CN107007477A - 一种多层改性法的改性膜布制备工艺及其产品 - Google Patents

一种多层改性法的改性膜布制备工艺及其产品 Download PDF

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CN107007477A
CN107007477A CN201610055095.6A CN201610055095A CN107007477A CN 107007477 A CN107007477 A CN 107007477A CN 201610055095 A CN201610055095 A CN 201610055095A CN 107007477 A CN107007477 A CN 107007477A
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李和伟
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Abstract

本发明涉及膜制用品技术领域，涉及一种膜布的制备工艺，特别是一种通过多层改性法制备的改性膜布及其产品，以使本发明提供的改性膜布具有较好的保湿功能、更强的皮肤驻留性，且在保存及使用时无需额外添加防腐体系。同时对比单层改性的膜布，具有使用体验更为舒适、功效物质溶出和吸收更佳等特性。

Description

一种多层改性法的改性膜布制备工艺及其产品
技术领域
本发明涉及膜制用品技术领域，涉及一种膜布的制备工艺，特别是一种通过多层改性法制备的改性膜布及其产品。
背景技术
面膜和湿纸巾等采用膜布为基材或载体，配合一定量的水、功效成分或营养成分来使用，属于膜制用品。目前比较常见的面膜布有无纺布面膜布和蚕丝面膜布等，市场上的面膜产品通常需要将这些面膜布浸泡在水体系环境，如精华液中以包装销售。
为了获得更好的肤感，以及避免精华液很快挥发掉等，需要在面膜的精华液体系中加入油相和水相，而由于在液体环境中同时有油相和水相，则需要纳入乳化剂和消泡剂等表面活性剂；由于水体系配合功效成分或营养成分后会变得极易变质、氧化和发酵等，在面膜中还需要添加防腐剂和杀菌、抑菌剂等添加剂，才能保证面膜的保水性和在货架期内不变质。
但是，面膜等产品中的防腐剂和抑菌剂等会带来一系列负面效果，如发生过敏、接触性皮炎，这样非但不能保护皮肤，得到预想效果，反而会损害皮肤；而面膜等产品如果不纳入防腐体系，那么，其在货架期内的产品质量则难以得到保证。
发明内容
为了解决以上技术问题，本发明提供一种改性膜布的多层法制备工艺及其应用。
本发明提供的改性膜布具有较好的保湿功能、更强的皮肤驻留性，且在保存及使用时无需额外添加防腐体系。同时对比单层改性的膜布，具有使用体验更为舒适、功效物质溶出和吸收更佳等特性。
一种多层改性法的改性膜布制备工艺，其特征在于，包括如下步骤：
A、干燥膜布涂布含有高分子材料的含水溶液并干燥，得到预改性膜布；
B、将预改性膜布涂布含有高分子材料的含水溶液并干燥；
C、将预改性膜布直接涂布市售预配制的高分子分散体或涂布高分子材料的油溶液；
D、如果需要，可以重复以上B、C步骤，直至得到所需性质的改性膜布。
所述步骤A、B和C中所述高分子材料的含量优选为0.01～95％，更优选为5～80％。
所述聚合物或聚合物分散体对膜布的比例为0.01g/m2～100g/m2。优选0.3g/m2～50g/m2，0.3g/m2～30g/m2，0.3g/m2～10g/m2，0.5g/m2～50g/m2，0.5g/m2～30g/m2，0.5g/m2～10g/m2，0.7g/m2～50g/m2，0.7g/m2～30g/m2，0.7g/m2～10g/m2，1.2g/m2～50g/m2，1.2g/m2～30g/m2，1.2g/m2～10g/m2，1.5g/m2～50g/m2，1.5g/m2～30g/m2，1.5g/m2～10g/m2，1.8g/m2～50g/m2，1.8g/m2～30g/m2，1.8g/m2～10g/m2，最优选为1g/m2～15g/m2。
所述干燥是指使膜布或改性膜布呈不含或基本不含水或者酒精等有机溶媒的干燥状态。
所述涂布方式选自浸泡、喷雾、喷洒、滚筒或涂膜中的一种。
