CN1070079C - Disinfacting method for oral liquid preparation - Google Patents
Disinfacting method for oral liquid preparation Download PDFInfo
- Publication number
- CN1070079C CN1070079C CN 95107846 CN95107846A CN1070079C CN 1070079 C CN1070079 C CN 1070079C CN 95107846 CN95107846 CN 95107846 CN 95107846 A CN95107846 A CN 95107846A CN 1070079 C CN1070079 C CN 1070079C
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- CN
- China
- Prior art keywords
- oral liquid
- fengwangjiang
- heating
- koufuye
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- Apparatus For Disinfection Or Sterilisation (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a disinfecting method. If a steam heating disinfecting method is adopted to treat an oral liquid preparation, the appearance quality of the product can be influenced, and effective components can be destroyed. In the method of the present invention, an oral liquid preparation is heated by water with temperature lower than 75 DEG C for 5 to 30 minutes. Yeast can be killed, and the oral liquid preparation is uniformly heated, so that the external appearance and the internal quality of the product can not be influenced.
Description
What the present invention relates to is a kind of sterilizing methods, particularly a kind of method of sterilizing with heating.
To oral liquid, for example various oral Chinese patent medicine liquid, nutritional solution and beverage etc. adopt the Steam Heating sterilizing methods usually.Steam-heated temperature height, and be easy to generate the hot-spot phenomenon.Many oral liquids particularly contain the oral liquid of Lac regis apis, as adopt this Steam Heating method, and are very big to the influence of its face shaping and active ingredient thereof.In order to address these problems, to containing FENGWANGJIANG KOUFUYE, the Lac regis apis raw material is adopted freezing sterilization treatment at present, yet concerning yeast wherein, only play a kind of effect that suppresses its breeding, do not reach the effect of sterilization at all.And yeast distributes and extensively, all very likely microbiological contaminations of overall process in that oral liquid is produced cause the yeast in the product can't obtain real control.Product usually causes " sudden and violent bottle " problem because of microbiological contamination.This not only makes the quality of product descend, and has a strong impact on the prestige of Producer.
The object of the present invention is to provide and a kind ofly can play good sterilization effect, do not influence the sterilizing methods that contains FENGWANGJIANG KOUFUYE of product quality.
The object of the present invention is achieved like this: will contain FENGWANGJIANG KOUFUYE and be heated to more than 58 ℃ with 60-75 ℃ water, and keep 5-30 minute.
The mode of water heating can be spray heating, heating in water bath or spray heating and heating in water bath.
The water heating has temperature constant, heating gentleness, the advantage that is heated evenly.The method of water heating is carried out sterilization treatment to oral liquid, can eliminate the hot-spot phenomenon.The temperature of the heating water that the present invention is used is not higher than 75 ℃, with the oral liquid heat treated, can receive the saccharomycetic effect of good elimination under this temperature.Can fundamentally solve " the sudden and violent bottle " of oral liquid finished product, denaturalization phenomenon, the limit of extending the expiration date.Heating-up temperature of the present invention is low, the heat treated time short, can not influence the outward appearance of oral liquid, and can guarantee that the active ingredient in the oral liquid is unaffected.The sterilization treatment of the preparation that oral liquid that method of the present invention is particularly suitable for containing Lac regis apis etc. is at high temperature apt to deteriorate.
Below for example to the present invention's more detailed description again:
1, will contain FENGWANGJIANG KOUFUYE and spray heat treated with 60-75 ℃ hot water.The temperature of oral liquid is reached more than 58 ℃, and kept 5-30 minute.
2, will contain FENGWANGJIANG KOUFUYE and carry out heat treated with 60-75 ℃ hot bath.The temperature of oral liquid is reached more than 58 ℃, and kept 5-30 minute.
3, will contain FENGWANGJIANG KOUFUYE and spray heat treated with 60-70 ℃ hot water.Make the temperature of oral liquid reach 58-65 ℃, and kept 5-10 minute.
