus for a chromatography column according to an embodiment.
Detailed Description
For the purpose of enhancing the understanding of the present invention, the present invention will be described in further detail with reference to the accompanying drawings and examples, which are provided for the purpose of illustration only and are not intended to limit the scope of the present invention.
Examples
As shown in fig. 1 to 3, a chromatography column vent apparatus includes a piston plate 1; a plurality of piston columns 2 are connected to the piston plate 1; the bottom of the piston plate 1 is provided with an air collecting plate 3; a valve body 4 is arranged in the middle of the piston plate 1; an exhaust chamber 8 is arranged in the valve body 4; the bottom of the exhaust chamber 8 is contracted to form an air inlet 15; the air inlet 15 is arranged at the central position of the air collecting plate 3; a valve rod 7 is also arranged in the exhaust chamber 8; the top of the valve body 4 is fixed with a cylinder 5 through a cylinder fixing seat 6; the cylinder 5 is connected with a valve rod 7; a mobile phase pipe 9 is arranged on one side of the valve body 4, and an exhaust pipe 10 is arranged on the other side; the end part of the exhaust pipe 10 is provided with an exhaust port 11 and a cleaning port 12; the piston plate 1 is arranged in the chromatographic column 13, and a sealing ring 14 is arranged between the piston plate 1 and the layer plate column 13; the air collecting plate 3 is provided with a taper, and the center position of the air collecting plate is slightly higher than the peripheral positions of the air collecting plate; when the exhaust chamber 8 is cleaned, the air cylinder 5 drives the bottom of the valve rod 7 to block the air inlet 15, and a cleaning pipe 16 is inserted into the cleaning opening 12; the tail end of the cleaning pipe 16 extends to the bottom of the exhaust chamber 8, and the cleaning liquid is discharged through an exhaust port 11 after being cleaned; the valve body 4 is fixed with the piston plate 1, and a plurality of seals are arranged between the valve body and the piston plate.
The utility model provides a chromatographic column exhaust apparatus, the piston board is down along with the piston post, and the bubble is concentrated near the air inlet through the collection of gas collection board, and gas gets into the exhaust chamber from the air inlet after, discharges from the gas vent through the blast pipe, and gaseous complete discharge back, cylinder drive valve rod plug up the air inlet downwards, then, insert the scavenge pipe to the exhaust chamber bottom along the blast pipe through the purge port, pours into 0.1M's sodium hydroxide washing pipeline, and the washing liquid is discharged from the gas vent.
The utility model provides a chromatography column exhaust apparatus, convenient operation through cylinder automatic control, can relax the bubble in the quick row's of emptying chromatography column, and exhaust efficiency is high, can thoroughly arrange the bubble, and it is convenient to wash, convenient disinfection is preserved.
The above embodiments should not limit the present invention in any way, and all technical solutions obtained by using equivalent alternatives or equivalent transformations fall within the protection scope of the present invention.
Claims (5)
1. A chromatographic column exhaust device is characterized in that: it comprises a piston plate; a plurality of piston columns are connected to the piston plate; the bottom of the piston plate is provided with an air collecting plate; a valve body is arranged in the middle of the piston plate; an exhaust chamber is arranged in the valve body; the bottom of the exhaust chamber is contracted to form an air inlet; the air inlet is arranged at the central position of the air collecting plate; a valve rod is also arranged in the exhaust chamber; the top of the valve body is fixed with an air cylinder through an air cylinder fixing seat; the cylinder is connected with the valve rod; one side of the valve body is provided with a mobile phase pipe, and the other side of the valve body is provided with an exhaust pipe; the tip of blast pipe is provided with gas vent and washing mouth, the piston board is installed in the chromatography column.
2. A chromatography column venting device according to claim 1, wherein: and a sealing ring is arranged between the piston plate and the laminate column.
3. A chromatography column venting device according to claim 1, wherein: the air collecting plate is provided with a taper, and the center position of the air collecting plate is higher than the peripheral positions of the air collecting plate.
4. A chromatography column venting device according to claim 1, wherein: when the exhaust chamber is cleaned, the bottom of the valve rod is driven by the cylinder to block the air inlet, and a cleaning pipe is inserted into the cleaning port; the tail end of the cleaning pipe extends to the bottom of the exhaust chamber, and the cleaning liquid is exhausted through the exhaust port after being cleaned.
5. A chromatography column venting device according to claim 1, wherein: the valve body is fixed with the piston plate, and a plurality of seals are arranged between the valve body and the piston plate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710420689.7A CN107008033B (en) | 2017-06-06 | 2017-06-06 | Chromatographic column exhaust device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710420689.7A CN107008033B (en) | 2017-06-06 | 2017-06-06 | Chromatographic column exhaust device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107008033A CN107008033A (en) | 2017-08-04 |
| CN107008033B true CN107008033B (en) | 2022-04-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710420689.7A Active CN107008033B (en) | 2017-06-06 | 2017-06-06 | Chromatographic column exhaust device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107008033B (en) |
Citations (10)
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| WO2007093690A1 (en) * | 2006-02-10 | 2007-08-23 | Novasep | Separating method and device |
| CN201477087U (en) * | 2009-09-01 | 2010-05-19 | 福建省福州电业局 | Fully degassing system of chromatographic high-performance overall analysis online monitoring device |
| EP2232084A1 (en) * | 2008-01-07 | 2010-09-29 | Bio-Rad Laboratories, Inc. | Piston position detection for preparative chromatography column |
| GB201020148D0 (en) * | 2010-11-29 | 2011-01-12 | Ge Healthcare Bio Sciences Ab | Chromatography column |
| JP2014006240A (en) * | 2012-05-30 | 2014-01-16 | Arkray Inc | Bubble reduction device, chromatography device, bubble reduction method, and bubble reduction program |
| CN104345112A (en) * | 2013-08-07 | 2015-02-11 | 爱科来株式会社 | LIQUID CHROMATOGRAPHY DEVICE, and LIQUID CHROMATOGRAPHY ANALYSIS method |
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| CN105158376A (en) * | 2015-08-21 | 2015-12-16 | 许继集团有限公司 | Oil-gas separation cylinder, oil-gas separation device and oil chromatography |
| CN205127464U (en) * | 2015-11-12 | 2016-04-06 | 河北智同生物制药有限公司 | Corrosion resistant multi -functional adsorption tower |
| CN206809829U (en) * | 2017-06-06 | 2017-12-29 | 利穗科技(苏州)有限公司 | A kind of chromatographic column exhaust apparatus |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0614315D0 (en) * | 2006-07-19 | 2006-08-30 | Ge Healthcare Bio Sciences Ab | Chromatography columns, systems and methods |
| US7862716B2 (en) * | 2009-04-13 | 2011-01-04 | Sielc Technologies Corporation | HPLC schematic with integrated sample cleaning system |
| GB201504695D0 (en) * | 2015-03-19 | 2015-05-06 | Biotechflow Ltd | Chromatography columns and processes |
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2017
- 2017-06-06 CN CN201710420689.7A patent/CN107008033B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007093690A1 (en) * | 2006-02-10 | 2007-08-23 | Novasep | Separating method and device |
| EP2232084A1 (en) * | 2008-01-07 | 2010-09-29 | Bio-Rad Laboratories, Inc. | Piston position detection for preparative chromatography column |
| CN201477087U (en) * | 2009-09-01 | 2010-05-19 | 福建省福州电业局 | Fully degassing system of chromatographic high-performance overall analysis online monitoring device |
| GB201020148D0 (en) * | 2010-11-29 | 2011-01-12 | Ge Healthcare Bio Sciences Ab | Chromatography column |
| JP2014006240A (en) * | 2012-05-30 | 2014-01-16 | Arkray Inc | Bubble reduction device, chromatography device, bubble reduction method, and bubble reduction program |
| CN104345112A (en) * | 2013-08-07 | 2015-02-11 | 爱科来株式会社 | LIQUID CHROMATOGRAPHY DEVICE, and LIQUID CHROMATOGRAPHY ANALYSIS method |
| CN104801066A (en) * | 2015-04-07 | 2015-07-29 | 利穗科技(苏州)有限公司 | Chromatographic column with maintenance mechanism |
| CN105158376A (en) * | 2015-08-21 | 2015-12-16 | 许继集团有限公司 | Oil-gas separation cylinder, oil-gas separation device and oil chromatography |
| CN205127464U (en) * | 2015-11-12 | 2016-04-06 | 河北智同生物制药有限公司 | Corrosion resistant multi -functional adsorption tower |
| CN206809829U (en) * | 2017-06-06 | 2017-12-29 | 利穗科技(苏州)有限公司 | A kind of chromatographic column exhaust apparatus |
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| Publication number | Publication date |
|---|---|
| CN107008033A (en) | 2017-08-04 |
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