所述脱水方式选自烘干、减压干燥、冷冻干燥、微波干燥、红外干燥、RW薄层干燥中的一种或几种。
所述膜布的材质为选自蚕丝、果纤、天丝、竹炭、纸、全棉、涤纶和混纺布中的一种或一种以上的组合。
所述所述聚合物或聚合物分散体中的聚合物选自多糖、多肽或蛋白质；也可选自人工高分子聚合物；或者是经过改性的天然高分子材料或其混合物，包括但不限于明胶类(明胶、水解明胶等)、纤维素醚类(羧甲基纤维素，羟乙基甲基纤维素等)、改性淀粉类(普鲁兰糖、羟丙基淀粉等)、PVP、PVA、透明质酸类、白蛋白、壳聚糖、右旋糖酐、阿拉伯胶、黄原胶、卡拉胶、果胶、魔芋胶、琼脂、卡波姆、角叉菜胶、聚乙烯吡咯烷酮、聚丙烯酰胺、聚丙烯酸酯和聚丙烯酸及其衍生物中的一种或多种。
所述聚合物分散体可以来源于市场采购或自行配制。
所述来源于市场采购的聚合物分散体，可以选自SEPPIC公司型号为Sepigel305的产品或道康宁公司型号为DC2501的产品或BASF公司型号为Luvigel的产品。
所述自行配制的聚合物分散体，可以将聚合物分散于液态油脂制得，所述液态油脂与聚合物的质量比为1：10～10：1；更优选为1:5～5:1，1:4～4:1，1:3-3:1，1:2～2:1，最优选1:3-3:1。
所述液态油脂选自扁桃油、杏仁油、橄榄油、芝麻油、茶籽油、棕榈酸乙基己酯、牛油果树果酯、月桂酸己酯、碳酸二辛酯、辛酸丙基庚酯、油醇或甘油三酯中的一种或一种以上的组合。
所述聚合物或聚合物分散体中还含有活性物质，所述活性物质选自化学药物成分、中药成分、生物活性成分、皮肤有益成分、微量元素和天然提取物中的一种或一种以上的组合。
化学药物成分(药物活性成分)：
解热镇痛抗炎药，例如阿司匹林、二氟尼柳、双水杨酯、对乙酰氨基酚、吲哚美辛、布洛芬、萘普生、酮洛芬、吡洛芬、舒洛芬、氟比洛芬、吡罗昔康、美洛昔康、尼美舒利、苯溴马隆等；
中枢兴奋药，例如匹莫林、阿屈非尼、吡拉西坦等；
治疗偏头痛药，例如琥珀酸舒马普坦；
镇痛药，例如罗通定、丁丙诺啡、喷他佐辛、纳洛酮等；
抗帕金森病和治疗老年痴呆药，例如左旋多巴、复方卡比多巴、复方苄丝肼、盐酸金刚烷胺、吡贝地尔、普罗酚胺、多奈哌齐、石杉碱甲等；
抗精神失常药，例如氯丙嗪、异丙嗪、哌替啶、硫利达嗪、氯普噻吨、氯氮平、舒必利、泰必利、五氟利多、利培酮等；
抗癫痫病和抗惊厥药，例如苯妥英钠、卡马西平、扑米酮、加巴喷丁、拉莫三嗪、丙戊酸钠、氯硝西泮等。镇静催眠药，例如地西泮、硝西泮、奥沙西泮、劳拉西泮、苯巴比妥等；
胆碱酯酶抑制药，例如东莨菪碱等；
抗心律失常药，例如丙吡啶、妥卡尼、美西律、乙吗噻嗪、苯妥英钠、普罗帕酮、胺碘酮等；
抗心绞痛与抗动脉粥样硬化药，例如普萘洛尔、硝苯地平、吉非贝齐、苯扎贝特、洛伐他汀、辛伐他汀、普伐他汀等；
抗高血压药，例如依拉普利、卡托普利、氢氯噻嗪、氨氯地平等；
肾上腺受体阻断剂，例如醋丁洛尔、阿普洛尔等；
皮质甾类药，例如倍他米松、醋酸可的松等；
抗糖尿病药，例如瑞格列奈等；
抗甲状腺药，例如丙硫氧嘧啶、卡比马唑、甲巯咪唑等；
抗组织胺药，例如盐酸西替利嗪、氯雷他定等；
自体活性物质，例如地诺前列酮、前列地尔、倍他司汀等；
消化系统用药，例如丁溴东莨菪碱、盐酸格拉司琼等；
血液系统药，例如EPO、腺苷钴胺等；
泌尿系统药，例如阿佐塞米、呋塞米等；
生殖系统药，例如雌激素、苯丙酸诺龙等；
抗寄生虫药，例如阿苯达唑、坎苯达唑等；
抗肿瘤药，例如氨鲁米特、安吖啶等；
抗微生物药，例如氨苄西林、磺苄西林钠等；
抗生素类药，例如阿莫西林、头孢氨苄、头孢丙烯、头孢呋辛酯、罗红霉素、琥乙红霉素、交沙霉素等。中药成分：
中药有效成分单体，如：灯盏花素、青蒿素、石杉碱甲、延胡索乙素等；
单味中药材提取物及复方中药提取物，如：丹参酮提取物、丹参总酚酸提取物、复方丹参滴丸提取物、牛黄上清丸复方提取物、人参茎叶总皂苷、北豆根提取物、人参总皂苷、西洋参总皂苷、灯盏花素、肿节风浸膏、三七总皂苷、茵陈提取物、大黄浸膏、穿心莲内酯、山楂叶提取物、积雪草总苷、银杏叶提取物等。天然植物提取物：如芦荟提取物、山药提取物、越橘提取物、苦瓜提取物、紫锥菊提取物、小白菊提取物、山竹提取物、松针及松树皮提取物、巴西黑莓提取物、桑葚提取物、接骨木果提取物、蔓越莓提取物、虾青素、番茄红素、绿茶提取物、葡萄籽及葡萄皮提取物、光甘草定、芍药苷、甘草黄酮、丹皮提取物等。生物活性成分：EGF、bFGF、aFGF、KGF、IGF、NGF、TGF、HGH等。
皮肤护理有益成分：维生素A、维生素B1、维生素B2、维生素B3、维生素B6、维生素B12、维生素C、维生素D、维生素E、维生素K、辅酶类、蛋白酶、金属硫蛋白、珍珠及其水解物、牛乳及其提取物、花粉及其提取物、蜂王浆、蜂胶等。
本发明提供产品，为上述任意一项制备方法制备得到的产品。
所述产品为任意尺寸、形状、颜色、气味，并可以应用于化妆品、医疗器械或药品领域。
与现有技术相比，本发明通过对聚合物或聚合物分散体的物理性质进行比对，与膜布高附着性的预改性层对膜布的使用感受起到了提升作用，同时使后续进行的多次涂布更易脱离膜布纤维，在使用时被吸收。
同时，上述高分子聚合物本身不易产生变质，且改性膜布在保存期内由于不会接触到水分而免于纳入防腐体系，使产品本身更安全，使用者可更少接触到防腐剂和抗菌剂等不利于健康的添加剂。
具体实施方式
为了进一步理解本发明，下面结合实施例对本发明优选实施方案进行描述，但是应当理解，这些描述只是为进一步说明本发明的特征和优点，而不是对本发明权利要求的限制。
实施例1
将银耳多糖加水搅拌溶解，制成含量为0.8％的高分子聚合物水溶液；
将上述水溶液喷涂到备好的全棉膜布上，其银耳多糖对膜布的比例为5g/㎡，得到预涂布高分子聚合物膜布；
将上述膜布放入烘箱中烘干去除水分，作为预改性膜布。
将透明质酸加水搅拌溶解，制成含量为1％的高分子聚合物水溶液；
将上述水溶液喷涂到预改性膜布上，其透明质酸对膜布的比例为10g/m2，并通过红外薄膜干燥去除水分，得到改性膜布产品。
使用时将纯化水加入上述改性膜布中，加入量为200ml/m2，形成一个具有一定保湿性和液体驻留性的新型面膜。将所述新型面膜敷在皮肤表面，保持膜布处于垂直状态，能够保持30分钟以上，且面膜依然湿润、紧贴于皮肤表面。
实施例2
将扁桃油与将聚乙烯吡咯烷酮按1:8的质量比例进行溶解分散，得到聚合物分散体；
将上述聚合物分散体按照2g/m2的比例滚涂到备好的无纺布膜布上，得到预涂布高分子聚合物膜布，经过红外薄膜干燥去除水分，作为预改性膜布。
将卡波姆：三乙醇胺＝3:2质量比例溶解于水溶液中，得到聚合物分散体；
将上述聚合物分散体按照10g/m2的比例喷涂到预改性膜布上，再次进行红外薄膜干燥去除水分，得到改性膜布。
使用时将纯化水加入上述改性膜布中，加入量为100ml/m2，形成一个具有一定保湿性和液体驻留性的新型医用敷料。将所述新型敷料敷在皮肤表面，保持膜布处于垂直状态，能够保持30分钟以上，且面膜依然湿润、紧贴于皮肤表面。
实施例3
将黄原胶加水搅拌溶解，制成含量为0.2％的高分子聚合物水溶液，将无纺布药用敷贴浸入上述水溶液中，再将上述膜布放入冻干机中冷冻干燥去除水分，得到预改性膜布，其中黄原胶对贴片的比例为2g/m2。
配制0.5％透明质酸钠水溶液，将适量水杨酸酯进行分散，涂布于预改性膜布上，再次进行冷冻干燥，得到改性膜布，其中透明质酸钠-水杨酸酯对贴片的比例是10g/m2。
使用时，将水按照50mL/m2的比例加入新型改性膜布镇痛贴片；上述镇痛贴片在皮肤表面，保持膜布处于垂直状态，能够保持30分钟以上，且膜布依然湿润紧贴于皮肤表面。
实施例4
将0.3％羟丙基纤维素、0.2％聚谷氨酸、0.1％熊果苷制成水溶液分散体；
将上述聚合物分散体按照3g/m2的比例滚涂到备好的蚕丝面膜上，得到预涂布高分子聚合物面膜，进行烘干去除水分，作为预改性膜布。
将橄榄油与聚丙烯酸按照1:1的质量比例进行溶解分散，得到聚合物分散体，直接喷涂于预改性膜布上，得到改性膜布。
与维生素C冻干赋型制剂、纯化水分别包装后得到新型即配即用的美白面膜，本产品无需添加任何防腐抑菌成分。
使用时将纯化水与维生素C冻干赋型制剂混合溶解得到美白精华液，再按照120mL/m2的比例将所述美白精华液加入上述改性膜布面膜中，形成一个具有一定保湿性和液体驻留性的新型美白面膜。上述美白面膜敷在面部，保持膜布处于垂直状态，能够保持30分钟以上，且膜布依然湿润、紧贴于面部。
本发明所涉及的成分组成、形态和制备方式并不限于实施例中所列举的形式，实施例仅为本发明的较佳实施例而已，不能以此限定保护范围。凡以本发明的权利要求范围所述的简单的或等效的变化及修饰，皆属于本发明的保护范围。

Claims (12)

1.一种多层改性法的改性膜布制备工艺，其特征在于，包括如下步骤：
A、干燥膜布涂布含有高分子材料的含水溶液并干燥，得到预改性膜布；
B、将预改性膜布涂布含有高分子材料的含水溶液并干燥；
C、将预改性膜布直接涂布市售预配制的高分子分散体或涂布高分子材料的油溶液；
D、如果需要，可以重复以上B、C步骤，直至得到所需性质的改性膜布。
2.根据权利要求1所述的制备工艺，其特征在于，步骤A、B和C中所述高分子材料的含量优选为0.01～95％，更优选为5～80％。
3.根据权利要求1和2所述的制备工艺，其特征在于，所述高分子材料对膜布的比例为0.01g/m2～100g/m2。
4.根据权利要求1至3所述的制备工艺，其特征在于，所述干燥是指使膜布或改性膜布呈不含或基本不含水或者酒精等有机溶媒的干燥状态。
5.根据权利要求1至4所述的制备工艺，其特征在于，所述涂布方式选自浸泡、喷雾、喷洒、滚筒或涂膜中的一种。
6.根据权利要求1至5所述的制备工艺，其特征在于，所述脱水方式选自烘干、减压干燥、冷冻干燥、微波干燥、红外干燥、RW薄层干燥中的一种或几种。
7.根据权利要求1至6任一项所述的制备工艺，其特征在于，所述膜布的材质为选自蚕丝、果纤、天丝、竹炭、纸、全棉、涤纶和混纺布中的一种或一种以上的组合。
8.根据权利要求1至7所述的制备工艺，其特征在于，所述所述高分子材料选自多糖、多肽或蛋白质；也可选自人工高分子聚合物；或者是经过改性的天然高分子材料或其混合物，包括但不限于明胶类(明胶、水解明胶等)、纤维素醚类(羧甲基纤维素，羟乙基甲基纤维素等)、改性淀粉类(普鲁兰糖、羟丙基淀粉等)、PVP、PVA、透明质酸类、白蛋白、壳聚糖、右旋糖酐、阿拉伯胶、黄原胶、卡拉胶、果胶、魔芋胶、琼脂、卡波姆、角叉菜胶、聚乙烯吡咯烷酮、聚丙烯酰胺、聚丙烯酸酯和聚丙烯酸及其衍生物中的一种或多种；还可以是聚合物分散体，可以选自SEPPIC公司型号为Sepigel305的产品或道康宁公司型号为DC2501的产品或BASF公司型号为Luvigel的产品，也可以将聚合物分散于液态油脂制得，所述液态油脂选自扁桃油、杏仁油、橄榄油、芝麻油、茶籽油、棕榈酸乙基己酯、牛油果树果酯、月桂酸己酯、碳酸二辛酯、辛酸丙基庚酯、油醇或甘油三酯中的一种或一种以上的组合，所述液态油脂与聚合物的质量比为1：10～10：1。
9.根据权利要求1-8任一项所述的制备工艺，其特征在于，所述高分子材料溶液中还含有活性物质，所述活性物质选自化学药物成分、中药成分、生物活性成分、皮肤有益成分、微量元素和天然提取物中的一种或一种以上的组合。
10.由权利要求1-9中任意一项制备方法制备得到的产品。
11.根据权利要求10所述的产品，其特征在于，其为任意尺寸、形状、颜色、气味。
12.根据权利要求10、11所述的产品，其特征在于，可以应用于化妆品、医疗器械或药品领域。
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