4, will contain FENGWANGJIANG KOUFUYE and carry out heat treated with 60-75 ℃ hot bath.Make the temperature of oral liquid reach 58-65 ℃, and kept 5-15 minute.
5, will contain the first hot water with 60-75 ℃ of FENGWANGJIANG KOUFUYE sprayed The pre-heat treatment 2-5 minute.In 60-75 ℃ water-bath, carry out heat treated again.What spray The pre-heat treatment and heating in water bath were handled is no more than 25 minutes total time.The spray The pre-heat treatment is handled with heating in water bath and is combined, and can make being heated of oral liquid more even.
6, will contain FENGWANGJIANG KOUFUYE sprayed The pre-heat treatment 2-5 minute with 60-75 ℃ of hot water earlier.In 60-65 ℃ water-bath, carry out heat treated again.What spray The pre-heat treatment and heating in water bath were handled is no more than 25 minutes total time.
Claims (8)
1, a kind of sterilizing methods that contains FENGWANGJIANG KOUFUYE is characterized in that: will contain FENGWANGJIANG KOUFUYE and be heated to more than 58 ℃ with 60-75 ℃ water, and keep 5-30 minute.
2, the sterilizing methods that contains FENGWANGJIANG KOUFUYE according to claim 1 is characterized in that: the mode of heating is the spray heating.
3, the sterilizing methods that contains FENGWANGJIANG KOUFUYE according to claim 2, it is characterized in that: oral liquid sprays heat treated with 60-70 ℃ hot water, makes the temperature of oral liquid remain on 58-65 ℃, handles 5-10 minute.
4, the sterilizing methods that contains FENGWANGJIANG KOUFUYE according to claim 1, it is characterized in that: the mode of heating is a heating in water bath.
5, the sterilizing methods that contains FENGWANGJIANG KOUFUYE according to claim 4 is characterized in that: oral liquid carries out heat treated with 60-70 ℃ hot bath, makes the temperature of oral liquid remain on 58-65 ℃, and keeps 5-10 minute.
6, the sterilizing methods that contains FENGWANGJIANG KOUFUYE according to claim 1 is characterized in that: mode of heating is spray preheating and heating in water bath.
7, the sterilizing methods that contains FENGWANGJIANG KOUFUYE according to claim 6, it is characterized in that: oral liquid elder generation sprayed The pre-heat treatment 2-5 minute with 60-75 ℃ hot water, heat treated in 60-70 ℃ water-bath again, what spray The pre-heat treatment and heating in water bath were handled is no more than 25 minutes total time.
8, the sterilizing methods that contains FENGWANGJIANG KOUFUYE according to claim 7 is characterized in that: the temperature of heating in water bath is 60-65 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95107846 CN1070079C (en) | 1995-07-17 | 1995-07-17 | Disinfacting method for oral liquid preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95107846 CN1070079C (en) | 1995-07-17 | 1995-07-17 | Disinfacting method for oral liquid preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1140610A CN1140610A (en) | 1997-01-22 |
| CN1070079C true CN1070079C (en) | 2001-08-29 |
Family
ID=5076469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 95107846 Expired - Fee Related CN1070079C (en) | 1995-07-17 | 1995-07-17 | Disinfacting method for oral liquid preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1070079C (en) |
-
1995
- 1995-07-17 CN CN 95107846 patent/CN1070079C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1140610A (en) | 1997-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: HAOYAO GROUP SANJING PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: HARBIN NO.3 PHARMACEUTICAL FACTORY Effective date: 20010817 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20010817 Address after: 150090 No. 34, Nangang, Harbin District, Heilongjiang, Hengshan Road Patentee after: Sanjing Pharmaceutical Co., Ltd., Hayao Group Address before: 150010 Heilongjiang city of Harbin province Daoli District Jihong Street No. 24 Patentee before: Harbin No.3 Pharmaceutical Factory |
|
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |